2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Inflammation in 72 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Previous studies have shown that during severe acute pancreatitis (SAP) attacks, hydrogen sulfide (H2S) is released in the colon." | 7.96 | Release of endogenous hydrogen sulfide in enteric nerve cells suppresses intestinal motility during severe acute pancreatitis. ( Liao, R; Liu, Y; Qiang, Z; Xue, L; Zhang, C, 2020) |
| "These data suggest that the PI3K/Akt/mTOR pathway contributes to sevoflurane-induced neuroinflammation and that activation of PI3K/Akt/mTOR signaling by DEX could help reduce the neuroinflammatory effects of sevoflurane." | 7.91 | Dexmedetomidine suppresses sevoflurane anesthesia-induced neuroinflammation through activation of the PI3K/Akt/mTOR pathway. ( Wang, M; Wang, N, 2019) |
| "Ivabradine not only reduces heart rate but has other cardiac and vascular protective effects including anti-inflammation and anti-oxidation." | 7.83 | Ivabradine Prevents Low Shear Stress Induced Endothelial Inflammation and Oxidative Stress via mTOR/eNOS Pathway. ( Chen, S; Li, B; Wang, Z; Zhang, J, 2016) |
| "Previous studies have shown that during severe acute pancreatitis (SAP) attacks, hydrogen sulfide (H2S) is released in the colon." | 3.96 | Release of endogenous hydrogen sulfide in enteric nerve cells suppresses intestinal motility during severe acute pancreatitis. ( Liao, R; Liu, Y; Qiang, Z; Xue, L; Zhang, C, 2020) |
| "These data suggest that the PI3K/Akt/mTOR pathway contributes to sevoflurane-induced neuroinflammation and that activation of PI3K/Akt/mTOR signaling by DEX could help reduce the neuroinflammatory effects of sevoflurane." | 3.91 | Dexmedetomidine suppresses sevoflurane anesthesia-induced neuroinflammation through activation of the PI3K/Akt/mTOR pathway. ( Wang, M; Wang, N, 2019) |
| "Ivabradine not only reduces heart rate but has other cardiac and vascular protective effects including anti-inflammation and anti-oxidation." | 3.83 | Ivabradine Prevents Low Shear Stress Induced Endothelial Inflammation and Oxidative Stress via mTOR/eNOS Pathway. ( Chen, S; Li, B; Wang, Z; Zhang, J, 2016) |
| "Uveitis is a prevalent inflammatory eye disease that damages the vision of patients and even leads to blindness." | 1.72 | LY294002 attenuates inflammatory response in endotoxin-induced uveitis by downregulating JAK3 and inactivating the PI3K/Akt signaling. ( Chen, W; Li, D; Pu, L; Wu, G; Wu, X; Zhao, Q; Zhu, H, 2022) |
| "To observe the effect of acupuncture preconditioning combined with PI3K blocker LY294002 on the expression of PI3K and Akt proteins and genes in the lung tissue and the contents of serum IL-12 and IL-13 in asthmatic rats, so as to explore its preprotective mechanism underlying improving asthma." | 1.72 | [Effect of acupuncture preconditioning combined with PI3K blocker LY294002 on airway inflammation in asthmatic rats]. ( Chen, F; Gong, JJ; Hua, JS; Li, HJ; Yan, HY; Zhang, YY, 2022) |
| "Zileuton and LY294002 were used to inhibit expression of 5-LOX and Akt, respectively." | 1.62 | 5-Lipoxygenase inhibition reduces inflammation and neuronal apoptosis via AKT signaling after subarachnoid hemorrhage in rats. ( Chen, H; Deng, Y; Guo, Z; He, Z; Liang, Y; Liu, L; Sun, X; Zhang, P; Zhang, Z, 2021) |
| "TNF-α treatment enhanced inflammation and suppressed autophagy in HaCaT and NHEK cells, which were largely reversed by overexpression of lncRNA MEG3." | 1.62 | LncRNA MEG3 suppresses PI3K/AKT/mTOR signalling pathway to enhance autophagy and inhibit inflammation in TNF-α-treated keratinocytes and psoriatic mice. ( Jia, HY; Lv, SC; Tang, ZL; Xu, GW; Zhang, JF; Zhang, K, 2021) |
| "Trigonelline is a plant alkaloid that has generated interest for its neuroprotective roles in brain pathology." | 1.56 | Trigonelline protects hippocampal neurons from oxygen-glucose deprivation-induced injury through activating the PI3K/Akt pathway. ( Fan, X; Jiang, C; Li, J; Qiu, Z; Su, Y; Wang, K; Xue, S; Yao, L, 2020) |
| "Inflammation is a critical component involved in tumor progression." | 1.43 | Non-tumor tissue derived interleukin-17B activates IL-17RB/AKT/β-catenin pathway to enhance the stemness of gastric cancer. ( Bie, Q; Gong, A; Guo, Q; Ji, X; Li, C; Su, Z; Sun, C; Wang, S; Wu, Y; Xu, H; Zheng, D, 2016) |
| "In conclusion, DGAEE alleviates septic shock through DGA in an IL-10-dependent manner, and the mechanism is related to inactivation of GSK3β." | 1.42 | DGAEE, a newly synthesized derivative of glycyrrhetinic acid, potently attenuates mouse septic shock via its main metabolite DGA in an IL-10-dependent manner. ( Dai, Y; Dou, Y; Liu, M; Luo, J; Wei, Z; Wu, X; Xia, Y, 2015) |
| "Leptin is an adipocyte-derived hormone/cytokine that links nutritional status with neuroendocrine and immune functions." | 1.35 | Leptin induces macrophage lipid body formation by a phosphatidylinositol 3-kinase- and mammalian target of rapamycin-dependent mechanism. ( Almeida, PE; Bozza, PT; Castro-Faria-Neto, H; D'Avila, H; Martins, AS; Maya-Monteiro, CM; Rezende, AP, 2008) |
| " Importantly, this was achieved when dosing well after myocardial reperfusion (up to 3 h after), the same time period when patients are most accessible for therapeutic intervention." | 1.33 | Phosphoinositide 3-kinase gamma/delta inhibition limits infarct size after myocardial ischemia/reperfusion injury. ( Cheresh, D; Demaria, A; Dneprovskaia, E; Doukas, J; Fine, R; Hood, J; Noronha, G; Soll, R; Weis, S; Wrasidlo, W, 2006) |
| "Wortmannin treatment also increased the number of macrophages in the liver and kidney of endotoxemic mice." | 1.32 | PI3K-Akt pathway suppresses coagulation and inflammation in endotoxemic mice. ( Mackman, N; Pawlinski, R; Pedersen, B; Schabbauer, G; Tencati, M, 2004) |
| "Therefore, PI3K induces heat hyperalgesia, possibly by regulating TRPV1 activity, in an ERK-dependent manner." | 1.32 | Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization. ( Clapham, DE; Ji, RR; Xu, H; Zhuang, ZY, 2004) |
| "Inflammatory breast cancer (IBC) is the most lethal form of locally advanced breast cancer known." | 1.31 | Mitogen activated protein kinase pathway is involved in RhoC GTPase induced motility, invasion and angiogenesis in inflammatory breast cancer. ( Bao, LW; Merajver, SD; Miller, FR; Pan, Q; van Golen, KL; Wu, ZF, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 26 (36.11) | 29.6817 |
| 2010's | 34 (47.22) | 24.3611 |
| 2020's | 12 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Doukas, J | 1 |
| Wrasidlo, W | 1 |
| Noronha, G | 1 |
| Dneprovskaia, E | 1 |
| Fine, R | 1 |
| Weis, S | 1 |
| Hood, J | 1 |
| Demaria, A | 1 |
| Soll, R | 1 |
| Cheresh, D | 1 |
| Cushing, TD | 1 |
| Metz, DP | 1 |
| Whittington, DA | 1 |
| McGee, LR | 1 |
| Eräsalo, H | 2 |
| Hämäläinen, M | 2 |
| Leppänen, T | 2 |
| Mäki-Opas, I | 1 |
| Laavola, M | 2 |
| Haavikko, R | 1 |
| Yli-Kauhaluoma, J | 1 |
| Moilanen, E | 2 |
| Wu, X | 2 |
| Pu, L | 1 |
| Chen, W | 1 |
| Zhao, Q | 1 |
| Wu, G | 1 |
| Li, D | 1 |
| Zhu, H | 2 |
| Hua, JS | 1 |
| Li, HJ | 1 |
| Chen, F | 1 |
| Gong, JJ | 1 |
| Zhang, YY | 1 |
| Yan, HY | 1 |
| Lin, Y | 1 |
| Zhu, X | 1 |
| Li, Y | 1 |
| Dou, Y | 2 |
| Wang, J | 2 |
| Qi, R | 2 |
| Ma, L | 1 |
| Ye, C | 1 |
| Huang, C | 2 |
| Zou, M | 1 |
| Hu, Y | 1 |
| Luo, L | 2 |
| Wei, Y | 1 |
| Wan, X | 1 |
| Zhao, H | 1 |
| Li, W | 1 |
| Cai, S | 1 |
| Dong, H | 1 |
| Liao, R | 1 |
| Xue, L | 1 |
| Qiang, Z | 1 |
| Zhang, C | 1 |
| Liu, Y | 1 |
| Qiu, Z | 1 |
| Wang, K | 1 |
| Jiang, C | 1 |
| Su, Y | 1 |
| Fan, X | 1 |
| Li, J | 3 |
| Xue, S | 1 |
| Yao, L | 1 |
| Hu, Z | 1 |
| Su, H | 1 |
| Zeng, Y | 1 |
| Lin, C | 1 |
| Guo, Z | 2 |
| Zhong, F | 1 |
| Jiang, K | 1 |
| Yuan, G | 2 |
| He, S | 1 |
| Patruno, A | 1 |
| Costantini, E | 1 |
| Ferrone, A | 1 |
| Pesce, M | 1 |
| Diomede, F | 1 |
| Trubiani, O | 1 |
| Reale, M | 1 |
| Yang, Y | 2 |
| Zhu, M | 1 |
| Shi, X | 1 |
| Ye, L | 1 |
| Zhang, S | 1 |
| Fang, H | 1 |
| Yu, W | 1 |
| Jian, X | 1 |
| Sun, H | 1 |
| Qin, J | 1 |
| Wang, Y | 2 |
| Zhang, J | 2 |
| Shen, Z | 1 |
| Yang, D | 1 |
| Li, C | 2 |
| Zhao, P | 1 |
| Liu, M | 3 |
| Tian, Z | 1 |
| Zhou, Y | 1 |
| Ni, XQ | 1 |
| Zhang, YR | 1 |
| Jia, LX | 1 |
| Lu, WW | 1 |
| Zhu, Q | 1 |
| Ren, JL | 1 |
| Chen, Y | 2 |
| Zhang, LS | 1 |
| Liu, X | 1 |
| Yu, YR | 1 |
| Jia, MZ | 1 |
| Ning, ZP | 1 |
| Du, J | 1 |
| Tang, CS | 1 |
| Qi, YF | 1 |
| Liu, L | 1 |
| Zhang, P | 1 |
| Zhang, Z | 1 |
| Liang, Y | 1 |
| Chen, H | 1 |
| He, Z | 2 |
| Sun, X | 1 |
| Deng, Y | 1 |
| Tang, ZL | 1 |
| Zhang, K | 1 |
| Lv, SC | 1 |
| Xu, GW | 1 |
| Zhang, JF | 1 |
| Jia, HY | 1 |
| Chen, J | 2 |
| Wang, Z | 3 |
| Zheng, Z | 1 |
| Khor, S | 1 |
| Shi, K | 1 |
| Wang, Q | 1 |
| Zhao, Y | 1 |
| Zhang, H | 1 |
| Li, X | 3 |
| Yin, J | 1 |
| Wang, X | 1 |
| Xiao, J | 1 |
| Feng, S | 1 |
| Zhang, L | 1 |
| Bian, XH | 1 |
| Luo, Y | 1 |
| Qin, GH | 1 |
| Shi, RM | 1 |
| Zhang, N | 1 |
| Wang, S | 2 |
| Wen, Y | 1 |
| Wu, Y | 2 |
| Gao, M | 1 |
| Wu, J | 1 |
| Hu, P | 1 |
| Xu, X | 1 |
| Zhang, Y | 1 |
| Wang, D | 1 |
| Chen, Z | 1 |
| Wang, N | 1 |
| Wang, M | 1 |
| Chen, X | 2 |
| Hu, C | 1 |
| Wang, G | 1 |
| Li, L | 1 |
| Kong, X | 1 |
| Ding, Y | 1 |
| Jin, Y | 1 |
| Stachel, I | 1 |
| Geismann, C | 1 |
| Aden, K | 1 |
| Deisinger, F | 1 |
| Rosenstiel, P | 1 |
| Schreiber, S | 1 |
| Sebens, S | 1 |
| Arlt, A | 1 |
| Schäfer, H | 1 |
| Nieminen, R | 1 |
| Huang, JD | 1 |
| Amaral, J | 1 |
| Lee, JW | 1 |
| Rodriguez, IR | 1 |
| Huang, J | 1 |
| Yue, S | 1 |
| Ke, B | 1 |
| Zhu, J | 1 |
| Shen, XD | 1 |
| Zhai, Y | 1 |
| Yamamoto, M | 1 |
| Busuttil, RW | 1 |
| Kupiec-Weglinski, JW | 1 |
| Zha, L | 1 |
| Sun, S | 1 |
| Mao, L | 1 |
| Chu, X | 1 |
| Deng, H | 1 |
| Cai, J | 1 |
| Liu, Z | 1 |
| Cao, W | 1 |
| Choi, S | 1 |
| Nguyen, VT | 1 |
| Tae, N | 1 |
| Lee, S | 1 |
| Ryoo, S | 1 |
| Min, BS | 1 |
| Lee, JH | 1 |
| Bao, W | 1 |
| Fu, Y | 1 |
| Jia, X | 1 |
| Vangan, N | 1 |
| Bao, L | 1 |
| Hao, H | 1 |
| Chen, L | 1 |
| Tao, Y | 1 |
| Jiang, Y | 1 |
| Kim, YM | 1 |
| Kim, JH | 1 |
| Park, SW | 1 |
| Kim, HJ | 1 |
| Chang, KC | 1 |
| Tian, Y | 1 |
| Mao-Ying, QL | 1 |
| Liu, H | 1 |
| Wang, ZF | 1 |
| Zhang, MT | 1 |
| Li, Q | 1 |
| Liu, SB | 1 |
| Mi, WL | 1 |
| Ma, HJ | 1 |
| Wu, GC | 1 |
| Wang, YQ | 1 |
| Sun, Z | 1 |
| Mohamed, MAA | 1 |
| Park, SY | 1 |
| Yi, TH | 1 |
| Luo, J | 1 |
| Xia, Y | 1 |
| Dai, Y | 1 |
| Wei, Z | 1 |
| Li, B | 1 |
| Chen, S | 1 |
| Bie, Q | 1 |
| Sun, C | 1 |
| Gong, A | 1 |
| Su, Z | 1 |
| Zheng, D | 1 |
| Ji, X | 1 |
| Guo, Q | 1 |
| Xu, H | 3 |
| Fang, Q | 1 |
| Guo, S | 1 |
| Zhou, H | 1 |
| Han, R | 1 |
| Wu, P | 1 |
| Han, C | 1 |
| Simões, RL | 1 |
| Niconi-de-Almeida, Y | 1 |
| da-Fé, AR | 1 |
| Barja-Fidalgo, C | 1 |
| Fierro, IM | 1 |
| Siragusa, M | 1 |
| Katare, R | 1 |
| Meloni, M | 1 |
| Damilano, F | 1 |
| Hirsch, E | 1 |
| Emanueli, C | 1 |
| Madeddu, P | 1 |
| Hyun, E | 1 |
| Ramachandran, R | 1 |
| Cenac, N | 1 |
| Houle, S | 1 |
| Rousset, P | 1 |
| Saxena, A | 1 |
| Liblau, RS | 1 |
| Hollenberg, MD | 1 |
| Vergnolle, N | 1 |
| Mitroulis, I | 1 |
| Kourtzelis, I | 1 |
| Kambas, K | 1 |
| Rafail, S | 1 |
| Chrysanthopoulou, A | 1 |
| Speletas, M | 1 |
| Ritis, K | 1 |
| Eken, C | 1 |
| Martin, PJ | 1 |
| Sadallah, S | 1 |
| Treves, S | 1 |
| Schaller, M | 1 |
| Schifferli, JA | 1 |
| Medina, EA | 1 |
| Morris, IR | 1 |
| Berton, MT | 1 |
| Paterniti, I | 1 |
| Esposito, E | 1 |
| Mazzon, E | 1 |
| Bramanti, P | 1 |
| Cuzzocrea, S | 1 |
| Keuper, M | 1 |
| Blüher, M | 1 |
| Schön, MR | 1 |
| Möller, P | 1 |
| Dzyakanchuk, A | 1 |
| Amrein, K | 1 |
| Debatin, KM | 1 |
| Wabitsch, M | 1 |
| Fischer-Posovszky, P | 1 |
| Badrnya, S | 1 |
| Butler, LM | 1 |
| Söderberg-Naucler, C | 1 |
| Volf, I | 1 |
| Assinger, A | 1 |
| Chen, BR | 1 |
| Cheng, HH | 1 |
| Lin, WC | 1 |
| Wang, KH | 1 |
| Liou, JY | 1 |
| Chen, PF | 1 |
| Wu, KK | 1 |
| Kwak, YG | 1 |
| Song, CH | 1 |
| Yi, HK | 1 |
| Hwang, PH | 1 |
| Kim, JS | 1 |
| Lee, KS | 1 |
| Lee, YC | 1 |
| Kristof, AS | 1 |
| Marks-Konczalik, J | 1 |
| Billings, E | 1 |
| Moss, J | 1 |
| Sadhu, C | 1 |
| Dick, K | 1 |
| Tino, WT | 1 |
| Staunton, DE | 1 |
| Lee, HT | 1 |
| Lee, JG | 1 |
| Na, M | 1 |
| Kay, EP | 1 |
| Schabbauer, G | 1 |
| Tencati, M | 1 |
| Pedersen, B | 1 |
| Pawlinski, R | 1 |
| Mackman, N | 1 |
| Zhuang, ZY | 1 |
| Clapham, DE | 1 |
| Ji, RR | 1 |
| Chandrasekar, B | 1 |
| Mummidi, S | 1 |
| Claycomb, WC | 1 |
| Mestril, R | 1 |
| Nemer, M | 1 |
| Connelly, L | 1 |
| Madhani, M | 1 |
| Hobbs, AJ | 1 |
| An, H | 1 |
| Zhang, M | 1 |
| Zhou, J | 1 |
| Feng, T | 1 |
| Qian, C | 1 |
| Cao, X | 1 |
| Pinho, V | 1 |
| Souza, DG | 1 |
| Barsante, MM | 1 |
| Hamer, FP | 1 |
| De Freitas, MS | 1 |
| Rossi, AG | 1 |
| Teixeira, MM | 1 |
| Sheu, ML | 1 |
| Chao, KF | 1 |
| Sung, YJ | 1 |
| Lin, WW | 1 |
| Lin-Shiau, SY | 1 |
| Liu, SH | 1 |
| Wang, YY | 1 |
| Myhre, AE | 1 |
| Pettersen, SJ | 1 |
| Dahle, MK | 1 |
| Foster, SJ | 1 |
| Thiemermann, C | 1 |
| Bjørnland, K | 1 |
| Aasen, AO | 1 |
| Wang, JE | 1 |
| Singleton, PA | 1 |
| Dudek, SM | 1 |
| Chiang, ET | 1 |
| Garcia, JG | 1 |
| Suuronen, T | 1 |
| Huuskonen, J | 1 |
| Nuutinen, T | 1 |
| Salminen, A | 1 |
| van Thienen, JV | 1 |
| Fledderus, JO | 1 |
| Dekker, RJ | 1 |
| Rohlena, J | 1 |
| van Ijzendoorn, GA | 1 |
| Kootstra, NA | 1 |
| Pannekoek, H | 1 |
| Horrevoets, AJ | 1 |
| Dos Santos, S | 1 |
| Delattre, AI | 1 |
| De Longueville, F | 1 |
| Bult, H | 1 |
| Raes, M | 1 |
| Ma, Q | 1 |
| Qiao, J | 1 |
| Li, R | 1 |
| Li, S | 1 |
| Tang, J | 1 |
| Zhou, L | 1 |
| Song, H | 1 |
| Chen, M | 1 |
| Wang, MJ | 1 |
| Lin, SZ | 1 |
| Kuo, JS | 1 |
| Huang, HY | 1 |
| Tzeng, SF | 1 |
| Liao, CH | 1 |
| Chen, DC | 1 |
| Chen, WF | 1 |
| Maya-Monteiro, CM | 1 |
| Almeida, PE | 1 |
| D'Avila, H | 1 |
| Martins, AS | 1 |
| Rezende, AP | 1 |
| Castro-Faria-Neto, H | 1 |
| Bozza, PT | 1 |
| Pezet, S | 1 |
| Marchand, F | 1 |
| D'Mello, R | 1 |
| Grist, J | 1 |
| Clark, AK | 1 |
| Malcangio, M | 1 |
| Dickenson, AH | 1 |
| Williams, RJ | 1 |
| McMahon, SB | 1 |
| Pahan, K | 1 |
| Khan, M | 1 |
| Singh, I | 1 |
| Sandau, KB | 1 |
| Faus, HG | 1 |
| Brüne, B | 1 |
| Lee, J | 1 |
| Mira-Arbibe, L | 1 |
| Ulevitch, RJ | 1 |
| Abreu, MT | 1 |
| Arnold, ET | 1 |
| Chow, JY | 1 |
| Barrett, KE | 1 |
| van Golen, KL | 1 |
| Bao, LW | 1 |
| Pan, Q | 1 |
| Miller, FR | 1 |
| Wu, ZF | 1 |
| Merajver, SD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Lepidium Sativum Extract Versus Simvastatin as an Adjunctive Local Delivery Agents to Non-Surgical Periodontal Therapy: A Randomized Controlled Clinical Trial With Biochemical Analysis[NCT05657015] | Phase 4 | 30 participants (Actual) | Interventional | 2021-09-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Inflammation
| Article | Year |
|---|---|
PI3Kδ and PI3Kγ as targets for autoimmune and inflammatory diseases.
Topics: Animals; Autoimmune Diseases; B-Lymphocytes; Class Ia Phosphatidylinositol 3-Kinase; Class Ib Phosph | 2012 |
71 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Inflammation
| Article | Year |
|---|---|
Phosphoinositide 3-kinase gamma/delta inhibition limits infarct size after myocardial ischemia/reperfusion injury.
Topics: Animals; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Humans; Inflammation; Intercel | 2006 |
Natural Stilbenoids Have Anti-Inflammatory Properties in Vivo and Down-Regulate the Production of Inflammatory Mediators NO, IL6, and MCP1 Possibly in a PI3K/Akt-Dependent Manner.
Topics: Animals; Anti-Inflammatory Agents; Biological Products; Cell Line; Chemokine CCL2; Down-Regulation; | 2018 |
LY294002 attenuates inflammatory response in endotoxin-induced uveitis by downregulating JAK3 and inactivating the PI3K/Akt signaling.
Topics: Animals; Chromones; Cytokines; Endotoxins; Inflammation; Lipopolysaccharides; Morpholines; Phosphati | 2022 |
[Effect of acupuncture preconditioning combined with PI3K blocker LY294002 on airway inflammation in asthmatic rats].
Topics: Acupuncture Therapy; Animals; Asthma; Chromones; Inflammation; Interleukin-12; Interleukin-13; Male; | 2022 |
LY294002 ameliorates psoriatic skin inflammation in mice via blocking the Notch1/Hes1-PTEN/AKT/IL-17A feedback loop.
Topics: Animals; Disease Models, Animal; Feedback; Inflammation; Interleukin-17; Mice; Phosphatidylinositol | 2023 |
The role of secreted Hsp90α in HDM-induced asthmatic airway epithelial barrier dysfunction.
Topics: Animals; Asthma; Bronchi; Cadherins; Cell Line; Chromones; Cytokines; Electric Impedance; Epithelial | 2019 |
Release of endogenous hydrogen sulfide in enteric nerve cells suppresses intestinal motility during severe acute pancreatitis.
Topics: Animals; Cell Movement; Chromones; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Cytokines | 2020 |
Trigonelline protects hippocampal neurons from oxygen-glucose deprivation-induced injury through activating the PI3K/Akt pathway.
Topics: Alkaloids; Animals; Brain Ischemia; Cell Survival; Chromones; Glucose; Hippocampus; Inflammation; Mo | 2020 |
Tetramethylpyrazine ameliorates hepatic fibrosis through autophagy-mediated inflammation.
Topics: Animals; Autophagy; Carbon Tetrachloride; Cell Line, Tumor; Chromones; Chronic Disease; Fibrinolytic | 2020 |
Short ELF-EMF Exposure Targets SIRT1/Nrf2/HO-1 Signaling in THP-1 Cells.
Topics: Cell Line; Cell Movement; Chromones; Electromagnetic Fields; Extracellular Signal-Regulated MAP Kina | 2020 |
Alteration in the expression of inflammatory cytokines in primary hippocampal astrocytes in response to MK-801 through ERK1/2 and PI3K signals.
Topics: Animals; Animals, Newborn; Apoptosis; Astrocytes; Cell Proliferation; Chromones; Cytokines; Dizocilp | 2021 |
Cartilage endplate stem cells inhibit intervertebral disc degeneration by releasing exosomes to nucleus pulposus cells to activate Akt/autophagy.
Topics: Adult; Aged; Animals; Autophagy; Cartilage; Case-Control Studies; Chromones; Exosomes; Female; Gene | 2021 |
Inhibition of Notch1-mediated inflammation by intermedin protects against abdominal aortic aneurysm via PI3K/Akt signaling pathway.
Topics: ADAM10 Protein; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Calcium Chloride; Cell Movement | 2021 |
5-Lipoxygenase inhibition reduces inflammation and neuronal apoptosis via AKT signaling after subarachnoid hemorrhage in rats.
Topics: Administration, Oral; Animals; Apoptosis; Arachidonate 5-Lipoxygenase; Brain Injuries; Chromones; Di | 2021 |
LncRNA MEG3 suppresses PI3K/AKT/mTOR signalling pathway to enhance autophagy and inhibit inflammation in TNF-α-treated keratinocytes and psoriatic mice.
Topics: Animals; Autophagy; Chromones; Female; HaCaT Cells; Humans; Inflammation; Keratinocytes; Mice, Inbre | 2021 |
Neuron and microglia/macrophage-derived FGF10 activate neuronal FGFR2/PI3K/Akt signaling and inhibit microglia/macrophages TLR4/NF-κB-dependent neuroinflammation to improve functional recovery after spinal cord injury.
Topics: Animals; Apoptosis; Chromones; Disease Models, Animal; Fibroblast Growth Factor 10; Gene Expression | 2017 |
Role of the TSLP-DC-OX40L pathway in asthma pathogenesis and airway inflammation in mice.
Topics: Animals; Asthma; Chromones; Cytokines; Dendritic Cells; Disease Models, Animal; Eosinophils; Immunog | 2018 |
MicroRNA-155 Regulates Inflammatory Response in Ischemic Cerebral Tissues through Autophagy.
Topics: Administration, Oral; Animals; Autophagy; Cell Hypoxia; Cell Line, Transformed; Chromones; Disease M | 2018 |
Sulforaphane triggers a functional elongation of microglial process via the Akt signal.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Cells, Cultured; Chromones; Cyto | 2019 |
Dexmedetomidine suppresses sevoflurane anesthesia-induced neuroinflammation through activation of the PI3K/Akt/mTOR pathway.
Topics: Anesthetics, Inhalation; Animals; Cerebral Cortex; Chromones; Cytokines; Dexmedetomidine; Disease Mo | 2019 |
Nuclear factor-κB modulates osteogenesis of periodontal ligament stem cells through competition with β-catenin signaling in inflammatory microenvironments.
Topics: Adult; Animals; beta Catenin; Cell Differentiation; Cells, Cultured; Cellular Microenvironment; Chro | 2013 |
Modulation of nuclear factor E2-related factor-2 (Nrf2) activation by the stress response gene immediate early response-3 (IER3) in colonic epithelial cells: a novel mechanism of cellular adaption to inflammatory stress.
Topics: Animals; Apoptosis Regulatory Proteins; Cell Line; Chromones; Colitis; Colon; Dextran Sulfate; Enzym | 2014 |
PI3K inhibitors LY294002 and IC87114 reduce inflammation in carrageenan-induced paw oedema and down-regulate inflammatory gene expression in activated macrophages.
Topics: Adenine; Animals; Carrageenan; Chemokine CCL2; Chromones; Down-Regulation; Edema; Enzyme Inhibitors; | 2015 |
7-Ketocholesterol-induced inflammation signals mostly through the TLR4 receptor both in vitro and in vivo.
Topics: Animals; Cell Death; Cell Line; Chromones; Cyclopropanes; Endoplasmic Reticulum Stress; Enzyme Activ | 2014 |
Nuclear factor erythroid 2-related factor 2 regulates toll-like receptor 4 innate responses in mouse liver ischemia-reperfusion injury through Akt-forkhead box protein O1 signaling network.
Topics: Animals; Apoptosis; Chromones; Forkhead Box Protein O1; Forkhead Transcription Factors; Homeostasis; | 2014 |
Soyasaponins can blunt inflammation by inhibiting the reactive oxygen species-mediated activation of PI3K/Akt/NF-kB pathway.
Topics: Animals; Cell Line; Chromones; Cyclooxygenase 2; Dinoprostone; Glycine max; I-kappa B Kinase; Inflam | 2014 |
Anti-inflammatory and heme oxygenase-1 inducing activities of lanostane triterpenes isolated from mushroom Ganoderma lucidum in RAW264.7 cells.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents; Cell Line; Cell Survival; Chromones; Enzyme Inhib | 2014 |
mTORC1 Regulates Flagellin-Induced Inflammatory Response in Macrophages.
Topics: Animals; Cell Line; Cell Proliferation; Cell Survival; Chromones; Cytokines; Dose-Response Relations | 2015 |
Apelin activates the expression of inflammatory cytokines in microglial BV2 cells via PI-3K/Akt and MEK/Erk pathways.
Topics: Adipokines; Animals; Apelin; Apelin Receptors; Butadienes; Chemokine CCL2; Chemokine CCL3; Chromones | 2015 |
Retinoic acid inhibits tissue factor and HMGB1 via modulation of AMPK activity in TNF-α activated endothelial cells and LPS-injected mice.
Topics: AMP-Activated Protein Kinases; Animals; Chromones; Culture Media; Endothelial Cells; Fibrin; HMGB1 P | 2015 |
Early single Aspirin-triggered Lipoxin blocked morphine anti-nociception tolerance through inhibiting NALP1 inflammasome: Involvement of PI3k/Akt signaling pathway.
Topics: Analgesics; Animals; Astrocytes; Caspase 1; Cells, Cultured; Chromones; Drug Tolerance; Inflammasome | 2015 |
Fucosterol protects cobalt chloride induced inflammation by the inhibition of hypoxia-inducible factor through PI3K/Akt pathway.
Topics: Cell Line; Chromones; Cobalt; Cytokines; Gene Expression Regulation; Humans; Hypoxia-Inducible Facto | 2015 |
DGAEE, a newly synthesized derivative of glycyrrhetinic acid, potently attenuates mouse septic shock via its main metabolite DGA in an IL-10-dependent manner.
Topics: Animals; Antibodies, Neutralizing; Cell Line; Chromones; Gene Expression Regulation; Glycogen Syntha | 2015 |
Ivabradine Prevents Low Shear Stress Induced Endothelial Inflammation and Oxidative Stress via mTOR/eNOS Pathway.
Topics: Benzazepines; Cell Nucleus; Chromones; Enzyme Activation; Fluorescent Antibody Technique; Gene Expre | 2016 |
Non-tumor tissue derived interleukin-17B activates IL-17RB/AKT/β-catenin pathway to enhance the stemness of gastric cancer.
Topics: Aged; beta Catenin; Cell Line, Tumor; Chromones; Disease Progression; Dose-Response Relationship, Im | 2016 |
Astaxanthin protects against early burn-wound progression in rats by attenuating oxidative stress-induced inflammation and mitochondria-related apoptosis.
Topics: Animals; Apoptosis; bcl-Associated Death Protein; Burns; Chromones; Disease Progression; Inflammatio | 2017 |
A synthetic analog of 15-epi-lipoxin A4 inhibits human monocyte apoptosis: involvement of ERK-2 and PI3-kinase.
Topics: Active Transport, Cell Nucleus; Animals; Apoptosis; bcl-2-Associated X Protein; Cell Survival; Chrom | 2010 |
Involvement of phosphoinositide 3-kinase gamma in angiogenesis and healing of experimental myocardial infarction in mice.
Topics: Animals; Apoptosis; Cell Movement; Cell Proliferation; Cell Survival; Cells, Cultured; Chromones; Di | 2010 |
Insulin modulates protease-activated receptor 2 signaling: implications for the innate immune response.
Topics: Animals; Calcium; Cell Line; Cells, Cultured; Chromones; Diabetes Mellitus, Type 1; Endothelial Cell | 2010 |
Regulation of the autophagic machinery in human neutrophils.
Topics: Adenine; Autophagy; Cadaverine; Chromones; Coloring Agents; Escherichia coli; Guanosine; Humans; Hyd | 2010 |
Ectosomes released by polymorphonuclear neutrophils induce a MerTK-dependent anti-inflammatory pathway in macrophages.
Topics: Androstadienes; c-Mer Tyrosine Kinase; Cell-Derived Microparticles; Chromones; Humans; Inflammation; | 2010 |
Phosphatidylinositol 3-kinase activation attenuates the TLR2-mediated macrophage proinflammatory cytokine response to Francisella tularensis live vaccine strain.
Topics: Androstadienes; Animals; Bacterial Vaccines; Bone Marrow Cells; Chromones; Dual Specificity Phosphat | 2010 |
Evidence for the role of PI(3) -kinase-AKT-eNOS signalling pathway in secondary inflammatory process after spinal cord compression injury in mice.
Topics: Animals; bcl-2-Associated X Protein; Chromones; Enzyme Activation; Enzyme Inhibitors; Fas Ligand Pro | 2011 |
An inflammatory micro-environment promotes human adipocyte apoptosis.
Topics: Adipocytes; Adipose Tissue; Adult; Aged; Aged, 80 and over; Apoptosis; CD11c Antigen; Cells, Culture | 2011 |
Platelets directly enhance neutrophil transmigration in response to oxidised low-density lipoprotein.
Topics: Aspirin; Atherosclerosis; Blood Platelets; CD11b Antigen; Cell Aggregation; Cell Communication; Cell | 2012 |
Quiescent fibroblasts are more active in mounting robust inflammatory responses than proliferative fibroblasts.
Topics: Acetophenones; Benzopyrans; Cell Movement; Cell Proliferation; Chromones; Cyclooxygenase 2; Enzyme I | 2012 |
Involvement of PTEN in airway hyperresponsiveness and inflammation in bronchial asthma.
Topics: Allergens; Androstadienes; Animals; Asthma; Blood Proteins; Blotting, Western; Bronchoalveolar Lavag | 2003 |
Stimulation of signal transducer and activator of transcription-1 (STAT1)-dependent gene transcription by lipopolysaccharide and interferon-gamma is regulated by mammalian target of rapamycin.
Topics: Androstadienes; Apoptosis; Blotting, Northern; Cell Division; Chromones; Cytokines; DNA-Binding Prot | 2003 |
Selective role of PI3K delta in neutrophil inflammatory responses.
Topics: Adenine; Androstadienes; Animals; Anti-Inflammatory Agents; Chromones; Class I Phosphatidylinositol | 2003 |
FGF-2 induced by interleukin-1 beta through the action of phosphatidylinositol 3-kinase mediates endothelial mesenchymal transformation in corneal endothelial cells.
Topics: Actins; Amino Acid Sequence; Animals; Blotting, Western; Cells, Cultured; Chromones; Cornea; Culture | 2004 |
PI3K-Akt pathway suppresses coagulation and inflammation in endotoxemic mice.
Topics: Androstadienes; Animals; Blood Coagulation; Chemokines; Chromones; Cytokines; Disease Models, Animal | 2004 |
Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization.
Topics: Androstadienes; Animals; Capsaicin; Cells, Cultured; Chromones; Enzyme Activation; Enzyme Inhibitors | 2004 |
Interleukin-18 is a pro-hypertrophic cytokine that acts through a phosphatidylinositol 3-kinase-phosphoinositide-dependent kinase-1-Akt-GATA4 signaling pathway in cardiomyocytes.
Topics: Androstadienes; Animals; Atrial Natriuretic Factor; Blotting, Northern; Blotting, Western; Cell Line | 2005 |
Resistance to endotoxic shock in endothelial nitric-oxide synthase (eNOS) knock-out mice: a pro-inflammatory role for eNOS-derived no in vivo.
Topics: Animals; Aorta; Blood Pressure; Blotting, Western; Bone Marrow Cells; Cells, Cultured; Chromones; Cy | 2005 |
Src homology 2 domain-containing inositol-5-phosphatase 1 (SHIP1) negatively regulates TLR4-mediated LPS response primarily through a phosphatase activity- and PI-3K-independent mechanism.
Topics: Adaptor Proteins, Signal Transducing; Androstadienes; Animals; Antigens, Differentiation; Blotting, | 2005 |
Phosphoinositide-3 kinases critically regulate the recruitment and survival of eosinophils in vivo: importance for the resolution of allergic inflammation.
Topics: Androstadienes; Animals; Cell Movement; Cell Survival; Chromones; Class Ib Phosphatidylinositol 3-Ki | 2005 |
Activation of phosphoinositide 3-kinase in response to inflammation and nitric oxide leads to the up-regulation of cyclooxygenase-2 expression and subsequent cell proliferation in mesangial cells.
Topics: Animals; Cell Proliferation; Cells, Cultured; Chromones; Cyclooxygenase 2; Dose-Response Relationshi | 2005 |
Peptidoglycan of Staphylococcus aureus induces enhanced levels of matrix metalloproteinase-9 in human blood originating from neutrophils.
Topics: Chromones; Dose-Response Relationship, Drug; Endotoxemia; Enzyme Inhibitors; Enzyme-Linked Immunosor | 2005 |
Regulation of sphingosine 1-phosphate-induced endothelial cytoskeletal rearrangement and barrier enhancement by S1P1 receptor, PI3 kinase, Tiam1/Rac1, and alpha-actinin.
Topics: Actinin; Catalytic Domain; Caveolin 1; Cells, Cultured; Cholesterol; Chromones; Cytoskeleton; Electr | 2005 |
Characterization of the pro-inflammatory signaling induced by protein acetylation in microglia.
Topics: Acetylation; Animals; Chromones; DNA; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Enzym | 2006 |
Shear stress sustains atheroprotective endothelial KLF2 expression more potently than statins through mRNA stabilization.
Topics: Atherosclerosis; Cells, Cultured; Chromones; Endothelial Cells; Endothelium, Vascular; Fluorescent A | 2006 |
Gene expression profiling of LPS-stimulated murine macrophages and role of the NF-kappaB and PI3K/mTOR signaling pathways.
Topics: Animals; Chromones; Gene Expression Profiling; Gene Expression Regulation; Inflammation; Lipopolysac | 2007 |
C-reactive protein inhibits adiponectin gene expression and secretion in 3T3-L1 adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Adiponectin; Animals; C-Reactive Protein; Chromones; Dose-Response Relatio | 2007 |
Urocortin modulates inflammatory response and neurotoxicity induced by microglial activation.
Topics: Aging; Animals; Cell Death; Cells, Cultured; Chromones; Cyclic AMP; Enzyme Activation; Glycogen Synt | 2007 |
Leptin induces macrophage lipid body formation by a phosphatidylinositol 3-kinase- and mammalian target of rapamycin-dependent mechanism.
Topics: Adipocytes; Animals; Cell Differentiation; Cells, Cultured; Chromones; Enzyme Inhibitors; Inflammati | 2008 |
Phosphatidylinositol 3-kinase is a key mediator of central sensitization in painful inflammatory conditions.
Topics: Animals; Chromones; Formaldehyde; Inflammation; Inflammation Mediators; Male; Morpholines; Pain; Pai | 2008 |
Interleukin-10 and interleukin-13 inhibit proinflammatory cytokine-induced ceramide production through the activation of phosphatidylinositol 3-kinase.
Topics: Androstadienes; Animals; Astrocytes; Brain; Cells, Cultured; Ceramides; Chromones; Diacylglycerol Ki | 2000 |
Induction of hypoxia-inducible-factor 1 by nitric oxide is mediated via the PI 3K pathway.
Topics: Androstadienes; Animals; Blotting, Western; Cell Line; Cell Nucleus; Chromones; DNA; DNA-Binding Pro | 2000 |
TAK1 regulates multiple protein kinase cascades activated by bacterial lipopolysaccharide.
Topics: Androstadienes; Animals; Apoptosis; Cell Line; Chromones; Cysteine Proteinase Inhibitors; Enzyme Act | 2000 |
Phosphatidylinositol 3-kinase-dependent pathways oppose Fas-induced apoptosis and limit chloride secretion in human intestinal epithelial cells. Implications for inflammatory diarrheal states.
Topics: 3T3 Cells; Actins; Androstadienes; Animals; Apoptosis; Blotting, Western; Caspases; Cell Adhesion; C | 2001 |
Mitogen activated protein kinase pathway is involved in RhoC GTPase induced motility, invasion and angiogenesis in inflammatory breast cancer.
Topics: Adenocarcinoma; ADP Ribose Transferases; Botulinum Toxins; Breast Neoplasms; Chromones; Endothelial | 2002 |