2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Glioma in 43 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The introduction of temozolomide (TMZ) has advanced chemotherapy for malignant gliomas." | 7.78 | LY294002 enhances cytotoxicity of temozolomide in glioma by down-regulation of the PI3K/Akt pathway. ( Chen, L; Han, L; Jiang, C; Jiang, T; Kang, C; Liu, Y; Pu, P; Shi, Z; Zhang, K; Zheng, Y, 2012) |
| "We recently demonstrated that endothelin-1 (ET-1) activates two types of Ca2+-permeable nonselective cation channels (designated NSCC-1 and NSCC-2) in C6 glioma cells." | 7.72 | Effects of nonselective cation channels and PI3K on endothelin-1-induced PYK2 tyrosine phosphorylation in C6 glioma cells. ( Hashimoto, N; Kawanabe, Y; Masaki, T, 2003) |
| "Gliomas are aggressive brain tumors with very high resistance to chemotherapy throughout the overexpression of multiple intracellular survival pathways." | 5.62 | LY294002 and sorafenib as inhibitors of intracellular survival pathways in the elimination of human glioma cells by programmed cell death. ( A, M; A, Z; E, L; I, W; J, JG; J, SW; W, R, 2021) |
| "Leptin plays a role in glioma invasion, however, whether and how leptin contributes to the biological properties of glioma stem-like cells, such as invasion, remains to be explored." | 5.40 | Leptin enhances the invasive ability of glioma stem-like cells depending on leptin receptor expression. ( Han, G; Hu, X; Li, Y; Liu, J; Wang, L; Yue, Z; Zhao, R; Zhao, W; Zhou, X, 2014) |
| " Dose-response studies with SH-6 administered to glioma cell lines were performed using a luminescent cell-viability assay (0." | 5.33 | Cotreatment with a novel phosphoinositide analogue inhibitor and carmustine enhances chemotherapeutic efficacy by attenuating AKT activity in gliomas. ( Broaddus, WC; Cash, D; Fillmore, H; Van Meter, TE, 2006) |
| "The introduction of temozolomide (TMZ) has advanced chemotherapy for malignant gliomas." | 3.78 | LY294002 enhances cytotoxicity of temozolomide in glioma by down-regulation of the PI3K/Akt pathway. ( Chen, L; Han, L; Jiang, C; Jiang, T; Kang, C; Liu, Y; Pu, P; Shi, Z; Zhang, K; Zheng, Y, 2012) |
| " Using the human malignant glioma cell lines U87, A172, LN18, and LN229, we examined effects of the PI3K inhibitor LY294002 on both apoptosis and cytotoxicity induced by chemotherapeutic agents, including antimicrotubule agents vincristine and paclitaxel, an alkylating agent 1,3-bis(2-chloroethyl)-1-nitrosourea, a topoisomerase II inhibitor etoposide, and a DNA cross-linking agent cisplatin (cis-diamminedichloroplatinum), and we compared the LY294002-induced enhancement of effects of those agents." | 3.72 | Synergistic augmentation of antimicrotubule agent-induced cytotoxicity by a phosphoinositide 3-kinase inhibitor in human malignant glioma cells. ( Hara, N; Moritake, K; Osago, H; Shingu, T; Terashima, M; Tsuchiya, M; Uemura, T; Yamada, K; Yamasaki, T, 2003) |
| "We recently demonstrated that endothelin-1 (ET-1) activates two types of Ca2+-permeable nonselective cation channels (designated NSCC-1 and NSCC-2) in C6 glioma cells." | 3.72 | Effects of nonselective cation channels and PI3K on endothelin-1-induced PYK2 tyrosine phosphorylation in C6 glioma cells. ( Hashimoto, N; Kawanabe, Y; Masaki, T, 2003) |
| "Gliomas are aggressive brain tumors with very high resistance to chemotherapy throughout the overexpression of multiple intracellular survival pathways." | 1.62 | LY294002 and sorafenib as inhibitors of intracellular survival pathways in the elimination of human glioma cells by programmed cell death. ( A, M; A, Z; E, L; I, W; J, JG; J, SW; W, R, 2021) |
| "Glioma is a malignant brain cancer that exhibits high invasive ability and poor prognosis." | 1.56 | miR‑181d promotes cell proliferation via the IGF1/PI3K/AKT axis in glioma. ( Chen, Q; Gao, W; Ge, J; Liu, B; Liu, J; Tang, D; Yang, J; Zhao, J, 2020) |
| "Leptin plays a role in glioma invasion, however, whether and how leptin contributes to the biological properties of glioma stem-like cells, such as invasion, remains to be explored." | 1.40 | Leptin enhances the invasive ability of glioma stem-like cells depending on leptin receptor expression. ( Han, G; Hu, X; Li, Y; Liu, J; Wang, L; Yue, Z; Zhao, R; Zhao, W; Zhou, X, 2014) |
| "Gliomas are primary brain tumors with poor prognosis that exhibit frequent abnormalities in phosphatidylinositol 3-kinase (PI3 kinase) signaling." | 1.35 | Molecular pharmacology of phosphatidylinositol 3-kinase inhibition in human glioma. ( Bjerke, L; Clarke, PA; Eccles, SA; Guillard, S; Mohri, Z; Raynaud, F; Te Poele, R; Valenti, M; Workman, P, 2009) |
| "Temozolomide, the standard treatment of gliomas, although not an ABCG2 substrate, increases the SP in glioma cells, especially in cells missing PTEN." | 1.35 | PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells. ( Bleau, AM; Brennan, CW; Fomchenko, EI; Hambardzumyan, D; Holland, EC; Huse, JT; Ozawa, T, 2009) |
| "Malignant gliomas are highly invasive tumors which are lethal despite aggressive therapy." | 1.33 | Deregulated human glioma cell motility: inhibitory effect of somatostatin. ( Cattaneo, MG; Gentilini, D; Vicentini, LM, 2006) |
| " Dose-response studies with SH-6 administered to glioma cell lines were performed using a luminescent cell-viability assay (0." | 1.33 | Cotreatment with a novel phosphoinositide analogue inhibitor and carmustine enhances chemotherapeutic efficacy by attenuating AKT activity in gliomas. ( Broaddus, WC; Cash, D; Fillmore, H; Van Meter, TE, 2006) |
| " Consistent with a mechanistic link between migration and apoptosis, the dose-response for stimulation of migration on laminin was inversely proportional to apoptosis induction." | 1.32 | Migrating glioma cells activate the PI3-K pathway and display decreased susceptibility to apoptosis. ( Beaudry, CE; Berens, ME; Demuth, T; Holz, DR; Joy, AM; Ponce, FA; Tran, NL, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 18 (41.86) | 29.6817 |
| 2010's | 23 (53.49) | 24.3611 |
| 2020's | 2 (4.65) | 2.80 |
| Authors | Studies |
|---|---|
| Tang, D | 1 |
| Gao, W | 1 |
| Yang, J | 1 |
| Liu, J | 2 |
| Zhao, J | 1 |
| Ge, J | 1 |
| Chen, Q | 1 |
| Liu, B | 1 |
| A, Z | 1 |
| J, SW | 1 |
| A, M | 1 |
| E, L | 1 |
| I, W | 1 |
| W, R | 1 |
| J, JG | 1 |
| Nan, Y | 1 |
| Guo, L | 1 |
| Song, Y | 1 |
| Wang, L | 3 |
| Yu, K | 1 |
| Huang, Q | 1 |
| Zhong, Y | 1 |
| Gupta, P | 1 |
| Singh, P | 1 |
| Pandey, HS | 1 |
| Seth, P | 1 |
| Mukhopadhyay, CK | 1 |
| Sun, H | 1 |
| Yang, B | 1 |
| Zhang, H | 1 |
| Song, J | 1 |
| Zhang, Y | 2 |
| Xing, J | 1 |
| Yang, Z | 1 |
| Wei, C | 1 |
| Xu, T | 1 |
| Yu, Z | 1 |
| Xu, Z | 1 |
| Hou, M | 1 |
| Ji, M | 1 |
| Wang, MH | 1 |
| Lin, CL | 1 |
| Zhang, JJ | 1 |
| Weng, ZP | 1 |
| Hu, T | 1 |
| Xie, Q | 1 |
| Zhong, XY | 1 |
| Yang, YL | 1 |
| Huang, PH | 1 |
| Chiu, HC | 1 |
| Kulp, SK | 1 |
| Chen, CS | 2 |
| Kuo, CJ | 1 |
| Chen, HD | 1 |
| Millet, P | 1 |
| Granotier, C | 1 |
| Etienne, O | 1 |
| Boussin, FD | 1 |
| Han, G | 1 |
| Zhao, W | 1 |
| Yue, Z | 1 |
| Zhao, R | 1 |
| Li, Y | 1 |
| Zhou, X | 1 |
| Hu, X | 1 |
| Giuliani, P | 1 |
| Ballerini, P | 1 |
| Buccella, S | 1 |
| Ciccarelli, R | 1 |
| Rathbone, MP | 1 |
| Romano, S | 1 |
| D'Alimonte, I | 1 |
| Caciagli, F | 1 |
| Di Iorio, P | 1 |
| Pokorski, M | 1 |
| Cai, H | 1 |
| Xue, Y | 2 |
| Li, Z | 2 |
| Hu, Y | 3 |
| Wang, Z | 1 |
| Liu, W | 1 |
| Liu, Y | 3 |
| Grimaldi, A | 1 |
| D'Alessandro, G | 1 |
| Golia, MT | 1 |
| Grössinger, EM | 1 |
| Di Angelantonio, S | 1 |
| Ragozzino, D | 1 |
| Santoro, A | 1 |
| Esposito, V | 1 |
| Wulff, H | 1 |
| Catalano, M | 1 |
| Limatola, C | 1 |
| Cai, RP | 1 |
| Xue, YX | 2 |
| Huang, J | 1 |
| Wang, JH | 2 |
| Zhao, SY | 1 |
| Guan, TT | 1 |
| Zhang, Z | 1 |
| Gu, YT | 1 |
| Guillard, S | 1 |
| Clarke, PA | 1 |
| Te Poele, R | 1 |
| Mohri, Z | 1 |
| Bjerke, L | 1 |
| Valenti, M | 1 |
| Raynaud, F | 1 |
| Eccles, SA | 1 |
| Workman, P | 1 |
| Bleau, AM | 1 |
| Hambardzumyan, D | 1 |
| Ozawa, T | 1 |
| Fomchenko, EI | 1 |
| Huse, JT | 1 |
| Brennan, CW | 1 |
| Holland, EC | 1 |
| Zhou, YH | 1 |
| Mayes, D | 1 |
| Siegel, E | 1 |
| Kim, JG | 1 |
| Mathews, MS | 1 |
| Hsu, N | 1 |
| Eskander, D | 1 |
| Yu, O | 1 |
| Tromberg, BJ | 1 |
| Linskey, ME | 1 |
| Shi, J | 1 |
| Zhang, L | 1 |
| Shen, A | 1 |
| Zhang, J | 2 |
| Wang, Y | 2 |
| Zhao, Y | 1 |
| Zou, L | 1 |
| Ke, Q | 1 |
| He, F | 1 |
| Wang, P | 2 |
| Cheng, C | 1 |
| Shi, G | 1 |
| Gopinath, S | 1 |
| Malla, RR | 1 |
| Gondi, CS | 1 |
| Alapati, K | 1 |
| Fassett, D | 1 |
| Klopfenstein, JD | 1 |
| Dinh, DH | 1 |
| Gujrati, M | 1 |
| Rao, JS | 1 |
| Han, L | 2 |
| Yang, Y | 1 |
| Yue, X | 1 |
| Huang, K | 1 |
| Liu, X | 1 |
| Pu, P | 3 |
| Jiang, H | 1 |
| Yan, W | 2 |
| Jiang, T | 3 |
| Kang, C | 3 |
| Desai, S | 1 |
| Pillai, P | 1 |
| Win-Piazza, H | 1 |
| Acevedo-Duncan, M | 1 |
| Lu, X | 1 |
| Qian, C | 2 |
| Li, P | 1 |
| Shi, L | 1 |
| Zhao, P | 1 |
| Fu, Z | 1 |
| Liu, N | 1 |
| You, Y | 1 |
| Chen, L | 1 |
| Shi, Z | 1 |
| Zhang, K | 1 |
| Zheng, Y | 1 |
| Jiang, C | 1 |
| Cheng, P | 1 |
| Liu, YH | 1 |
| Tanabe, K | 1 |
| Matsushima-Nishiwaki, R | 1 |
| Iida, M | 1 |
| Kozawa, O | 1 |
| Iida, H | 1 |
| Zhong, D | 1 |
| Ran, JH | 1 |
| Tang, WY | 1 |
| Zhang, XD | 1 |
| Tan, Y | 1 |
| Chen, GJ | 1 |
| Li, XS | 1 |
| Yan, Y | 1 |
| Yang, XJ | 1 |
| Chen, GL | 1 |
| Yu, SC | 1 |
| Xu, C | 1 |
| Xin, YH | 1 |
| Li, TT | 1 |
| Shi, Y | 1 |
| Gu, A | 1 |
| Duan, JJ | 1 |
| Cui, YH | 1 |
| Zhang, X | 2 |
| Bian, XW | 1 |
| Shingu, T | 2 |
| Yamada, K | 2 |
| Hara, N | 2 |
| Moritake, K | 2 |
| Osago, H | 2 |
| Terashima, M | 2 |
| Uemura, T | 2 |
| Yamasaki, T | 2 |
| Tsuchiya, M | 2 |
| Su, JD | 1 |
| Mayo, LD | 1 |
| Donner, DB | 1 |
| Durden, DL | 1 |
| Kawanabe, Y | 1 |
| Hashimoto, N | 1 |
| Masaki, T | 1 |
| Joy, AM | 1 |
| Beaudry, CE | 1 |
| Tran, NL | 1 |
| Ponce, FA | 1 |
| Holz, DR | 1 |
| Demuth, T | 1 |
| Berens, ME | 1 |
| Li, B | 1 |
| Yuan, M | 1 |
| Kim, IA | 1 |
| Chang, CM | 1 |
| Bernhard, EJ | 1 |
| Shu, HK | 1 |
| Dawson, G | 1 |
| Moskal, JR | 1 |
| Dawson, SA | 1 |
| Takeuchi, H | 1 |
| Kondo, Y | 1 |
| Fujiwara, K | 1 |
| Kanzawa, T | 1 |
| Aoki, H | 1 |
| Mills, GB | 1 |
| Kondo, S | 1 |
| Levitt, RJ | 1 |
| Georgescu, MM | 1 |
| Pollak, M | 1 |
| Premkumar, DR | 1 |
| Arnold, B | 1 |
| Jane, EP | 1 |
| Pollack, IF | 1 |
| Cattaneo, MG | 1 |
| Gentilini, D | 1 |
| Vicentini, LM | 1 |
| Van Meter, TE | 1 |
| Broaddus, WC | 1 |
| Cash, D | 1 |
| Fillmore, H | 1 |
| Zheng, X | 1 |
| Jiang, F | 1 |
| Katakowski, M | 1 |
| Kalkanis, SN | 1 |
| Hong, X | 1 |
| Zhang, ZG | 1 |
| Yang, H | 1 |
| Chopp, M | 1 |
| Flores, DG | 1 |
| de Farias, CB | 1 |
| Leites, J | 1 |
| de Oliveira, MS | 1 |
| Lima, RC | 1 |
| Tamajusuku, AS | 1 |
| Di Leone, LP | 1 |
| Meurer, L | 1 |
| Brunetto, AL | 1 |
| Schwartsmann, G | 1 |
| Lenz, G | 1 |
| Roesler, R | 1 |
| Gottschalk, AR | 1 |
| Basila, D | 1 |
| Wong, M | 1 |
| Dean, NM | 1 |
| Brandts, CH | 1 |
| Stokoe, D | 1 |
| Haas-Kogan, DA | 1 |
| Roymans, D | 1 |
| Grobben, B | 1 |
| Claes, P | 1 |
| Slegers, H | 1 |
43 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Glioma
| Article | Year |
|---|---|
miR‑181d promotes cell proliferation via the IGF1/PI3K/AKT axis in glioma.
Topics: Animals; Apoptosis; Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromones; Gl | 2020 |
LY294002 and sorafenib as inhibitors of intracellular survival pathways in the elimination of human glioma cells by programmed cell death.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Chromones; Glioma; Humans; Morpholines; S | 2021 |
Combinatorial therapy with adenoviral-mediated PTEN and a PI3K inhibitor suppresses malignant glioma cell growth in vitro and in vivo by regulating the PI3K/AKT signaling pathway.
Topics: Adenoviridae; Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Chromones; Combined Modality | 2017 |
Phosphoinositide-3-kinase inhibition elevates ferritin level resulting depletion of labile iron pool and blocking of glioma cell proliferation.
Topics: Adenine; Animals; Brain Neoplasms; Cell Proliferation; Cells, Cultured; Chromones; Down-Regulation; | 2019 |
RRM2 is a potential prognostic biomarker with functional significance in glioma.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromones; Flavonoids; Flow | 2019 |
Role of PTEN in cholera toxin-induced SWO‑38 glioma cell differentiation.
Topics: Cell Differentiation; Cell Line, Tumor; Cell Movement; Cholera Toxin; Chromones; Cyclin D1; G1 Phase | 2013 |
Histone deacetylase inhibitor AR42 regulates telomerase activity in human glioma cells via an Akt-dependent mechanism.
Topics: Cell Line, Tumor; Chromones; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation, Enzymolo | 2013 |
Radiation-induced upregulation of telomerase activity escapes PI3-kinase inhibition in two malignant glioma cell lines.
Topics: Cell Line, Tumor; Chromones; DNA Breaks, Double-Stranded; DNA Repair; Enzyme Activation; Enzyme Inhi | 2013 |
Leptin enhances the invasive ability of glioma stem-like cells depending on leptin receptor expression.
Topics: AC133 Antigen; Antigens, CD; Brain Neoplasms; Cell Movement; Chromones; Colony-Forming Units Assay; | 2014 |
Guanosine protects glial cells against 6-hydroxydopamine toxicity.
Topics: Animals; Apoptosis; Astrocytes; Biological Transport; Butadienes; Cell Line, Tumor; Chromones; DNA F | 2015 |
Roundabout4 suppresses glioma-induced endothelial cell proliferation, migration and tube formation in vitro by inhibiting VEGR2-mediated PI3K/AKT and FAK signaling pathways.
Topics: Cell Line; Cell Movement; Cell Proliferation; Chromones; Cinnamates; Culture Media, Conditioned; End | 2015 |
KCa3.1 inhibition switches the phenotype of glioma-infiltrating microglia/macrophages.
Topics: Animals; Brain; Cell Line, Tumor; Chromones; Focal Adhesion Kinase 1; Glioma; Humans; Interleukin-4; | 2016 |
NS1619 regulates the expression of caveolin-1 protein in a time-dependent manner via ROS/PI3K/PKB/FoxO1 signaling pathway in brain tumor microvascular endothelial cells.
Topics: Animals; Antineoplastic Agents; Benzimidazoles; Brain Neoplasms; Carotid Arteries; Caveolin 1; Cell | 2016 |
Molecular pharmacology of phosphatidylinositol 3-kinase inhibition in human glioma.
Topics: Animals; Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Chromones; Enzyme Inhibitors; Furans; Gene E | 2009 |
PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; ATP Binding Cassette Transporter, | 2009 |
PAX6 suppression of glioma angiogenesis and the expression of vascular endothelial growth factor A.
Topics: Analysis of Variance; Animals; Cell Line, Tumor; Chromones; Enzyme Inhibitors; Enzyme-Linked Immunos | 2010 |
Clinical and biological significance of forkhead class box O 3a expression in glioma: mediation of glioma malignancy by transcriptional regulation of p27kip1.
Topics: Adult; Aged; Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Chromones; Cyclin-Dependent Kinase Inhib | 2010 |
Co-depletion of cathepsin B and uPAR induces G0/G1 arrest in glioma via FOXO3a mediated p27 upregulation.
Topics: Animals; Blotting, Western; Cathepsin B; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromones | 2010 |
Inactivation of PI3K/AKT signaling inhibits glioma cell growth through modulation of β-catenin-mediated transcription.
Topics: Animals; beta Catenin; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromones; Disease Models, | 2010 |
PKC-ι promotes glioblastoma cell survival by phosphorylating and inhibiting BAD through a phosphatidylinositol 3-kinase pathway.
Topics: 14-3-3 Proteins; Androstadienes; Apoptosis; bcl-Associated Death Protein; bcl-X Protein; Blotting, W | 2011 |
Overexpression of osteopontin induces angiogenesis of endothelial progenitor cells via the avβ3/PI3K/AKT/eNOS/NO signaling pathway in glioma cells.
Topics: Antibodies, Monoclonal; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromones; Endothelial | 2011 |
Regulation of cellular growth, apoptosis, and Akt activity in human U251 glioma cells by a combination of cisplatin with CRM197.
Topics: Androstadienes; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Bacterial Proteins; Cell | 2012 |
LY294002 enhances cytotoxicity of temozolomide in glioma by down-regulation of the PI3K/Akt pathway.
Topics: Antineoplastic Agents, Alkylating; bcl-2-Associated X Protein; Caspase 3; Cell Line, Tumor; Chromone | 2012 |
Glioma cells promote the expression of vascular cell adhesion molecule-1 on bone marrow-derived mesenchymal stem cells: a possible mechanism for their tropism toward gliomas.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Neutralizing; Bone Marrow Cells; Cell Communication; Ce | 2012 |
Involvement of phosphatidylinositol 3-kinase/Akt on basic fibroblast growth factor-induced glial cell line-derived neurotrophic factor release from rat glioma cells.
Topics: Animals; Cell Line; Cell Line, Tumor; Chromones; Fibroblast Growth Factor 2; Glial Cell Line-Derived | 2012 |
Mda-9/syntenin promotes human brain glioma migration through focal adhesion kinase (FAK)-JNK and FAK-AKT signaling.
Topics: Anthracenes; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Chromones; Focal Adhesion Protein-Tyr | 2012 |
TGF-β1 enhances tumor-induced angiogenesis via JNK pathway and macrophage infiltration in an improved zebrafish embryo/xenograft glioma model.
Topics: Angiogenesis Inhibitors; Animals; Animals, Genetically Modified; Anthracenes; Cell Line, Tumor; Cell | 2013 |
Growth inhibition of human malignant glioma cells induced by the PI3-K-specific inhibitor.
Topics: Apoptosis; Cell Division; Chromones; Enzyme Inhibitors; Glioma; Growth Inhibitors; Humans; In Vitro | 2003 |
PTEN and phosphatidylinositol 3'-kinase inhibitors up-regulate p53 and block tumor-induced angiogenesis: evidence for an effect on the tumor and endothelial compartment.
Topics: Angiogenesis Inhibitors; Brain Neoplasms; Cell Division; Cell Line; Cell Survival; Cerebrovascular C | 2003 |
Synergistic augmentation of antimicrotubule agent-induced cytotoxicity by a phosphoinositide 3-kinase inhibitor in human malignant glioma cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carmustine; Chromones; Cisplatin; Drug Synergism; En | 2003 |
Effects of nonselective cation channels and PI3K on endothelin-1-induced PYK2 tyrosine phosphorylation in C6 glioma cells.
Topics: Androstadienes; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cations; Cell Division | 2003 |
Migrating glioma cells activate the PI3-K pathway and display decreased susceptibility to apoptosis.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Camptothecin; Cell Movement; Chromones; Enzyme Ac | 2003 |
Mutant epidermal growth factor receptor displays increased signaling through the phosphatidylinositol-3 kinase/AKT pathway and promotes radioresistance in cells of astrocytic origin.
Topics: Astrocytes; Cell Division; Cell Line, Transformed; Central Nervous System Neoplasms; Chromones; Enzy | 2004 |
Transfection of 2,6 and 2,3-sialyltransferase genes and GlcNAc-transferase genes into human glioma cell line U-373 MG affects glycoconjugate expression and enhances cell death.
Topics: Antineoplastic Agents; beta-D-Galactoside alpha 2-6-Sialyltransferase; Caspase 3; Caspases; Cell Dea | 2004 |
Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors.
Topics: Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; C | 2005 |
PTEN-induction in U251 glioma cells decreases the expression of insulin-like growth factor binding protein-2.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Chromones; Enzyme Induction; Gene Expression Regula | 2005 |
Synergistic interaction between 17-AAG and phosphatidylinositol 3-kinase inhibition in human malignant glioma cells.
Topics: Apoptosis; Benzoquinones; Blotting, Western; Caspase 3; Caspases; Cell Line, Tumor; Chromones; Drug | 2006 |
Deregulated human glioma cell motility: inhibitory effect of somatostatin.
Topics: Butadienes; Cell Line, Tumor; Cell Movement; Chemotactic Factors; Chromones; Enzyme Inhibitors; Extr | 2006 |
Cotreatment with a novel phosphoinositide analogue inhibitor and carmustine enhances chemotherapeutic efficacy by attenuating AKT activity in gliomas.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Carmustine; Caspases; Cell Survival; Chemotherap | 2006 |
Inhibition of ADAM17 reduces hypoxia-induced brain tumor cell invasiveness.
Topics: ADAM Proteins; ADAM17 Protein; Animals; Blotting, Western; Cell Hypoxia; Cell Line, Tumor; Cell Move | 2007 |
Gastrin-releasing peptide receptors regulate proliferation of C6 Glioma cells through a phosphatidylinositol 3-kinase-dependent mechanism.
Topics: Animals; Antineoplastic Agents; Bombesin; Cell Line, Tumor; Cell Proliferation; Chromones; Enzyme In | 2008 |
p27Kip1 is required for PTEN-induced G1 growth arrest.
Topics: CDC2-CDC28 Kinases; Cell Cycle Proteins; Cell Division; Chromones; Cyclin-Dependent Kinase 2; Cyclin | 2001 |
Protein tyrosine kinase-dependent regulation of adenylate cyclase and phosphatidylinositol 3-kinase activates the expression of glial fibrillary acidic protein upon induction of differentiation in rat c6 glioma.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Androstadienes; Animals; Anti-Bacterial Agents; Benzoqu | 2001 |