2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Granulocytic Leukemia, Chronic in 19 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
| Excerpt | Relevance | Reference |
|---|---|---|
| "Neoplasm cells from patients with chronic myeloid leukemia (CML) interact with stromal cells of the surrounding microenvironment." | 1.46 | Overexpression of heme oxygenase-1 in bone marrow stromal cells promotes microenvironment-mediated imatinib resistance in chronic myeloid leukemia. ( Fang, Q; Huang, J; Liu, P; Ma, D; Ren, M; Wang, J; Wang, P; Yu, M; Yu, Z; Zhe, N, 2017) |
| "Chronic myelogenous leukemia is characterized by the reciprocal chromosomal translocation (9;22), which generates a novel fusion gene, BCR-ABL." | 1.35 | HOXA10 expression induced by Abl kinase inhibitors enhanced apoptosis through PI3K pathway in CML cells. ( Hirano, I; Nakamura, S; Ohnishi, K; Okinaka, K; Ono, T; Shigeno, K; Shinjo, K; Sugimoto, Y, 2008) |
| "The growth of maturing chronic myeloid leukemia cells is independent of BCR-ABL in the presence of growth factors." | 1.31 | The tyrosine kinase inhibitor CGP 57148 (ST1 571) induces apoptosis in BCR-ABL-positive cells by down-regulating BCL-X. ( Aulitzky, WE; Duyster, J; Götz, A; Hallek, M; Jonuleit, T; Michels, H; Oetzel, C; van der Kuip, H, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 12 (63.16) | 29.6817 |
| 2010's | 7 (36.84) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, P | 1 |
| Ma, D | 1 |
| Yu, Z | 1 |
| Zhe, N | 1 |
| Ren, M | 1 |
| Wang, P | 1 |
| Yu, M | 1 |
| Huang, J | 1 |
| Fang, Q | 1 |
| Wang, J | 1 |
| Borges, CS | 1 |
| Ferreira, AF | 1 |
| Almeida, VH | 1 |
| Gomes, FG | 1 |
| Berzoti-Coelho, MG | 1 |
| Cacemiro, MDC | 1 |
| Nunes, NS | 1 |
| Figueiredo-Pontes, LL | 1 |
| Simões, BP | 1 |
| Castro, FA | 1 |
| Monteiro, RQ | 1 |
| Ciarcia, R | 1 |
| Damiano, S | 1 |
| Montagnaro, S | 1 |
| Pagnini, U | 1 |
| Ruocco, A | 1 |
| Caparrotti, G | 1 |
| d'Angelo, D | 1 |
| Boffo, S | 1 |
| Morales, F | 1 |
| Rizzolio, F | 1 |
| Florio, S | 1 |
| Giordano, A | 1 |
| Huang, FF | 1 |
| Zhang, L | 1 |
| Wu, DS | 1 |
| Yuan, XY | 1 |
| Yu, YH | 1 |
| Zhao, XL | 1 |
| Chen, FP | 1 |
| Zeng, H | 1 |
| Cheng, YL | 1 |
| Huang, WC | 1 |
| Chen, CL | 1 |
| Tsai, CC | 1 |
| Wang, CY | 1 |
| Chiu, WH | 1 |
| Chen, YL | 1 |
| Lin, YS | 1 |
| Chang, CF | 1 |
| Lin, CF | 1 |
| Yang, KT | 1 |
| Wang, MC | 1 |
| Chen, JY | 1 |
| Hsu, MC | 1 |
| Hung, WC | 1 |
| Kumano, K | 1 |
| Arai, S | 1 |
| Hosoi, M | 1 |
| Taoka, K | 1 |
| Takayama, N | 1 |
| Otsu, M | 1 |
| Nagae, G | 1 |
| Ueda, K | 1 |
| Nakazaki, K | 1 |
| Kamikubo, Y | 1 |
| Eto, K | 1 |
| Aburatani, H | 1 |
| Nakauchi, H | 1 |
| Kurokawa, M | 1 |
| Klejman, A | 1 |
| Rushen, L | 1 |
| Morrione, A | 1 |
| Slupianek, A | 1 |
| Skorski, T | 1 |
| Rahmani, M | 1 |
| Yu, C | 1 |
| Reese, E | 1 |
| Ahmed, W | 1 |
| Hirsch, K | 1 |
| Dent, P | 1 |
| Grant, S | 1 |
| Kubota, Y | 1 |
| Tanaka, T | 1 |
| Ohnishi, H | 1 |
| Kitanaka, A | 1 |
| Okutani, Y | 1 |
| Taminato, T | 1 |
| Ishida, T | 1 |
| Kamano, H | 1 |
| Marley, SB | 1 |
| Lewis, JL | 1 |
| Schneider, H | 1 |
| Rudd, CE | 1 |
| Gordon, MY | 1 |
| Jørgensen, HG | 1 |
| Allan, EK | 1 |
| Graham, SM | 1 |
| Godden, JL | 1 |
| Richmond, L | 1 |
| Elliott, MA | 1 |
| Mountford, JC | 1 |
| Eaves, CJ | 1 |
| Holyoake, TL | 1 |
| Hickey, FB | 1 |
| Cotter, TG | 1 |
| Jin, L | 1 |
| Kato, A | 1 |
| Tabe, Y | 1 |
| Svensson, E | 1 |
| Vidovic, K | 1 |
| Lassen, C | 1 |
| Richter, J | 1 |
| Olofsson, T | 1 |
| Fioretos, T | 1 |
| Gullberg, U | 1 |
| Sugimoto, Y | 1 |
| Nakamura, S | 1 |
| Okinaka, K | 1 |
| Hirano, I | 1 |
| Ono, T | 1 |
| Shigeno, K | 1 |
| Shinjo, K | 1 |
| Ohnishi, K | 1 |
| Oetzel, C | 1 |
| Jonuleit, T | 2 |
| Götz, A | 1 |
| van der Kuip, H | 2 |
| Michels, H | 2 |
| Duyster, J | 2 |
| Hallek, M | 2 |
| Aulitzky, WE | 2 |
| Miething, C | 1 |
| Bhatia, R | 1 |
| Munthe, HA | 1 |
| Forman, SJ | 1 |
19 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Granulocytic Leukemia, Chronic
| Article | Year |
|---|---|
Overexpression of heme oxygenase-1 in bone marrow stromal cells promotes microenvironment-mediated imatinib resistance in chronic myeloid leukemia.
Topics: Adolescent; Adult; Aged; Apoptosis; Bone Marrow Cells; Cell Line, Tumor; Cellular Microenvironment; | 2017 |
Crosstalk between BCR-ABL and protease-activated receptor 1 (PAR1) suggests a novel target in chronic myeloid leukemia.
Topics: Adult; Aged; Antineoplastic Agents; Apoptosis; Case-Control Studies; Cell Line, Tumor; Chromones; Di | 2018 |
Combined effects of PI3K and SRC kinase inhibitors with imatinib on intracellular calcium levels, autophagy, and apoptosis in CML-PBL cells.
Topics: Apoptosis; Autophagy; Benzamides; Calcium; Calcium Signaling; Cell Line, Tumor; Chromones; Drug Syne | 2013 |
PTEN regulates BCRP/ABCG2 and the side population through the PI3K/Akt pathway in chronic myeloid leukemia.
Topics: Adult; Aged; Apoptosis; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassett | 2014 |
Increased galectin-3 facilitates leukemia cell survival from apoptotic stimuli.
Topics: Apoptosis; bcl-X Protein; Cell Line, Tumor; Cell Survival; Chromones; Drug Resistance, Neoplasm; Gal | 2011 |
Bcr-Abl oncogene stimulates Jab1 expression via cooperative interaction of β-catenin and STAT1 in chronic myeloid leukemia cells.
Topics: Antineoplastic Agents; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Benzamides; beta | 2011 |
Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia patient samples.
Topics: Animals; Butadienes; Cell Differentiation; Cells, Cultured; Chromones; Cluster Analysis; Coculture T | 2012 |
Phosphatidylinositol-3 kinase inhibitors enhance the anti-leukemia effect of STI571.
Topics: Androstadienes; Antineoplastic Agents; Benzamides; Caspase 3; Caspases; Chromones; Drug Synergism; E | 2002 |
Inhibition of PI-3 kinase sensitizes human leukemic cells to histone deacetylase inhibitor-mediated apoptosis through p44/42 MAP kinase inactivation and abrogation of p21(CIP1/WAF1) induction rather than AKT inhibition.
Topics: Apoptosis; Benzamides; Butyrates; Chromones; Complement Membrane Attack Complex; Complement System P | 2003 |
Constitutively activated phosphatidylinositol 3-kinase primes platelets from patients with chronic myelogenous leukemia for thrombopoietin-induced aggregation.
Topics: Androstadienes; Blood Platelets; Chromones; Dose-Response Relationship, Drug; Enzyme Activation; Enz | 2004 |
Phosphatidylinositol-3 kinase inhibitors reproduce the selective antiproliferative effects of imatinib on chronic myeloid leukaemia progenitor cells.
Topics: Alkyl and Aryl Transferases; Androstadienes; Antineoplastic Agents; Benzamides; Blotting, Western; C | 2004 |
Lonafarnib reduces the resistance of primitive quiescent CML cells to imatinib mesylate in vitro.
Topics: Antigens, CD34; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Benzoquinones; Cell Line | 2005 |
Identification of transcriptional targets associated with the expression of p210 Bcr-Abl.
Topics: Animals; Benzamides; Cell Line; Cell Proliferation; Cells, Cultured; Chromones; Class I Phosphatidyl | 2006 |
[The anti-tumoral effect of PI3K inhibitor and MEK inhibitor combined with STI571 on chronic myeloid leukemia cells in a bone marrow stromal cell co-culture system].
Topics: Antineoplastic Agents; Apoptosis; Benzamides; Bone Marrow Cells; Cell Proliferation; Chromones; Cocu | 2006 |
Deregulation of the Wilms' tumour gene 1 protein (WT1) by BCR/ABL1 mediates resistance to imatinib in human leukaemia cells.
Topics: Apoptosis; Benzamides; Cell Line, Tumor; Cells, Cultured; Chromones; Drug Resistance, Neoplasm; Etop | 2007 |
HOXA10 expression induced by Abl kinase inhibitors enhanced apoptosis through PI3K pathway in CML cells.
Topics: Adult; Apoptosis; Benzamides; Blotting, Western; Bone Marrow; Case-Control Studies; Cell Cycle; Cell | 2008 |
The tyrosine kinase inhibitor CGP 57148 (ST1 571) induces apoptosis in BCR-ABL-positive cells by down-regulating BCL-X.
Topics: Animals; Apoptosis; bcl-X Protein; Benzamides; Caspase 3; Caspases; Cell Count; Cell Division; Chrom | 2000 |
Bcr-Abl kinase down-regulates cyclin-dependent kinase inhibitor p27 in human and murine cell lines.
Topics: Animals; Blotting, Western; Cell Cycle Proteins; Cell Division; Cell Line; Chromones; Culture Media; | 2000 |
Abnormal growth factor modulation of beta1-integrin-mediated adhesion in chronic myelogenous leukaemia haematopoietic progenitors.
Topics: Androstadienes; Case-Control Studies; Cell Adhesion; Cell Cycle Proteins; Cell Movement; Cells, Cult | 2001 |