Compounds > 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one

2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Disease Models, Animal

2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Disease Models, Animal in 158 studies

Research

Studies (158)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	29 (18.35)	29.6817
2010's	110 (69.62)	24.3611
2020's	19 (12.03)	2.80

Authors

Authors	Studies
Cheresh, D; Demaria, A; Dneprovskaia, E; Doukas, J; Fine, R; Hood, J; Noronha, G; Soll, R; Weis, S; Wrasidlo, W	1
Braisted, J; Dranchak, P; Earnest, TW; Gu, X; Hoon, MA; Inglese, J; Oliphant, E; Solinski, HJ	1
Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV	1
Huang, S; Jin, F; Liu, Y; Qi, F; Yang, S	1
Arosh, JA; Banu, SK; Lee, J	1
Chen, Z; Li, H; Li, L; Li, T; Xie, J; Zhou, Y	1
Gao, Y; Lu, R; Nie, Z; Sun, H; Yu, Z; Zhang, L; Zhu, W	1
Cevey, ÁC; Goren, NB; Mascolo, PD; Mirkin, GA; Penas, FN; Pieralisi, AV; Sequeyra, AS	1
Dou, Y; Li, Y; Lin, Y; Ma, L; Qi, R; Wang, J; Zhu, X	1
Ho, YC; Kapupara, K; Nguyen Ngo Le, MA; Tsai, RK; Wen, YT	1
Jiang, J; Liu, Y; Lu, X; Qin, X	1
Kumari, S; Mazumder, AG; Singh, D	1
Al-Masri, A; Alyahya, AM; El Eter, E; Hersi, A; Husain, S; Lateef, R; Mawlana, OH	1
Baker, A; Barretto, TA; Gallagher, D; Gauthier-Fisher, A; Kenigsberg, S; Librach, C; Liu, E; Maghen, L; Park, E; Park, K	1
Chen, K; Lin, K; Shang, X; Wang, L; Xu, J; Yu, R; Zhang, Y; Zhu, P	1
Chen, C; Gao, S; Gong, J; Guo, Y; Huang, T; Li, C; Li, Z; Ling, C; Wang, H; Zhang, L	1
Chen, L; Gu, Y; Su, X; Zhao, C	1
Dong, W; Jiang, X; Liu, W; Luo, B; Qiu, C; Shen, B; Zhang, L; Zhang, W	1
Chen, L; Du, S; Gao, L; Han, J; Li, J; Niu, Z; Shi, Y; Tian, H; Wei, L; Yang, P	1
Chen, Y; Du, J; Jia, LX; Jia, MZ; Liu, X; Lu, WW; Ni, XQ; Ning, ZP; Qi, YF; Ren, JL; Tang, CS; Yu, YR; Zhang, LS; Zhang, YR; Zhu, Q	1
Hou, X; Kong, M; Ni, H; Shao, Z; Shen, Q	1
Chen, H; Deng, Y; Guo, Z; He, Z; Liang, Y; Liu, L; Sun, X; Zhang, P; Zhang, Z	1
Cheng, D; Li, H; Li, Y; Qu, M; Xing, F; Xing, N; Zhang, W	1
Baker, W; Cambow, D; Gogerty, D; Herlihy, B; Leda, AR; Park, M; Pavlenko, D; Toborek, M; Van Den Nieuwenhuizen, S	1
Chen, J; Gu, Z; Hong, C; Hu, B; Liu, C; Lu, R; Shen, B; Yang, W; Ye, S; Zhang, M	1
Gong, N; Hou, S; Kuang, B; Li, Q; Sun, K; Wang, M; Wang, MMZ; Zhang, J	1
Cai, S; Chen, J; Dong, H; Hu, Y; Huang, C; Le, Y; Liu, L; Luo, L; Xie, Z; Yu, C; Zhao, H; Zou, F; Zou, M	1
Dai, H; Li, J; Ling, S; Liu, J; Lu, D; Shan, Q; Song, P; Wen, X; Xie, H; Xu, X; Zheng, S; Zhou, L	1
Fan, TT; Feng, XY; Gao, F; Liu, Q; Yang, YZ	1
Broide, DH; Cao, L; Dong, L; Li, S; Liu, L; Liu, T; Liu, Y; Miller, M; Wang, J; Wu, J; Xu, J; Zhao, J; Zou, M	1
Cui, C; Cui, J; Cui, Y; Gao, J; Jiang, X; Li, R; Sheng, H; Tian, Y; Wang, K	1
Black, GE; Capley, G; Gillespie, M; Gorodnya, O; Martin, MJ; Moe, DM; Muscat, D; Pastukh, V; Roth, MB; Ruchko, M; Simmons, JD; Sokol, KK	1
Bian, H; Duan, J; Li, W; Lin, R; Ma, T; Mu, F; Wei, G; Wen, A; Wu, X; Xi, M; Yang, Q	1
Chen, J; Chen, Y; He, Z; Khor, S; Li, J; Li, X; Shi, K; Wang, Q; Wang, X; Wang, Z; Xiao, J; Yin, J; Zhang, H; Zhao, Y; Zheng, Z	1
Enkhjargal, B; Gospodarev, V; Hu, X; Sun, C; Tang, J; Wu, L; Xie, Z; You, C; Zhang, JH; Zhou, K	1
Bian, XH; Feng, S; Luo, Y; Qin, GH; Shi, RM; Zhang, L	1
Chen, Q; Hu, J; Liu, J; Meng, Z; Ni, Z; Sun, L; Tang, L; Wang, X; Zhu, L	1
Chen, Q; Deng, S; Dong, Y; Duan, X; Fan, H; Liu, X; Liu, Y; Nan, Z; Shou, Z; Tang, Q; Wu, H; Xu, M; Yang, J; Zhang, L; Zuo, D	1
Dong, Y; Duan, Y; Liu, X; Lu, T; Shang, C; Wei, N; Wu, X; Zhou, Y	1
Chattopadhyay, A; Jin, S; Mao, X; Salama, G; Xing, S; Xu, G; Yang, X	1
Chen, HS; Ma, N; Zhang, NN; Zhao, ZA	1
Gao, M; He, D; Shen, J; Zhang, B	1
He, C; Jiang, W; Li, J; Xing, J; Zeng, C; Zheng, R	1
Dong, HP; He, ZZ; Ma, XX; Wang, ZH; Zhou, W	1
Wang, S; Wen, Y; Yang, Y; Zhang, N	1
Enkhjargal, B; Huang, L; Mo, J; Sun, C; Tang, J; Wu, P; Xie, Z; Zhang, JH; Zhang, T; Zhu, Q	1
Han, C; Li, J; Li, S; Liu, X; Ma, Y; Wang, X; Zhang, J; Zhang, L; Zheng, L	1
Duan, Z; Li, J; Pang, X; Su, Z; Wang, H	1
Gong, X; He, D; Luan, Q; Pan, L; Zhou, H	1
Fu, A; Luo, KQ; Ngan, W; Peh, YM; Wei, N	1
Chen, J; Chen, Q; Feng, Z; Hang, W; He, B; Wang, S; Wang, X; Wu, N; Xia, L; Zhang, Q; Zhou, X	1
Jang, CG; Jeong, JH; Kim, DJ; Kim, HC; Lee, YJ; Nabeshima, T; Park, SJ; Sharma, N; Shin, EJ; Tran, HQ; Tran, TV	1
Chen, D; Chen, Z; Dai, C; Han, Z; He, F; Li, Y; Tan, R; Tian, H; Wang, G; Wang, M; Wei, L; Yang, B; Yang, H; Zhang, B	1
Gao, F; Li, F; Li, XY; Liu, ST; Miao, Y; Sun, XH; Wang, X; Wang, Z; Yang, XL; Zhang, ML; Zhong, SM; Zhu, K	1
Gao, D; Li, S; Sun, H; Tang, T; Tang, Y; Zhu, J	1
Chen, YH; Huang, CH; Lee, JC; Liaw, CC; Lin, CK; Lin, CY; Tseng, CK; Wang, WH; Wu, YH	1
Hou, C; Huang, Q; Huang, X; Li, M; Liang, Y; Qu, D	1
Luo, Z; Niu, X; Tang, J; Zhang, M	1
Cao, B; Hu, Z; Jiang, F; Li, JD; Li, X; Wu, K; Xia, K; Xing, X; Zhang, J	1
Cortés, M; Darling, DS; Ninfali, C; Postigo, A; Siles, L	1
Chu, T; Jiang, P; Li, ST; Liu, H; Wu, J	1
Bao, XQ; Chen, G; Han, YP; Hu, M; Jiang, W; Yan, Y	1
Wang, M; Wang, N	1
Chen, JW; Chen, SQ; Chen, SY; Li, HY; Zhang, QG	1
Chen, L; Fu, W; Li, X; Liao, X; Ruan, J; Wang, B; Wang, K; Zhou, J	1
Fu, W; Hu, X; Jiang, H; Wang, J; Xie, J; Xu, W; Yang, H; Zhou, X	1
Cai, X; Chong, L; Li, C; Liang, Y; Lin, B; Nie, Y; Zhang, H; Zhang, W	1
Chai, JJ; Chen, H; Chen, LZ; Guo, JP; Lu, JH; Shen, Y; Tu, JF; Yang, XH; Yuan, SR; Zhai, CL; Zhang, MQ; Zheng, YL	1
Durden, DL; Joshi, S; Kesari, S; Makale, MT; Muh, CR; Singh, AR	1
Drabsch, Y; He, S; Snaar-Jagalska, BE; ten Dijke, P; Zhang, L	1
Cai, Q; Li, H; Yao, Z	1
Guan, D; Jin, J; Tan, R; Wang, S; Xu, Y; Yang, H; Yin, K; Yu, L; Zhao, H; Zhu, X	1
Hou, Y; Jeong, CH; Jeun, SS; Jun, JA; Kim, SM; Ryu, CH	1
Chen, J; Li, J; Liu, CF; Miao, Z; Xu, X	1
Ding, X; Fang, Y; Liang, M; Liu, S; Liu, T; Yu, X; Zhang, H	1
Chen, X; Cui, W; Li, C; Lu, Y; Wang, C; Wang, Q; Wang, W; Wei, X; Xue, Z; Zhang, J; Zhao, X; Zhou, W	1
Abdillahi, M; Ananthakrishnan, R; Deckelbaum, RJ; Quadri, N; Ramasamy, R; Rosario, R; Wang, L; Zhu, Z; Zirpoli, H	1
Dong, J; Fang, H; He, S; Huang, K; Kushwaha, KK; Li, D; Lin, J; Mohabeer, N; Su, Y; Wang, B; Wu, C	1
Cai, Y; Dong, K; Gao, Y; Geng, J; Han, X; Jin, Z; Li, H; Li, Y; Liang, W; Lipinski, M; Liu, M; Najafov, A; Pandolfi, PP; Peng, T; Qi, C; Sun, A; Xia, H; Xiao, J; Xiong, Y; Xu, D; Yu, Q; Yuan, J; Zhang, Q; Zhang, T; Zhu, H	1
Du, ZD; Hu, LT; Li, Y; Ma, ZZ; Zhao, GQ	1
Chen, HJ; Potteti, HR; Reddy, NM; Reddy, SP; Tamatam, CM; Vegiraju, S	1
Kana, K; Laschinger, C; Radisic, M; Song, H; Zandstra, PW	1
Fan, C; Feng, Y; Hu, L; Mo, X; Wen, Z; Yang, L; Yin, KJ; Yu, D; Zhang, W	1
Kay, JC; Liu, M; Qiao, LY; Shen, S	1
Fernyhough, P; Habash, T; Roy Chowdhury, SK; Saleh, A; Smith, DR	1
Arai, K; Egawa, N; Ihara, M; Itoh, K; Liang, AC; Lo, EK; Lok, J; Maeda, M; Maki, T; Miyamoto, N; Shindo, A	1
Bao, YY; Fan, J; Lu, ZJ; Luo, XM; Xu, B; Zhou, ML; Zhou, SH	1
Bai, H; Chu, Y; Feng, B; Li, H; Liu, H; Liu, S; Wang, X; Yuan, X; Zhao, B	1
Chen, Z; Lei, S; Liu, H; Xia, Z; Zhao, B	1
Deng, H; Fu, W; Li, E; Tian, S; Wang, B; You, Y	1
Chu, H; Dong, Q; Tang, Y; Yang, X	1
Greenwood, JA; Punnoose, A; Tanguay, RL; Wehmas, LC	1
Fang, F; Li, H; Peng, T; Wang, W; Yang, S; Zhang, Y	1
Lei, P; Ma, L; Sun, N; Wang, H; Zhang, Q	1
Black, GE; Eckert, MJ; Hoffer, ZS; Keyes, CC; Marko, ST; Martin, MJ; Roth, MB; Salgar, S; Shawhan, RR; Sokol, KK	1
Hu, J; Peng, X; Wang, C; Wang, H; Wu, D; Wu, W; Zhang, Y	1
Corrigan, CJ; Huang, K; Huang, P; Li, Y; Lv, Z; Wang, J; Wang, W; Yao, X; Ying, S; Zhang, Q	1
Hou, P; Liu, X; Liu, Z; Ma, K; Sun, B; Wang, Z; Yuan, S; Zhang, R; Zhang, X	1
Chen, D; Gou, X; Li, J; Liang, S	1
Agafonov, VI; Chaikovskii, AV; Dygai, AM; Khrichkova, TY; Minakova, MY; Miroshnichenko, LA; Sherstoboev, EY; Simanina, EV; Stavrova, LA; Udut, EV; Zhdanov, VV; Zyuz'kov, GN	1
Domin, H; Pochwat, B; Śmiałowska, M; Szewczyk, B; Woźniak, M	1
Chen, L; Chen, WF; Chen, XH; Du, ZR; Teng, JJ; Wong, MS; Wu, L; Xu, AL	1
Hsieh, CL; Huang, CP; Liao, HY; Lin, YW	1
Chen, J; Zhang, F	1
Han, D; Li, C; Wen, XR; Xu, J; Yu, CZ; Zhang, GY; Zong, YY	1
Chen, T; Hanley, G; Miao, J; Stuart, C; Sun, X; Yin, D; Zhang, Y	1
Morgan, DA; Rahmouni, K; Thedens, DR; Weiss, R	1
Codeluppi, S; Hefferan, MP; Marsala, M; Oshiro, M; Pasquale, EB; Silldorff, MD; Svensson, CI; Valencia, F	1
Choi, A; Javadov, S; Karmazyn, M; Kilić, A; Rajapurohitam, V; Zeidan, A	1
Fujimoto, M; Gomi, M; Hashimoto, N; Hayase, M; Marumo, T; Masutani, H; Nozaki, K; Takagi, Y; Yodoi, J; Zhou, F	1
Dolga, AM; Eisel, UL; Granic, I; Luiten, PG; Nijholt, IM; Nyakas, C; van der Zee, EA	1
Gurley, KE; Hoon-Kim, K; Kelly-Spratt, KS; Kemp, CJ; Knoblaugh, S; Philipp-Staheli, J	1
Bennett, MR; Choy, MK; Foo, RS; Movassagh, M	1
Damilano, F; Emanueli, C; Hirsch, E; Katare, R; Madeddu, P; Meloni, M; Siragusa, M	1
Chang, YC; Huang, CC; Lee, HT; Tu, YF	1
Chu, ZG; Dang, YM; Huang, YS; Song, HP; Yan, H; Zhang, L	1
Caporali, A; Emanueli, C; Katare, RG; Madeddu, P; Meloni, M; Oikawa, A	1
Li, D; Li, M; Qu, Z; Ruan, Q; Yan, D; Yu, J	1
Tapia, R; Tovar-Y-Romo, LB	1
Morgan, DA; Rahmouni, K	1
Cho, KH; Doo, AR; Eun-Kyung, K; Hong, J; Jung, JH; Jung, WS; Kim, SN; Lee, H; Moon, SK; Park, HJ; Park, JY	1
Achim, CL; Digicaylioglu, M; Fletcher, L; Kang, YJ; Kaul, M; Lipton, SA; Masliah, E; Russo, R	1
Han, L; Huang, K; Jiang, H; Jiang, T; Kang, C; Liu, X; Pu, P; Yan, W; Yang, Y; Yue, X	1
Guo, Q; Pingping, X; Song, Z; Wang, N; Ye, Z; Yuan, Y	1
Chen, JL; Chen, S; Cheng, SW; Chong, BH; Deng, R; Lau, CP; Li, CK; Li, J; Liang, SX; Liu, C; Meng, FY; Pong, NH; Yan, H; Yang, M; Yang, ST; Ye, JY	1
Agrawal, R; Nath, C; Shukla, R; Tyagi, E	1
Chen, M; Huo, Y; Li, J; Lou, L; Pan, C; Singh, G; Wang, S; Wu, A; Zhang, D; Zhao, M	1
Chae, Y; Doo, AR; Kim, SN; Kim, ST; Lee, H; Moon, W; Park, HJ; Park, JY; Yin, CS	1
Chen, D; Fang, F; Li, D; Pan, H; Qi, L; Sun, H; Zhang, R	1
Chang, KC; Jun, MS; Kim, HJ; Kim, HS; Kim, YM; Kim, YS; Lee, JH; Lee, KR; Park, EJ	1
Bassell, GJ; Gross, C; Swanger, SA; Yao, X	1
Deng, Q; Harvie, EA; Huttenlocher, A	1
Guo, QL; He, ZJ; Peng, B; Wang, N; Ye, Z; Yuan, YJ; Zhou, J	1
Chen, J; He, J; Hua, F; Liu, CF; Pei, A; Qian, X; Xu, X; Yu, H; Zhang, ZL	1
Chen, LL; Chung, SK; Durairajan, SS; Huang, JD; Huang, L; Li, M; Li, XS; Liu, LF; Lu, JH; Yuan, Q	1
Gao, M; Ha, T; Kalbfleisch, JH; Kao, RL; Li, C; Williams, DL; Zhang, X	1
Dhammu, TS; Khan, M; Sakakima, H; Shunmugavel, A; Singh, AK; Singh, I; Yoshida, Y	1
Ji, XM; Liu, XR; Luo, M; Luo, YM; Qi, ZF; Song, ZJ; Wang, RL; Yan, F; Zhao, HP	1
Asai, M; Asai, N; Enomoto, A; Ito, T; Iwase, S; Komeima, K; Takahashi, M; Terasaki, H; Yasuma, T	1
Izzo, E; Koob, GF; Martin-Fardon, R; Sanna, PP; Weiss, F	1
Greco, CR; Parvathenani, LK; Posmantur, R; Roberts, SB; Robertson, B; Tertyshnikova, S	1
Dick, K; Sadhu, C; Staunton, DE; Tino, WT	1
Hayflick, JS; Northcott, CA; Watts, SW	1
Mackman, N; Pawlinski, R; Pedersen, B; Schabbauer, G; Tencati, M	1
Hada, Y; Itai, A; Ito, Y; Kadowaki, T; Kamon, J; Kasuga, M; Muto, S; Ogawa, W; Takekawa, S; Tobe, K; Yamauchi, T	1
Bose, AK; Brand, CL; Carr, RD; Mocanu, MM; Yellon, DM	1
Aguinaldo Datiles, AM; Duan, W; Leung, BP; Vlahos, CJ; Wong, WS	1
Miao, B; Yin, XH; Zhang, GY; Zhang, QG	1
Dell, S; Joussen, AM; Kociok, N; Müther, P; Peters, S	1
Han, D; Lü, Q; Wang, R; Xu, J; Zhang, GY; Zhang, QG	1
Browder, IW; Gao, X; Ha, T; Hua, F; Kao, RL; Kelley, J; Li, C; Li, Y; Ma, J; Williams, DL	1
Bian, JS; Chen, X; Hu, Y; Khin, ES; Lee, SW; Moore, PK; Neo, KL; Pan, TT	1
Venneti, S; Wang, G; Wiley, CA	1
Bhamra, GS; Carr, RD; Davidson, SM; Hausenloy, DJ; Mocanu, MM; Paiva, M; Wynne, AM; Yellon, DM	1
Fischer, G; Jamnicki, M; Lucchinetti, E; Zaugg, M	1
Browder, W; Gao, X; Ha, T; Hua, F; Izumo, S; Kao, RL; Kelley, J; Li, C; Liu, X; Ma, J; McMullen, JR; Shioi, T; Williams, DL	1
Kimura, H; Meguro, T; Sasaki, K; Zhang, JH	1
Hofmann, J; Hu, L; Jaffe, RB; Lu, Y; Mills, GB	1

Other Studies

158 other study(ies) available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Disease Models, Animal

Article	Year
Phosphoinositide 3-kinase gamma/delta inhibition limits infarct size after myocardial ischemia/reperfusion injury. Proceedings of the National Academy of Sciences of the United States of America, 2006, Dec-26, Volume: 103, Issue:52 Topics: Animals; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Humans; Inflammation; Intercellular Signaling Peptides and Proteins; Models, Molecular; Myocardial Ischemia; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Protein Structure, Tertiary; Protein Subunits; Rats; Reperfusion Injury; Signal Transduction; Swine	2006
Inhibition of natriuretic peptide receptor 1 reduces itch in mice. Science translational medicine, 2019, 07-10, Volume: 11, Issue:500 Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, Spinal; Humans; Mice, Inbred C57BL; Mice, Knockout; Neurons; Pruritus; Receptors, Atrial Natriuretic Factor; Reproducibility of Results; Signal Transduction; Small Molecule Libraries	2019
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. Proceedings of the National Academy of Sciences of the United States of America, 2020, 12-08, Volume: 117, Issue:49 Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection	2020
Sevoflurane and isoflurane inhibit KCl-induced, Rho kinase-mediated, and PI3K-participated vasoconstriction in aged diabetic rat aortas. BMC anesthesiology, 2021, 09-01, Volume: 21, Issue:1 Topics: Aging; Amides; Anesthetics, Inhalation; Animals; Aorta; Chromones; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Isoflurane; Morpholines; Phosphatidylinositol 3-Kinases; Potassium Chloride; Pyridines; Rats, Inbred OLETF; Rats, Wistar; rho-Associated Kinases; Sevoflurane; Vasoconstriction	2021
Effects of dual inhibition of AKT and ERK1/2 pathways on endometrial pro-inflammatory, hormonal, and epigenetic microenvironment in endometriosis. Molecular and cellular endocrinology, 2022, 01-01, Volume: 539 Topics: Animals; Butadienes; Cell Line; Cell Proliferation; Cell Survival; Chromones; Cytokines; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Endometriosis; Epigenesis, Genetic; Female; Gene Expression Regulation; Humans; MAP Kinase Signaling System; Mice; Morpholines; Nitriles; Proto-Oncogene Proteins c-akt; Receptors, Progesterone	2022
Resveratrol Pretreatment Inhibits Myocardial Apoptosis in Rats Following Coronary Microembolization via Inducing the PI3K/Akt/GSK-3β Signaling Cascade. Drug design, development and therapy, 2021, Volume: 15 Topics: Animals; Apoptosis; Chromones; Disease Models, Animal; Glycogen Synthase Kinase 3 beta; Male; Morpholines; Myocardial Infarction; Myocytes, Cardiac; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Resveratrol; Signal Transduction	2021
Study on the Effect and Mechanism of miR-185 on Lower Extremity Deep Venous Thrombosis. Molecular biotechnology, 2022, Volume: 64, Issue:3 Topics: Animals; Cell Proliferation; Cells, Cultured; Chromones; Disease Models, Animal; Endothelial Cells; Fibrin; Male; MAP Kinase Signaling System; Mice; MicroRNAs; Morpholines; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Thromboplastin; Venous Thrombosis	2022
Benznidazole Anti-Inflammatory Effects in Murine Cardiomyocytes and Macrophages Are Mediated by Class I PI3Kδ. Frontiers in immunology, 2021, Volume: 12 Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents; Chagas Cardiomyopathy; Chromones; Class I Phosphatidylinositol 3-Kinases; Disease Models, Animal; Female; Humans; Lipopolysaccharides; Macrophages; Male; Mice; Morpholines; Myocytes, Cardiac; Nitroimidazoles; Primary Cell Culture; RAW 264.7 Cells	2021
LY294002 ameliorates psoriatic skin inflammation in mice via blocking the Notch1/Hes1-PTEN/AKT/IL-17A feedback loop. Clinical and experimental immunology, 2023, Jul-05, Volume: 213, Issue:1 Topics: Animals; Disease Models, Animal; Feedback; Inflammation; Interleukin-17; Mice; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Psoriasis; Skin; Transcription Factor HES-1	2023
Therapeutic Effects of Puerarin Against Anterior Ischemic Optic Neuropathy Through Antiapoptotic and Anti-Inflammatory Actions. Investigative ophthalmology & visual science, 2019, 08-01, Volume: 60, Issue:10 Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Blotting, Western; Chromones; Disease Models, Animal; Enzyme Inhibitors; Evoked Potentials, Visual; In Situ Nick-End Labeling; Intravitreal Injections; Isoflavones; Male; Morpholines; Optic Neuropathy, Ischemic; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Retinal Ganglion Cells; Tomography, Optical Coherence; Vasodilator Agents	2019
Effects of inhibiting the PI3K/Akt/mTOR signaling pathway on the pain of sciatic endometriosis in a rat model. Canadian journal of physiology and pharmacology, 2019, Volume: 97, Issue:10 Topics: Animals; Behavior Observation Techniques; Behavior, Animal; Chromones; Disease Models, Animal; Endometriosis; Female; Injections, Spinal; Morpholines; Pain Measurement; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sciatica; Signal Transduction; TOR Serine-Threonine Kinases	2019
Anticonvulsant action of a selective phosphatidylinositol-3-kinase inhibitor LY294002 in pentylenetetrazole-mediated convulsions in zebrafish. Epilepsy research, 2019, Volume: 157 Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Chromones; Class I Phosphatidylinositol 3-Kinases; Class Ia Phosphatidylinositol 3-Kinase; Disease Models, Animal; Gene Expression; Morpholines; Pentylenetetrazole; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-fos; Seizures; TOR Serine-Threonine Kinases; Zebrafish	2019
The Effects of Progranulin in a Rat Model of Acute Myocardial Ischemia/Reperfusion are Mediated by Activation of the P13K/Akt Signaling Pathway. Medical science monitor basic research, 2019, Nov-07, Volume: 25 Topics: Adipokines; Animals; Apoptosis; Atherosclerosis; Chromones; Disease Models, Animal; Male; Morpholines; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; Phosphatidylinositol 3-Kinases; Progranulins; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Reperfusion Injury; Signal Transduction	2019
Axon Degeneration Is Rescued with Human Umbilical Cord Perivascular Cells: A Potential Candidate for Neuroprotection After Traumatic Brain Injury. Stem cells and development, 2020, 02-15, Volume: 29, Issue:4 Topics: Animals; Axons; Brain Injuries, Traumatic; Cell- and Tissue-Based Therapy; Chromones; Coculture Techniques; Disease Models, Animal; Embryo, Mammalian; Fibroblasts; Gene Expression Regulation; Glucose; Humans; Morpholines; Nerve Growth Factor; Neurofilament Proteins; Neurons; Oxygen; Pericytes; Primary Cell Culture; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Superior Cervical Ganglion; Umbilical Cord	2020
Resveratrol Protects the Myocardium in Sepsis by Activating the Phosphatidylinositol 3-Kinases (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Pathway and Inhibiting the Nuclear Factor-κB (NF-κB) Signaling Pathway. Medical science monitor : international medical journal of experimental and clinical research, 2019, Dec-06, Volume: 25 Topics: Animals; Apoptosis; Cardiomyopathies; China; Chromones; Disease Models, Animal; Heart; Male; Morpholines; Myocardium; NF-kappa B; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Resveratrol; Sepsis; Signal Transduction; TOR Serine-Threonine Kinases; Tumor Necrosis Factor-alpha	2019
Increasing the expression of microRNA-126-5p in the temporal muscle can promote angiogenesis in the chronically ischemic brains of rats subjected to two-vessel occlusion plus encephalo-myo-synangiosis. Aging, 2020, 07-09, Volume: 12, Issue:13 Topics: Adult; Animals; Brain; Brain Ischemia; Cell Proliferation; Cerebrovascular Circulation; Chromones; Chronic Disease; Cognition; Disease Models, Animal; Dura Mater; Endothelial Cells; Female; Human Umbilical Vein Endothelial Cells; Humans; Male; MicroRNAs; Middle Aged; Morpholines; Moyamoya Disease; Neovascularization, Physiologic; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Temporal Muscle; Up-Regulation	2020
Upregulation of FoxO3a expression through PI3K/Akt pathway attenuates the progression of lupus nephritis in MRL/lpr mice. International immunopharmacology, 2020, Volume: 89, Issue:Pt A Topics: Animals; Antibodies, Antinuclear; Antigen-Antibody Complex; Chromones; Disease Models, Animal; Disease Progression; Female; Fibrosis; Forkhead Box Protein O3; Kidney; Lupus Nephritis; Mice, Inbred C57BL; Mice, Inbred MRL lpr; Morpholines; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; RNA Interference; RNA, Small Interfering; Signal Transduction; Up-Regulation	2020
TRIM3 attenuates apoptosis in Parkinson's disease via activating PI3K/AKT signal pathway. Aging, 2020, 11-30, Volume: 13, Issue:1 Topics: Aged; Animals; Apoptosis; Carrier Proteins; Case-Control Studies; Cell Line; Cell Survival; Chromones; Disease Models, Animal; Female; Glutathione; Humans; Male; Mesencephalon; Mice; Middle Aged; Morpholines; Parkinson Disease; Parkinsonian Disorders; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase	2020
Rapamycin ameliorates corneal injury after alkali burn through methylation modification in mouse TSC1 and mTOR genes. Experimental eye research, 2021, Volume: 203 Topics: Actins; Animals; Blotting, Western; Burns, Chemical; Chromones; Corneal Injuries; Disease Models, Animal; DNA Methylation; Eye Burns; Fluorescent Antibody Technique, Indirect; Gene Expression Regulation; Immunosuppressive Agents; Male; Mice; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Real-Time Polymerase Chain Reaction; Sirolimus; Sodium Hydroxide; TOR Serine-Threonine Kinases; Tuberous Sclerosis Complex 1 Protein; Vascular Endothelial Growth Factor A	2021
Inhibition of Notch1-mediated inflammation by intermedin protects against abdominal aortic aneurysm via PI3K/Akt signaling pathway. Aging, 2021, 02-01, Volume: 13, Issue:4 Topics: ADAM10 Protein; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Calcium Chloride; Cell Movement; Chromones; Disease Models, Animal; Humans; Inflammation; Lipopolysaccharides; Macrophages; Mice; Mice, Knockout; Mice, Transgenic; Morpholines; Neuropeptides; NLR Family, Pyrin Domain-Containing 3 Protein; Peptide Hormones; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Receptor, Notch1; Transcription Factor HES-1	2021
Involvement of GPR30 in protection effect of Dexmedetomidine against myocardial ischemia/reperfusion injury in rat via AKT pathway. Acta biochimica Polonica, 2021, Feb-25, Volume: 68, Issue:1 Topics: Animals; Apoptosis; Cardiotonic Agents; Cell Survival; Cells, Cultured; Chromones; Dexmedetomidine; Disease Models, Animal; Drug Synergism; Gene Knockdown Techniques; Male; Morpholines; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; Proto-Oncogene Proteins c-akt; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Signal Transduction; Transfection	2021
5-Lipoxygenase inhibition reduces inflammation and neuronal apoptosis via AKT signaling after subarachnoid hemorrhage in rats. Aging, 2021, 04-20, Volume: 13, Issue:8 Topics: Administration, Oral; Animals; Apoptosis; Arachidonate 5-Lipoxygenase; Brain Injuries; Chromones; Disease Models, Animal; Humans; Hydroxyurea; Inflammation; Infusions, Intraventricular; Lipoxygenase Inhibitors; Male; Morpholines; Neurons; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Subarachnoid Hemorrhage	2021
The Protective Mechanism of Dexmedetomidine in Regulating Atg14L-Beclin1-Vps34 Complex Against Myocardial Ischemia-Reperfusion Injury. Journal of cardiovascular translational research, 2021, Volume: 14, Issue:6 Topics: Adaptor Proteins, Vesicular Transport; Animals; Autophagy; Autophagy-Related Proteins; Beclin-1; Chromones; Class III Phosphatidylinositol 3-Kinases; Dexmedetomidine; Disease Models, Animal; Morpholines; Myocytes, Cardiac; Phosphorylation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction	2021
Methamphetamine Enhances HIV-Induced Aberrant Proliferation of Neural Progenitor Cells via the FOXO3-Mediated Mechanism. Molecular neurobiology, 2021, Volume: 58, Issue:11 Topics: AIDS Dementia Complex; Animals; Brain; Cell Cycle; Cell Division; Cells, Cultured; Chemokine CXCL12; Chromones; Disease Models, Animal; Forkhead Box Protein O3; Gene Expression Regulation, Viral; HIV Infections; HIV-1; Humans; Lateral Ventricles; Male; Methamphetamine; Mice; Mice, Inbred C57BL; Morpholines; Nerve Tissue Proteins; Neural Stem Cells; Proto-Oncogene Proteins c-akt; Receptors, CXCR4; RNA, Messenger; Signal Transduction; Substance-Related Disorders	2021
Acacetin Protects Myocardial Cells against Hypoxia-Reoxygenation Injury through Activation of Autophagy. Journal of immunology research, 2021, Volume: 2021 Topics: Animals; Apoptosis; Autophagy; Cell Hypoxia; Cell Line; Chromones; Disease Models, Animal; Flavones; Humans; Morpholines; Myocardial Reperfusion Injury; Myocytes, Cardiac; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction	2021
Methyl eugenol attenuates liver ischemia reperfusion injury via activating PI3K/Akt signaling. International immunopharmacology, 2021, Volume: 99 Topics: Animals; Cell Line; Chromones; Disease Models, Animal; Eugenol; Hepatocytes; Humans; Liver; Male; Mice; Morpholines; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Reperfusion Injury; Signal Transduction; Warm Ischemia	2021
TSLP signaling blocking alleviates E-cadherin dysfunction of airway epithelium in a HDM-induced asthma model. Cellular immunology, 2017, Volume: 315 Topics: Administration, Inhalation; Animals; Antibodies, Monoclonal; Asthma; beta Catenin; Bronchi; Bronchial Hyperreactivity; Cadherins; Cell Line; Chromones; Cytokines; Disease Models, Animal; Epithelial Cells; Humans; Lung; Mice; Mice, Inbred BALB C; Morpholines; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Processing, Post-Translational; Pyroglyphidae; Random Allocation; Signal Transduction; Specific Pathogen-Free Organisms; Thymic Stromal Lymphopoietin	2017
USP22 mediates the multidrug resistance of hepatocellular carcinoma via the SIRT1/AKT/MRP1 signaling pathway. Molecular oncology, 2017, Volume: 11, Issue:6 Topics: Adaptor Proteins, Signal Transducing; Analysis of Variance; Animals; Apoptosis Regulatory Proteins; ATP Binding Cassette Transporter, Subfamily B; Carcinoma, Hepatocellular; Cell Line, Tumor; Chromones; Disease Models, Animal; Down-Regulation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Enzyme Inhibitors; Humans; Liver Neoplasms; Male; Mice; Mice, Nude; Morpholines; Multidrug Resistance-Associated Proteins; Sirtuin 1; Thiolester Hydrolases; Ubiquitin Thiolesterase; Xenograft Model Antitumor Assays	2017
Downregulation of PI3K-γ in a mouse model of sepsis-induced myocardial dysfunction. Cytokine, 2017, Volume: 96 Topics: Animals; Cardiomyopathies; Chromones; Class II Phosphatidylinositol 3-Kinases; Cytokines; Disease Models, Animal; Down-Regulation; Interleukin-6; Lipopolysaccharides; Mice; Morpholines; Myocardium; Quinoxalines; Sepsis; Signal Transduction; Thiazolidinediones; Tumor Necrosis Factor-alpha	2017
Autophagy plays a role in FSTL1-induced epithelial mesenchymal transition and airway remodeling in asthma. American journal of physiology. Lung cellular and molecular physiology, 2017, 07-01, Volume: 313, Issue:1 Topics: Adult; Airway Remodeling; Animals; Asthma; Autophagosomes; Autophagy; Biomarkers; Bronchoalveolar Lavage Fluid; Chromones; Disease Models, Animal; Epithelial-Mesenchymal Transition; Female; Follistatin-Related Proteins; Humans; Lung; Male; Mice, Inbred C57BL; Morpholines; Ovalbumin; Rats; Respiratory Hypersensitivity; Up-Regulation	2017
Bone Marrow Mesenchymal Stem Cell Transplantation Increases GAP-43 Expression via ERK1/2 and PI3K/Akt Pathways in Intracerebral Hemorrhage. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2017, Volume: 42, Issue:1 Topics: Animals; Axons; Bone Marrow Cells; Cells, Cultured; Cerebral Hemorrhage; Chromones; Disease Models, Animal; Flavonoids; GAP-43 Protein; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Regeneration; Signal Transduction; Up-Regulation	2017
Impact of a novel phosphoinositol-3 kinase inhibitor in preventing mitochondrial DNA damage and damage-associated molecular pattern accumulation: Results from the Biochronicity Project. The journal of trauma and acute care surgery, 2017, Volume: 83, Issue:4 Topics: Animals; Chromones; Disease Models, Animal; DNA Damage; DNA, Mitochondrial; Energy Metabolism; Enzyme Inhibitors; Morpholines; Multiple Organ Failure; Shock, Traumatic; Swine	2017
Beneficial effects of extracts from Lucilia sericata maggots on burn wounds in rats. Molecular medicine reports, 2017, Volume: 16, Issue:5 Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Burns; Chromones; Diptera; Disease Models, Animal; Escherichia coli; Hydroxyproline; Interleukin-6; Larva; Male; Malondialdehyde; Morpholines; NF-kappa B; Proto-Oncogene Proteins c-akt; Rats; Superoxide Dismutase; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A; Wound Healing	2017
Neuron and microglia/macrophage-derived FGF10 activate neuronal FGFR2/PI3K/Akt signaling and inhibit microglia/macrophages TLR4/NF-κB-dependent neuroinflammation to improve functional recovery after spinal cord injury. Cell death & disease, 2017, 10-05, Volume: 8, Issue:10 Topics: Animals; Apoptosis; Chromones; Disease Models, Animal; Fibroblast Growth Factor 10; Gene Expression Regulation; Humans; Inflammation; Macrophages; Mice; Microglia; Morpholines; Neurites; Neurons; NF-kappa B; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Receptor, Fibroblast Growth Factor, Type 2; Signal Transduction; Spinal Cord Injuries; Toll-Like Receptor 4	2017
Exendin-4 attenuates neuronal death via GLP-1R/PI3K/Akt pathway in early brain injury after subarachnoid hemorrhage in rats. Neuropharmacology, 2018, Volume: 128 Topics: Animals; Apoptosis; Brain Injuries; Calcium-Binding Proteins; Chromones; Disease Models, Animal; Enzyme Inhibitors; Exenatide; Glucagon-Like Peptide 1; Injections, Intraventricular; Male; Microfilament Proteins; Morpholines; Nerve Tissue Proteins; Neuroprotective Agents; Oncogene Protein v-akt; Peptides; Phosphatidylinositol 3-Kinases; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Signal Transduction; Subarachnoid Hemorrhage; Venoms	2018
Role of the TSLP-DC-OX40L pathway in asthma pathogenesis and airway inflammation in mice. Biochemistry and cell biology = Biochimie et biologie cellulaire, 2018, Volume: 96, Issue:3 Topics: Animals; Asthma; Chromones; Cytokines; Dendritic Cells; Disease Models, Animal; Eosinophils; Immunoglobulin E; Immunoglobulins; Inflammation; Interferon-gamma; Interleukin-13; Male; Mice; Morpholines; Ovalbumin; OX40 Ligand; Receptors, Cytokine	2018
Suppression of Sirtuin-1 Increases IL-6 Expression by Activation of the Akt Pathway During Allergic Asthma. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2017, Volume: 43, Issue:5 Topics: Animals; Asthma; Blotting, Western; Cell Line; Chromones; Disease Models, Animal; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Humans; Immunohistochemistry; Interleukin-6; Lung; Morpholines; Naphthols; Phenylpropionates; Proto-Oncogene Proteins c-akt; Resveratrol; RNA, Small Interfering; Signal Transduction; Sirtuin 1; Stilbenes	2017
Oxymatrine protects against DSS-induced colitis via inhibiting the PI3K/AKT signaling pathway. International immunopharmacology, 2017, Volume: 53 Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Cell Differentiation; Cells, Cultured; Chromones; Colitis; Colitis, Ulcerative; Dextran Sulfate; Disease Models, Animal; Humans; Male; Mice; Mice, Inbred BALB C; Morpholines; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Quinolizines; Signal Transduction; Sophora; Th1 Cells; Th17 Cells	2017
Lipoxin A4 protects against spinal cord injury via regulating Akt/nuclear factor (erythroid-derived 2)-like 2/heme oxygenase-1 signaling. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 97 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromones; Disease Models, Animal; Gene Expression Regulation; Heme Oxygenase-1; Lipoxins; Male; Morpholines; Neuroprotective Agents; NF-E2-Related Factor 2; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Spinal Cord Injuries	2018
Estradiol up-regulates L-type Ca Heart rhythm, 2018, Volume: 15, Issue:5 Topics: Animals; Blotting, Western; Calcium Channels, L-Type; Carrier Proteins; Cell Line; Chromones; CREB-Binding Protein; Disease Models, Animal; DNA; Enzyme Inhibitors; Estradiol; Estrogens; Gene Expression Regulation; Heterocyclic Compounds, 3-Ring; Long QT Syndrome; Morpholines; Myocytes, Cardiac; Patch-Clamp Techniques; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Up-Regulation	2018
Intra-arterial human urinary kallidinogenase alleviates brain injury in rats with permanent middle cerebral artery occlusion through PI3K/AKT/FoxO1 signaling pathway. Brain research, 2018, 05-15, Volume: 1687 Topics: Animals; Brain Injuries; Caspase 3; Chromones; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Forkhead Box Protein O1; Gene Expression Regulation; Humans; In Situ Nick-End Labeling; Infarction, Middle Cerebral Artery; Injections, Intra-Arterial; Kallikreins; Male; Morpholines; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction	2018
Inhaled Methane Protects Rats Against Neurological Dysfunction Induced by Cerebral Ischemia and Reperfusion Injury: PI3K/Akt/HO-1 Pathway Involved. Archives of medical research, 2017, Volume: 48, Issue:6 Topics: Analysis of Variance; Animals; Antioxidants; Biomarkers; Brain Diseases; Brain Ischemia; Chromones; Disease Models, Animal; Enzyme Inhibitors; Heme Oxygenase-1; Male; Malondialdehyde; Methane; Morpholines; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Ribonucleosides; Signal Transduction; Tumor Necrosis Factor-alpha	2017
Cardioprotection of tilianin ameliorates myocardial ischemia-reperfusion injury: Role of the apoptotic signaling pathway. PloS one, 2018, Volume: 13, Issue:3 Topics: Administration, Oral; Animals; Apoptosis; Cardiotonic Agents; Chromones; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Enzyme Inhibitors; Flavonoids; Glycosides; Male; Molecular Structure; Morpholines; Myocardial Reperfusion Injury; Myocytes, Cardiac; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Random Allocation; Rats, Sprague-Dawley; Signal Transduction	2018
Salvinorin A preserves cerebral pial artery autoregulation after forebrain ischemia via the PI3K/AKT/cGMP pathway. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2018, Mar-15, Volume: 51, Issue:5 Topics: Animals; Brain Ischemia; Cerebral Arteries; Chromones; Cyclic GMP; Disease Models, Animal; Diterpenes, Clerodane; Male; Morpholines; Naltrexone; NG-Nitroarginine Methyl Ester; Phosphatidylinositol 3-Kinases; Pia Mater; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction	2018
MicroRNA-155 Regulates Inflammatory Response in Ischemic Cerebral Tissues through Autophagy. Current neurovascular research, 2018, Volume: 15, Issue:2 Topics: Administration, Oral; Animals; Autophagy; Cell Hypoxia; Cell Line, Transformed; Chromones; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation; Glucose; Infarction, Middle Cerebral Artery; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; MicroRNAs; Morpholines; Neurologic Examination; NF-kappa B; RNA, Messenger; Signal Transduction; Toll-Like Receptor 4	2018
Aggf1 attenuates neuroinflammation and BBB disruption via PI3K/Akt/NF-κB pathway after subarachnoid hemorrhage in rats. Journal of neuroinflammation, 2018, Jun-09, Volume: 15, Issue:1 Topics: Angiogenic Proteins; Animals; Blood-Brain Barrier; Brain Edema; Capillary Permeability; Chromones; Disease Models, Animal; Encephalitis; Enzyme Inhibitors; Humans; Injections, Intraventricular; Male; Maze Learning; Morpholines; Nerve Tissue Proteins; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Signal Transduction; Subarachnoid Hemorrhage	2018
Exenatide ameliorates hepatic steatosis and attenuates fat mass and FTO gene expression through PI3K signaling pathway in nonalcoholic fatty liver disease. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2018, Volume: 51, Issue:8 Topics: Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Animals; Blood Glucose; Body Weight; Chromones; Diet, High-Fat; Disease Models, Animal; Eating; Enzyme Inhibitors; Exenatide; Fatty Liver; Gene Expression Regulation; In Vitro Techniques; Insulin; Male; Malondialdehyde; Morpholines; Non-alcoholic Fatty Liver Disease; Obesity; Oxidative Stress; Peptides; Phosphatidylinositol 3-Kinases; Protective Agents; Rabbits; Superoxide Dismutase; Venoms	2018
Blocking Mammalian Target of Rapamycin (mTOR) Alleviates Neuropathic Pain Induced by Chemotherapeutic Bortezomib. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018, Volume: 48, Issue:1 Topics: Animals; Behavior, Animal; Bortezomib; Calcitonin Gene-Related Peptide; Carrier Proteins; Chromones; Disease Models, Animal; Intracellular Signaling Peptides and Proteins; Male; Morpholines; Neuralgia; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Spinal Cord; Substance P; TOR Serine-Threonine Kinases; Up-Regulation	2018
SC79, the AKT Activator Protects Cerebral Ischemia in a Rat Model of Ischemia/Reperfusion Injury. Medical science monitor : international medical journal of experimental and clinical research, 2018, Aug-03, Volume: 24 Topics: Acetates; Animals; Apoptosis; Benzopyrans; Brain; Brain Ischemia; Cell Death; Chromones; Disease Models, Animal; Infarction, Middle Cerebral Artery; Male; Morpholines; Neuroprotective Agents; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction	2018
Rapid identification of antimicrometastases drugs using integrated model systems with two dimensional monolayer, three dimensional spheroids, and zebrafish xenotransplantation tumors. Biotechnology and bioengineering, 2018, Volume: 115, Issue:11 Topics: Animals; Antineoplastic Agents; Apoptosis; Biosensing Techniques; Caspase 3; Cell Line, Tumor; Cell Proliferation; Chromones; Disease Models, Animal; Drug Evaluation, Preclinical; Fluorescence Resonance Energy Transfer; Humans; Melanoma; Models, Theoretical; Morpholines; Neoplasm Metastasis; Phosphoinositide-3 Kinase Inhibitors; Spheroids, Cellular; Time Factors; Transplantation, Heterologous; Tumor Cells, Cultured; Zebrafish	2018
Berberine Alleviates Tau Hyperphosphorylation and Axonopathy-Associated with Diabetic Encephalopathy via Restoring PI3K/Akt/GSK3β Pathway. Journal of Alzheimer's disease : JAD, 2018, Volume: 65, Issue:4 Topics: Animals; Axons; Berberine; Cells, Cultured; Chromones; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Disease Models, Animal; Embryo, Mammalian; Enzyme Inhibitors; Female; Glucose; Male; Morpholines; Pregnancy; Rats; Rats, Wistar; Signal Transduction; Streptozocin; tau Proteins	2018
Clozapine attenuates mitochondrial burdens and abnormal behaviors elicited by phencyclidine in mice via inhibition of p47 Journal of psychopharmacology (Oxford, England), 2018, Volume: 32, Issue:11 Topics: Animals; Antioxidants; Antipsychotic Agents; Behavior, Animal; Chromones; Clozapine; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Morpholines; NADPH Oxidases; Oxidative Stress; Phencyclidine; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Schizophrenia; Signal Transduction	2018
Autophagy and Akt in the protective effect of erythropoietin helix B surface peptide against hepatic ischaemia/reperfusion injury in mice. Scientific reports, 2018, 10-02, Volume: 8, Issue:1 Topics: Adenine; Animals; Autophagosomes; Autophagy; Cell Line; Chemical and Drug Induced Liver Injury; Chromones; Cobalt; Disease Models, Animal; Erythropoietin; Humans; Liver; Liver Function Tests; Mice; Mice, Inbred C57BL; Morpholines; Peptide Fragments; Proto-Oncogene Proteins c-akt; Random Allocation; Reperfusion Injury; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases	2018
EphrinB/EphB forward signaling in Müller cells causes apoptosis of retinal ganglion cells by increasing tumor necrosis factor alpha production in rat experimental glaucomatous model. Acta neuropathologica communications, 2018, 10-24, Volume: 6, Issue:1 Topics: Animals; Animals, Newborn; Antioxidants; Apoptosis; Cells, Cultured; Chromones; Disease Models, Animal; Ephrin-B1; Excitatory Amino Acid Agents; Glaucoma; Glial Fibrillary Acidic Protein; Intercellular Signaling Peptides and Proteins; Male; Morpholines; Phenols; Piperidines; Proline; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Eph Family; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells; Signal Transduction; Thiocarbamates; Tumor Necrosis Factor-alpha	2018
CXCL12 has therapeutic value in facial nerve injury and promotes Schwann cells autophagy and migration via PI3K-AKT-mTOR signal pathway. International journal of biological macromolecules, 2019, Mar-01, Volume: 124 Topics: Adenine; Animals; Autophagy; Cell Movement; Cell Proliferation; Chemokine CXCL12; Chromones; Cranial Nerves; Disease Models, Animal; Facial Nerve; Facial Nerve Injuries; Gene Expression Regulation; Humans; Insulin-Like Growth Factor I; Male; Microtubule-Associated Proteins; Morpholines; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Primary Cell Culture; Protein Isoforms; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Schwann Cells; Signal Transduction; TOR Serine-Threonine Kinases	2019
Prostasin Impairs Epithelial Growth Factor Receptor Activation to Suppress Dengue Virus Propagation. The Journal of infectious diseases, 2019, 04-16, Volume: 219, Issue:9 Topics: Animals; Cell Line; Chromones; Cyclooxygenase 2; Dengue; Dengue Virus; Disease Models, Animal; Enzyme Inhibitors; ErbB Receptors; Humans; Mice; Monocytes; Morpholines; RNA, Messenger; RNA, Small Interfering; RNA, Viral; Serine Endopeptidases; Signal Transduction; Transfection; Virus Replication	2019
Elevated S100A4 in asthmatics and an allergen-induced mouse asthma model. Journal of cellular biochemistry, 2019, Volume: 120, Issue:6 Topics: Allergens; Animals; Asthma; Chromones; Disease Models, Animal; Female; Humans; Male; Mice; Mice, Inbred BALB C; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; S100 Calcium-Binding Protein A4	2019
Inhibition of the PI3K/Akt signaling pathway impedes the restoration of neurological function following hypoxic-ischemic brain damage in a neonatal rabbit model. Journal of cellular biochemistry, 2019, Volume: 120, Issue:6 Topics: Animals; Animals, Newborn; Apoptosis; Apoptosis Regulatory Proteins; Brain; Caspase 3; Chromones; Disease Models, Animal; Enzyme Inhibitors; Female; Humans; Hypoxia-Ischemia, Brain; Male; Morpholines; Neurons; Phosphatidylinositol 3-Kinases; Pregnancy; Proto-Oncogene Proteins c-akt; Rabbits; Signal Transduction	2019
Suppression of Akt-mTOR pathway rescued the social behavior in Cntnap2-deficient mice. Scientific reports, 2019, 02-28, Volume: 9, Issue:1 Topics: Animals; Autism Spectrum Disorder; Chromones; Disease Models, Animal; Hippocampus; Humans; Hyperkinesis; Male; Membrane Proteins; Mice; Mice, Knockout; Morpholines; Nerve Tissue Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Sirolimus; Social Behavior; Stereotyped Behavior; TOR Serine-Threonine Kinases	2019
ZEB1 protects skeletal muscle from damage and is required for its regeneration. Nature communications, 2019, 03-25, Volume: 10, Issue:1 Topics: Animals; Chemokine CCL2; Chromones; Disease Models, Animal; Flavonoids; Gene Expression Regulation; Humans; Insulin-Like Growth Factor I; Laminin; Macrophages; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Muscle, Skeletal; Muscular Dystrophies; p38 Mitogen-Activated Protein Kinases; Phenotype; Phosphorylation; Regeneration; RNA, Messenger; Satellite Cells, Skeletal Muscle; Signal Transduction; Zinc Finger E-box-Binding Homeobox 1	2019
Neuregulin-1β attenuates sepsis-induced diaphragm atrophy by activating the PI3K/Akt signaling pathway. Journal of muscle research and cell motility, 2019, Volume: 40, Issue:1 Topics: Animals; Chromones; Diaphragm; Disease Models, Animal; Humans; Male; Morpholines; Muscle Contraction; Muscular Atrophy; Neuregulin-1; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Sepsis; Signal Transduction	2019
A study on regulatory mechanism of miR-223 in ulcerative colitis through PI3K/Akt-mTOR signaling pathway. European review for medical and pharmacological sciences, 2019, Volume: 23, Issue:11 Topics: Animals; Apoptosis; Chromones; Colitis, Ulcerative; Dextran Sulfate; Dimethylhydrazines; Disease Models, Animal; Humans; Interleukin-1beta; Interleukin-6; MicroRNAs; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; TOR Serine-Threonine Kinases; Up-Regulation	2019
Dexmedetomidine suppresses sevoflurane anesthesia-induced neuroinflammation through activation of the PI3K/Akt/mTOR pathway. BMC anesthesiology, 2019, 07-27, Volume: 19, Issue:1 Topics: Anesthetics, Inhalation; Animals; Cerebral Cortex; Chromones; Cytokines; Dexmedetomidine; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hippocampus; Hypnotics and Sedatives; Inflammation; Morpholines; Neuroprotective Agents; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Random Allocation; Rats, Sprague-Dawley; Sevoflurane; Signal Transduction; TOR Serine-Threonine Kinases	2019
The fibrotic role of phosphatidylinositol-3-kinase/Akt pathway in injured skeletal muscle after acute contusion. International journal of sports medicine, 2013, Volume: 34, Issue:9 Topics: Animals; Athletic Injuries; Blotting, Western; Chromones; Cicatrix; Collagen; Contusions; Disease Models, Animal; Fibrosis; Male; Mice; Mice, Inbred C57BL; Morpholines; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; TOR Serine-Threonine Kinases; Transforming Growth Factor beta	2013
Recombinant human erythropoietin preconditioning attenuates liver ischemia reperfusion injury through the phosphatidylinositol-3 kinase/AKT/endothelial nitric oxide synthase pathway. The Journal of surgical research, 2013, Volume: 183, Issue:2 Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chromones; Disease Models, Animal; Enzyme Inhibitors; Erythropoietin; Humans; Ischemic Preconditioning; L-Lactate Dehydrogenase; Liver; Male; Morpholines; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Reperfusion Injury; Signal Transduction	2013
Dobutamine-mediated heme oxygenase-1 induction via PI3K and p38 MAPK inhibits high mobility group box 1 protein release and attenuates rat myocardial ischemia/reperfusion injury in vivo. The Journal of surgical research, 2013, Volume: 183, Issue:2 Topics: Adrenergic beta-1 Receptor Agonists; Animals; Chromones; Disease Models, Animal; Dobutamine; Enzyme Inhibitors; Heart; Heme Oxygenase-1; HMGB1 Protein; Imidazoles; Male; Morpholines; Myocardial Reperfusion Injury; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Protoporphyrins; Pyridines; Rats; Rats, Sprague-Dawley	2013
PI3K and Notch signal pathways coordinately regulate the activation and proliferation of T lymphocytes in asthma. Life sciences, 2013, May-20, Volume: 92, Issue:17-19 Topics: Animals; Asthma; CD4-Positive T-Lymphocytes; Cell Proliferation; Chromones; Cyclin A; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p27; Dipeptides; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Male; Mice; Mice, Inbred BALB C; Morpholines; Ovalbumin; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Receptors, Notch; RNA, Messenger; Signal Transduction; Spleen; Time Factors; Up-Regulation	2013
Sodium tanshinone IIA sulfonate protects rat myocardium against ischemia-reperfusion injury via activation of PI3K/Akt/FOXO3A/Bim pathway. Acta pharmacologica Sinica, 2013, Volume: 34, Issue:11 Topics: Animals; Animals, Newborn; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Cardiotonic Agents; Chromones; Disease Models, Animal; Flow Cytometry; Forkhead Box Protein O3; Forkhead Transcription Factors; Gene Expression Regulation; In Situ Nick-End Labeling; Male; Membrane Proteins; Morpholines; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; Phenanthrenes; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction	2013
PTEN status mediates 2ME2 anti-tumor efficacy in preclinical glioblastoma models: role of HIF1α suppression. Journal of neuro-oncology, 2014, Volume: 116, Issue:1 Topics: 2-Methoxyestradiol; Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Chromones; Disease Models, Animal; Enzyme Inhibitors; Estradiol; Female; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Mice, Nude; Morpholines; PTEN Phosphohydrolase; Xenograft Model Antitumor Assays	2014
Transforming growth factor-β signalling controls human breast cancer metastasis in a zebrafish xenograft model. Breast cancer research : BCR, 2013, Nov-07, Volume: 15, Issue:6 Topics: Animals; Benzamides; Breast Neoplasms; Chromones; Dioxoles; Dipeptides; Disease Models, Animal; Drug Screening Assays, Antitumor; Embryo, Nonmammalian; Enzyme Inhibitors; Female; Humans; Matrix Metalloproteinase Inhibitors; Morpholines; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; RNA, Small Interfering; Signal Transduction; Smad2 Protein; Smad4 Protein; Small Molecule Libraries; Transforming Growth Factor beta; Xenograft Model Antitumor Assays; Zebrafish; Zebrafish Proteins	2013
Catalpol promotes oligodendrocyte survival and oligodendrocyte progenitor differentiation via the Akt signaling pathway in rats with chronic cerebral hypoperfusion. Brain research, 2014, Apr-29, Volume: 1560 Topics: Animals; Apoptosis; Carotid Artery, Common; Cell Differentiation; Cell Survival; Cerebrovascular Disorders; Chromones; Chronic Disease; Disease Models, Animal; Enzyme Inhibitors; Iridoid Glucosides; Male; Morpholines; Neural Stem Cells; Neuroprotective Agents; Oligodendroglia; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats, Wistar; Signal Transduction	2014
TL-2 attenuates β-amyloid induced neuronal apoptosis through the AKT/GSK-3β/β-catenin pathway. The international journal of neuropsychopharmacology, 2014, Volume: 17, Issue:9 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; beta Catenin; Caspase 3; Caspase 9; Cells, Cultured; Cerebral Cortex; Chromones; Disease Models, Animal; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Maze Learning; Memory Disorders; Mice; Morpholines; Neurons; Neuroprotective Agents; Oncogene Protein v-akt; Peptide Fragments; Polycyclic Aromatic Hydrocarbons; Signal Transduction	2014
IL-8 enhances the angiogenic potential of human bone marrow mesenchymal stem cells by increasing vascular endothelial growth factor. Cell biology international, 2014, Volume: 38, Issue:9 Topics: Animals; Bone Marrow Cells; Brain; Cells, Cultured; Chromones; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Interleukin-8; Ischemia; Mesenchymal Stem Cells; Mice; Morpholines; Neovascularization, Physiologic; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Vascular Endothelial Growth Factor A	2014
XAV939, a small molecular inhibitor, provides neuroprotective effects on oligodentrocytes. Journal of neuroscience research, 2014, Volume: 92, Issue:10 Topics: Animals; Animals, Newborn; Apoptosis; beta Catenin; Brain Infarction; Brain Ischemia; Caspases; Cell Line, Transformed; Cells, Cultured; Chromones; Disease Models, Animal; Enzyme Inhibitors; Heterocyclic Compounds, 3-Ring; Morpholines; Neurons; Neuroprotective Agents; Oligodendroglia; Rats; Rats, Sprague-Dawley; Serum; Time Factors	2014
Limb ischemic preconditioning protects against contrast-induced acute kidney injury in rats via phosphorylation of GSK-3β. Free radical biology & medicine, 2015, Volume: 81 Topics: Acute Kidney Injury; Androstadienes; Animals; Apoptosis; Chromones; Contrast Media; Disease Models, Animal; Gene Expression Regulation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Indoles; Iohexol; Ischemic Preconditioning; Kidney Tubules; Male; Maleimides; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Morpholines; Nephrectomy; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Wortmannin	2015
Rapid-acting antidepressant-like effects of acetyl-l-carnitine mediated by PI3K/AKT/BDNF/VGF signaling pathway in mice. Neuroscience, 2015, Jan-29, Volume: 285 Topics: Acetylcarnitine; Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Chromones; Depressive Disorder; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hippocampus; Male; Mice; Morpholines; Nerve Growth Factors; Neuropeptides; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Prefrontal Cortex; Proto-Oncogene Proteins c-akt; Signal Transduction; Stress, Psychological; Time Factors	2015
Acute administration of n-3 rich triglyceride emulsions provides cardioprotection in murine models after ischemia-reperfusion. PloS one, 2015, Volume: 10, Issue:1 Topics: Animals; Apoptosis Regulatory Proteins; Beclin-1; Chromones; Disease Models, Animal; Echocardiography; Emulsions; Fatty Acids, Omega-3; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Indoles; Male; Maleimides; Mice; Mice, Inbred C57BL; Morpholines; Myocardial Reperfusion Injury; Phosphorylation; PPAR gamma; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Signal Transduction	2015
Inflammatory cytokine TSLP stimulates platelet secretion and potentiates platelet aggregation via a TSLPR-dependent PI3K/Akt signaling pathway. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2015, Volume: 35, Issue:1 Topics: Androstadienes; Animals; Blood Platelets; Carotid Artery Thrombosis; Chlorides; Chromones; Cytokines; Disease Models, Animal; Ferric Compounds; Humans; Immunoglobulins; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; P-Selectin; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Proto-Oncogene Proteins c-akt; Receptors, Cytokine; Signal Transduction; Thymic Stromal Lymphopoietin; Wortmannin	2015
G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L. eLife, 2015, Mar-30, Volume: 4 Topics: Animals; Autophagy; Autophagy-Related Proteins; Benzylamines; Carrier Proteins; Cell Line, Tumor; Chromones; Cullin Proteins; Cyclams; Disease Models, Animal; Gene Expression Regulation; HEK293 Cells; Heterocyclic Compounds; Humans; Huntington Disease; Kruppel-Like Transcription Factors; Mice; Morpholines; Phagosomes; Phosphatidylinositol Phosphates; Promyelocytic Leukemia Zinc Finger Protein; Proteasome Endopeptidase Complex; Proteolysis; Psychomotor Performance; Receptors, CXCR4; Rotarod Performance Test; Signal Transduction; Survival Analysis; Ubiquitination; Vesicular Transport Proteins	2015
Protein tyrosine phosphatase 1B regulates the activity of retinal pigment epithelial cells. Molecular vision, 2015, Volume: 21 Topics: Animals; Cell Differentiation; Cell Movement; Cell Proliferation; Cells, Cultured; Chromones; Disease Models, Animal; Enzyme Inhibitors; Epithelial-Mesenchymal Transition; Female; Flavonoids; Male; MAP Kinase Signaling System; Morpholines; Phosphatidylinositol 3-Kinases; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Retinal Detachment; Retinal Pigment Epithelium; Signal Transduction	2015
PI3K-AKT Signaling via Nrf2 Protects against Hyperoxia-Induced Acute Lung Injury, but Promotes Inflammation Post-Injury Independent of Nrf2 in Mice. PloS one, 2015, Volume: 10, Issue:6 Topics: Acute Lung Injury; Alveolar Epithelial Cells; Animals; Cell Line; Chromones; Disease Models, Animal; Gene Knockdown Techniques; Hyperoxia; Macrophages, Alveolar; Mice; Mice, Knockout; Morpholines; Neutrophil Infiltration; NF-E2-Related Factor 2; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction	2015
PI3K Phosphorylation Is Linked to Improved Electrical Excitability in an In Vitro Engineered Heart Tissue Disease Model System. Tissue engineering. Part A, 2015, Volume: 21, Issue:17-18 Topics: Animals; Animals, Newborn; Chlorpropamide; Chromones; Disease Models, Animal; Electrophysiological Phenomena; Gene Expression Profiling; Gene Expression Regulation; Heart; Insulin; Models, Biological; Morpholines; Myocytes, Cardiac; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Tissue Engineering	2015
Neuroprotective effect of nicorandil through inhibition of apoptosis by the PI3K/Akt1 pathway in a mouse model of deep hypothermic low flow. Journal of the neurological sciences, 2015, Oct-15, Volume: 357, Issue:1-2 Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Chromones; Circulatory Arrest, Deep Hypothermia Induced; Disease Models, Animal; Down-Regulation; Mice; Morpholines; Neuroprotective Agents; Nicorandil; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Reperfusion Injury; Signal Transduction; Up-Regulation	2015
Endogenous BDNF augments NMDA receptor phosphorylation in the spinal cord via PLCγ, PKC, and PI3K/Akt pathways during colitis. Journal of neuroinflammation, 2015, Aug-20, Volume: 12 Topics: Animals; Antibodies; Brain-Derived Neurotrophic Factor; Chromones; Colitis; Disease Models, Animal; Enzyme Inhibitors; Male; Morpholines; Organ Culture Techniques; Phosphatidylinositol 3-Kinase; Phosphorylation; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Spinal Cord; Time Factors; Trinitrobenzenesulfonic Acid; Up-Regulation	2015
The proinflammatory cytokine, interleukin-17A, augments mitochondrial function and neurite outgrowth of cultured adult sensory neurons derived from normal and diabetic rats. Experimental neurology, 2015, Volume: 273 Topics: Animals; Antibiotics, Antineoplastic; Butadienes; Cells, Cultured; Chromones; Diabetes Mellitus, Experimental; Disease Models, Animal; Electron Transport Complex IV; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Ganglia, Spinal; Interleukin-17; Male; MAP Kinase Signaling System; Mitochondria; Morpholines; Multienzyme Complexes; Neurites; Nitriles; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Streptozocin	2015
Astrocytes Promote Oligodendrogenesis after White Matter Damage via Brain-Derived Neurotrophic Factor. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015, Oct-14, Volume: 35, Issue:41 Topics: Animals; Antimutagenic Agents; Astrocytes; Brain Ischemia; Brain-Derived Neurotrophic Factor; Cell Differentiation; Cells, Cultured; Chromones; Cobalt; Culture Media, Conditioned; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Glutathione S-Transferase pi; Hypoxia-Inducible Factor 1, alpha Subunit; Leukoencephalopathies; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Morpholines; Myelin Basic Protein; Myelin Sheath; Phosphopyruvate Hydratase; Stem Cells	2015
Co-Inhibition of GLUT-1 Expression and the PI3K/Akt Signaling Pathway to Enhance the Radiosensitivity of Laryngeal Carcinoma Xenografts In Vivo. PloS one, 2015, Volume: 10, Issue:11 Topics: Androstadienes; Animals; Apoptosis; Cell Line, Tumor; Chromones; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Glucose Transporter Type 1; Humans; Laryngeal Neoplasms; Mice; Morpholines; Oligonucleotides, Antisense; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Radiation Tolerance; RNA, Messenger; Signal Transduction; Tumor Burden; Wortmannin; X-Rays; Xenograft Model Antitumor Assays	2015
Effects and mechanism of miR-23b on glucose-mediated epithelial-to-mesenchymal transition in diabetic nephropathy. The international journal of biochemistry & cell biology, 2016, Volume: 70 Topics: Animals; Cell Line; Chromones; Diabetic Nephropathies; Disease Models, Animal; Epithelial Cells; Epithelial-Mesenchymal Transition; Gene Expression Regulation; Glucose; Glycogen; HMGA2 Protein; Humans; Kidney Tubules, Proximal; Mice; Mice, Transgenic; MicroRNAs; Morpholines; Oligoribonucleotides; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction	2016
LY294002 prevents lipopolysaccharide‑induced hepatitis in a murine model by suppressing IκB phosphorylation. Molecular medicine reports, 2016, Volume: 13, Issue:1 Topics: Acute Disease; Animals; Blotting, Western; Chromones; Cytokines; Disease Models, Animal; Female; Hepatitis; I-kappa B Proteins; Inflammation Mediators; Lipopolysaccharides; Liver; Mice, Inbred BALB C; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors	2016
Apelin-13 exerts antidepressant-like and recognition memory improving activities in stressed rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2016, Volume: 26, Issue:3 Topics: Animals; Antidepressive Agents; Chromones; Corticosterone; Depression; Disease Models, Animal; Enzyme Inhibitors; Flavonoids; Helplessness, Learned; Injections, Intraventricular; Intercellular Signaling Peptides and Proteins; Locomotion; Male; Memory Disorders; Morpholines; Rats; Rats, Wistar; Recognition, Psychology; Stress, Psychological; Swimming; Time Factors	2016
The role of connexin43 in hemorrhagic transformation after thrombolysis in vivo and in vitro. Neuroscience, 2016, 08-04, Volume: 329 Topics: Animals; Blood-Brain Barrier; Butadienes; Capillary Permeability; Cells, Cultured; Cerebral Hemorrhage; Chromones; Connexin 43; Disease Models, Animal; Endothelial Cells; Enzyme Inhibitors; Fibrinolytic Agents; Infarction, Middle Cerebral Artery; Male; Morpholines; Nitriles; Phosphorylation; Rats, Inbred SHR; Thrombolytic Therapy; Tissue Plasminogen Activator	2016
Developing a Novel Embryo-Larval Zebrafish Xenograft Assay to Prioritize Human Glioblastoma Therapeutics. Zebrafish, 2016, Volume: 13, Issue:4 Topics: Animals; Antineoplastic Agents; Chromones; Disease Models, Animal; Glioblastoma; Heterografts; Humans; Metal Nanoparticles; Morpholines; Transplantation, Heterologous; Zebrafish; Zinc Oxide	2016
Lycium barbarum polysaccharide attenuates the cytotoxicity of mutant huntingtin and increases the activity of AKT. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2016, Volume: 52 Topics: Analysis of Variance; Animals; Brain; Caspase 3; Cell Survival; Chromones; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Green Fluorescent Proteins; HEK293 Cells; Humans; Huntingtin Protein; Huntington Disease; Mice; Mice, Transgenic; Morpholines; Motor Activity; Mutation; Oncogene Protein v-akt; Survival Analysis; Transfection	2016
Ghrelin attenuates brain injury in septic mice via PI3K/Akt signaling activation. Brain research bulletin, 2016, Volume: 124 Topics: Animals; bcl-2-Associated X Protein; Blood-Brain Barrier; Brain Edema; Brain Injuries; Capillary Permeability; Chromones; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Ghrelin; Male; Mice; Mice, Inbred C57BL; Morpholines; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-bcl-2; Sepsis; Signal Transduction; Superoxide Dismutase	2016
Inducing metabolic suppression in severe hemorrhagic shock: Pilot study results from the Biochronicity Project. The journal of trauma and acute care surgery, 2016, Volume: 81, Issue:6 Topics: Animals; Blood Pressure; Cardiac Output; Chromones; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Morpholines; Oxygen Consumption; Phosphoinositide-3 Kinase Inhibitors; Resuscitation; Shock, Hemorrhagic; Swine	2016
A novel perspective for burn-induced myopathy: Membrane repair defect. Scientific reports, 2016, 08-22, Volume: 6 Topics: Animals; Burns; Carrier Proteins; Cell Line; Cell Membrane; Chromones; Dimerization; Disease Models, Animal; Gene Expression; Insulin; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Microscopy, Confocal; Morpholines; Muscle, Skeletal; Muscular Diseases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Physical Conditioning, Animal; Protein Disulfide-Isomerases; Suppressor of Cytokine Signaling 1 Protein; Suppressor of Cytokine Signaling 3 Protein	2016
Comprehensive attenuation of IL-25-induced airway hyperresponsiveness, inflammation and remodelling by the PI3K inhibitor LY294002. Respirology (Carlton, Vic.), 2017, Volume: 22, Issue:1 Topics: Airway Remodeling; Animals; Bronchoalveolar Lavage Fluid; Chromones; Disease Models, Animal; Enzyme Inhibitors; Interleukins; Mice; Mice, Inbred BALB C; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Respiratory Function Tests; Respiratory Hypersensitivity; Treatment Outcome	2017
Matrine alleviates early brain injury after experimental subarachnoid hemorrhage in rats: possible involvement of PI3K/Akt-mediated NF-κB inhibition and Keap1/Nrf2-dependent HO-1 inductionn. Cellular and molecular biology (Noisy-le-Grand, France), 2016, Sep-30, Volume: 62, Issue:11 Topics: Alkaloids; Animals; Blood-Brain Barrier; Brain Injuries; Chromones; Disease Models, Animal; Heme Oxygenase-1; Kelch-Like ECH-Associated Protein 1; Male; Matrines; Matrix Metalloproteinase 9; Morpholines; Neuroprotective Agents; NF-E2-Related Factor 2; NF-kappa B; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Quinolizines; Rats; Rats, Sprague-Dawley; Signal Transduction; Subarachnoid Hemorrhage; Tumor Necrosis Factor-alpha	2016
Blocking mammalian target of rapamycin alleviates bladder hyperactivity and pain in rats with cystitis. Molecular pain, 2016, Volume: 12 Topics: Animals; Calcitonin Gene-Related Peptide; Chromones; Cyclophosphamide; Cystitis; Disease Models, Animal; Enzyme Inhibitors; Female; Hypersensitivity; Immunosuppressive Agents; Morpholines; Pain; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Urinary Bladder	2016
Role of PI3K, MAPK/ERK 1/2, and p38 in Production of Erythropoietic Activity by Bone Marrow Cells after Blood Loss. Bulletin of experimental biology and medicine, 2016, Volume: 162, Issue:1 Topics: Anemia; Animals; Bone Marrow Cells; Chromones; Disease Models, Animal; Erythropoiesis; Erythropoietin; Flavonoids; Gene Expression Regulation; Hemorrhage; Imidazoles; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Pyridines; Signal Transduction	2016
Antidepressant-like activity of the neuropeptide Y Y5 receptor antagonist Lu AA33810: behavioral, molecular, and immunohistochemical evidence. Psychopharmacology, 2017, Volume: 234, Issue:4 Topics: Animals; Antidepressive Agents; Behavior, Animal; Benzothiepins; Brain-Derived Neurotrophic Factor; Chromones; Depression; Disease Models, Animal; Enzyme Inhibitors; Male; Morpholines; Neuropeptide Y; Phosphoinositide-3 Kinase Inhibitors; Prefrontal Cortex; Rats; Signal Transduction; Sulfonamides; Swimming	2017
Neuroprotective properties of icariin in MPTP-induced mouse model of Parkinson's disease: Involvement of PI3K/Akt and MEK/ERK signaling pathways. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2017, Feb-15, Volume: 25 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Chromones; Corpus Striatum; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Drugs, Chinese Herbal; Enzyme Inhibitors; Epimedium; Female; Flavonoids; MAP Kinase Signaling System; Mice, Inbred C57BL; Morpholines; Neuroprotective Agents; Parkinson Disease; Phosphatidylinositol 3-Kinase; Phosphorylation; Phytotherapy; Proto-Oncogene Proteins c-akt; Signal Transduction; Tyrosine 3-Monooxygenase	2017
Electroacupuncture Attenuates CFA-induced Inflammatory Pain by suppressing Nav1.8 through S100B, TRPV1, Opioid, and Adenosine Pathways in Mice. Scientific reports, 2017, 02-13, Volume: 7 Topics: Acupuncture Analgesia; Adenosine; Analgesics, Opioid; Animals; Behavior, Animal; Biomarkers; Chromones; Disease Models, Animal; Electroacupuncture; Freund's Adjuvant; Gene Deletion; Gene Expression; Gene Knockout Techniques; Glial Fibrillary Acidic Protein; Male; Mice; Morpholines; NAV1.8 Voltage-Gated Sodium Channel; Neurons; Pain; Pain Management; Proto-Oncogene Proteins c-akt; S100 Calcium Binding Protein beta Subunit; Signal Transduction; Spinal Cord Dorsal Horn; TOR Serine-Threonine Kinases; TRPV Cation Channels; Xanthines	2017
Leptin protects hippocampal CA1 neurons against ischemic injury. Journal of neurochemistry, 2008, Volume: 107, Issue:2 Topics: Animals; Brain Ischemia; Brain-Derived Neurotrophic Factor; Chromones; CREB-Binding Protein; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Hippocampus; In Situ Nick-End Labeling; Leptin; Male; Morpholines; Neurons; Neuroprotective Agents; Oncogene Protein v-akt; Rats; Rats, Sprague-Dawley; Time Factors	2008
Dual inhibitory roles of geldanamycin on the c-Jun NH2-terminal kinase 3 signal pathway through suppressing the expression of mixed-lineage kinase 3 and attenuating the activation of apoptosis signal-regulating kinase 1 via facilitating the activation of Neuroscience, 2008, Oct-15, Volume: 156, Issue:3 Topics: Analysis of Variance; Animals; Behavior, Animal; Benzoquinones; Brain Injuries; Cells, Cultured; Chromones; Disease Models, Animal; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors; Glucose; Hippocampus; Infarction, Middle Cerebral Artery; Lactams, Macrocyclic; Male; MAP Kinase Kinase Kinase 5; Mitogen-Activated Protein Kinase 10; Morpholines; Neurons; Oncogene Protein v-akt; Oxygen; Rats; Rats, Sprague-Dawley; Signal Transduction; Time Factors	2008
Chronic restraint stress promotes immune suppression through toll-like receptor 4-mediated phosphoinositide 3-kinase signaling. Journal of neuroimmunology, 2008, Nov-15, Volume: 204, Issue:1-2 Topics: Androstadienes; Animals; Chromones; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation, Enzymologic; Immunosuppression Therapy; Lymphocyte Count; Lymphocytes; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Morpholines; Phosphatidylinositol 3-Kinases; Signal Transduction; Stress, Psychological; Th1 Cells; Th2 Cells; Toll-Like Receptor 4; Wortmannin	2008
Mechanisms mediating renal sympathetic activation to leptin in obesity. American journal of physiology. Regulatory, integrative and comparative physiology, 2008, Volume: 295, Issue:6 Topics: Adipose Tissue, Brown; Animals; Body Weight; Chromones; Dietary Fats; Disease Models, Animal; Dose-Response Relationship, Drug; Eating; Injections, Intraperitoneal; Injections, Intraventricular; Kidney; Leptin; Lumbar Vertebrae; Male; Melanocyte-Stimulating Hormones; Mice; Mice, Inbred C57BL; Mice, Obese; Morpholines; Obesity; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Receptors, Melanocortin; Signal Transduction; Sympathetic Nervous System; Time Factors	2008
The Rheb-mTOR pathway is upregulated in reactive astrocytes of the injured spinal cord. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, Jan-28, Volume: 29, Issue:4 Topics: Analysis of Variance; Animals; Astrocytes; Cells, Cultured; Chromones; Disease Models, Animal; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Excitatory Amino Acid Transporter 2; Flavonoids; Glial Fibrillary Acidic Protein; Immunosuppressive Agents; Male; Monomeric GTP-Binding Proteins; Morpholines; Neuropeptides; Protein Kinases; Ras Homolog Enriched in Brain Protein; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Sirolimus; Spinal Cord Injuries; TOR Serine-Threonine Kinases; Transcription Factors; Transfection; Up-Regulation; Vimentin	2009
Anti-hypertrophic effect of NHE-1 inhibition involves GSK-3beta-dependent attenuation of mitochondrial dysfunction. Journal of molecular and cellular cardiology, 2009, Volume: 46, Issue:6 Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Blotting, Western; Cardiomegaly; Cells, Cultured; Chromones; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Endothelin-1; Flavonoids; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hypoglycemic Agents; Immunoprecipitation; Male; Membrane Potential, Mitochondrial; Microscopy, Confocal; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Morpholines; Myocytes, Cardiac; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Polymerase Chain Reaction; Protein Binding; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Ribonucleotides; Sodium-Hydrogen Exchangers; Voltage-Dependent Anion Channels	2009
Attenuation of neuronal degeneration in thioredoxin-1 overexpressing mice after mild focal ischemia. Brain research, 2009, May-26, Volume: 1272 Topics: Analysis of Variance; Animals; Caspase 3; Cell Death; Chromones; Dicarbethoxydihydrocollidine; Disease Models, Animal; Enzyme Inhibitors; Humans; In Situ Nick-End Labeling; Infarction, Middle Cerebral Artery; Injections, Intraventricular; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Morpholines; Nerve Degeneration; Proto-Oncogene Proteins c-akt; Stilbamidines; Thioredoxins; Time Factors	2009
Pretreatment with lovastatin prevents N-methyl-D-aspartate-induced neurodegeneration in the magnocellular nucleus basalis and behavioral dysfunction. Journal of Alzheimer's disease : JAD, 2009, Volume: 17, Issue:2 Topics: Analysis of Variance; Animals; Avoidance Learning; Basal Nucleus of Meynert; Behavioral Symptoms; Choline O-Acetyltransferase; Chromones; Disease Models, Animal; Drug Administration Schedule; Drug Interactions; Enzyme Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; Maze Learning; Mice; Mice, Inbred C57BL; Morpholines; N-Methylaspartate; Neurodegenerative Diseases; Reaction Time	2009
Inhibition of PI-3K restores nuclear p27Kip1 expression in a mouse model of Kras-driven lung cancer. Oncogene, 2009, Oct-15, Volume: 28, Issue:41 Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Nucleus; Chromones; Cyclin-Dependent Kinase Inhibitor p27; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Mice; Morpholines; Mutation; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins p21(ras); RNA, Messenger; Urethane	2009
PKB/Akt activation inhibits p53-mediated HIF1A degradation that is independent of MDM2. Journal of cellular physiology, 2010, Volume: 222, Issue:3 Topics: Animals; Cardiomegaly; Cell Line; Cell Size; Chromones; Deferoxamine; Disease Models, Animal; Fibroblasts; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Mice, Knockout; Morpholines; Myoblasts, Cardiac; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proteasome Endopeptidase Complex; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-mdm2; Rats; RNA, Messenger; Serine; Time Factors; Transfection; Tumor Suppressor Protein p53; Ubiquitination	2010
Involvement of phosphoinositide 3-kinase gamma in angiogenesis and healing of experimental myocardial infarction in mice. Circulation research, 2010, Mar-05, Volume: 106, Issue:4 Topics: Animals; Apoptosis; Cell Movement; Cell Proliferation; Cell Survival; Cells, Cultured; Chromones; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelial Cells; Humans; Inflammation; Leukocytes; Male; Mice; Morpholines; Myocardial Infarction; Myocardium; Neovascularization, Physiologic; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinoxalines; Recovery of Function; Regeneration; RNA Interference; Signal Transduction; Thiazolidinediones; Time Factors; Transfection; Ventricular Function, Left	2010
CREB activation mediates VEGF-A's protection of neurons and cerebral vascular endothelial cells. Journal of neurochemistry, 2010, Volume: 113, Issue:1 Topics: Animals; Animals, Newborn; Brain Injuries; Cell Survival; Cells, Cultured; Chromones; CREB-Binding Protein; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Glial Fibrillary Acidic Protein; Glucose; Hypoxia; Hypoxia-Ischemia, Brain; Indoles; Injections, Intraventricular; Male; Morpholines; Neurons; Phosphorylation; Placenta Growth Factor; Platelet Endothelial Cell Adhesion Molecule-1; Pregnancy Proteins; Pyrroles; Rats; Rats, Sprague-Dawley; Serine; Signal Transduction; Time Factors; Transfection; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2	2010
The phosphatidylinositol 3-kinase-Akt pathway protects cardiomyocytes from ischaemic and hypoxic apoptosis via mitochondrial function. Clinical and experimental pharmacology & physiology, 2010, Volume: 37, Issue:5-6 Topics: Animals; Animals, Newborn; Apoptosis; Burns; Calcium; Caspase 3; Cell Hypoxia; Cell Survival; Cells, Cultured; Chromones; Disease Models, Animal; Enzyme Inhibitors; Female; Male; Membrane Potential, Mitochondrial; Mitochondria, Heart; Morpholines; Myocardial Ischemia; Myocytes, Cardiac; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Tumor Suppressor Protein p53	2010
Vitamin B1 analog benfotiamine prevents diabetes-induced diastolic dysfunction and heart failure through Akt/Pim-1-mediated survival pathway. Circulation. Heart failure, 2010, Volume: 3, Issue:2 Topics: Analysis of Variance; Animals; Apoptosis; Blood Flow Velocity; Blotting, Western; Carrier Proteins; Cells, Cultured; Chromones; Diabetes Mellitus, Experimental; Diastole; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Fibrosis; Heart Failure; Immunohistochemistry; Mice; Microfilament Proteins; Morpholines; Oxidative Stress; Proto-Oncogene Proteins c-pim-1; Random Allocation; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; STAT3 Transcription Factor; Thiamine; Up-Regulation	2010
SDF-1/CXCR4-mediated migration of transplanted bone marrow stromal cells toward areas of heart myocardial infarction through activation of PI3K/Akt. Journal of cardiovascular pharmacology, 2010, Volume: 55, Issue:5 Topics: Animals; Blotting, Western; Bone Marrow Cells; Chemokine CXCL12; Chemotaxis; Chromones; Disease Models, Animal; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Morpholines; Myocardial Infarction; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Receptors, CXCR4; Reverse Transcriptase Polymerase Chain Reaction; Stromal Cells	2010
VEGF protects spinal motor neurons against chronic excitotoxic degeneration in vivo by activation of PI3-K pathway and inhibition of p38MAPK. Journal of neurochemistry, 2010, Volume: 115, Issue:5 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Choline O-Acetyltransferase; Chromones; Cinnamates; Disease Models, Animal; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Imidazoles; Infusion Pumps, Implantable; Male; Morpholines; Motor Activity; Motor Neurons; Nerve Degeneration; Neurotoxicity Syndromes; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Pyridines; Rats; Rats, Wistar; Spinal Cord; Time Factors; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2	2010
Differential effects of insulin on sympathetic nerve activity in agouti obese mice. Journal of hypertension, 2010, Volume: 28, Issue:9 Topics: Animals; Blood Glucose; Chromones; Disease Models, Animal; Enzyme Inhibitors; Injections, Intraventricular; Insulin; Insulin Resistance; Lumbosacral Region; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Morpholines; Obesity; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Signal Transduction; Sympathetic Nervous System	2010
Neuroprotective effects of an herbal medicine, Yi-Gan San on MPP+/MPTP-induced cytotoxicity in vitro and in vivo. Journal of ethnopharmacology, 2010, Sep-15, Volume: 131, Issue:2 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Caspase 3; Cell Line, Tumor; Chromones; Cytotoxins; Disease Models, Animal; Dopamine; Drugs, Chinese Herbal; Enzyme Inhibitors; Humans; Magnoliopsida; Male; Mice; Mice, Inbred C57BL; Morpholines; Motor Activity; Neuroblastoma; Neurons; Neuroprotective Agents; Parkinson Disease; Phosphorylation; Phytotherapy; Proto-Oncogene Proteins c-akt	2010
Erythropoietin plus insulin-like growth factor-I protects against neuronal damage in a murine model of human immunodeficiency virus-associated neurocognitive disorders. Annals of neurology, 2010, Volume: 68, Issue:3 Topics: Administration, Intranasal; Adult; Animals; Apoptosis; Cells, Cultured; Cerebral Cortex; Chromones; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Embryo, Mammalian; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Erythropoietin; Female; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; HIV Envelope Protein gp120; HIV Infections; Humans; Immunoprecipitation; Insulin-Like Growth Factor I; Male; Mice; Mice, Transgenic; Middle Aged; Morpholines; Nerve Tissue Proteins; Neuroglia; Neurons; Neuroprotective Agents; Olfactory Bulb; Phosphorylation; Rats; tau Proteins	2010
Inactivation of PI3K/AKT signaling inhibits glioma cell growth through modulation of β-catenin-mediated transcription. Brain research, 2010, Dec-17, Volume: 1366 Topics: Animals; beta Catenin; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromones; Disease Models, Animal; Enzyme Inhibitors; Female; Gene Expression Regulation; Glioma; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Morpholines; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Serine; Signal Transduction; Time Factors; Transfection	2010
Ischemic postconditioning protects brain from ischemia/reperfusion injury by attenuating endoplasmic reticulum stress-induced apoptosis through PI3K-Akt pathway. Brain research, 2011, Jan-07, Volume: 1367 Topics: Animals; Apoptosis; Brain; Brain Infarction; Caspase 12; Chromones; Disease Models, Animal; Endoplasmic Reticulum; Enzyme Inhibitors; Heat-Shock Proteins; In Situ Nick-End Labeling; Ischemic Postconditioning; Male; Morpholines; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Time Factors; Transcription Factor CHOP	2011
Polysaccharides from the root of Angelica sinensis promotes hematopoiesis and thrombopoiesis through the PI3K/AKT pathway. BMC complementary and alternative medicine, 2010, Dec-21, Volume: 10 Topics: Angelica sinensis; Animals; Apoptosis; Blood Cells; Cell Proliferation; Chromones; Disease Models, Animal; Drugs, Chinese Herbal; Hematopoiesis; Megakaryocytes; Mice; Morpholines; Phosphatidylinositol 3-Kinase; Plant Roots; Polysaccharides; Proto-Oncogene Proteins c-akt; Signal Transduction; Stem Cells; Thrombopoiesis	2010
Insulin receptor signaling in rat hippocampus: a study in STZ (ICV) induced memory deficit model. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2011, Volume: 21, Issue:3 Topics: Animals; Blood Glucose; Chromones; Disease Models, Animal; Donepezil; Gene Expression; Hippocampus; Indans; Infusions, Intraventricular; Male; Maze Learning; Melatonin; Memory; Memory Disorders; Morpholines; Nootropic Agents; Phosphoinositide-3 Kinase Inhibitors; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Insulin; Signal Transduction; Streptozocin	2011
Salvianolic acid B and tanshinone IIA attenuate myocardial ischemia injury in mice by NO production through multiple pathways. Therapeutic advances in cardiovascular disease, 2011, Volume: 5, Issue:2 Topics: Abietanes; Amino Acid Transport Systems, Basic; AMP-Activated Protein Kinases; Analysis of Variance; Animals; Arginine; Benzofurans; Cardiovascular Agents; Cationic Amino Acid Transporter 1; Cells, Cultured; Chromones; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Endothelial Cells; Enzyme Inhibitors; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Myocardial Infarction; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; RNA, Messenger; Signal Transduction; Time Factors; Vasodilation	2011
Phosphatidylinositol 3-kinase/Akt signaling pathway mediates acupuncture-induced dopaminergic neuron protection and motor function improvement in a mouse model of Parkinson's disease. The International journal of neuroscience, 2011, Volume: 121, Issue:10 Topics: Acupuncture; Acupuncture Points; Administration, Intranasal; Animals; Chromones; Disease Models, Animal; Dopaminergic Neurons; Enzyme Inhibitors; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Morpholines; Motor Activity; MPTP Poisoning; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-jun; Rotarod Performance Test; Signal Transduction; Substantia Nigra; Tyrosine 3-Monooxygenase	2011
Luteolin inhibits apoptosis and improves cardiomyocyte contractile function through the PI3K/Akt pathway in simulated ischemia/reperfusion. Pharmacology, 2011, Volume: 88, Issue:3-4 Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Calcium-Binding Proteins; Cardiotonic Agents; Chromones; Disease Models, Animal; Heart; L-Lactate Dehydrogenase; Luteolin; Male; Morpholines; Myocardial Contraction; Myocardial Reperfusion Injury; Myocytes, Cardiac; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Sarcoplasmic Reticulum Calcium-Transporting ATPases	2011
Ethanol extract of Prunella vulgaris var. lilacina inhibits HMGB1 release by induction of heme oxygenase-1 in LPS-activated RAW 264.7 cells and CLP-induced septic mice. Phytotherapy research : PTR, 2012, Volume: 26, Issue:4 Topics: Animals; Anthracenes; Cecum; Cell Line; Cell Survival; Chromones; Cyclooxygenase 2; Disease Models, Animal; Drug Evaluation, Preclinical; Enzyme Activation; Enzyme Induction; Ethanol; Flavonoids; Flowers; Genetic Vectors; Heme Oxygenase-1; HMGB1 Protein; Imidazoles; Lipopolysaccharides; Lung; Macrophages; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Morpholines; NF-E2-Related Factor 2; NF-kappa B; Nitric Oxide Synthase Type II; Plant Extracts; Protein Transport; Prunella; Pyridines; Sepsis; Signal Transduction; Transfection	2012
Automated 4D analysis of dendritic spine morphology: applications to stimulus-induced spine remodeling and pharmacological rescue in a disease model. Molecular brain, 2011, Oct-07, Volume: 4 Topics: Animals; Automation; Brain-Derived Neurotrophic Factor; Chromones; Dendritic Spines; Diagnostic Imaging; Disease Models, Animal; Fragile X Mental Retardation Protein; Mice; Mice, Knockout; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Rats; Synapses	2011
Distinct signalling mechanisms mediate neutrophil attraction to bacterial infection and tissue injury. Cellular microbiology, 2012, Volume: 14, Issue:4 Topics: Animal Fins; Animals; Chromones; Disease Models, Animal; Embryo, Nonmammalian; Enzyme Activation; Hydrogen Peroxide; Microinjections; Morpholines; NADPH Oxidases; Neutrophil Infiltration; Neutrophils; Onium Compounds; Otitis; Phagocytosis; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Pseudomonas aeruginosa; Pseudomonas Infections; Signal Transduction; Streptococcal Infections; Streptococcus; Zebrafish	2012
Remote ischemic postconditioning protects the brain from global cerebral ischemia/reperfusion injury by up-regulating endothelial nitric oxide synthase through the PI3K/Akt pathway. Brain research, 2012, Mar-22, Volume: 1445 Topics: Analysis of Variance; Animals; Avoidance Learning; Brain; Brain Infarction; Brain Ischemia; Cell Death; Chromones; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation; In Situ Nick-End Labeling; Ischemic Postconditioning; Male; Maze Learning; Morpholines; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Nitroarginine; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinase; Rats; Rats, Sprague-Dawley; Reaction Time; Reperfusion Injury	2012
Carvacrol, a food-additive, provides neuroprotection on focal cerebral ischemia/reperfusion injury in mice. PloS one, 2012, Volume: 7, Issue:3 Topics: Animals; Apoptosis; Brain Ischemia; Caspase 3; Chromones; Cymenes; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Food Additives; Infarction, Middle Cerebral Artery; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Monoterpenes; Morpholines; Neurons; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Reperfusion Injury; Signal Transduction	2012
Berberine ameliorates β-amyloid pathology, gliosis, and cognitive impairment in an Alzheimer's disease transgenic mouse model. Neurobiology of aging, 2012, Volume: 33, Issue:12 Topics: ADAM Proteins; ADAM10 Protein; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Analysis of Variance; Animals; Aspartic Acid Endopeptidases; Berberine; Brain; Cell Line, Tumor; Chromones; Cognition Disorders; Disease Models, Animal; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Gliosis; Glycogen Synthase Kinase 3; Humans; Maze Learning; Membrane Proteins; Memory; Mice; Mice, Inbred C57BL; Mice, Transgenic; Morpholines; Mutation; Peptide Fragments; Transfection	2012
The toll-like receptor 9 agonist, CpG-oligodeoxynucleotide 1826, ameliorates cardiac dysfunction after trauma-hemorrhage. Shock (Augusta, Ga.), 2012, Volume: 38, Issue:2 Topics: Adjuvants, Immunologic; Animals; Chromones; Disease Models, Animal; Enzyme Inhibitors; Heart Diseases; Hemorrhage; Hypotension; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Morpholines; Oligodeoxyribonucleotides; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Soft Tissue Injuries; Toll-Like Receptor 9	2012
Stimulation of functional recovery via the mechanisms of neurorepair by S-nitrosoglutathione and motor exercise in a rat model of transient cerebral ischemia and reperfusion. Restorative neurology and neuroscience, 2012, Volume: 30, Issue:5 Topics: Analysis of Variance; Animals; Apoptosis; Brain Infarction; Brain-Derived Neurotrophic Factor; Caspase 3; Chromones; Disease Models, Animal; Drug Administration Schedule; Enzyme Inhibitors; Exercise Therapy; Gene Expression Regulation; Glial Fibrillary Acidic Protein; In Situ Nick-End Labeling; Infarction, Middle Cerebral Artery; Locomotion; Male; Morpholines; Neuroprotective Agents; Oncogene Protein v-akt; Phosphopyruvate Hydratase; Platelet Endothelial Cell Adhesion Molecule-1; Rats; Rats, Sprague-Dawley; Receptor, trkB; Recovery of Function; Reperfusion; S-Nitrosoglutathione; Severity of Illness Index; Time Factors	2012
AKT/GSK3β-dependent autophagy contributes to the neuroprotection of limb remote ischemic postconditioning in the transient cerebral ischemic rat model. CNS neuroscience & therapeutics, 2012, Volume: 18, Issue:12 Topics: Animals; Autophagy; Brain; Caspase 3; Chromones; Disease Models, Animal; Enzyme Inhibitors; Femoral Artery; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; Ischemic Postconditioning; Male; Morpholines; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Severity of Illness Index; Time Factors	2012
Girdin and its phosphorylation dynamically regulate neonatal vascular development and pathological neovascularization in the retina. The American journal of pathology, 2013, Volume: 182, Issue:2 Topics: Animals; Animals, Newborn; Blood Vessels; Cell Movement; Cell Proliferation; Chromones; Disease Models, Animal; Female; Gene Knockdown Techniques; Human Umbilical Vein Endothelial Cells; Humans; Mice; Microfilament Proteins; Morpholines; Neovascularization, Physiologic; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Transport; Proto-Oncogene Proteins c-akt; Retina; Retinal Neovascularization; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Vascular Endothelial Growth Factor A; Vesicular Transport Proteins	2013
Neural plasticity and addiction: PI3-kinase and cocaine behavioral sensitization. Nature neuroscience, 2002, Volume: 5, Issue:12 Topics: Animals; Behavior, Animal; Brain; Chromones; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Enzyme Inhibitors; Male; Morpholines; Motor Activity; Neuronal Plasticity; Neurons; Phosphatidylinositol 3-Kinases; Rats; Rats, Wistar; Signal Transduction	2002
P2X7 mediates superoxide production in primary microglia and is up-regulated in a transgenic mouse model of Alzheimer's disease. The Journal of biological chemistry, 2003, Apr-11, Volume: 278, Issue:15 Topics: Adenosine Triphosphate; Alzheimer Disease; Animals; Animals, Newborn; Calcium; Cerebral Cortex; Chromones; Disease Models, Animal; Embryo, Mammalian; Enzyme Inhibitors; Female; Humans; Kinetics; MAP Kinase Signaling System; Mice; Mice, Transgenic; Microglia; Morpholines; NADPH Oxidases; Neutrophils; Phosphoinositide-3 Kinase Inhibitors; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Superoxides; Up-Regulation	2003
Selective role of PI3K delta in neutrophil inflammatory responses. Biochemical and biophysical research communications, 2003, Sep-05, Volume: 308, Issue:4 Topics: Adenine; Androstadienes; Animals; Anti-Inflammatory Agents; Chromones; Class I Phosphatidylinositol 3-Kinases; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Exocytosis; Inflammation; Leukocyte Elastase; Mice; Mice, Inbred BALB C; Morpholines; Neutrophils; Phosphatidylinositol 3-Kinases; Protein Isoforms; Quinazolines; Signal Transduction; Superoxides; Time Factors; Wortmannin	2003
PI3-kinase upregulation and involvement in spontaneous tone in arteries from DOCA-salt rats: is p110delta the culprit? Hypertension (Dallas, Tex. : 1979), 2004, Volume: 43, Issue:4 Topics: Adenine; Animals; Aorta; Chromones; Class I Phosphatidylinositol 3-Kinases; Desoxycorticosterone; Disease Models, Animal; Enzyme Induction; Enzyme Inhibitors; Hypertension; Male; Mesenteric Arteries; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Isoforms; Protein Subunits; Quinazolines; Rats; Rats, Sprague-Dawley; Sodium Chloride; Vascular Resistance	2004
PI3K-Akt pathway suppresses coagulation and inflammation in endotoxemic mice. Arteriosclerosis, thrombosis, and vascular biology, 2004, Volume: 24, Issue:10 Topics: Androstadienes; Animals; Blood Coagulation; Chemokines; Chromones; Cytokines; Disease Models, Animal; Endothelial Cells; Endothelium, Vascular; Endotoxemia; Humans; Inflammation; Kidney; Lipopolysaccharides; Liver; Macrophage Activation; Mice; Mice, Inbred C57BL; Monocytes; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Wortmannin	2004
A novel IKKbeta inhibitor stimulates adiponectin levels and ameliorates obesity-linked insulin resistance. Biochemical and biophysical research communications, 2004, Oct-08, Volume: 323, Issue:1 Topics: 3T3-L1 Cells; Adipocytes; Adiponectin; Animals; Benzamides; Blood Glucose; Body Weight; Chromones; Diabetes Mellitus; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Gene Expression Regulation; Genes, Dominant; Glucose; I-kappa B Kinase; Insulin; Insulin Resistance; Intercellular Signaling Peptides and Proteins; Leptin; Mice; Mice, Obese; Models, Biological; Morpholines; Obesity; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Time Factors; Up-Regulation	2004
Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injury. Diabetes, 2005, Volume: 54, Issue:1 Topics: Animals; Blood Pressure; Butadienes; Chromones; Disease Models, Animal; Enzyme Inhibitors; Glucagon; Glucagon-Like Peptide 1; Heart Rate; In Vitro Techniques; Insulin; Insulin Secretion; Male; MAP Kinase Signaling System; Morpholines; Myocardial Infarction; Myocardial Reperfusion Injury; Nitriles; Peptide Fragments; Phosphoinositide-3 Kinase Inhibitors; Protein Precursors; Rats; Rats, Sprague-Dawley; Time Factors	2005
An anti-inflammatory role for a phosphoinositide 3-kinase inhibitor LY294002 in a mouse asthma model. International immunopharmacology, 2005, Volume: 5, Issue:3 Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Cell Movement; Chromones; Cytokines; Disease Models, Animal; Eosinophils; Lung; Male; Mice; Mice, Inbred BALB C; Morpholines; Mucus; Ovalbumin; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pulmonary Eosinophilia; Respiratory Hypersensitivity	2005
Neuroprotective effects of preconditioning ischaemia on ischaemic brain injury through inhibition of mixed-lineage kinase 3 via NMDA receptor-mediated Akt1 activation. Journal of neurochemistry, 2005, Volume: 93, Issue:4 Topics: Animals; Blotting, Western; Brain; Brain Ischemia; Cell Death; Chromones; Dimethyl Sulfoxide; Disease Models, Animal; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Free Radical Scavengers; Ischemic Preconditioning; Ketamine; Male; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinase Kinase Kinase 11; Mitogen-Activated Protein Kinase Kinases; Models, Biological; Morpholines; N-Methylaspartate; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Receptors, N-Methyl-D-Aspartate; Reperfusion; Time Factors	2005
The role of PDGF receptor inhibitors and PI3-kinase signaling in the pathogenesis of corneal neovascularization. Investigative ophthalmology & visual science, 2006, Volume: 47, Issue:5 Topics: Androstadienes; Angiopoietin-1; Angiopoietin-2; Animals; Chromones; Cornea; Corneal Neovascularization; Disease Models, Animal; Enzyme Inhibitors; Mice; Mice, Inbred C57BL; Morpholines; Pericytes; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-akt; Receptor Protein-Tyrosine Kinases; Receptors, Platelet-Derived Growth Factor; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tyrphostins; Vascular Endothelial Growth Factor A; Wortmannin	2006
Inhibition of MLK3-MKK4/7-JNK1/2 pathway by Akt1 in exogenous estrogen-induced neuroprotection against transient global cerebral ischemia by a non-genomic mechanism in male rats. Journal of neurochemistry, 2006, Volume: 99, Issue:6 Topics: Animals; Blotting, Western; Chromones; Disease Models, Animal; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Estrogens; Fulvestrant; Hippocampus; Immunohistochemistry; Immunoprecipitation; Ischemic Attack, Transient; Male; MAP Kinase Kinase 7; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase Kinase Kinase 11; Morpholines; Neuroprotective Agents; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Serine; Signal Transduction	2006
Protection against myocardial ischemia/reperfusion injury in TLR4-deficient mice is mediated through a phosphoinositide 3-kinase-dependent mechanism. Journal of immunology (Baltimore, Md. : 1950), 2007, Jun-01, Volume: 178, Issue:11 Topics: Androstadienes; Animals; Apoptosis; Chromones; Disease Models, Animal; Down-Regulation; Enzyme Inhibitors; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Morpholines; Myocardial Reperfusion Injury; Myocytes, Cardiac; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Signal Transduction; Toll-Like Receptor 4; Up-Regulation; Wortmannin	2007
Cardioprotection induced by hydrogen sulfide preconditioning involves activation of ERK and PI3K/Akt pathways. Pflugers Archiv : European journal of physiology, 2008, Volume: 455, Issue:4 Topics: Animals; Benzophenanthridines; Cardiotonic Agents; Cell Survival; Chromones; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glyburide; Hydrogen Sulfide; Ischemic Preconditioning, Myocardial; KATP Channels; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Myocardial Contraction; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Potassium Channel Blockers; Protein Kinase C; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Sulfides; Time Factors	2008
Activated macrophages in HIV encephalitis and a macaque model show increased [3H](R)-PK11195 binding in a PI3-kinase-dependent manner. Neuroscience letters, 2007, Oct-16, Volume: 426, Issue:2 Topics: Analysis of Variance; Animals; Antineoplastic Agents; Autoradiography; Binding, Competitive; Butadienes; Chromones; Disease Models, Animal; Dose-Response Relationship, Drug; Encephalitis; Enzyme Inhibitors; HIV; Isoquinolines; Lipopolysaccharides; Macaca; Macrophage Activation; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Positron-Emission Tomography; Simian Immunodeficiency Virus; Tritium	2007
Metformin protects the ischemic heart by the Akt-mediated inhibition of mitochondrial permeability transition pore opening. Basic research in cardiology, 2008, Volume: 103, Issue:3 Topics: Animals; Chromones; Diabetes Mellitus; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Hypoglycemic Agents; Ischemic Contracture; Male; Metformin; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Morpholines; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar	2008
Preconditioning by isoflurane retains its protection against ischemia-reperfusion injury in postinfarct remodeled rat hearts. Anesthesia and analgesia, 2008, Volume: 106, Issue:1 Topics: Anesthetics, Inhalation; Animals; Cardiotonic Agents; Chromones; Coronary Vessels; Decanoic Acids; Disease Models, Animal; Hydroxy Acids; Isoflurane; L-Lactate Dehydrogenase; Ligation; Male; Morpholines; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Potassium Channel Blockers; Potassium Channels; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Signal Transduction; Time Factors; Ventricular Remodeling	2008
Lipopolysaccharide-induced myocardial protection against ischaemia/reperfusion injury is mediated through a PI3K/Akt-dependent mechanism. Cardiovascular research, 2008, Jun-01, Volume: 78, Issue:3 Topics: Animals; Apoptosis; Caspase 3; Chromones; Disease Models, Animal; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; Lipopolysaccharides; Male; Mice; Mice, Transgenic; Morpholines; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction	2008
Phosphatidylinositol 3-kinase inhibitor failed to reduce cerebral vasospasm in dog model of experimental subarachnoid hemorrhage. Stroke, 2002, Volume: 33, Issue:2 Topics: Androstadienes; Animals; Basilar Artery; Blotting, Western; Brain; Cerebral Angiography; Chromones; Disease Models, Animal; Dogs; Enzyme Inhibitors; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Subarachnoid Hemorrhage; Treatment Failure; Vascular Patency; Vasospasm, Intracranial; Wortmannin	2002
Inhibition of phosphatidylinositol 3'-kinase increases efficacy of paclitaxel in in vitro and in vivo ovarian cancer models. Cancer research, 2002, Feb-15, Volume: 62, Issue:4 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Division; Chromones; Disease Models, Animal; Drug Synergism; Enzyme Inhibitors; Female; Humans; Mice; Mice, Nude; Morpholines; Ovarian Neoplasms; Paclitaxel; Phosphoinositide-3 Kinase Inhibitors; Tumor Cells, Cultured	2002