2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Hypertrophy in 15 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
Hypertrophy: General increase in bulk of a part or organ due to CELL ENLARGEMENT and accumulation of FLUIDS AND SECRETIONS, not due to tumor formation, nor to an increase in the number of cells (HYPERPLASIA).
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the potential effect of curcumin on cardiomyocyte hypertrophy and a possible mechanism involving the PPARγ/Akt/NO signaling pathway in diabetes." | 7.81 | Curcumin attenuates cardiomyocyte hypertrophy induced by high glucose and insulin via the PPARγ/Akt/NO signaling pathway. ( Chen, R; Du, W; Huang, B; Jiang, Q; Peng, X; Qiu, H; Wu, Q; Wu, Y; Xue, L, 2015) |
| "Our results show that leptin induced glomerular mesangial cell hypertrophy via PI 3-kinase and ERK1/2, and that hyperplasia and apoptosis were not altered by leptin." | 7.73 | Leptin induces rat glomerular mesangial cell hypertrophy, but does not regulate hyperplasia or apoptosis. ( Lee, MP; Orlov, D; Sweeney, G, 2005) |
| "To investigate the potential effect of curcumin on cardiomyocyte hypertrophy and a possible mechanism involving the PPARγ/Akt/NO signaling pathway in diabetes." | 3.81 | Curcumin attenuates cardiomyocyte hypertrophy induced by high glucose and insulin via the PPARγ/Akt/NO signaling pathway. ( Chen, R; Du, W; Huang, B; Jiang, Q; Peng, X; Qiu, H; Wu, Q; Wu, Y; Xue, L, 2015) |
| "Our results show that leptin induced glomerular mesangial cell hypertrophy via PI 3-kinase and ERK1/2, and that hyperplasia and apoptosis were not altered by leptin." | 3.73 | Leptin induces rat glomerular mesangial cell hypertrophy, but does not regulate hyperplasia or apoptosis. ( Lee, MP; Orlov, D; Sweeney, G, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (53.33) | 29.6817 |
| 2010's | 6 (40.00) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Lin, YA | 1 |
| Li, YR | 1 |
| Chang, YC | 1 |
| Hsu, MC | 1 |
| Chen, ST | 1 |
| Qiao, LY | 2 |
| Xia, C | 2 |
| Shen, S | 2 |
| Lee, SH | 1 |
| Ratz, PH | 1 |
| Fraser, MO | 1 |
| Miner, A | 1 |
| Speich, JE | 1 |
| Lysiak, JJ | 1 |
| Steers, WD | 1 |
| Das, F | 1 |
| Ghosh-Choudhury, N | 1 |
| Lee, DY | 1 |
| Gorin, Y | 1 |
| Kasinath, BS | 1 |
| Choudhury, GG | 1 |
| Deane, CS | 1 |
| Hughes, DC | 1 |
| Sculthorpe, N | 1 |
| Lewis, MP | 1 |
| Stewart, CE | 1 |
| Sharples, AP | 1 |
| Qiao, Z | 1 |
| Corwin, FD | 1 |
| Liu, M | 1 |
| Guan, R | 1 |
| Grider, JR | 1 |
| Chen, R | 1 |
| Peng, X | 1 |
| Du, W | 1 |
| Wu, Y | 1 |
| Huang, B | 1 |
| Xue, L | 1 |
| Wu, Q | 1 |
| Qiu, H | 1 |
| Jiang, Q | 1 |
| Wang, GJ | 1 |
| Yao, YS | 1 |
| Li, ZP | 1 |
| Wang, HX | 1 |
| Chandrasekar, B | 1 |
| Mummidi, S | 1 |
| Claycomb, WC | 1 |
| Mestril, R | 1 |
| Nemer, M | 1 |
| Zhou, L | 2 |
| Goldsmith, AM | 2 |
| Bentley, JK | 2 |
| Jia, Y | 2 |
| Rodriguez, ML | 1 |
| Abe, MK | 1 |
| Fingar, DC | 2 |
| Hershenson, MB | 2 |
| Lee, MP | 1 |
| Orlov, D | 1 |
| Sweeney, G | 1 |
| Nagai, K | 1 |
| Matsubara, T | 1 |
| Mima, A | 1 |
| Sumi, E | 1 |
| Kanamori, H | 1 |
| Iehara, N | 1 |
| Fukatsu, A | 1 |
| Yanagita, M | 1 |
| Nakano, T | 1 |
| Ishimoto, Y | 1 |
| Kita, T | 1 |
| Doi, T | 1 |
| Arai, H | 1 |
| Bitar, KN | 1 |
| Ulici, V | 1 |
| Hoenselaar, KD | 1 |
| Gillespie, JR | 1 |
| Beier, F | 1 |
| Rocic, P | 1 |
| Govindarajan, G | 1 |
| Sabri, A | 1 |
| Lucchesi, PA | 1 |
| Pham, FH | 1 |
| Cole, SM | 1 |
| Clerk, A | 1 |
15 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Hypertrophy
| Article | Year |
|---|---|
Activation of IGF-1 pathway and suppression of atrophy related genes are involved in Epimedium extract (icariin) promoted C2C12 myotube hypertrophy.
Topics: Animals; Cell Differentiation; Cell Line; Chromones; Flavonoids; Gene Expression Regulation; Hypertr | 2021 |
Urinary bladder organ hypertrophy is partially regulated by Akt1-mediated protein synthesis pathway.
Topics: Animals; Biosynthetic Pathways; Chromones; Enzyme Inhibitors; Fibrosis; Hypertrophy; Male; Morpholin | 2018 |
Akt2 causes TGFβ-induced deptor downregulation facilitating mTOR to drive podocyte hypertrophy and matrix protein expression.
Topics: Animals; Cell Line; Chromones; Down-Regulation; Fibronectins; Gene Expression Regulation, Enzymologi | 2018 |
Impaired hypertrophy in myoblasts is improved with testosterone administration.
Topics: Animals; Cells, Cultured; Chromones; Hypertrophy; Mice; Morpholines; Muscle Fibers, Skeletal; Myobla | 2013 |
Suppression of the PI3K pathway in vivo reduces cystitis-induced bladder hypertrophy and restores bladder capacity examined by magnetic resonance imaging.
Topics: Animals; Blotting, Western; Cells, Cultured; Chromones; Cyclophosphamide; Cystitis; Enzyme Inhibitor | 2014 |
Curcumin attenuates cardiomyocyte hypertrophy induced by high glucose and insulin via the PPARγ/Akt/NO signaling pathway.
Topics: Anilides; Animals; Atrial Natriuretic Factor; Cells, Cultured; Chromones; Curcumin; Glucose; Hypertr | 2015 |
[Ca2+ is involved in tumor necrosis factor-alpha induced cardiomyocyte hypertrophy through PI3-kinase pathway in rats].
Topics: Animals; Calcium; Calcium Channels, L-Type; Chromones; Female; Hypertrophy; Male; Morpholines; Myocy | 2010 |
Interleukin-18 is a pro-hypertrophic cytokine that acts through a phosphatidylinositol 3-kinase-phosphoinositide-dependent kinase-1-Akt-GATA4 signaling pathway in cardiomyocytes.
Topics: Androstadienes; Animals; Atrial Natriuretic Factor; Blotting, Northern; Blotting, Western; Cell Line | 2005 |
4E-binding protein phosphorylation and eukaryotic initiation factor-4E release are required for airway smooth muscle hypertrophy.
Topics: Adaptor Proteins, Signal Transducing; Bronchi; Carrier Proteins; Cell Cycle Proteins; Cell Enlargeme | 2005 |
Leptin induces rat glomerular mesangial cell hypertrophy, but does not regulate hyperplasia or apoptosis.
Topics: Animals; Apoptosis; Cell Size; Cells, Cultured; Chromones; Extracellular Signal-Regulated MAP Kinase | 2005 |
Gas6 induces Akt/mTOR-mediated mesangial hypertrophy in diabetic nephropathy.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antibiotics, Antineoplastic; Butadienes; Carrier Prot | 2005 |
Transforming growth factor-beta induces airway smooth muscle hypertrophy.
Topics: Acetylcholine; Actin Cytoskeleton; Actins; Actomyosin; Adaptor Proteins, Signal Transducing; Bronchi | 2006 |
The PI3K pathway regulates endochondral bone growth through control of hypertrophic chondrocyte differentiation.
Topics: Animals; Biomarkers; Bone Development; Cell Differentiation; Cells, Cultured; Chondrocytes; Chromone | 2008 |
A role for PYK2 in regulation of ERK1/2 MAP kinases and PI 3-kinase by ANG II in vascular smooth muscle.
Topics: Adaptor Proteins, Signal Transducing; Angiotensin II; Animals; Calcium; Cells, Cultured; Chromones; | 2001 |
Regulation of cardiac myocyte protein synthesis through phosphatidylinositol 3' kinase and protein kinase B.
Topics: Animals; Animals, Newborn; Apoptosis; Blotting, Western; Carcinogens; Carrier Proteins; Chromones; E | 2001 |