2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Diabetes Mellitus, Adult-Onset in 16 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
| Excerpt | Relevance | Reference |
|---|---|---|
| "Increased levels of C-peptide, a cleavage product of proinsulin, circulate in patients with insulin resistance and early type 2 diabetes, a high-risk population for the development of a diffuse and extensive pattern of arteriosclerosis." | 3.72 | C-peptide colocalizes with macrophages in early arteriosclerotic lesions of diabetic subjects and induces monocyte chemotaxis in vitro. ( Aleksic, M; Bach, H; Grüb, M; Hombach, V; Homma, S; Libby, P; Marx, N; Raichle, C; Strong, J; Walcher, D; Zieske, A, 2004) |
| "Berberine was administered p." | 1.48 | Berberine Alleviates Tau Hyperphosphorylation and Axonopathy-Associated with Diabetic Encephalopathy via Restoring PI3K/Akt/GSK3β Pathway. ( Chen, J; Chen, Q; Feng, Z; Hang, W; He, B; Wang, S; Wang, X; Wu, N; Xia, L; Zhang, Q; Zhou, X, 2018) |
| "Insulin resistance was induced by glucosamine (GlcN) or palmitate in human hepatocellular carcinoma (HepG2) cells and mouse primary hepatocytes." | 1.42 | Irisin inhibits hepatic gluconeogenesis and increases glycogen synthesis via the PI3K/Akt pathway in type 2 diabetic mice and hepatocytes. ( Chen, Q; Ding, L; Gao, R; Kang, YM; Li, YH; Liu, TY; Shi, CX; Sun, HJ; Wang, JJ; Xiong, XQ; Zhu, GQ, 2015) |
| "Two human pancreatic cancer cell lines were used to evaluate the in vitro effects of the GLP-1R agonist liraglutide on cell growth, migration and invasion." | 1.40 | Activation of glucagon-like peptide-1 receptor inhibits tumourigenicity and metastasis of human pancreatic cancer cells via PI3K/Akt pathway. ( Hong, T; Ke, J; Liu, Y; Tao, M; Wang, L; Wei, R; Xiu, D; Yang, J; Zhao, H, 2014) |
| "Type 2 diabetes mellitus is thought to be a significant risk factor for Alzheimer's disease." | 1.38 | Brain insulin resistance accelerates Aβ fibrillogenesis by inducing GM1 ganglioside clustering in the presynaptic membranes. ( Kasahara, R; Matsubara, T; Naruse, K; Sato, T; Sobue, K; Suzuki, K; Tanida, M; Taniura, H; Yamamoto, N, 2012) |
| "Platelets from patients with type 2 diabetes mellitus showed increased TRPC6 expression compared to nondiabetic individuals (P<0." | 1.35 | High glucose enhances transient receptor potential channel canonical type 6-dependent calcium influx in human platelets via phosphatidylinositol 3-kinase-dependent pathway. ( Boltzen, U; Liu, D; Maier, A; Rauch, U; Scholze, A; Tepel, M; Zhao, Z; Zhu, Z, 2008) |
| "The molecular pathogenesis of diabetic nephropathy (DN), the leading cause of end-stage renal disease worldwide, is complex and not fully understood." | 1.35 | Protein kinase B/Akt activity is involved in renal TGF-beta1-driven epithelial-mesenchymal transition in vitro and in vivo. ( Brazil, DP; Carew, RM; Godson, C; Heljic, M; Kattla, JJ, 2008) |
| " In this report, we have studied the effects of insulin and ethanol on ADH gene expression in a highly differentiated rat hepatoma cell line (FGC-4), as well as the in vivo effects of chronic intake of an ethanol-containing diet on hepatic insulin signaling." | 1.33 | Chronic ethanol intake impairs insulin signaling in rats by disrupting Akt association with the cell membrane. Role of TRB3 in inhibition of Akt/protein kinase B activation. ( Badger, TM; He, L; Mehendale, HM; Ronis, MJ; Simmen, FA, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (6.25) | 18.2507 |
| 2000's | 5 (31.25) | 29.6817 |
| 2010's | 8 (50.00) | 24.3611 |
| 2020's | 2 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, S | 1 |
| Liu, Y | 2 |
| Huang, S | 1 |
| Jin, F | 1 |
| Qi, F | 1 |
| Yang, H | 1 |
| Cao, Q | 1 |
| Xiong, X | 1 |
| Zhao, P | 1 |
| Shen, D | 1 |
| Zhang, Y | 1 |
| Zhang, N | 2 |
| Wang, S | 1 |
| He, B | 1 |
| Hang, W | 1 |
| Wu, N | 1 |
| Xia, L | 1 |
| Wang, X | 1 |
| Zhang, Q | 1 |
| Zhou, X | 1 |
| Feng, Z | 1 |
| Chen, Q | 2 |
| Chen, J | 1 |
| Zhao, H | 1 |
| Wang, L | 1 |
| Wei, R | 1 |
| Xiu, D | 1 |
| Tao, M | 1 |
| Ke, J | 1 |
| Yang, J | 1 |
| Hong, T | 1 |
| Kitahara, A | 1 |
| Takahashi, K | 1 |
| Moriya, R | 1 |
| Onuma, H | 1 |
| Handa, K | 1 |
| Sumitani, Y | 1 |
| Tanaka, T | 1 |
| Katsuta, H | 1 |
| Nishida, S | 1 |
| Sakurai, T | 1 |
| Inukai, K | 1 |
| Ohno, H | 1 |
| Ishida, H | 1 |
| Liu, TY | 1 |
| Shi, CX | 1 |
| Gao, R | 1 |
| Sun, HJ | 1 |
| Xiong, XQ | 1 |
| Ding, L | 1 |
| Li, YH | 1 |
| Wang, JJ | 1 |
| Kang, YM | 1 |
| Zhu, GQ | 1 |
| Yang, M | 1 |
| Ren, Y | 1 |
| Lin, Z | 1 |
| Tang, C | 1 |
| Jia, Y | 1 |
| Lai, Y | 1 |
| Zhou, T | 1 |
| Wu, S | 1 |
| Liu, H | 2 |
| Yang, G | 1 |
| Li, L | 1 |
| Xing, Y | 1 |
| Lai, J | 1 |
| Liu, X | 1 |
| Ming, J | 1 |
| Zhang, X | 1 |
| Peterson, SJ | 1 |
| Kim, DH | 1 |
| Li, M | 1 |
| Positano, V | 1 |
| Vanella, L | 1 |
| Rodella, LF | 1 |
| Piccolomini, F | 1 |
| Puri, N | 1 |
| Gastaldelli, A | 1 |
| Kusmic, C | 1 |
| L'Abbate, A | 1 |
| Abraham, NG | 1 |
| Yue, P | 1 |
| Jin, H | 1 |
| Aillaud, M | 1 |
| Deng, AC | 1 |
| Azuma, J | 1 |
| Asagami, T | 1 |
| Kundu, RK | 1 |
| Reaven, GM | 1 |
| Quertermous, T | 1 |
| Tsao, PS | 1 |
| Yamamoto, N | 1 |
| Matsubara, T | 1 |
| Sobue, K | 1 |
| Tanida, M | 1 |
| Kasahara, R | 1 |
| Naruse, K | 1 |
| Taniura, H | 1 |
| Sato, T | 1 |
| Suzuki, K | 1 |
| Marx, N | 1 |
| Walcher, D | 1 |
| Raichle, C | 1 |
| Aleksic, M | 1 |
| Bach, H | 1 |
| Grüb, M | 1 |
| Hombach, V | 1 |
| Libby, P | 1 |
| Zieske, A | 1 |
| Homma, S | 1 |
| Strong, J | 1 |
| He, L | 1 |
| Simmen, FA | 1 |
| Mehendale, HM | 1 |
| Ronis, MJ | 1 |
| Badger, TM | 1 |
| Liu, D | 1 |
| Maier, A | 1 |
| Scholze, A | 1 |
| Rauch, U | 1 |
| Boltzen, U | 1 |
| Zhao, Z | 1 |
| Zhu, Z | 1 |
| Tepel, M | 1 |
| Kattla, JJ | 1 |
| Carew, RM | 1 |
| Heljic, M | 1 |
| Godson, C | 1 |
| Brazil, DP | 1 |
| Harvey, J | 1 |
| Ashford, ML | 1 |
16 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Diabetes Mellitus, Adult-Onset
| Article | Year |
|---|---|
Sevoflurane and isoflurane inhibit KCl-induced, Rho kinase-mediated, and PI3K-participated vasoconstriction in aged diabetic rat aortas.
Topics: Aging; Amides; Anesthetics, Inhalation; Animals; Aorta; Chromones; Diabetes Mellitus, Experimental; | 2021 |
Fluoxetine regulates glucose and lipid metabolism via the PI3K‑AKT signaling pathway in diabetic rats.
Topics: Animals; Cell Line; Chromones; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Fluoxetin | 2020 |
Berberine Alleviates Tau Hyperphosphorylation and Axonopathy-Associated with Diabetic Encephalopathy via Restoring PI3K/Akt/GSK3β Pathway.
Topics: Animals; Axons; Berberine; Cells, Cultured; Chromones; Diabetes Mellitus, Type 2; Diabetic Nephropat | 2018 |
Activation of glucagon-like peptide-1 receptor inhibits tumourigenicity and metastasis of human pancreatic cancer cells via PI3K/Akt pathway.
Topics: Androstadienes; Animals; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromones; Diabetes Me | 2014 |
Ghrelin augments the expressions and secretions of proinflammatory adipokines, VEGF120 and MCP-1, in differentiated 3T3-L1 adipocytes.
Topics: 3T3 Cells; Adipocytes; Adiponectin; AMP-Activated Protein Kinases; Androstadienes; Animals; Anthrace | 2015 |
Irisin inhibits hepatic gluconeogenesis and increases glycogen synthesis via the PI3K/Akt pathway in type 2 diabetic mice and hepatocytes.
Topics: Animals; Blotting, Western; Cells, Cultured; Chromones; Class I Phosphatidylinositol 3-Kinases; Diab | 2015 |
Krüppel-like factor 14 increases insulin sensitivity through activation of PI3K/Akt signal pathway.
Topics: Adipose Tissue; Animals; Antigens, CD; Biological Transport; Cell Line, Tumor; Chromones; Diabetes M | 2015 |
Netrin-1 restores cell injury and impaired angiogenesis in vascular endothelial cells upon high glucose by PI3K/AKT-eNOS.
Topics: Adenoviridae; Case-Control Studies; Caspase 3; Cell Survival; Cells, Cultured; Chromones; Diabetes M | 2017 |
The L-4F mimetic peptide prevents insulin resistance through increased levels of HO-1, pAMPK, and pAKT in obese mice.
Topics: Adipocytes; Adipose Tissue; AMP-Activated Protein Kinases; Animals; Body Weight; Chromones; Diabetes | 2009 |
Apelin is necessary for the maintenance of insulin sensitivity.
Topics: Adipokines; AMP-Activated Protein Kinases; Animals; Apelin; Carrier Proteins; Cells, Cultured; Chrom | 2010 |
Brain insulin resistance accelerates Aβ fibrillogenesis by inducing GM1 ganglioside clustering in the presynaptic membranes.
Topics: Aging; Amyloid beta-Peptides; Animals; Blotting, Western; Brain Chemistry; Cell Separation; Cells, C | 2012 |
C-peptide colocalizes with macrophages in early arteriosclerotic lesions of diabetic subjects and induces monocyte chemotaxis in vitro.
Topics: Adolescent; Adult; Androstadienes; Aorta, Thoracic; Aortic Diseases; Arteriosclerosis; C-Peptide; Ce | 2004 |
Chronic ethanol intake impairs insulin signaling in rats by disrupting Akt association with the cell membrane. Role of TRB3 in inhibition of Akt/protein kinase B activation.
Topics: Alcohol Dehydrogenase; Animals; Binding Sites; Blotting, Northern; Blotting, Western; Cell Different | 2006 |
High glucose enhances transient receptor potential channel canonical type 6-dependent calcium influx in human platelets via phosphatidylinositol 3-kinase-dependent pathway.
Topics: Aged; Androstadienes; Blood Glucose; Blood Platelets; Calcium Signaling; Case-Control Studies; Chrom | 2008 |
Protein kinase B/Akt activity is involved in renal TGF-beta1-driven epithelial-mesenchymal transition in vitro and in vivo.
Topics: Animals; Cell Transdifferentiation; Chromones; Diabetes Mellitus, Experimental; Diabetes Mellitus, T | 2008 |
Insulin occludes leptin activation of ATP-sensitive K+ channels in rat CRI-G1 insulin secreting cells.
Topics: Adenosine Triphosphate; Androstadienes; Animals; Binding, Competitive; Chromones; Diabetes Mellitus, | 1998 |