Compounds > 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one
Page last updated: 2024-10-30

2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Disease Models, Animal

2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Disease Models, Animal in 158 studies

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source

Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.

Research Excerpts

ExcerptRelevanceReference
"This study investigated the therapeutic effects of puerarin (PR) on a rat model of anterior ischemic optic neuropathy (rAION)."7.91Therapeutic Effects of Puerarin Against Anterior Ischemic Optic Neuropathy Through Antiapoptotic and Anti-Inflammatory Actions. ( Ho, YC; Kapupara, K; Nguyen Ngo Le, MA; Tsai, RK; Wen, YT, 2019)
"These data suggest that the PI3K/Akt/mTOR pathway contributes to sevoflurane-induced neuroinflammation and that activation of PI3K/Akt/mTOR signaling by DEX could help reduce the neuroinflammatory effects of sevoflurane."7.91Dexmedetomidine suppresses sevoflurane anesthesia-induced neuroinflammation through activation of the PI3K/Akt/mTOR pathway. ( Wang, M; Wang, N, 2019)
"This study aimed to investigate the protective effect of salvinorin A on the cerebral pial artery after forebrain ischemia and explore related mechanisms."7.88Salvinorin A preserves cerebral pial artery autoregulation after forebrain ischemia via the PI3K/AKT/cGMP pathway. ( Dong, HP; He, ZZ; Ma, XX; Wang, ZH; Zhou, W, 2018)
"Non-alcoholic fatty liver disease (NAFLD) is a common disease associated with metabolic syndrome and can lead to life-threatening complications like hepatic carcinoma and cirrhosis."5.48Exenatide ameliorates hepatic steatosis and attenuates fat mass and FTO gene expression through PI3K signaling pathway in nonalcoholic fatty liver disease. ( Han, C; Li, J; Li, S; Liu, X; Ma, Y; Wang, X; Zhang, J; Zhang, L; Zheng, L, 2018)
"Methane was mixed with air to achieve a final concentration of 2."5.46Inhaled Methane Protects Rats Against Neurological Dysfunction Induced by Cerebral Ischemia and Reperfusion Injury: PI3K/Akt/HO-1 Pathway Involved. ( Gao, M; He, D; Shen, J; Zhang, B, 2017)
"Pain is associated with several conditions, such as inflammation, that result from altered peripheral nerve properties."5.46Electroacupuncture Attenuates CFA-induced Inflammatory Pain by suppressing Nav1.8 through S100B, TRPV1, Opioid, and Adenosine Pathways in Mice. ( Hsieh, CL; Huang, CP; Liao, HY; Lin, YW, 2017)
"Leptin plays a critical role in the control of energy homeostasis."5.35Mechanisms mediating renal sympathetic activation to leptin in obesity. ( Morgan, DA; Rahmouni, K; Thedens, DR; Weiss, R, 2008)
"This study investigated the therapeutic effects of puerarin (PR) on a rat model of anterior ischemic optic neuropathy (rAION)."3.91Therapeutic Effects of Puerarin Against Anterior Ischemic Optic Neuropathy Through Antiapoptotic and Anti-Inflammatory Actions. ( Ho, YC; Kapupara, K; Nguyen Ngo Le, MA; Tsai, RK; Wen, YT, 2019)
"These data suggest that the PI3K/Akt/mTOR pathway contributes to sevoflurane-induced neuroinflammation and that activation of PI3K/Akt/mTOR signaling by DEX could help reduce the neuroinflammatory effects of sevoflurane."3.91Dexmedetomidine suppresses sevoflurane anesthesia-induced neuroinflammation through activation of the PI3K/Akt/mTOR pathway. ( Wang, M; Wang, N, 2019)
"This study aimed to investigate the protective effect of salvinorin A on the cerebral pial artery after forebrain ischemia and explore related mechanisms."3.88Salvinorin A preserves cerebral pial artery autoregulation after forebrain ischemia via the PI3K/AKT/cGMP pathway. ( Dong, HP; He, ZZ; Ma, XX; Wang, ZH; Zhou, W, 2018)
"The transforming growth factor beta (TGF-β) signalling pathway is known to control human breast cancer invasion and metastasis."3.79Transforming growth factor-β signalling controls human breast cancer metastasis in a zebrafish xenograft model. ( Drabsch, Y; He, S; Snaar-Jagalska, BE; ten Dijke, P; Zhang, L, 2013)
"Ovalbumin (OVA) sensitized murine model of asthma was used to investigate the expression of cyclin D1, cyclin A, and p27kip1 by splenic CD4(+) T lymphocytes."3.79PI3K and Notch signal pathways coordinately regulate the activation and proliferation of T lymphocytes in asthma. ( Cai, X; Chong, L; Li, C; Liang, Y; Lin, B; Nie, Y; Zhang, H; Zhang, W, 2013)
" We observed that Sal B and Tan IIA have cardioprotective effects in an in vivo myocardial infarction model of C57 mice, have vasodilator action in a ex vivo micro-artery system through the endothelial nitric oxide synthase (eNOS)/nitric oxide (NO) pathway and are involved in the regulation of the L-arginine/eNOS/NO pathways in human umbilical vein endothelial cells (HUVECs)."3.77Salvianolic acid B and tanshinone IIA attenuate myocardial ischemia injury in mice by NO production through multiple pathways. ( Chen, M; Huo, Y; Li, J; Lou, L; Pan, C; Singh, G; Wang, S; Wu, A; Zhang, D; Zhao, M, 2011)
"Lower extremity deep venous thrombosis (LEDVT) is a venous reflux disorder caused by abnormal coagulation of blood."1.72Study on the Effect and Mechanism of miR-185 on Lower Extremity Deep Venous Thrombosis. ( Gao, Y; Lu, R; Nie, Z; Sun, H; Yu, Z; Zhang, L; Zhu, W, 2022)
"Zileuton and LY294002 were used to inhibit expression of 5-LOX and Akt, respectively."1.625-Lipoxygenase inhibition reduces inflammation and neuronal apoptosis via AKT signaling after subarachnoid hemorrhage in rats. ( Chen, H; Deng, Y; Guo, Z; He, Z; Liang, Y; Liu, L; Sun, X; Zhang, P; Zhang, Z, 2021)
"Liver ischemia reperfusion injury (LIRI) often occurs during liver transplantation, resection, and various circulatory shock procedures, leading to severe metabolic disorders, inflammatory immune responses, oxidative stress injury, and cell apoptosis."1.62Methyl eugenol attenuates liver ischemia reperfusion injury via activating PI3K/Akt signaling. ( Gong, N; Hou, S; Kuang, B; Li, Q; Sun, K; Wang, M; Wang, MMZ; Zhang, J, 2021)
"Furthermore, PTZ evoked seizure severity was considerably decreased, while latency to clonic-like seizure was increased in adult zebrafish group treated with 100 nM of LY294002."1.51Anticonvulsant action of a selective phosphatidylinositol-3-kinase inhibitor LY294002 in pentylenetetrazole-mediated convulsions in zebrafish. ( Kumari, S; Mazumder, AG; Singh, D, 2019)
"The role that CXCL12 plays after facial nerve injury remains unknown."1.51CXCL12 has therapeutic value in facial nerve injury and promotes Schwann cells autophagy and migration via PI3K-AKT-mTOR signal pathway. ( Gao, D; Li, S; Sun, H; Tang, T; Tang, Y; Zhu, J, 2019)
"Sepsis was induced by cecal ligation and puncture (CLP)."1.51Neuregulin-1β attenuates sepsis-induced diaphragm atrophy by activating the PI3K/Akt signaling pathway. ( Chu, T; Jiang, P; Li, ST; Liu, H; Wu, J, 2019)
"Berberine was administered p."1.48Berberine Alleviates Tau Hyperphosphorylation and Axonopathy-Associated with Diabetic Encephalopathy via Restoring PI3K/Akt/GSK3β Pathway. ( Chen, J; Chen, Q; Feng, Z; Hang, W; He, B; Wang, S; Wang, X; Wu, N; Xia, L; Zhang, Q; Zhou, X, 2018)
"Treating systemic metastases at the micrometastatic stage is a potential strategy to inhibit cancer metastasis."1.48Rapid identification of antimicrometastases drugs using integrated model systems with two dimensional monolayer, three dimensional spheroids, and zebrafish xenotransplantation tumors. ( Fu, A; Luo, KQ; Ngan, W; Peh, YM; Wei, N, 2018)
"Tilianin pretreatment was beneficial for activating the PI3K/Akt signaling pathway and inhibiting myocardial apoptosis."1.48Cardioprotection of tilianin ameliorates myocardial ischemia-reperfusion injury: Role of the apoptotic signaling pathway. ( He, C; Jiang, W; Li, J; Xing, J; Zeng, C; Zheng, R, 2018)
"Non-alcoholic fatty liver disease (NAFLD) is a common disease associated with metabolic syndrome and can lead to life-threatening complications like hepatic carcinoma and cirrhosis."1.48Exenatide ameliorates hepatic steatosis and attenuates fat mass and FTO gene expression through PI3K signaling pathway in nonalcoholic fatty liver disease. ( Han, C; Li, J; Li, S; Liu, X; Ma, Y; Wang, X; Zhang, J; Zhang, L; Zheng, L, 2018)
"Airway remodeling is the important reason of refractory asthma and is associated with differentiation of airway epithelia into myofibroblasts via epithelial-mesenchymal transition (EMT) to increase the process of subepithelial fibrosis."1.46Autophagy plays a role in FSTL1-induced epithelial mesenchymal transition and airway remodeling in asthma. ( Broide, DH; Cao, L; Dong, L; Li, S; Liu, L; Liu, T; Liu, Y; Miller, M; Wang, J; Wu, J; Xu, J; Zhao, J; Zou, M, 2017)
"Icariin pretreatment could ameliorate the decreased striatum DA content and the loss of TH-IR neurons in the SNpc induced by MPTP."1.46Neuroprotective properties of icariin in MPTP-induced mouse model of Parkinson's disease: Involvement of PI3K/Akt and MEK/ERK signaling pathways. ( Chen, L; Chen, WF; Chen, XH; Du, ZR; Teng, JJ; Wong, MS; Wu, L; Xu, AL, 2017)
"Pain is associated with several conditions, such as inflammation, that result from altered peripheral nerve properties."1.46Electroacupuncture Attenuates CFA-induced Inflammatory Pain by suppressing Nav1.8 through S100B, TRPV1, Opioid, and Adenosine Pathways in Mice. ( Hsieh, CL; Huang, CP; Liao, HY; Lin, YW, 2017)
"Drug treatments for hepatocellular carcinoma (HCC) often fail because of multidrug resistance (MDR)."1.46USP22 mediates the multidrug resistance of hepatocellular carcinoma via the SIRT1/AKT/MRP1 signaling pathway. ( Dai, H; Li, J; Ling, S; Liu, J; Lu, D; Shan, Q; Song, P; Wen, X; Xie, H; Xu, X; Zheng, S; Zhou, L, 2017)
"Methane was mixed with air to achieve a final concentration of 2."1.46Inhaled Methane Protects Rats Against Neurological Dysfunction Induced by Cerebral Ischemia and Reperfusion Injury: PI3K/Akt/HO-1 Pathway Involved. ( Gao, M; He, D; Shen, J; Zhang, B, 2017)
"Glioblastoma is an aggressive brain cancer requiring improved treatments."1.43Developing a Novel Embryo-Larval Zebrafish Xenograft Assay to Prioritize Human Glioblastoma Therapeutics. ( Greenwood, JA; Punnoose, A; Tanguay, RL; Wehmas, LC, 2016)
"However, its effectiveness against subarachnoid hemorrhage (SAH) is not well known."1.43Matrine alleviates early brain injury after experimental subarachnoid hemorrhage in rats: possible involvement of PI3K/Akt-mediated NF-κB inhibition and Keap1/Nrf2-dependent HO-1 inductionn. ( Hou, P; Liu, X; Liu, Z; Ma, K; Sun, B; Wang, Z; Yuan, S; Zhang, R; Zhang, X, 2016)
"Glioblastoma (GBM) is the most common brain cancer and is highly lethal in both adults and children."1.40PTEN status mediates 2ME2 anti-tumor efficacy in preclinical glioblastoma models: role of HIF1α suppression. ( Durden, DL; Joshi, S; Kesari, S; Makale, MT; Muh, CR; Singh, AR, 2014)
"Global cerebral ischemia was performed via 8min of four-vessel occlusion."1.38Remote ischemic postconditioning protects the brain from global cerebral ischemia/reperfusion injury by up-regulating endothelial nitric oxide synthase through the PI3K/Akt pathway. ( Guo, QL; He, ZJ; Peng, B; Wang, N; Ye, Z; Yuan, YJ; Zhou, J, 2012)
"Trauma-hemorrhage was induced in a murine model by soft tissue injury and blood withdrawals from the jugular vein to a mean arterial pressure of 35 ± 5 mmHg."1.38The toll-like receptor 9 agonist, CpG-oligodeoxynucleotide 1826, ameliorates cardiac dysfunction after trauma-hemorrhage. ( Gao, M; Ha, T; Kalbfleisch, JH; Kao, RL; Li, C; Williams, DL; Zhang, X, 2012)
"Stroke was induced by middle cerebral artery occlusion for 60 min followed by reperfusion in adult male rats."1.38Stimulation of functional recovery via the mechanisms of neurorepair by S-nitrosoglutathione and motor exercise in a rat model of transient cerebral ischemia and reperfusion. ( Dhammu, TS; Khan, M; Sakakima, H; Shunmugavel, A; Singh, AK; Singh, I; Yoshida, Y, 2012)
"In the mouse Parkinson's disease model, treatment with Yi-Gan San also significantly improved motor functioning and prevented dopaminergic loss related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine challenge."1.36Neuroprotective effects of an herbal medicine, Yi-Gan San on MPP+/MPTP-induced cytotoxicity in vitro and in vivo. ( Cho, KH; Doo, AR; Eun-Kyung, K; Hong, J; Jung, JH; Jung, WS; Kim, SN; Lee, H; Moon, SK; Park, HJ; Park, JY, 2010)
"Leptin plays a critical role in the control of energy homeostasis."1.35Mechanisms mediating renal sympathetic activation to leptin in obesity. ( Morgan, DA; Rahmouni, K; Thedens, DR; Weiss, R, 2008)
"Leptin is an adipose hormone with well characterized roles in regulating food intake and energy balance."1.35Leptin protects hippocampal CA1 neurons against ischemic injury. ( Chen, J; Zhang, F, 2008)
" Importantly, this was achieved when dosing well after myocardial reperfusion (up to 3 h after), the same time period when patients are most accessible for therapeutic intervention."1.33Phosphoinositide 3-kinase gamma/delta inhibition limits infarct size after myocardial ischemia/reperfusion injury. ( Cheresh, D; Demaria, A; Dneprovskaia, E; Doukas, J; Fine, R; Hood, J; Noronha, G; Soll, R; Weis, S; Wrasidlo, W, 2006)
"Corneal neovascularization was induced in C57 mice by removal of the limbal epithelium."1.33The role of PDGF receptor inhibitors and PI3-kinase signaling in the pathogenesis of corneal neovascularization. ( Dell, S; Joussen, AM; Kociok, N; Müther, P; Peters, S, 2006)
"Wortmannin treatment also increased the number of macrophages in the liver and kidney of endotoxemic mice."1.32PI3K-Akt pathway suppresses coagulation and inflammation in endotoxemic mice. ( Mackman, N; Pawlinski, R; Pedersen, B; Schabbauer, G; Tencati, M, 2004)
"inoculation with OVCAR-3 ovarian cancer cells, mice were treated i."1.31Inhibition of phosphatidylinositol 3'-kinase increases efficacy of paclitaxel in in vitro and in vivo ovarian cancer models. ( Hofmann, J; Hu, L; Jaffe, RB; Lu, Y; Mills, GB, 2002)

Research

Studies (158)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's29 (18.35)29.6817
2010's110 (69.62)24.3611
2020's19 (12.03)2.80

Authors

AuthorsStudies
Doukas, J1
Wrasidlo, W1
Noronha, G1
Dneprovskaia, E1
Fine, R1
Weis, S1
Hood, J1
Demaria, A1
Soll, R1
Cheresh, D1
Solinski, HJ1
Dranchak, P1
Oliphant, E1
Gu, X1
Earnest, TW1
Braisted, J1
Inglese, J1
Hoon, MA1
Abrams, RPM1
Yasgar, A1
Teramoto, T1
Lee, MH1
Dorjsuren, D1
Eastman, RT1
Malik, N1
Zakharov, AV1
Li, W2
Bachani, M1
Brimacombe, K1
Steiner, JP1
Hall, MD1
Balasubramanian, A1
Jadhav, A1
Padmanabhan, R1
Simeonov, A1
Nath, A1
Yang, S2
Liu, Y4
Huang, S1
Jin, F1
Qi, F1
Arosh, JA1
Lee, J1
Banu, SK1
Li, T1
Chen, Z3
Zhou, Y2
Li, H7
Xie, J2
Li, L1
Lu, R2
Zhu, W1
Sun, H3
Zhang, L8
Yu, Z1
Nie, Z1
Gao, Y2
Cevey, ÁC1
Mascolo, PD1
Penas, FN1
Pieralisi, AV1
Sequeyra, AS1
Mirkin, GA1
Goren, NB1
Lin, Y1
Zhu, X2
Li, Y7
Dou, Y1
Wang, J4
Qi, R1
Ma, L2
Nguyen Ngo Le, MA1
Wen, YT1
Ho, YC1
Kapupara, K1
Tsai, RK1
Qin, X1
Lu, X1
Jiang, J1
Mazumder, AG1
Kumari, S1
Singh, D1
Alyahya, AM1
Al-Masri, A1
Hersi, A1
El Eter, E1
Husain, S1
Lateef, R1
Mawlana, OH1
Barretto, TA1
Park, K1
Maghen, L1
Park, E1
Kenigsberg, S1
Gallagher, D1
Liu, E1
Gauthier-Fisher, A1
Librach, C1
Baker, A1
Shang, X1
Lin, K1
Yu, R1
Zhu, P1
Zhang, Y5
Wang, L2
Xu, J4
Chen, K1
Chen, C1
Ling, C1
Gong, J1
Li, C7
Gao, S1
Li, Z1
Huang, T1
Wang, H4
Guo, Y1
Zhao, C1
Gu, Y1
Chen, L4
Su, X1
Dong, W1
Luo, B1
Qiu, C1
Jiang, X2
Shen, B2
Liu, W1
Zhang, W4
Li, J10
Du, S1
Shi, Y1
Han, J1
Niu, Z1
Wei, L2
Yang, P1
Tian, H2
Gao, L1
Ni, XQ1
Zhang, YR1
Jia, LX1
Lu, WW1
Zhu, Q2
Ren, JL1
Chen, Y2
Zhang, LS1
Liu, X7
Yu, YR1
Jia, MZ1
Ning, ZP1
Du, J1
Tang, CS1
Qi, YF1
Shao, Z1
Shen, Q1
Kong, M1
Ni, H1
Hou, X1
Liu, L3
Zhang, P1
Zhang, Z1
Liang, Y3
Chen, H2
He, Z2
Sun, X2
Guo, Z1
Deng, Y1
Qu, M1
Xing, F1
Cheng, D1
Xing, N1
Park, M1
Baker, W1
Cambow, D1
Gogerty, D1
Leda, AR1
Herlihy, B1
Pavlenko, D1
Van Den Nieuwenhuizen, S1
Toborek, M1
Liu, C2
Zhang, M2
Ye, S1
Hong, C1
Chen, J7
Hu, B1
Yang, W1
Gu, Z1
Wang, M3
Zhang, J5
Sun, K1
Li, Q1
Kuang, B1
Wang, MMZ1
Hou, S1
Gong, N1
Hu, Y2
Dong, H1
Zou, M2
Huang, C1
Luo, L1
Yu, C1
Xie, Z4
Zhao, H2
Le, Y1
Zou, F1
Cai, S1
Ling, S1
Shan, Q1
Dai, H1
Lu, D1
Wen, X1
Song, P1
Xie, H1
Zhou, L1
Liu, J2
Xu, X3
Zheng, S1
Fan, TT1
Feng, XY1
Yang, YZ1
Gao, F2
Liu, Q1
Liu, T2
Miller, M1
Cao, L1
Zhao, J1
Wu, J2
Li, S3
Broide, DH1
Dong, L1
Cui, J1
Cui, C1
Cui, Y1
Li, R1
Sheng, H1
Tian, Y1
Wang, K2
Gao, J1
Black, GE2
Sokol, KK2
Moe, DM1
Simmons, JD1
Muscat, D1
Pastukh, V1
Capley, G1
Gorodnya, O1
Ruchko, M1
Roth, MB2
Gillespie, M1
Martin, MJ2
Bian, H1
Yang, Q1
Ma, T1
Duan, J1
Wei, G1
Wu, X2
Mu, F1
Lin, R1
Wen, A1
Xi, M1
Wang, Z3
Zheng, Z1
Khor, S1
Shi, K1
Wang, Q2
Zhao, Y1
Zhang, H3
Li, X3
Yin, J1
Wang, X6
Xiao, J2
Enkhjargal, B2
Wu, L2
Zhou, K1
Sun, C2
Hu, X2
Gospodarev, V1
Tang, J3
You, C1
Zhang, JH3
Feng, S1
Bian, XH1
Luo, Y1
Qin, GH1
Shi, RM1
Tang, L1
Chen, Q3
Meng, Z1
Sun, L1
Zhu, L1
Hu, J2
Ni, Z1
Duan, X1
Fan, H1
Xu, M1
Tang, Q1
Shou, Z1
Zuo, D1
Yang, J1
Deng, S1
Dong, Y2
Wu, H1
Nan, Z1
Lu, T1
Wei, N2
Shang, C1
Duan, Y1
Yang, X2
Mao, X1
Xu, G1
Xing, S1
Chattopadhyay, A1
Jin, S1
Salama, G1
Ma, N1
Zhao, ZA1
Zhang, NN1
Chen, HS1
Zhang, B2
Gao, M2
Shen, J1
He, D2
Zeng, C1
Jiang, W2
Zheng, R1
He, C1
Xing, J1
Dong, HP1
Zhou, W2
Ma, XX1
He, ZZ1
Wang, ZH1
Yang, Y2
Zhang, N1
Wang, S4
Wen, Y1
Huang, L2
Zhang, T2
Wu, P1
Mo, J1
Ma, Y1
Han, C1
Zheng, L1
Duan, Z1
Pang, X1
Su, Z1
Luan, Q1
Pan, L1
Gong, X1
Zhou, H1
Fu, A1
Peh, YM1
Ngan, W1
Luo, KQ1
He, B1
Hang, W1
Wu, N1
Xia, L1
Zhang, Q4
Zhou, X2
Feng, Z1
Tran, HQ1
Park, SJ1
Shin, EJ1
Tran, TV1
Sharma, N1
Lee, YJ1
Jeong, JH1
Jang, CG1
Kim, DJ1
Nabeshima, T1
Kim, HC1
Tan, R2
Yang, B1
Dai, C1
Han, Z1
Chen, D3
Wang, G2
Yang, H3
He, F1
Liu, ST1
Zhong, SM1
Li, XY1
Li, F1
Zhang, ML1
Zhu, K1
Sun, XH1
Miao, Y1
Yang, XL1
Gao, D1
Tang, T1
Zhu, J1
Tang, Y2
Lin, CK1
Tseng, CK1
Wu, YH1
Lin, CY1
Huang, CH1
Wang, WH1
Liaw, CC1
Chen, YH1
Lee, JC1
Huang, X1
Qu, D1
Huang, Q1
Li, M3
Hou, C1
Luo, Z1
Niu, X1
Xing, X1
Wu, K1
Cao, B1
Jiang, F1
Hu, Z1
Xia, K1
Li, JD1
Siles, L1
Ninfali, C1
Cortés, M1
Darling, DS1
Postigo, A1
Liu, H3
Chu, T1
Jiang, P1
Li, ST1
Han, YP1
Hu, M1
Bao, XQ1
Yan, Y1
Chen, G1
Wang, N3
Li, HY1
Zhang, QG3
Chen, JW1
Chen, SQ1
Chen, SY1
Fu, W3
Liao, X1
Ruan, J1
Wang, B3
Zhou, J2
Xu, W1
Jiang, H2
Nie, Y1
Chong, L1
Cai, X1
Lin, B1
Zhang, MQ1
Zheng, YL1
Tu, JF1
Shen, Y1
Guo, JP1
Yang, XH1
Yuan, SR1
Chen, LZ1
Chai, JJ1
Lu, JH2
Zhai, CL1
Muh, CR1
Joshi, S1
Singh, AR1
Kesari, S1
Durden, DL1
Makale, MT1
Drabsch, Y1
He, S2
Snaar-Jagalska, BE1
ten Dijke, P1
Cai, Q1
Yao, Z1
Yu, L1
Yin, K1
Jin, J1
Guan, D1
Xu, Y1
Hou, Y1
Ryu, CH1
Jun, JA1
Kim, SM1
Jeong, CH1
Jeun, SS1
Miao, Z1
Liu, CF2
Fang, Y1
Liu, S2
Yu, X1
Liang, M1
Ding, X1
Wang, W3
Lu, Y2
Xue, Z1
Wang, C2
Zhao, X1
Wei, X1
Chen, X2
Cui, W1
Zirpoli, H1
Abdillahi, M1
Quadri, N1
Ananthakrishnan, R1
Rosario, R1
Zhu, Z1
Deckelbaum, RJ1
Ramasamy, R1
Dong, J2
Lin, J1
Wu, C1
Kushwaha, KK1
Mohabeer, N1
Su, Y1
Fang, H1
Huang, K3
Li, D3
Dong, K1
Liang, W1
Xu, D1
Xia, H1
Geng, J1
Najafov, A1
Liu, M2
Han, X1
Jin, Z1
Peng, T2
Cai, Y1
Qi, C1
Sun, A1
Lipinski, M1
Zhu, H1
Xiong, Y1
Pandolfi, PP1
Yu, Q1
Yuan, J1
Du, ZD1
Hu, LT1
Zhao, GQ1
Ma, ZZ1
Reddy, NM1
Potteti, HR1
Vegiraju, S1
Chen, HJ1
Tamatam, CM1
Reddy, SP1
Kana, K1
Song, H1
Laschinger, C1
Zandstra, PW1
Radisic, M1
Yu, D1
Fan, C1
Wen, Z1
Hu, L2
Yang, L1
Feng, Y1
Yin, KJ1
Mo, X1
Kay, JC1
Shen, S1
Qiao, LY1
Habash, T1
Saleh, A1
Roy Chowdhury, SK1
Smith, DR1
Fernyhough, P1
Miyamoto, N1
Maki, T1
Shindo, A1
Liang, AC1
Maeda, M1
Egawa, N1
Itoh, K1
Lo, EK1
Lok, J1
Ihara, M1
Arai, K1
Luo, XM1
Xu, B1
Zhou, ML1
Bao, YY1
Zhou, SH1
Fan, J1
Lu, ZJ1
Yuan, X1
Feng, B1
Bai, H1
Zhao, B2
Chu, Y1
Lei, S1
Xia, Z1
Li, E1
Deng, H1
You, Y1
Tian, S1
Chu, H1
Dong, Q1
Wehmas, LC1
Tanguay, RL1
Punnoose, A1
Greenwood, JA1
Fang, F2
Sun, N1
Lei, P1
Shawhan, RR1
Eckert, MJ1
Salgar, S1
Marko, ST1
Hoffer, ZS1
Keyes, CC1
Wu, D1
Wu, W1
Peng, X1
Huang, P1
Lv, Z1
Yao, X2
Corrigan, CJ1
Ying, S1
Zhang, X2
Ma, K1
Zhang, R2
Hou, P1
Sun, B1
Yuan, S1
Liu, Z1
Liang, S1
Gou, X1
Zhdanov, VV1
Miroshnichenko, LA1
Udut, EV1
Zyuz'kov, GN1
Khrichkova, TY1
Simanina, EV1
Sherstoboev, EY1
Stavrova, LA1
Agafonov, VI1
Chaikovskii, AV1
Minakova, MY1
Dygai, AM1
Domin, H1
Szewczyk, B1
Pochwat, B1
Woźniak, M1
Śmiałowska, M1
Chen, WF1
Du, ZR1
Xu, AL1
Chen, XH1
Teng, JJ1
Wong, MS1
Liao, HY1
Hsieh, CL1
Huang, CP1
Lin, YW1
Zhang, F1
Wen, XR1
Zong, YY1
Yu, CZ1
Han, D2
Zhang, GY3
Miao, J1
Hanley, G1
Stuart, C1
Chen, T1
Yin, D1
Morgan, DA2
Thedens, DR1
Weiss, R1
Rahmouni, K2
Codeluppi, S1
Svensson, CI1
Hefferan, MP1
Valencia, F1
Silldorff, MD1
Oshiro, M1
Marsala, M1
Pasquale, EB1
Javadov, S1
Rajapurohitam, V1
Kilić, A1
Zeidan, A1
Choi, A1
Karmazyn, M1
Zhou, F1
Gomi, M1
Fujimoto, M1
Hayase, M1
Marumo, T1
Masutani, H1
Yodoi, J1
Hashimoto, N1
Nozaki, K1
Takagi, Y1
Dolga, AM1
Granic, I1
Nijholt, IM1
Nyakas, C1
van der Zee, EA1
Luiten, PG1
Eisel, UL1
Kelly-Spratt, KS1
Philipp-Staheli, J1
Gurley, KE1
Hoon-Kim, K1
Knoblaugh, S1
Kemp, CJ1
Choy, MK1
Movassagh, M1
Bennett, MR1
Foo, RS1
Siragusa, M1
Katare, R1
Meloni, M2
Damilano, F1
Hirsch, E1
Emanueli, C2
Madeddu, P2
Lee, HT1
Chang, YC1
Tu, YF1
Huang, CC1
Song, HP1
Dang, YM1
Yan, H2
Chu, ZG1
Huang, YS1
Katare, RG1
Caporali, A1
Oikawa, A1
Yu, J1
Qu, Z1
Yan, D1
Ruan, Q1
Tovar-Y-Romo, LB1
Tapia, R1
Doo, AR2
Kim, SN2
Park, JY2
Cho, KH1
Hong, J1
Eun-Kyung, K1
Moon, SK1
Jung, WS1
Lee, H2
Jung, JH1
Park, HJ2
Kang, YJ1
Digicaylioglu, M1
Russo, R1
Kaul, M1
Achim, CL1
Fletcher, L1
Masliah, E1
Lipton, SA1
Han, L1
Yue, X1
Pu, P1
Yan, W1
Jiang, T1
Kang, C1
Yuan, Y1
Guo, Q1
Ye, Z2
Pingping, X1
Song, Z1
Meng, FY1
Liang, SX1
Deng, R1
Li, CK1
Pong, NH1
Lau, CP1
Cheng, SW1
Ye, JY1
Chen, JL1
Yang, ST1
Chen, S1
Chong, BH1
Yang, M1
Agrawal, R1
Tyagi, E1
Shukla, R1
Nath, C1
Pan, C1
Lou, L1
Huo, Y1
Singh, G1
Chen, M1
Zhang, D1
Wu, A1
Zhao, M1
Kim, ST1
Moon, W1
Chae, Y1
Yin, CS1
Pan, H1
Qi, L1
Jun, MS1
Kim, HS1
Kim, YM1
Kim, HJ1
Park, EJ1
Lee, JH1
Lee, KR1
Kim, YS1
Chang, KC1
Swanger, SA1
Gross, C1
Bassell, GJ1
Deng, Q1
Harvie, EA1
Huttenlocher, A1
Peng, B1
Guo, QL1
He, ZJ1
Yuan, YJ1
Yu, H1
Zhang, ZL1
Pei, A1
Hua, F3
Qian, X1
He, J1
Durairajan, SS1
Liu, LF1
Chen, LL1
Yuan, Q1
Chung, SK1
Li, XS1
Huang, JD1
Ha, T3
Kalbfleisch, JH1
Williams, DL3
Kao, RL3
Sakakima, H1
Khan, M1
Dhammu, TS1
Shunmugavel, A1
Yoshida, Y1
Singh, I1
Singh, AK1
Qi, ZF1
Luo, YM1
Liu, XR1
Wang, RL1
Zhao, HP1
Yan, F1
Song, ZJ1
Luo, M1
Ji, XM1
Ito, T1
Komeima, K1
Yasuma, T1
Enomoto, A1
Asai, N1
Asai, M1
Iwase, S1
Takahashi, M1
Terasaki, H1
Izzo, E1
Martin-Fardon, R1
Koob, GF1
Weiss, F1
Sanna, PP1
Parvathenani, LK1
Tertyshnikova, S1
Greco, CR1
Roberts, SB1
Robertson, B1
Posmantur, R1
Sadhu, C1
Dick, K1
Tino, WT1
Staunton, DE1
Northcott, CA1
Hayflick, JS1
Watts, SW1
Schabbauer, G1
Tencati, M1
Pedersen, B1
Pawlinski, R1
Mackman, N1
Kamon, J1
Yamauchi, T1
Muto, S1
Takekawa, S1
Ito, Y1
Hada, Y1
Ogawa, W1
Itai, A1
Kasuga, M1
Tobe, K1
Kadowaki, T1
Bose, AK1
Mocanu, MM2
Carr, RD2
Brand, CL1
Yellon, DM2
Duan, W1
Aguinaldo Datiles, AM1
Leung, BP1
Vlahos, CJ1
Wong, WS1
Yin, XH1
Miao, B1
Dell, S1
Peters, S1
Müther, P1
Kociok, N1
Joussen, AM1
Wang, R1
Lü, Q1
Ma, J2
Kelley, J2
Gao, X2
Browder, IW1
Pan, TT1
Neo, KL1
Lee, SW1
Khin, ES1
Moore, PK1
Bian, JS1
Venneti, S1
Wiley, CA1
Bhamra, GS1
Hausenloy, DJ1
Davidson, SM1
Paiva, M1
Wynne, AM1
Lucchinetti, E1
Jamnicki, M1
Fischer, G1
Zaugg, M1
McMullen, JR1
Shioi, T1
Izumo, S1
Browder, W1
Kimura, H1
Sasaki, K1
Meguro, T1
Hofmann, J1
Mills, GB1
Jaffe, RB1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effects of Exercise and GLP-1 Agonism on Muscle Microvascular Perfusion and Insulin Action in Adults With Metabolic Syndrome[NCT04575844]Phase 480 participants (Anticipated)Interventional2020-11-01Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

158 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Disease Models, Animal

ArticleYear
Phosphoinositide 3-kinase gamma/delta inhibition limits infarct size after myocardial ischemia/reperfusion injury.
    Proceedings of the National Academy of Sciences of the United States of America, 2006, Dec-26, Volume: 103, Issue:52

    Topics: Animals; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Humans; Inflammation; Intercel

2006
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
    Science translational medicine, 2019, 07-10, Volume: 11, Issue:500

    Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S

2019
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
    Proceedings of the National Academy of Sciences of the United States of America, 2020, 12-08, Volume: 117, Issue:49

    Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr

2020
Sevoflurane and isoflurane inhibit KCl-induced, Rho kinase-mediated, and PI3K-participated vasoconstriction in aged diabetic rat aortas.
    BMC anesthesiology, 2021, 09-01, Volume: 21, Issue:1

    Topics: Aging; Amides; Anesthetics, Inhalation; Animals; Aorta; Chromones; Diabetes Mellitus, Experimental;

2021
Effects of dual inhibition of AKT and ERK1/2 pathways on endometrial pro-inflammatory, hormonal, and epigenetic microenvironment in endometriosis.
    Molecular and cellular endocrinology, 2022, 01-01, Volume: 539

    Topics: Animals; Butadienes; Cell Line; Cell Proliferation; Cell Survival; Chromones; Cytokines; Disease Mod

2022
Resveratrol Pretreatment Inhibits Myocardial Apoptosis in Rats Following Coronary Microembolization via Inducing the PI3K/Akt/GSK-3β Signaling Cascade.
    Drug design, development and therapy, 2021, Volume: 15

    Topics: Animals; Apoptosis; Chromones; Disease Models, Animal; Glycogen Synthase Kinase 3 beta; Male; Morpho

2021
Study on the Effect and Mechanism of miR-185 on Lower Extremity Deep Venous Thrombosis.
    Molecular biotechnology, 2022, Volume: 64, Issue:3

    Topics: Animals; Cell Proliferation; Cells, Cultured; Chromones; Disease Models, Animal; Endothelial Cells;

2022
Benznidazole Anti-Inflammatory Effects in Murine Cardiomyocytes and Macrophages Are Mediated by Class I PI3Kδ.
    Frontiers in immunology, 2021, Volume: 12

    Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents; Chagas Cardiomyopathy; Chromones; Class I Phosp

2021
LY294002 ameliorates psoriatic skin inflammation in mice via blocking the Notch1/Hes1-PTEN/AKT/IL-17A feedback loop.
    Clinical and experimental immunology, 2023, Jul-05, Volume: 213, Issue:1

    Topics: Animals; Disease Models, Animal; Feedback; Inflammation; Interleukin-17; Mice; Phosphatidylinositol

2023
Therapeutic Effects of Puerarin Against Anterior Ischemic Optic Neuropathy Through Antiapoptotic and Anti-Inflammatory Actions.
    Investigative ophthalmology & visual science, 2019, 08-01, Volume: 60, Issue:10

    Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Blotting, Western; Chromones; Disease Models, Animal;

2019
Effects of inhibiting the PI3K/Akt/mTOR signaling pathway on the pain of sciatic endometriosis in a rat model.
    Canadian journal of physiology and pharmacology, 2019, Volume: 97, Issue:10

    Topics: Animals; Behavior Observation Techniques; Behavior, Animal; Chromones; Disease Models, Animal; Endom

2019
Anticonvulsant action of a selective phosphatidylinositol-3-kinase inhibitor LY294002 in pentylenetetrazole-mediated convulsions in zebrafish.
    Epilepsy research, 2019, Volume: 157

    Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Chromones; Class I Phosphatidylinositol 3-Kinases

2019
The Effects of Progranulin in a Rat Model of Acute Myocardial Ischemia/Reperfusion are Mediated by Activation of the P13K/Akt Signaling Pathway.
    Medical science monitor basic research, 2019, Nov-07, Volume: 25

    Topics: Adipokines; Animals; Apoptosis; Atherosclerosis; Chromones; Disease Models, Animal; Male; Morpholine

2019
Axon Degeneration Is Rescued with Human Umbilical Cord Perivascular Cells: A Potential Candidate for Neuroprotection After Traumatic Brain Injury.
    Stem cells and development, 2020, 02-15, Volume: 29, Issue:4

    Topics: Animals; Axons; Brain Injuries, Traumatic; Cell- and Tissue-Based Therapy; Chromones; Coculture Tech

2020
Resveratrol Protects the Myocardium in Sepsis by Activating the Phosphatidylinositol 3-Kinases (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Pathway and Inhibiting the Nuclear Factor-κB (NF-κB) Signaling Pathway.
    Medical science monitor : international medical journal of experimental and clinical research, 2019, Dec-06, Volume: 25

    Topics: Animals; Apoptosis; Cardiomyopathies; China; Chromones; Disease Models, Animal; Heart; Male; Morphol

2019
Increasing the expression of microRNA-126-5p in the temporal muscle can promote angiogenesis in the chronically ischemic brains of rats subjected to two-vessel occlusion plus encephalo-myo-synangiosis.
    Aging, 2020, 07-09, Volume: 12, Issue:13

    Topics: Adult; Animals; Brain; Brain Ischemia; Cell Proliferation; Cerebrovascular Circulation; Chromones; C

2020
Upregulation of FoxO3a expression through PI3K/Akt pathway attenuates the progression of lupus nephritis in MRL/lpr mice.
    International immunopharmacology, 2020, Volume: 89, Issue:Pt A

    Topics: Animals; Antibodies, Antinuclear; Antigen-Antibody Complex; Chromones; Disease Models, Animal; Disea

2020
TRIM3 attenuates apoptosis in Parkinson's disease via activating PI3K/AKT signal pathway.
    Aging, 2020, 11-30, Volume: 13, Issue:1

    Topics: Aged; Animals; Apoptosis; Carrier Proteins; Case-Control Studies; Cell Line; Cell Survival; Chromone

2020
Rapamycin ameliorates corneal injury after alkali burn through methylation modification in mouse TSC1 and mTOR genes.
    Experimental eye research, 2021, Volume: 203

    Topics: Actins; Animals; Blotting, Western; Burns, Chemical; Chromones; Corneal Injuries; Disease Models, An

2021
Inhibition of Notch1-mediated inflammation by intermedin protects against abdominal aortic aneurysm via PI3K/Akt signaling pathway.
    Aging, 2021, 02-01, Volume: 13, Issue:4

    Topics: ADAM10 Protein; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Calcium Chloride; Cell Movement

2021
Involvement of GPR30 in protection effect of Dexmedetomidine against myocardial ischemia/reperfusion injury in rat via AKT pathway.
    Acta biochimica Polonica, 2021, Feb-25, Volume: 68, Issue:1

    Topics: Animals; Apoptosis; Cardiotonic Agents; Cell Survival; Cells, Cultured; Chromones; Dexmedetomidine;

2021
5-Lipoxygenase inhibition reduces inflammation and neuronal apoptosis via AKT signaling after subarachnoid hemorrhage in rats.
    Aging, 2021, 04-20, Volume: 13, Issue:8

    Topics: Administration, Oral; Animals; Apoptosis; Arachidonate 5-Lipoxygenase; Brain Injuries; Chromones; Di

2021
The Protective Mechanism of Dexmedetomidine in Regulating Atg14L-Beclin1-Vps34 Complex Against Myocardial Ischemia-Reperfusion Injury.
    Journal of cardiovascular translational research, 2021, Volume: 14, Issue:6

    Topics: Adaptor Proteins, Vesicular Transport; Animals; Autophagy; Autophagy-Related Proteins; Beclin-1; Chr

2021
Methamphetamine Enhances HIV-Induced Aberrant Proliferation of Neural Progenitor Cells via the FOXO3-Mediated Mechanism.
    Molecular neurobiology, 2021, Volume: 58, Issue:11

    Topics: AIDS Dementia Complex; Animals; Brain; Cell Cycle; Cell Division; Cells, Cultured; Chemokine CXCL12;

2021
Acacetin Protects Myocardial Cells against Hypoxia-Reoxygenation Injury through Activation of Autophagy.
    Journal of immunology research, 2021, Volume: 2021

    Topics: Animals; Apoptosis; Autophagy; Cell Hypoxia; Cell Line; Chromones; Disease Models, Animal; Flavones;

2021
Methyl eugenol attenuates liver ischemia reperfusion injury via activating PI3K/Akt signaling.
    International immunopharmacology, 2021, Volume: 99

    Topics: Animals; Cell Line; Chromones; Disease Models, Animal; Eugenol; Hepatocytes; Humans; Liver; Male; Mi

2021
TSLP signaling blocking alleviates E-cadherin dysfunction of airway epithelium in a HDM-induced asthma model.
    Cellular immunology, 2017, Volume: 315

    Topics: Administration, Inhalation; Animals; Antibodies, Monoclonal; Asthma; beta Catenin; Bronchi; Bronchia

2017
USP22 mediates the multidrug resistance of hepatocellular carcinoma via the SIRT1/AKT/MRP1 signaling pathway.
    Molecular oncology, 2017, Volume: 11, Issue:6

    Topics: Adaptor Proteins, Signal Transducing; Analysis of Variance; Animals; Apoptosis Regulatory Proteins;

2017
Downregulation of PI3K-γ in a mouse model of sepsis-induced myocardial dysfunction.
    Cytokine, 2017, Volume: 96

    Topics: Animals; Cardiomyopathies; Chromones; Class II Phosphatidylinositol 3-Kinases; Cytokines; Disease Mo

2017
Autophagy plays a role in FSTL1-induced epithelial mesenchymal transition and airway remodeling in asthma.
    American journal of physiology. Lung cellular and molecular physiology, 2017, 07-01, Volume: 313, Issue:1

    Topics: Adult; Airway Remodeling; Animals; Asthma; Autophagosomes; Autophagy; Biomarkers; Bronchoalveolar La

2017
Bone Marrow Mesenchymal Stem Cell Transplantation Increases GAP-43 Expression via ERK1/2 and PI3K/Akt Pathways in Intracerebral Hemorrhage.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2017, Volume: 42, Issue:1

    Topics: Animals; Axons; Bone Marrow Cells; Cells, Cultured; Cerebral Hemorrhage; Chromones; Disease Models,

2017
Impact of a novel phosphoinositol-3 kinase inhibitor in preventing mitochondrial DNA damage and damage-associated molecular pattern accumulation: Results from the Biochronicity Project.
    The journal of trauma and acute care surgery, 2017, Volume: 83, Issue:4

    Topics: Animals; Chromones; Disease Models, Animal; DNA Damage; DNA, Mitochondrial; Energy Metabolism; Enzym

2017
Beneficial effects of extracts from Lucilia sericata maggots on burn wounds in rats.
    Molecular medicine reports, 2017, Volume: 16, Issue:5

    Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Burns; Chromones; Diptera; Disease Models,

2017
Neuron and microglia/macrophage-derived FGF10 activate neuronal FGFR2/PI3K/Akt signaling and inhibit microglia/macrophages TLR4/NF-κB-dependent neuroinflammation to improve functional recovery after spinal cord injury.
    Cell death & disease, 2017, 10-05, Volume: 8, Issue:10

    Topics: Animals; Apoptosis; Chromones; Disease Models, Animal; Fibroblast Growth Factor 10; Gene Expression

2017
Exendin-4 attenuates neuronal death via GLP-1R/PI3K/Akt pathway in early brain injury after subarachnoid hemorrhage in rats.
    Neuropharmacology, 2018, Volume: 128

    Topics: Animals; Apoptosis; Brain Injuries; Calcium-Binding Proteins; Chromones; Disease Models, Animal; Enz

2018
Role of the TSLP-DC-OX40L pathway in asthma pathogenesis and airway inflammation in mice.
    Biochemistry and cell biology = Biochimie et biologie cellulaire, 2018, Volume: 96, Issue:3

    Topics: Animals; Asthma; Chromones; Cytokines; Dendritic Cells; Disease Models, Animal; Eosinophils; Immunog

2018
Suppression of Sirtuin-1 Increases IL-6 Expression by Activation of the Akt Pathway During Allergic Asthma.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2017, Volume: 43, Issue:5

    Topics: Animals; Asthma; Blotting, Western; Cell Line; Chromones; Disease Models, Animal; Enzyme Inhibitors;

2017
Oxymatrine protects against DSS-induced colitis via inhibiting the PI3K/AKT signaling pathway.
    International immunopharmacology, 2017, Volume: 53

    Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Cell Differentiation; Cells, Cultured; Chromones; Coli

2017
Lipoxin A4 protects against spinal cord injury via regulating Akt/nuclear factor (erythroid-derived 2)-like 2/heme oxygenase-1 signaling.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 97

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromones; Disease Models, Animal; Gene Expression

2018
Estradiol up-regulates L-type Ca
    Heart rhythm, 2018, Volume: 15, Issue:5

    Topics: Animals; Blotting, Western; Calcium Channels, L-Type; Carrier Proteins; Cell Line; Chromones; CREB-B

2018
Intra-arterial human urinary kallidinogenase alleviates brain injury in rats with permanent middle cerebral artery occlusion through PI3K/AKT/FoxO1 signaling pathway.
    Brain research, 2018, 05-15, Volume: 1687

    Topics: Animals; Brain Injuries; Caspase 3; Chromones; Cytokines; Disease Models, Animal; Enzyme Inhibitors;

2018
Inhaled Methane Protects Rats Against Neurological Dysfunction Induced by Cerebral Ischemia and Reperfusion Injury: PI3K/Akt/HO-1 Pathway Involved.
    Archives of medical research, 2017, Volume: 48, Issue:6

    Topics: Analysis of Variance; Animals; Antioxidants; Biomarkers; Brain Diseases; Brain Ischemia; Chromones;

2017
Cardioprotection of tilianin ameliorates myocardial ischemia-reperfusion injury: Role of the apoptotic signaling pathway.
    PloS one, 2018, Volume: 13, Issue:3

    Topics: Administration, Oral; Animals; Apoptosis; Cardiotonic Agents; Chromones; Disease Models, Animal; Dos

2018
Salvinorin A preserves cerebral pial artery autoregulation after forebrain ischemia via the PI3K/AKT/cGMP pathway.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2018, Mar-15, Volume: 51, Issue:5

    Topics: Animals; Brain Ischemia; Cerebral Arteries; Chromones; Cyclic GMP; Disease Models, Animal; Diterpene

2018
MicroRNA-155 Regulates Inflammatory Response in Ischemic Cerebral Tissues through Autophagy.
    Current neurovascular research, 2018, Volume: 15, Issue:2

    Topics: Administration, Oral; Animals; Autophagy; Cell Hypoxia; Cell Line, Transformed; Chromones; Disease M

2018
Aggf1 attenuates neuroinflammation and BBB disruption via PI3K/Akt/NF-κB pathway after subarachnoid hemorrhage in rats.
    Journal of neuroinflammation, 2018, Jun-09, Volume: 15, Issue:1

    Topics: Angiogenic Proteins; Animals; Blood-Brain Barrier; Brain Edema; Capillary Permeability; Chromones; D

2018
Exenatide ameliorates hepatic steatosis and attenuates fat mass and FTO gene expression through PI3K signaling pathway in nonalcoholic fatty liver disease.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2018, Volume: 51, Issue:8

    Topics: Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Animals; Blood Glucose; Body Weight; Chromones; Diet,

2018
Blocking Mammalian Target of Rapamycin (mTOR) Alleviates Neuropathic Pain Induced by Chemotherapeutic Bortezomib.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018, Volume: 48, Issue:1

    Topics: Animals; Behavior, Animal; Bortezomib; Calcitonin Gene-Related Peptide; Carrier Proteins; Chromones;

2018
SC79, the AKT Activator Protects Cerebral Ischemia in a Rat Model of Ischemia/Reperfusion Injury.
    Medical science monitor : international medical journal of experimental and clinical research, 2018, Aug-03, Volume: 24

    Topics: Acetates; Animals; Apoptosis; Benzopyrans; Brain; Brain Ischemia; Cell Death; Chromones; Disease Mod

2018
Rapid identification of antimicrometastases drugs using integrated model systems with two dimensional monolayer, three dimensional spheroids, and zebrafish xenotransplantation tumors.
    Biotechnology and bioengineering, 2018, Volume: 115, Issue:11

    Topics: Animals; Antineoplastic Agents; Apoptosis; Biosensing Techniques; Caspase 3; Cell Line, Tumor; Cell

2018
Berberine Alleviates Tau Hyperphosphorylation and Axonopathy-Associated with Diabetic Encephalopathy via Restoring PI3K/Akt/GSK3β Pathway.
    Journal of Alzheimer's disease : JAD, 2018, Volume: 65, Issue:4

    Topics: Animals; Axons; Berberine; Cells, Cultured; Chromones; Diabetes Mellitus, Type 2; Diabetic Nephropat

2018
Clozapine attenuates mitochondrial burdens and abnormal behaviors elicited by phencyclidine in mice via inhibition of p47
    Journal of psychopharmacology (Oxford, England), 2018, Volume: 32, Issue:11

    Topics: Animals; Antioxidants; Antipsychotic Agents; Behavior, Animal; Chromones; Clozapine; Disease Models,

2018
Autophagy and Akt in the protective effect of erythropoietin helix B surface peptide against hepatic ischaemia/reperfusion injury in mice.
    Scientific reports, 2018, 10-02, Volume: 8, Issue:1

    Topics: Adenine; Animals; Autophagosomes; Autophagy; Cell Line; Chemical and Drug Induced Liver Injury; Chro

2018
EphrinB/EphB forward signaling in Müller cells causes apoptosis of retinal ganglion cells by increasing tumor necrosis factor alpha production in rat experimental glaucomatous model.
    Acta neuropathologica communications, 2018, 10-24, Volume: 6, Issue:1

    Topics: Animals; Animals, Newborn; Antioxidants; Apoptosis; Cells, Cultured; Chromones; Disease Models, Anim

2018
CXCL12 has therapeutic value in facial nerve injury and promotes Schwann cells autophagy and migration via PI3K-AKT-mTOR signal pathway.
    International journal of biological macromolecules, 2019, Mar-01, Volume: 124

    Topics: Adenine; Animals; Autophagy; Cell Movement; Cell Proliferation; Chemokine CXCL12; Chromones; Cranial

2019
Prostasin Impairs Epithelial Growth Factor Receptor Activation to Suppress Dengue Virus Propagation.
    The Journal of infectious diseases, 2019, 04-16, Volume: 219, Issue:9

    Topics: Animals; Cell Line; Chromones; Cyclooxygenase 2; Dengue; Dengue Virus; Disease Models, Animal; Enzym

2019
Elevated S100A4 in asthmatics and an allergen-induced mouse asthma model.
    Journal of cellular biochemistry, 2019, Volume: 120, Issue:6

    Topics: Allergens; Animals; Asthma; Chromones; Disease Models, Animal; Female; Humans; Male; Mice; Mice, Inb

2019
Inhibition of the PI3K/Akt signaling pathway impedes the restoration of neurological function following hypoxic-ischemic brain damage in a neonatal rabbit model.
    Journal of cellular biochemistry, 2019, Volume: 120, Issue:6

    Topics: Animals; Animals, Newborn; Apoptosis; Apoptosis Regulatory Proteins; Brain; Caspase 3; Chromones; Di

2019
Suppression of Akt-mTOR pathway rescued the social behavior in Cntnap2-deficient mice.
    Scientific reports, 2019, 02-28, Volume: 9, Issue:1

    Topics: Animals; Autism Spectrum Disorder; Chromones; Disease Models, Animal; Hippocampus; Humans; Hyperkine

2019
ZEB1 protects skeletal muscle from damage and is required for its regeneration.
    Nature communications, 2019, 03-25, Volume: 10, Issue:1

    Topics: Animals; Chemokine CCL2; Chromones; Disease Models, Animal; Flavonoids; Gene Expression Regulation;

2019
Neuregulin-1β attenuates sepsis-induced diaphragm atrophy by activating the PI3K/Akt signaling pathway.
    Journal of muscle research and cell motility, 2019, Volume: 40, Issue:1

    Topics: Animals; Chromones; Diaphragm; Disease Models, Animal; Humans; Male; Morpholines; Muscle Contraction

2019
A study on regulatory mechanism of miR-223 in ulcerative colitis through PI3K/Akt-mTOR signaling pathway.
    European review for medical and pharmacological sciences, 2019, Volume: 23, Issue:11

    Topics: Animals; Apoptosis; Chromones; Colitis, Ulcerative; Dextran Sulfate; Dimethylhydrazines; Disease Mod

2019
Dexmedetomidine suppresses sevoflurane anesthesia-induced neuroinflammation through activation of the PI3K/Akt/mTOR pathway.
    BMC anesthesiology, 2019, 07-27, Volume: 19, Issue:1

    Topics: Anesthetics, Inhalation; Animals; Cerebral Cortex; Chromones; Cytokines; Dexmedetomidine; Disease Mo

2019
The fibrotic role of phosphatidylinositol-3-kinase/Akt pathway in injured skeletal muscle after acute contusion.
    International journal of sports medicine, 2013, Volume: 34, Issue:9

    Topics: Animals; Athletic Injuries; Blotting, Western; Chromones; Cicatrix; Collagen; Contusions; Disease Mo

2013
Recombinant human erythropoietin preconditioning attenuates liver ischemia reperfusion injury through the phosphatidylinositol-3 kinase/AKT/endothelial nitric oxide synthase pathway.
    The Journal of surgical research, 2013, Volume: 183, Issue:2

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chromones; Disease Models, Animal; Enzym

2013
Dobutamine-mediated heme oxygenase-1 induction via PI3K and p38 MAPK inhibits high mobility group box 1 protein release and attenuates rat myocardial ischemia/reperfusion injury in vivo.
    The Journal of surgical research, 2013, Volume: 183, Issue:2

    Topics: Adrenergic beta-1 Receptor Agonists; Animals; Chromones; Disease Models, Animal; Dobutamine; Enzyme

2013
PI3K and Notch signal pathways coordinately regulate the activation and proliferation of T lymphocytes in asthma.
    Life sciences, 2013, May-20, Volume: 92, Issue:17-19

    Topics: Animals; Asthma; CD4-Positive T-Lymphocytes; Cell Proliferation; Chromones; Cyclin A; Cyclin D1; Cyc

2013
Sodium tanshinone IIA sulfonate protects rat myocardium against ischemia-reperfusion injury via activation of PI3K/Akt/FOXO3A/Bim pathway.
    Acta pharmacologica Sinica, 2013, Volume: 34, Issue:11

    Topics: Animals; Animals, Newborn; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Cardioto

2013
PTEN status mediates 2ME2 anti-tumor efficacy in preclinical glioblastoma models: role of HIF1α suppression.
    Journal of neuro-oncology, 2014, Volume: 116, Issue:1

    Topics: 2-Methoxyestradiol; Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Hypoxia; Cell L

2014
Transforming growth factor-β signalling controls human breast cancer metastasis in a zebrafish xenograft model.
    Breast cancer research : BCR, 2013, Nov-07, Volume: 15, Issue:6

    Topics: Animals; Benzamides; Breast Neoplasms; Chromones; Dioxoles; Dipeptides; Disease Models, Animal; Drug

2013
Catalpol promotes oligodendrocyte survival and oligodendrocyte progenitor differentiation via the Akt signaling pathway in rats with chronic cerebral hypoperfusion.
    Brain research, 2014, Apr-29, Volume: 1560

    Topics: Animals; Apoptosis; Carotid Artery, Common; Cell Differentiation; Cell Survival; Cerebrovascular Dis

2014
TL-2 attenuates β-amyloid induced neuronal apoptosis through the AKT/GSK-3β/β-catenin pathway.
    The international journal of neuropsychopharmacology, 2014, Volume: 17, Issue:9

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; beta Catenin; Caspase 3; Caspase 9; Ce

2014
IL-8 enhances the angiogenic potential of human bone marrow mesenchymal stem cells by increasing vascular endothelial growth factor.
    Cell biology international, 2014, Volume: 38, Issue:9

    Topics: Animals; Bone Marrow Cells; Brain; Cells, Cultured; Chromones; Disease Models, Animal; Extracellular

2014
XAV939, a small molecular inhibitor, provides neuroprotective effects on oligodentrocytes.
    Journal of neuroscience research, 2014, Volume: 92, Issue:10

    Topics: Animals; Animals, Newborn; Apoptosis; beta Catenin; Brain Infarction; Brain Ischemia; Caspases; Cell

2014
Limb ischemic preconditioning protects against contrast-induced acute kidney injury in rats via phosphorylation of GSK-3β.
    Free radical biology & medicine, 2015, Volume: 81

    Topics: Acute Kidney Injury; Androstadienes; Animals; Apoptosis; Chromones; Contrast Media; Disease Models,

2015
Rapid-acting antidepressant-like effects of acetyl-l-carnitine mediated by PI3K/AKT/BDNF/VGF signaling pathway in mice.
    Neuroscience, 2015, Jan-29, Volume: 285

    Topics: Acetylcarnitine; Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Chromones; Depre

2015
Acute administration of n-3 rich triglyceride emulsions provides cardioprotection in murine models after ischemia-reperfusion.
    PloS one, 2015, Volume: 10, Issue:1

    Topics: Animals; Apoptosis Regulatory Proteins; Beclin-1; Chromones; Disease Models, Animal; Echocardiograph

2015
Inflammatory cytokine TSLP stimulates platelet secretion and potentiates platelet aggregation via a TSLPR-dependent PI3K/Akt signaling pathway.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2015, Volume: 35, Issue:1

    Topics: Androstadienes; Animals; Blood Platelets; Carotid Artery Thrombosis; Chlorides; Chromones; Cytokines

2015
G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L.
    eLife, 2015, Mar-30, Volume: 4

    Topics: Animals; Autophagy; Autophagy-Related Proteins; Benzylamines; Carrier Proteins; Cell Line, Tumor; Ch

2015
Protein tyrosine phosphatase 1B regulates the activity of retinal pigment epithelial cells.
    Molecular vision, 2015, Volume: 21

    Topics: Animals; Cell Differentiation; Cell Movement; Cell Proliferation; Cells, Cultured; Chromones; Diseas

2015
PI3K-AKT Signaling via Nrf2 Protects against Hyperoxia-Induced Acute Lung Injury, but Promotes Inflammation Post-Injury Independent of Nrf2 in Mice.
    PloS one, 2015, Volume: 10, Issue:6

    Topics: Acute Lung Injury; Alveolar Epithelial Cells; Animals; Cell Line; Chromones; Disease Models, Animal;

2015
PI3K Phosphorylation Is Linked to Improved Electrical Excitability in an In Vitro Engineered Heart Tissue Disease Model System.
    Tissue engineering. Part A, 2015, Volume: 21, Issue:17-18

    Topics: Animals; Animals, Newborn; Chlorpropamide; Chromones; Disease Models, Animal; Electrophysiological P

2015
Neuroprotective effect of nicorandil through inhibition of apoptosis by the PI3K/Akt1 pathway in a mouse model of deep hypothermic low flow.
    Journal of the neurological sciences, 2015, Oct-15, Volume: 357, Issue:1-2

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Chromones; Circulatory Arrest, Deep Hypothermia Indu

2015
Endogenous BDNF augments NMDA receptor phosphorylation in the spinal cord via PLCγ, PKC, and PI3K/Akt pathways during colitis.
    Journal of neuroinflammation, 2015, Aug-20, Volume: 12

    Topics: Animals; Antibodies; Brain-Derived Neurotrophic Factor; Chromones; Colitis; Disease Models, Animal;

2015
The proinflammatory cytokine, interleukin-17A, augments mitochondrial function and neurite outgrowth of cultured adult sensory neurons derived from normal and diabetic rats.
    Experimental neurology, 2015, Volume: 273

    Topics: Animals; Antibiotics, Antineoplastic; Butadienes; Cells, Cultured; Chromones; Diabetes Mellitus, Exp

2015
Astrocytes Promote Oligodendrogenesis after White Matter Damage via Brain-Derived Neurotrophic Factor.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015, Oct-14, Volume: 35, Issue:41

    Topics: Animals; Antimutagenic Agents; Astrocytes; Brain Ischemia; Brain-Derived Neurotrophic Factor; Cell D

2015
Co-Inhibition of GLUT-1 Expression and the PI3K/Akt Signaling Pathway to Enhance the Radiosensitivity of Laryngeal Carcinoma Xenografts In Vivo.
    PloS one, 2015, Volume: 10, Issue:11

    Topics: Androstadienes; Animals; Apoptosis; Cell Line, Tumor; Chromones; Disease Models, Animal; Gene Expres

2015
Effects and mechanism of miR-23b on glucose-mediated epithelial-to-mesenchymal transition in diabetic nephropathy.
    The international journal of biochemistry & cell biology, 2016, Volume: 70

    Topics: Animals; Cell Line; Chromones; Diabetic Nephropathies; Disease Models, Animal; Epithelial Cells; Epi

2016
LY294002 prevents lipopolysaccharide‑induced hepatitis in a murine model by suppressing IκB phosphorylation.
    Molecular medicine reports, 2016, Volume: 13, Issue:1

    Topics: Acute Disease; Animals; Blotting, Western; Chromones; Cytokines; Disease Models, Animal; Female; Hep

2016
Apelin-13 exerts antidepressant-like and recognition memory improving activities in stressed rats.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2016, Volume: 26, Issue:3

    Topics: Animals; Antidepressive Agents; Chromones; Corticosterone; Depression; Disease Models, Animal; Enzym

2016
The role of connexin43 in hemorrhagic transformation after thrombolysis in vivo and in vitro.
    Neuroscience, 2016, 08-04, Volume: 329

    Topics: Animals; Blood-Brain Barrier; Butadienes; Capillary Permeability; Cells, Cultured; Cerebral Hemorrha

2016
Developing a Novel Embryo-Larval Zebrafish Xenograft Assay to Prioritize Human Glioblastoma Therapeutics.
    Zebrafish, 2016, Volume: 13, Issue:4

    Topics: Animals; Antineoplastic Agents; Chromones; Disease Models, Animal; Glioblastoma; Heterografts; Human

2016
Lycium barbarum polysaccharide attenuates the cytotoxicity of mutant huntingtin and increases the activity of AKT.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2016, Volume: 52

    Topics: Analysis of Variance; Animals; Brain; Caspase 3; Cell Survival; Chromones; Disease Models, Animal; D

2016
Ghrelin attenuates brain injury in septic mice via PI3K/Akt signaling activation.
    Brain research bulletin, 2016, Volume: 124

    Topics: Animals; bcl-2-Associated X Protein; Blood-Brain Barrier; Brain Edema; Brain Injuries; Capillary Per

2016
Inducing metabolic suppression in severe hemorrhagic shock: Pilot study results from the Biochronicity Project.
    The journal of trauma and acute care surgery, 2016, Volume: 81, Issue:6

    Topics: Animals; Blood Pressure; Cardiac Output; Chromones; Cytokines; Disease Models, Animal; Enzyme Inhibi

2016
A novel perspective for burn-induced myopathy: Membrane repair defect.
    Scientific reports, 2016, 08-22, Volume: 6

    Topics: Animals; Burns; Carrier Proteins; Cell Line; Cell Membrane; Chromones; Dimerization; Disease Models,

2016
Comprehensive attenuation of IL-25-induced airway hyperresponsiveness, inflammation and remodelling by the PI3K inhibitor LY294002.
    Respirology (Carlton, Vic.), 2017, Volume: 22, Issue:1

    Topics: Airway Remodeling; Animals; Bronchoalveolar Lavage Fluid; Chromones; Disease Models, Animal; Enzyme

2017
Matrine alleviates early brain injury after experimental subarachnoid hemorrhage in rats: possible involvement of PI3K/Akt-mediated NF-κB inhibition and Keap1/Nrf2-dependent HO-1 inductionn.
    Cellular and molecular biology (Noisy-le-Grand, France), 2016, Sep-30, Volume: 62, Issue:11

    Topics: Alkaloids; Animals; Blood-Brain Barrier; Brain Injuries; Chromones; Disease Models, Animal; Heme Oxy

2016
Blocking mammalian target of rapamycin alleviates bladder hyperactivity and pain in rats with cystitis.
    Molecular pain, 2016, Volume: 12

    Topics: Animals; Calcitonin Gene-Related Peptide; Chromones; Cyclophosphamide; Cystitis; Disease Models, Ani

2016
Role of PI3K, MAPK/ERK 1/2, and p38 in Production of Erythropoietic Activity by Bone Marrow Cells after Blood Loss.
    Bulletin of experimental biology and medicine, 2016, Volume: 162, Issue:1

    Topics: Anemia; Animals; Bone Marrow Cells; Chromones; Disease Models, Animal; Erythropoiesis; Erythropoieti

2016
Antidepressant-like activity of the neuropeptide Y Y5 receptor antagonist Lu AA33810: behavioral, molecular, and immunohistochemical evidence.
    Psychopharmacology, 2017, Volume: 234, Issue:4

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Benzothiepins; Brain-Derived Neurotrophic Factor;

2017
Neuroprotective properties of icariin in MPTP-induced mouse model of Parkinson's disease: Involvement of PI3K/Akt and MEK/ERK signaling pathways.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2017, Feb-15, Volume: 25

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Chromones; Corpus Striatum; Disease Models, A

2017
Electroacupuncture Attenuates CFA-induced Inflammatory Pain by suppressing Nav1.8 through S100B, TRPV1, Opioid, and Adenosine Pathways in Mice.
    Scientific reports, 2017, 02-13, Volume: 7

    Topics: Acupuncture Analgesia; Adenosine; Analgesics, Opioid; Animals; Behavior, Animal; Biomarkers; Chromon

2017
Leptin protects hippocampal CA1 neurons against ischemic injury.
    Journal of neurochemistry, 2008, Volume: 107, Issue:2

    Topics: Animals; Brain Ischemia; Brain-Derived Neurotrophic Factor; Chromones; CREB-Binding Protein; Disease

2008
Dual inhibitory roles of geldanamycin on the c-Jun NH2-terminal kinase 3 signal pathway through suppressing the expression of mixed-lineage kinase 3 and attenuating the activation of apoptosis signal-regulating kinase 1 via facilitating the activation of
    Neuroscience, 2008, Oct-15, Volume: 156, Issue:3

    Topics: Analysis of Variance; Animals; Behavior, Animal; Benzoquinones; Brain Injuries; Cells, Cultured; Chr

2008
Chronic restraint stress promotes immune suppression through toll-like receptor 4-mediated phosphoinositide 3-kinase signaling.
    Journal of neuroimmunology, 2008, Nov-15, Volume: 204, Issue:1-2

    Topics: Androstadienes; Animals; Chromones; Cytokines; Disease Models, Animal; Dose-Response Relationship, D

2008
Mechanisms mediating renal sympathetic activation to leptin in obesity.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2008, Volume: 295, Issue:6

    Topics: Adipose Tissue, Brown; Animals; Body Weight; Chromones; Dietary Fats; Disease Models, Animal; Dose-R

2008
The Rheb-mTOR pathway is upregulated in reactive astrocytes of the injured spinal cord.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, Jan-28, Volume: 29, Issue:4

    Topics: Analysis of Variance; Animals; Astrocytes; Cells, Cultured; Chromones; Disease Models, Animal; Enzym

2009
Anti-hypertrophic effect of NHE-1 inhibition involves GSK-3beta-dependent attenuation of mitochondrial dysfunction.
    Journal of molecular and cellular cardiology, 2009, Volume: 46, Issue:6

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Blotting, Western; Cardiomegaly;

2009
Attenuation of neuronal degeneration in thioredoxin-1 overexpressing mice after mild focal ischemia.
    Brain research, 2009, May-26, Volume: 1272

    Topics: Analysis of Variance; Animals; Caspase 3; Cell Death; Chromones; Dicarbethoxydihydrocollidine; Disea

2009
Pretreatment with lovastatin prevents N-methyl-D-aspartate-induced neurodegeneration in the magnocellular nucleus basalis and behavioral dysfunction.
    Journal of Alzheimer's disease : JAD, 2009, Volume: 17, Issue:2

    Topics: Analysis of Variance; Animals; Avoidance Learning; Basal Nucleus of Meynert; Behavioral Symptoms; Ch

2009
Inhibition of PI-3K restores nuclear p27Kip1 expression in a mouse model of Kras-driven lung cancer.
    Oncogene, 2009, Oct-15, Volume: 28, Issue:41

    Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Nucleus; Chromones; Cyclin-Dependent Kinase Inhibitor

2009
PKB/Akt activation inhibits p53-mediated HIF1A degradation that is independent of MDM2.
    Journal of cellular physiology, 2010, Volume: 222, Issue:3

    Topics: Animals; Cardiomegaly; Cell Line; Cell Size; Chromones; Deferoxamine; Disease Models, Animal; Fibrob

2010
Involvement of phosphoinositide 3-kinase gamma in angiogenesis and healing of experimental myocardial infarction in mice.
    Circulation research, 2010, Mar-05, Volume: 106, Issue:4

    Topics: Animals; Apoptosis; Cell Movement; Cell Proliferation; Cell Survival; Cells, Cultured; Chromones; Di

2010
CREB activation mediates VEGF-A's protection of neurons and cerebral vascular endothelial cells.
    Journal of neurochemistry, 2010, Volume: 113, Issue:1

    Topics: Animals; Animals, Newborn; Brain Injuries; Cell Survival; Cells, Cultured; Chromones; CREB-Binding P

2010
The phosphatidylinositol 3-kinase-Akt pathway protects cardiomyocytes from ischaemic and hypoxic apoptosis via mitochondrial function.
    Clinical and experimental pharmacology & physiology, 2010, Volume: 37, Issue:5-6

    Topics: Animals; Animals, Newborn; Apoptosis; Burns; Calcium; Caspase 3; Cell Hypoxia; Cell Survival; Cells,

2010
Vitamin B1 analog benfotiamine prevents diabetes-induced diastolic dysfunction and heart failure through Akt/Pim-1-mediated survival pathway.
    Circulation. Heart failure, 2010, Volume: 3, Issue:2

    Topics: Analysis of Variance; Animals; Apoptosis; Blood Flow Velocity; Blotting, Western; Carrier Proteins;

2010
SDF-1/CXCR4-mediated migration of transplanted bone marrow stromal cells toward areas of heart myocardial infarction through activation of PI3K/Akt.
    Journal of cardiovascular pharmacology, 2010, Volume: 55, Issue:5

    Topics: Animals; Blotting, Western; Bone Marrow Cells; Chemokine CXCL12; Chemotaxis; Chromones; Disease Mode

2010
VEGF protects spinal motor neurons against chronic excitotoxic degeneration in vivo by activation of PI3-K pathway and inhibition of p38MAPK.
    Journal of neurochemistry, 2010, Volume: 115, Issue:5

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Choline O-A

2010
Differential effects of insulin on sympathetic nerve activity in agouti obese mice.
    Journal of hypertension, 2010, Volume: 28, Issue:9

    Topics: Animals; Blood Glucose; Chromones; Disease Models, Animal; Enzyme Inhibitors; Injections, Intraventr

2010
Neuroprotective effects of an herbal medicine, Yi-Gan San on MPP+/MPTP-induced cytotoxicity in vitro and in vivo.
    Journal of ethnopharmacology, 2010, Sep-15, Volume: 131, Issue:2

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Caspase 3; Cell

2010
Erythropoietin plus insulin-like growth factor-I protects against neuronal damage in a murine model of human immunodeficiency virus-associated neurocognitive disorders.
    Annals of neurology, 2010, Volume: 68, Issue:3

    Topics: Administration, Intranasal; Adult; Animals; Apoptosis; Cells, Cultured; Cerebral Cortex; Chromones;

2010
Inactivation of PI3K/AKT signaling inhibits glioma cell growth through modulation of β-catenin-mediated transcription.
    Brain research, 2010, Dec-17, Volume: 1366

    Topics: Animals; beta Catenin; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromones; Disease Models,

2010
Ischemic postconditioning protects brain from ischemia/reperfusion injury by attenuating endoplasmic reticulum stress-induced apoptosis through PI3K-Akt pathway.
    Brain research, 2011, Jan-07, Volume: 1367

    Topics: Animals; Apoptosis; Brain; Brain Infarction; Caspase 12; Chromones; Disease Models, Animal; Endoplas

2011
Polysaccharides from the root of Angelica sinensis promotes hematopoiesis and thrombopoiesis through the PI3K/AKT pathway.
    BMC complementary and alternative medicine, 2010, Dec-21, Volume: 10

    Topics: Angelica sinensis; Animals; Apoptosis; Blood Cells; Cell Proliferation; Chromones; Disease Models, A

2010
Insulin receptor signaling in rat hippocampus: a study in STZ (ICV) induced memory deficit model.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2011, Volume: 21, Issue:3

    Topics: Animals; Blood Glucose; Chromones; Disease Models, Animal; Donepezil; Gene Expression; Hippocampus;

2011
Salvianolic acid B and tanshinone IIA attenuate myocardial ischemia injury in mice by NO production through multiple pathways.
    Therapeutic advances in cardiovascular disease, 2011, Volume: 5, Issue:2

    Topics: Abietanes; Amino Acid Transport Systems, Basic; AMP-Activated Protein Kinases; Analysis of Variance;

2011
Phosphatidylinositol 3-kinase/Akt signaling pathway mediates acupuncture-induced dopaminergic neuron protection and motor function improvement in a mouse model of Parkinson's disease.
    The International journal of neuroscience, 2011, Volume: 121, Issue:10

    Topics: Acupuncture; Acupuncture Points; Administration, Intranasal; Animals; Chromones; Disease Models, Ani

2011
Luteolin inhibits apoptosis and improves cardiomyocyte contractile function through the PI3K/Akt pathway in simulated ischemia/reperfusion.
    Pharmacology, 2011, Volume: 88, Issue:3-4

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Calcium-Binding Proteins; Cardiotonic Agents; Chromo

2011
Ethanol extract of Prunella vulgaris var. lilacina inhibits HMGB1 release by induction of heme oxygenase-1 in LPS-activated RAW 264.7 cells and CLP-induced septic mice.
    Phytotherapy research : PTR, 2012, Volume: 26, Issue:4

    Topics: Animals; Anthracenes; Cecum; Cell Line; Cell Survival; Chromones; Cyclooxygenase 2; Disease Models,

2012
Automated 4D analysis of dendritic spine morphology: applications to stimulus-induced spine remodeling and pharmacological rescue in a disease model.
    Molecular brain, 2011, Oct-07, Volume: 4

    Topics: Animals; Automation; Brain-Derived Neurotrophic Factor; Chromones; Dendritic Spines; Diagnostic Imag

2011
Distinct signalling mechanisms mediate neutrophil attraction to bacterial infection and tissue injury.
    Cellular microbiology, 2012, Volume: 14, Issue:4

    Topics: Animal Fins; Animals; Chromones; Disease Models, Animal; Embryo, Nonmammalian; Enzyme Activation; Hy

2012
Remote ischemic postconditioning protects the brain from global cerebral ischemia/reperfusion injury by up-regulating endothelial nitric oxide synthase through the PI3K/Akt pathway.
    Brain research, 2012, Mar-22, Volume: 1445

    Topics: Analysis of Variance; Animals; Avoidance Learning; Brain; Brain Infarction; Brain Ischemia; Cell Dea

2012
Carvacrol, a food-additive, provides neuroprotection on focal cerebral ischemia/reperfusion injury in mice.
    PloS one, 2012, Volume: 7, Issue:3

    Topics: Animals; Apoptosis; Brain Ischemia; Caspase 3; Chromones; Cymenes; Disease Models, Animal; Dose-Resp

2012
Berberine ameliorates β-amyloid pathology, gliosis, and cognitive impairment in an Alzheimer's disease transgenic mouse model.
    Neurobiology of aging, 2012, Volume: 33, Issue:12

    Topics: ADAM Proteins; ADAM10 Protein; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precur

2012
The toll-like receptor 9 agonist, CpG-oligodeoxynucleotide 1826, ameliorates cardiac dysfunction after trauma-hemorrhage.
    Shock (Augusta, Ga.), 2012, Volume: 38, Issue:2

    Topics: Adjuvants, Immunologic; Animals; Chromones; Disease Models, Animal; Enzyme Inhibitors; Heart Disease

2012
Stimulation of functional recovery via the mechanisms of neurorepair by S-nitrosoglutathione and motor exercise in a rat model of transient cerebral ischemia and reperfusion.
    Restorative neurology and neuroscience, 2012, Volume: 30, Issue:5

    Topics: Analysis of Variance; Animals; Apoptosis; Brain Infarction; Brain-Derived Neurotrophic Factor; Caspa

2012
AKT/GSK3β-dependent autophagy contributes to the neuroprotection of limb remote ischemic postconditioning in the transient cerebral ischemic rat model.
    CNS neuroscience & therapeutics, 2012, Volume: 18, Issue:12

    Topics: Animals; Autophagy; Brain; Caspase 3; Chromones; Disease Models, Animal; Enzyme Inhibitors; Femoral

2012
Girdin and its phosphorylation dynamically regulate neonatal vascular development and pathological neovascularization in the retina.
    The American journal of pathology, 2013, Volume: 182, Issue:2

    Topics: Animals; Animals, Newborn; Blood Vessels; Cell Movement; Cell Proliferation; Chromones; Disease Mode

2013
Neural plasticity and addiction: PI3-kinase and cocaine behavioral sensitization.
    Nature neuroscience, 2002, Volume: 5, Issue:12

    Topics: Animals; Behavior, Animal; Brain; Chromones; Cocaine; Cocaine-Related Disorders; Disease Models, Ani

2002
P2X7 mediates superoxide production in primary microglia and is up-regulated in a transgenic mouse model of Alzheimer's disease.
    The Journal of biological chemistry, 2003, Apr-11, Volume: 278, Issue:15

    Topics: Adenosine Triphosphate; Alzheimer Disease; Animals; Animals, Newborn; Calcium; Cerebral Cortex; Chro

2003
Selective role of PI3K delta in neutrophil inflammatory responses.
    Biochemical and biophysical research communications, 2003, Sep-05, Volume: 308, Issue:4

    Topics: Adenine; Androstadienes; Animals; Anti-Inflammatory Agents; Chromones; Class I Phosphatidylinositol

2003
PI3-kinase upregulation and involvement in spontaneous tone in arteries from DOCA-salt rats: is p110delta the culprit?
    Hypertension (Dallas, Tex. : 1979), 2004, Volume: 43, Issue:4

    Topics: Adenine; Animals; Aorta; Chromones; Class I Phosphatidylinositol 3-Kinases; Desoxycorticosterone; Di

2004
PI3K-Akt pathway suppresses coagulation and inflammation in endotoxemic mice.
    Arteriosclerosis, thrombosis, and vascular biology, 2004, Volume: 24, Issue:10

    Topics: Androstadienes; Animals; Blood Coagulation; Chemokines; Chromones; Cytokines; Disease Models, Animal

2004
A novel IKKbeta inhibitor stimulates adiponectin levels and ameliorates obesity-linked insulin resistance.
    Biochemical and biophysical research communications, 2004, Oct-08, Volume: 323, Issue:1

    Topics: 3T3-L1 Cells; Adipocytes; Adiponectin; Animals; Benzamides; Blood Glucose; Body Weight; Chromones; D

2004
Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injury.
    Diabetes, 2005, Volume: 54, Issue:1

    Topics: Animals; Blood Pressure; Butadienes; Chromones; Disease Models, Animal; Enzyme Inhibitors; Glucagon;

2005
An anti-inflammatory role for a phosphoinositide 3-kinase inhibitor LY294002 in a mouse asthma model.
    International immunopharmacology, 2005, Volume: 5, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Cell Movement; Chromones; C

2005
Neuroprotective effects of preconditioning ischaemia on ischaemic brain injury through inhibition of mixed-lineage kinase 3 via NMDA receptor-mediated Akt1 activation.
    Journal of neurochemistry, 2005, Volume: 93, Issue:4

    Topics: Animals; Blotting, Western; Brain; Brain Ischemia; Cell Death; Chromones; Dimethyl Sulfoxide; Diseas

2005
The role of PDGF receptor inhibitors and PI3-kinase signaling in the pathogenesis of corneal neovascularization.
    Investigative ophthalmology & visual science, 2006, Volume: 47, Issue:5

    Topics: Androstadienes; Angiopoietin-1; Angiopoietin-2; Animals; Chromones; Cornea; Corneal Neovascularizati

2006
Inhibition of MLK3-MKK4/7-JNK1/2 pathway by Akt1 in exogenous estrogen-induced neuroprotection against transient global cerebral ischemia by a non-genomic mechanism in male rats.
    Journal of neurochemistry, 2006, Volume: 99, Issue:6

    Topics: Animals; Blotting, Western; Chromones; Disease Models, Animal; Drug Interactions; Enzyme Activation;

2006
Protection against myocardial ischemia/reperfusion injury in TLR4-deficient mice is mediated through a phosphoinositide 3-kinase-dependent mechanism.
    Journal of immunology (Baltimore, Md. : 1950), 2007, Jun-01, Volume: 178, Issue:11

    Topics: Androstadienes; Animals; Apoptosis; Chromones; Disease Models, Animal; Down-Regulation; Enzyme Inhib

2007
Cardioprotection induced by hydrogen sulfide preconditioning involves activation of ERK and PI3K/Akt pathways.
    Pflugers Archiv : European journal of physiology, 2008, Volume: 455, Issue:4

    Topics: Animals; Benzophenanthridines; Cardiotonic Agents; Cell Survival; Chromones; Disease Models, Animal;

2008
Activated macrophages in HIV encephalitis and a macaque model show increased [3H](R)-PK11195 binding in a PI3-kinase-dependent manner.
    Neuroscience letters, 2007, Oct-16, Volume: 426, Issue:2

    Topics: Analysis of Variance; Animals; Antineoplastic Agents; Autoradiography; Binding, Competitive; Butadie

2007
Metformin protects the ischemic heart by the Akt-mediated inhibition of mitochondrial permeability transition pore opening.
    Basic research in cardiology, 2008, Volume: 103, Issue:3

    Topics: Animals; Chromones; Diabetes Mellitus; Disease Models, Animal; Dose-Response Relationship, Drug; Dru

2008
Preconditioning by isoflurane retains its protection against ischemia-reperfusion injury in postinfarct remodeled rat hearts.
    Anesthesia and analgesia, 2008, Volume: 106, Issue:1

    Topics: Anesthetics, Inhalation; Animals; Cardiotonic Agents; Chromones; Coronary Vessels; Decanoic Acids; D

2008
Lipopolysaccharide-induced myocardial protection against ischaemia/reperfusion injury is mediated through a PI3K/Akt-dependent mechanism.
    Cardiovascular research, 2008, Jun-01, Volume: 78, Issue:3

    Topics: Animals; Apoptosis; Caspase 3; Chromones; Disease Models, Animal; Glycogen Synthase Kinase 3; Glycog

2008
Phosphatidylinositol 3-kinase inhibitor failed to reduce cerebral vasospasm in dog model of experimental subarachnoid hemorrhage.
    Stroke, 2002, Volume: 33, Issue:2

    Topics: Androstadienes; Animals; Basilar Artery; Blotting, Western; Brain; Cerebral Angiography; Chromones;

2002
Inhibition of phosphatidylinositol 3'-kinase increases efficacy of paclitaxel in in vitro and in vivo ovarian cancer models.
    Cancer research, 2002, Feb-15, Volume: 62, Issue:4

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Division; Chromones; Diseas

2002