2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Colorectal Neoplasms in 29 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
| Excerpt | Relevance | Reference |
|---|---|---|
| "5-Fluorouracil (5-FU), a cell cycle-specific antimetabolite, is one of the most commonly used chemotherapeutic agents for colorectal cancer (CRC)." | 7.83 | Smad4 sensitizes colorectal cancer to 5-fluorouracil through cell cycle arrest by inhibiting the PI3K/Akt/CDC2/survivin cascade. ( Chen, X; Dou, L; Leng, C; Luo, X; Wu, C; Zhang, B; Zhang, Z, 2016) |
| "Paclitaxel, one of key drugs to treat a wide range of malignancies, exhibits relative low sensitivity for colorectal cancer." | 7.77 | Dual blockade of phosphatidylinositol 3'-kinase and mitogen-activated protein kinase pathways overcomes paclitaxel-resistance in colorectal cancer. ( Iwasaki, H; Katano, M; Kumagai, M; Mibu, R; Nakano, K; Onishi, H; Suzuki, H; Wakabayashi, R; Xu, R; Yamasaki, A, 2011) |
| "In HT-29 colorectal cancer cells, the ERK activities were increased by zinc, which was accompanied by the induction of p21(Cip/WAF1) and cyclin D1." | 5.31 | Differential modulation of zinc-stimulated p21(Cip/WAF1) and cyclin D1 induction by inhibition of PI3 kinase in HT-29 colorectal cancer cells. ( Choi, KY; Kim, JA; Oh, SY; Park, KS, 2002) |
| "5-Fluorouracil (5-FU), a cell cycle-specific antimetabolite, is one of the most commonly used chemotherapeutic agents for colorectal cancer (CRC)." | 3.83 | Smad4 sensitizes colorectal cancer to 5-fluorouracil through cell cycle arrest by inhibiting the PI3K/Akt/CDC2/survivin cascade. ( Chen, X; Dou, L; Leng, C; Luo, X; Wu, C; Zhang, B; Zhang, Z, 2016) |
| "Paclitaxel, one of key drugs to treat a wide range of malignancies, exhibits relative low sensitivity for colorectal cancer." | 3.77 | Dual blockade of phosphatidylinositol 3'-kinase and mitogen-activated protein kinase pathways overcomes paclitaxel-resistance in colorectal cancer. ( Iwasaki, H; Katano, M; Kumagai, M; Mibu, R; Nakano, K; Onishi, H; Suzuki, H; Wakabayashi, R; Xu, R; Yamasaki, A, 2011) |
| "Nevertheless, its role in colorectal cancer (CRC) remains unknown." | 1.51 | CDCA2 promotes the proliferation of colorectal cancer cells by activating the AKT/CCND1 pathway in vitro and in vivo. ( Feng, Y; Gu, Q; Ji, D; Li, J; Peng, W; Qian, W; Sun, Y; Wang, Q; Zhang, D; Zhang, Y; Zhang, Z, 2019) |
| "Expression and activity of metastasis‑related metalloproteinases (MMPs) were analyzed by western blotting and gelatin zymography, respectively." | 1.43 | CHRNA7 inhibits cell invasion and metastasis of LoVo human colorectal cancer cells through PI3K/Akt signaling. ( Chen, W; Fei, R; Qian, J; Xiang, T; Yu, F, 2016) |
| "During colorectal cancer progression, the loss of differentiation and cell-cell adhesion as well as a higher migratory potential are well-defined features; however, the signaling mechanism governing these events is not fully elucidated." | 1.36 | PI3K/Akt and GSK-3β prevents in a differential fashion the malignant phenotype of colorectal cancer cells. ( de Araújo, WM; de Freitas, JC; de Souza, W; de Souza, WF; Morgado-Diaz, JA; Vidal, FC, 2010) |
| "Therapeutic decisions for colorectal cancer are empirically based and currently do not emphasize molecular subclassification despite an increasing collection of gene expression information." | 1.35 | Gene expression patterns in mismatch repair-deficient colorectal cancers highlight the potential therapeutic role of inhibitors of the phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway. ( Fearon, ER; Giordano, TJ; Gruber, SB; Hanash, SM; Kuick, R; Misek, DE; Mukherjee, B; Raskin, L; Rennert, G; Taylor, JM; Vilar, E, 2009) |
| "In HT-29 colorectal cancer cells, the ERK activities were increased by zinc, which was accompanied by the induction of p21(Cip/WAF1) and cyclin D1." | 1.31 | Differential modulation of zinc-stimulated p21(Cip/WAF1) and cyclin D1 induction by inhibition of PI3 kinase in HT-29 colorectal cancer cells. ( Choi, KY; Kim, JA; Oh, SY; Park, KS, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 11 (37.93) | 29.6817 |
| 2010's | 16 (55.17) | 24.3611 |
| 2020's | 2 (6.90) | 2.80 |
| Authors | Studies |
|---|---|
| Yao, M | 1 |
| Li, R | 1 |
| Yang, Z | 1 |
| Ding, Y | 1 |
| Zhang, W | 1 |
| Li, W | 1 |
| Liu, M | 1 |
| Zhao, C | 1 |
| Wang, Y | 3 |
| Tang, H | 1 |
| Wang, J | 2 |
| Wen, A | 1 |
| Xu, M | 1 |
| Li, H | 1 |
| Zhang, Z | 3 |
| Cheng, Z | 1 |
| Feng, Y | 1 |
| Qian, W | 1 |
| Zhang, Y | 2 |
| Peng, W | 1 |
| Li, J | 2 |
| Gu, Q | 1 |
| Ji, D | 1 |
| Wang, Q | 1 |
| Zhang, D | 1 |
| Sun, Y | 1 |
| Khan, MW | 1 |
| Keshavarzian, A | 1 |
| Gounaris, E | 1 |
| Melson, JE | 1 |
| Cheon, EC | 1 |
| Blatner, NR | 1 |
| Chen, ZE | 1 |
| Tsai, FN | 1 |
| Lee, G | 1 |
| Ryu, H | 1 |
| Barrett, TA | 1 |
| Bentrem, DJ | 1 |
| Beckhove, P | 1 |
| Khazaie, K | 1 |
| Liu, J | 1 |
| Liao, Y | 1 |
| Ma, K | 1 |
| Zhang, G | 1 |
| Yang, R | 1 |
| Deng, J | 1 |
| Zhang, B | 4 |
| Chen, X | 2 |
| Bae, S | 1 |
| Singh, K | 1 |
| Washington, MK | 1 |
| Datta, PK | 1 |
| Leng, C | 1 |
| Wu, C | 1 |
| Dou, L | 1 |
| Luo, X | 1 |
| Xiang, T | 1 |
| Yu, F | 1 |
| Fei, R | 1 |
| Qian, J | 1 |
| Chen, W | 1 |
| Kim, MJ | 1 |
| Koo, JE | 1 |
| Han, GY | 1 |
| Kim, B | 1 |
| Lee, YS | 1 |
| Ahn, C | 1 |
| Kim, CW | 1 |
| Ren, H | 1 |
| Wang, Z | 1 |
| Zhang, S | 1 |
| Ma, H | 1 |
| Jia, L | 1 |
| Li, Y | 1 |
| Jing, Z | 1 |
| Fei, W | 1 |
| Zhou, J | 1 |
| Zhang, L | 1 |
| Chen, L | 1 |
| Zhang, X | 1 |
| Liang, X | 1 |
| Xie, J | 1 |
| Fang, Y | 2 |
| Sui, X | 1 |
| Han, W | 1 |
| Pan, H | 1 |
| Vilar, E | 1 |
| Mukherjee, B | 1 |
| Kuick, R | 1 |
| Raskin, L | 1 |
| Misek, DE | 1 |
| Taylor, JM | 1 |
| Giordano, TJ | 1 |
| Hanash, SM | 1 |
| Fearon, ER | 1 |
| Rennert, G | 1 |
| Gruber, SB | 1 |
| Matsumoto, K | 1 |
| Arao, T | 1 |
| Tanaka, K | 1 |
| Kaneda, H | 1 |
| Kudo, K | 1 |
| Fujita, Y | 1 |
| Tamura, D | 1 |
| Aomatsu, K | 1 |
| Tamura, T | 1 |
| Yamada, Y | 1 |
| Saijo, N | 1 |
| Nishio, K | 1 |
| de Araújo, WM | 1 |
| Vidal, FC | 1 |
| de Souza, WF | 1 |
| de Freitas, JC | 1 |
| de Souza, W | 1 |
| Morgado-Diaz, JA | 1 |
| Xu, R | 1 |
| Nakano, K | 1 |
| Iwasaki, H | 1 |
| Kumagai, M | 1 |
| Wakabayashi, R | 1 |
| Yamasaki, A | 1 |
| Suzuki, H | 1 |
| Mibu, R | 1 |
| Onishi, H | 1 |
| Katano, M | 1 |
| Mallawaaratchy, DM | 1 |
| Mactier, S | 1 |
| Kaufman, KL | 1 |
| Blomfield, K | 1 |
| Christopherson, RI | 1 |
| Wang, D | 2 |
| Chen, J | 1 |
| Chen, H | 1 |
| Duan, Z | 1 |
| Xu, Q | 1 |
| Wei, M | 1 |
| Wang, L | 1 |
| Zhong, M | 1 |
| Xiang, L | 1 |
| Xie, G | 1 |
| Ou, J | 1 |
| Wei, X | 1 |
| Pan, F | 1 |
| Liang, H | 1 |
| Zhu, YF | 1 |
| Yu, BH | 1 |
| Li, DL | 1 |
| Ke, HL | 1 |
| Guo, XZ | 1 |
| Xiao, XY | 1 |
| Li, A | 1 |
| Lu, D | 1 |
| Li, F | 1 |
| Sun, J | 1 |
| Itoh, N | 2 |
| Semba, S | 2 |
| Ito, M | 2 |
| Takeda, H | 1 |
| Kawata, S | 1 |
| Yamakawa, M | 2 |
| Youssef, EM | 1 |
| Harada, M | 1 |
| Moriya, T | 1 |
| Kimura, W | 1 |
| Wang, H | 1 |
| Shi, Q | 1 |
| Katkuri, S | 1 |
| Walhi, W | 1 |
| Desvergne, B | 1 |
| Das, SK | 1 |
| Dey, SK | 1 |
| DuBois, RN | 1 |
| Pajak, B | 1 |
| Gajkowska, B | 1 |
| Orzechowski, A | 1 |
| Yamaguchi, K | 1 |
| Lee, SH | 1 |
| Kim, JS | 1 |
| Wimalasena, J | 1 |
| Kitajima, S | 1 |
| Baek, SJ | 1 |
| Fedier, A | 1 |
| Erdmann, R | 1 |
| Boulikas, T | 1 |
| Fink, D | 1 |
| Zhang, YH | 1 |
| Wei, W | 1 |
| Xu, H | 1 |
| Wang, YY | 1 |
| Wu, WX | 1 |
| Oh, SY | 1 |
| Park, KS | 1 |
| Kim, JA | 1 |
| Choi, KY | 1 |
| Smith, V | 1 |
| Rowlands, MG | 1 |
| Barrie, E | 1 |
| Workman, P | 1 |
| Kelland, LR | 1 |
29 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Colorectal Neoplasms
| Article | Year |
|---|---|
PP9, a steroidal saponin, induces G2/M arrest and apoptosis in human colorectal cancer cells by inhibiting the PI3K/Akt/GSK3β pathway.
Topics: Animals; Apoptosis; Caspase 3; Cell Line, Tumor; Chromones; Colorectal Neoplasms; G2 Phase Cell Cycl | 2020 |
AIM2 inhibits colorectal cancer cell proliferation and migration through suppression of Gli1.
Topics: Adenocarcinoma; Aged; Animals; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromones; Color | 2020 |
CDCA2 promotes the proliferation of colorectal cancer cells by activating the AKT/CCND1 pathway in vitro and in vivo.
Topics: Animals; Carcinogenesis; Carrier Proteins; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation | 2019 |
PI3K/AKT signaling is essential for communication between tissue-infiltrating mast cells, macrophages, and epithelial cells in colitis-induced cancer.
Topics: Animals; Anticarcinogenic Agents; Cell Degranulation; Cell Line, Tumor; Cell Movement; Cell Prolifer | 2013 |
PI3K is required for the physical interaction and functional inhibition of NF-κB by β-catenin in colorectal cancer cells.
Topics: Androstadienes; Apoptosis; beta Catenin; Blotting, Western; Cell Line, Tumor; Chromones; Class Ia Ph | 2013 |
Loss of Smad4 in colorectal cancer induces resistance to 5-fluorouracil through activating Akt pathway.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis Regulatory Proteins; Cell Cycle Proteins; Cell L | 2014 |
Smad4 sensitizes colorectal cancer to 5-fluorouracil through cell cycle arrest by inhibiting the PI3K/Akt/CDC2/survivin cascade.
Topics: Animals; Apoptosis; CDC2 Protein Kinase; Cell Cycle Checkpoints; Cell Proliferation; Chromones; Colo | 2016 |
CHRNA7 inhibits cell invasion and metastasis of LoVo human colorectal cancer cells through PI3K/Akt signaling.
Topics: Adenocarcinoma; alpha7 Nicotinic Acetylcholine Receptor; Cell Division; Cell Line, Tumor; Cell Movem | 2016 |
Dual-Blocking of PI3K and mTOR Improves Chemotherapeutic Effects on SW620 Human Colorectal Cancer Stem Cells by Inducing Differentiation.
Topics: AC133 Antigen; Animals; Antineoplastic Agents; Cell Differentiation; Cell Line, Tumor; Cell Survival | 2016 |
IL-17A Promotes the Migration and Invasiveness of Colorectal Cancer Cells Through NF-κB-Mediated MMP Expression.
Topics: Cell Line, Tumor; Cell Movement; Chromones; Colorectal Neoplasms; Enzyme Inhibitors; HT29 Cells; Hum | 2016 |
Salvianolic acid B, a novel autophagy inducer, exerts antitumor activity as a single agent in colorectal cancer cells.
Topics: Adenine; Animals; Antineoplastic Agents; Autophagosomes; Autophagy; Autophagy-Related Protein 5; Ben | 2016 |
Gene expression patterns in mismatch repair-deficient colorectal cancers highlight the potential therapeutic role of inhibitors of the phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway.
Topics: Algorithms; Antineoplastic Agents; Benzoquinones; Cell Cycle; Cell Line, Tumor; Chromones; Colorecta | 2009 |
mTOR signal and hypoxia-inducible factor-1 alpha regulate CD133 expression in cancer cells.
Topics: AC133 Antigen; Antigens, CD; Cell Line, Tumor; Chromones; Colorectal Neoplasms; Down-Regulation; Gly | 2009 |
PI3K/Akt and GSK-3β prevents in a differential fashion the malignant phenotype of colorectal cancer cells.
Topics: Alkaline Phosphatase; beta Catenin; Cadherins; Cell Division; Cell Line, Tumor; Chromones; Colony-Fo | 2010 |
Dual blockade of phosphatidylinositol 3'-kinase and mitogen-activated protein kinase pathways overcomes paclitaxel-resistance in colorectal cancer.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Cell Proliferation; Chromones; Colo | 2011 |
The phosphoinositide 3-kinase inhibitor LY294002, decreases aminoacyl-tRNA synthetases, chaperones and glycolytic enzymes in human HT-29 colorectal cancer cells.
Topics: Adenosine Triphosphate; Amino Acyl-tRNA Synthetases; Apoptosis; Cell Line, Tumor; Chromones; Colorec | 2012 |
Leptin regulates proliferation and apoptosis of colorectal carcinoma through PI3K/Akt/mTOR signalling pathway.
Topics: Apoptosis; Asian People; Cell Proliferation; Chromones; Colorectal Neoplasms; Humans; Immunohistoche | 2012 |
The extra domain A of fibronectin increases VEGF-C expression in colorectal carcinoma involving the PI3K/AKT signaling pathway.
Topics: Aged; Animals; Carcinoma; Cell Line, Tumor; Cells, Cultured; Chromones; Colorectal Neoplasms; Enzyme | 2012 |
PI3K expression and PIK3CA mutations are related to colorectal cancer metastases.
Topics: Adult; Aged; Apoptosis; Cell Line, Tumor; Chromones; Class I Phosphatidylinositol 3-Kinases; Colorec | 2012 |
Critical role of aquaporin-3 in epidermal growth factor-induced migration of colorectal carcinoma cells and its clinical significance.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Aquaporin 3; Butadienes; Carcinoma; Cell Movem | 2013 |
Phosphorylation of Akt/PKB is required for suppression of cancer cell apoptosis and tumor progression in human colorectal carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Apoptosis; Caspase 3; Caspases; Chromones; Colorectal Neoplasms; Fem | 2002 |
Down-regulation of PIK3CG, a catalytic subunit of phosphatidylinositol 3-OH kinase, by CpG hypermethylation in human colorectal carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Azacitidine; Chromones; Chromosomes, Human, Pair 7; Colorectal Neopl | 2002 |
Prostaglandin E(2) promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-activated receptor delta.
Topics: Adenoma; Animals; Cell Survival; Chromones; Colorectal Neoplasms; Dinoprostone; Genes, APC; Humans; | 2004 |
Position of STAT-1 alpha in cycloheximide-dependent apoptosis triggered by TNF-alpha in human colorectal COLO 205 cancer cell line; role of polyphenolic compounds.
Topics: Apigenin; Apoptosis; CASP8 and FADD-Like Apoptosis Regulating Protein; Cell Line, Tumor; Cell Prolif | 2005 |
Activating transcription factor 3 and early growth response 1 are the novel targets of LY294002 in a phosphatidylinositol 3-kinase-independent pathway.
Topics: Activating Transcription Factor 3; Apoptosis; Caco-2 Cells; Chromones; Colorectal Neoplasms; Early G | 2006 |
Potential of the Akt inhibitor LY294005 to antagonize the efficacy of Cisplatin against HCT116 tumor cells in a DNA mismatch repair-dependent manner.
Topics: Adaptor Proteins, Signal Transducing; Adenocarcinoma; Antineoplastic Agents; Base Pair Mismatch; Car | 2006 |
Inducing effects of hepatocyte growth factor on the expression of vascular endothelial growth factor in human colorectal carcinoma cells through MEK and PI3K signaling pathways.
Topics: Butadienes; Cell Line, Tumor; Chromones; Colorectal Neoplasms; Gene Expression Regulation; Hepatocyt | 2007 |
Differential modulation of zinc-stimulated p21(Cip/WAF1) and cyclin D1 induction by inhibition of PI3 kinase in HT-29 colorectal cancer cells.
Topics: Chromones; Colorectal Neoplasms; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Enzyme A | 2002 |
Establishment and characterization of acquired resistance to the farnesyl protein transferase inhibitor R115777 in a human colon cancer cell line.
Topics: Alkyl and Aryl Transferases; Antineoplastic Agents; Blotting, Western; Cell Division; Chromones; Col | 2002 |