2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Huntington Disease in 3 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Here we demonstrate in precise genetic Huntington's disease mouse and striatal cell models that these early phenotypes are associated with activation of the Akt pro-survival signaling pathway." | 1.32 | Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-D-aspartate receptor activation in Huntington's disease knock-in striatal cells. ( Gines, S; Ivanova, E; MacDonald, ME; Saura, CA; Seong, IS, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, T | 1 |
| Dong, K | 1 |
| Liang, W | 1 |
| Xu, D | 1 |
| Xia, H | 1 |
| Geng, J | 1 |
| Najafov, A | 1 |
| Liu, M | 1 |
| Li, Y | 1 |
| Han, X | 1 |
| Xiao, J | 1 |
| Jin, Z | 1 |
| Peng, T | 2 |
| Gao, Y | 1 |
| Cai, Y | 1 |
| Qi, C | 1 |
| Zhang, Q | 1 |
| Sun, A | 1 |
| Lipinski, M | 1 |
| Zhu, H | 1 |
| Xiong, Y | 1 |
| Pandolfi, PP | 1 |
| Li, H | 2 |
| Yu, Q | 1 |
| Yuan, J | 1 |
| Fang, F | 1 |
| Yang, S | 1 |
| Wang, W | 1 |
| Zhang, Y | 1 |
| Gines, S | 1 |
| Ivanova, E | 1 |
| Seong, IS | 1 |
| Saura, CA | 1 |
| MacDonald, ME | 1 |
3 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Huntington Disease
| Article | Year |
|---|---|
G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L.
Topics: Animals; Autophagy; Autophagy-Related Proteins; Benzylamines; Carrier Proteins; Cell Line, Tumor; Ch | 2015 |
Lycium barbarum polysaccharide attenuates the cytotoxicity of mutant huntingtin and increases the activity of AKT.
Topics: Analysis of Variance; Animals; Brain; Caspase 3; Cell Survival; Chromones; Disease Models, Animal; D | 2016 |
Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-D-aspartate receptor activation in Huntington's disease knock-in striatal cells.
Topics: Alleles; Animals; beta Catenin; Cell Membrane; Cells, Cultured; Chromones; Corpus Striatum; Cyclin D | 2003 |