2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Colonic Neoplasms in 43 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
Colonic Neoplasms: Tumors or cancer of the COLON.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A nude mouse model for human colon cancer was constructed for tumor orthotopic expression." | 1.48 | Down-regulated paxillin suppresses cell proliferation and invasion by inhibiting M2 macrophage polarization in colon cancer. ( Shi, YB; Zhang, LF; Zhang, LL, 2018) |
| "Obesity has been associated with both the carcinogenesis and poor prognosis of colon cancer, one of the leading causes of cancer-related death." | 1.37 | Insulin decreases therapeutic efficacy in colon cancer cell line HT29 via the activation of the PI3K/Akt pathway. ( Chen, J; Hu, C; Huang, XF; Katsifis, A, 2011) |
| "Intriguingly, metastatic colon cancer cell lines such as HT29 and SW620 express higher levels of a splice variant of DR3 that has no trans-membrane domain and no death domain." | 1.37 | Survival advantages conferred to colon cancer cells by E-selectin-induced activation of the PI3K-NFκB survival axis downstream of Death receptor-3. ( Auger, FA; Gout, S; Houle, F; Huot, J; Klinck, R; Paquet, ER; Pin, AL; Poirier, A; Porquet, N; Tremblay, PL, 2011) |
| "In AZD6244-resistant cancer cells, we observed the impaired nuclear localization of FOXO3a, reduced FOXO3a-mediated transcriptional activity, and decreased the expression of FOXO3a target gene Bim after cell treatment with AZD6244." | 1.36 | Activation of FOXO3a is sufficient to reverse mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor chemoresistance in human cancer. ( Andreeff, M; Chang, CJ; Du, Y; Engelman, JA; Hortobagyi, GN; Hung, MC; Wang, Y; Wong, KK; Xia, W; Yang, JY, 2010) |
| "We also demonstrate that, in colon cancer cells, CAV-1 increased the amount of phosphorylated AKT in cells by inhibiting the activity of the AKT-negative regulators PP1 and PP2A." | 1.35 | Caveolin-1-mediated expression and secretion of kallikrein 6 in colon cancer cells. ( Cavallo-Medved, D; Gerner, EW; Henkhaus, RS; Ignatenko, NA; Roy, UK; Sloane, BF, 2008) |
| "Human colon cancer cell lines (DLD-1, LoVo, HCT15, and Colo205) and their mouse xenografts (DLD-1 and LoVo) were used in this study." | 1.31 | The in vitro and in vivo effects of 2-(4-morpholinyl)-8-phenyl-chromone (LY294002), a specific inhibitor of phosphatidylinositol 3'-kinase, in human colon cancer cells. ( Harada, M; Ito, M; Itoh, N; Semba, S; Yamakawa, M, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (6.98) | 18.2507 |
| 2000's | 18 (41.86) | 29.6817 |
| 2010's | 21 (48.84) | 24.3611 |
| 2020's | 1 (2.33) | 2.80 |
| Authors | Studies |
|---|---|
| Kaneko, R | 1 |
| Tsuji, N | 2 |
| Asanuma, K | 2 |
| Tanabe, H | 1 |
| Kobayashi, D | 1 |
| Watanabe, N | 2 |
| Sabbah, DA | 2 |
| Simms, NA | 2 |
| Brattain, MG | 4 |
| Vennerstrom, JL | 2 |
| Zhong, H | 1 |
| Melchini, A | 1 |
| Needs, PW | 1 |
| Mithen, RF | 1 |
| Traka, MH | 1 |
| Wang, W | 1 |
| Dong, Y | 1 |
| Ezell, EL | 1 |
| Zhong, HA | 1 |
| Miyazaki, K | 1 |
| Togo, S | 1 |
| Okamoto, R | 1 |
| Idiris, A | 1 |
| Kumagai, H | 1 |
| Miyagi, Y | 1 |
| Yang, C | 1 |
| Wang, MH | 1 |
| Zhou, JD | 1 |
| Chi, Q | 1 |
| Zhang, LL | 1 |
| Zhang, LF | 1 |
| Shi, YB | 1 |
| Zhang, T | 1 |
| Chen, Y | 1 |
| Wang, XP | 1 |
| Ping, Q | 1 |
| Lin, CL | 1 |
| Zhuo, SY | 1 |
| Li, XJ | 1 |
| Leem, SH | 1 |
| Park, MH | 1 |
| Kim, SM | 1 |
| Lee, H | 2 |
| Chin, H | 1 |
| Kim, K | 1 |
| Lee, D | 1 |
| Zhu, L | 1 |
| Derijard, B | 1 |
| Chakrabandhu, K | 1 |
| Wang, BS | 1 |
| Chen, HZ | 1 |
| Hueber, AO | 1 |
| Zhu, Z | 1 |
| Zhang, X | 1 |
| Guo, H | 1 |
| Fu, L | 1 |
| Pan, G | 1 |
| Sun, Y | 1 |
| Zhu, G | 2 |
| Li, X | 1 |
| Guo, B | 1 |
| Ke, Q | 1 |
| Dong, M | 1 |
| Li, F | 1 |
| Tian, S | 1 |
| Chang, W | 1 |
| Du, H | 1 |
| Bai, J | 1 |
| Sun, Z | 1 |
| Zhang, Q | 1 |
| Wang, H | 1 |
| Tao, K | 1 |
| Long, Y | 1 |
| Jiao, L | 1 |
| Li, DD | 1 |
| Yang, CL | 1 |
| Peng, RQ | 1 |
| Guo, YQ | 1 |
| Zhang, XS | 1 |
| Zhu, XF | 1 |
| Kim, DH | 1 |
| Kim, MJ | 1 |
| Sung, B | 1 |
| Suh, H | 1 |
| Jung, JH | 1 |
| Chung, HY | 1 |
| Kim, ND | 1 |
| Ikeda, R | 1 |
| Iwashita, K | 1 |
| Sumizawa, T | 1 |
| Beppu, S | 1 |
| Tabata, S | 1 |
| Tajitsu, Y | 1 |
| Shimamoto, Y | 1 |
| Yoshida, K | 1 |
| Furukawa, T | 1 |
| Che, XF | 1 |
| Yamaguchi, T | 1 |
| Ushiyama, M | 1 |
| Miyawaki, A | 1 |
| Takeda, Y | 1 |
| Yamamoto, M | 1 |
| Zhao, HY | 1 |
| Shibayama, Y | 1 |
| Yamada, K | 1 |
| Akiyama, S | 1 |
| Kline, CL | 1 |
| Olson, TL | 1 |
| Irby, RB | 1 |
| Shant, J | 1 |
| Cheng, K | 1 |
| Marasa, BS | 1 |
| Wang, JY | 1 |
| Raufman, JP | 1 |
| Liu, JJ | 1 |
| Duan, RD | 1 |
| Yang, JY | 1 |
| Chang, CJ | 1 |
| Xia, W | 1 |
| Wang, Y | 1 |
| Wong, KK | 1 |
| Engelman, JA | 1 |
| Du, Y | 1 |
| Andreeff, M | 1 |
| Hortobagyi, GN | 1 |
| Hung, MC | 1 |
| Nam, HJ | 1 |
| Chae, S | 1 |
| Jang, SH | 1 |
| Cho, H | 1 |
| Lee, JH | 1 |
| Liu, XQ | 1 |
| Rajput, A | 1 |
| Geng, L | 1 |
| Ongchin, M | 1 |
| Chaudhuri, A | 1 |
| Wang, J | 1 |
| Chen, J | 1 |
| Katsifis, A | 1 |
| Hu, C | 1 |
| Huang, XF | 1 |
| Porquet, N | 1 |
| Poirier, A | 1 |
| Houle, F | 1 |
| Pin, AL | 1 |
| Gout, S | 1 |
| Tremblay, PL | 1 |
| Paquet, ER | 1 |
| Klinck, R | 1 |
| Auger, FA | 1 |
| Huot, J | 1 |
| Duerr, EM | 1 |
| Mizukami, Y | 1 |
| Moriichi, K | 1 |
| Gala, M | 1 |
| Jo, WS | 1 |
| Kikuchi, H | 1 |
| Xavier, RJ | 1 |
| Chung, DC | 1 |
| Kisslov, L | 1 |
| Hadad, N | 1 |
| Rosengraten, M | 1 |
| Levy, R | 1 |
| Windham, TC | 1 |
| Parikh, NU | 1 |
| Siwak, DR | 1 |
| Summy, JM | 1 |
| McConkey, DJ | 1 |
| Kraker, AJ | 1 |
| Gallick, GE | 1 |
| Sordat, I | 1 |
| Decraene, C | 1 |
| Silvestre, T | 1 |
| Petermann, O | 1 |
| Auffray, C | 1 |
| Piétu, G | 1 |
| Sordat, B | 1 |
| Sawhney, RS | 1 |
| Sharma, B | 1 |
| Humphrey, LE | 1 |
| Lee, SO | 1 |
| Lou, W | 1 |
| Hou, M | 1 |
| Onate, SA | 1 |
| Gao, AC | 1 |
| Endoh, T | 1 |
| Yagihashi, A | 1 |
| Oehme, I | 1 |
| Bösser, S | 1 |
| Zörnig, M | 1 |
| Kim, IA | 1 |
| Bae, SS | 1 |
| Fernandes, A | 1 |
| Wu, J | 1 |
| Muschel, RJ | 1 |
| McKenna, WG | 1 |
| Birnbaum, MJ | 1 |
| Bernhard, EJ | 1 |
| Abdul-Ghani, R | 1 |
| Serra, V | 1 |
| Györffy, B | 1 |
| Jürchott, K | 1 |
| Solf, A | 1 |
| Dietel, M | 1 |
| Schäfer, R | 1 |
| Beales, IL | 1 |
| Ogunwobi, O | 1 |
| Henkhaus, RS | 1 |
| Roy, UK | 1 |
| Cavallo-Medved, D | 1 |
| Sloane, BF | 1 |
| Gerner, EW | 1 |
| Ignatenko, NA | 1 |
| Kotelevets, L | 1 |
| Noë, V | 1 |
| Bruyneel, E | 1 |
| Myssiakine, E | 1 |
| Chastre, E | 1 |
| Mareel, M | 1 |
| Gespach, C | 1 |
| Graness, A | 1 |
| Adomeit, A | 1 |
| Heinze, R | 1 |
| Wetzker, R | 1 |
| Liebmann, C | 1 |
| Okumura, K | 1 |
| Shirasawa, S | 1 |
| Nishioka, M | 1 |
| Sasazuki, T | 1 |
| Petiot, A | 1 |
| Ogier-Denis, E | 1 |
| Blommaart, EF | 1 |
| Meijer, AJ | 1 |
| Codogno, P | 1 |
| Venkateswarlu, S | 1 |
| Dawson, DM | 1 |
| St Clair, P | 1 |
| Gupta, A | 1 |
| Willson, JK | 1 |
| Semba, S | 1 |
| Itoh, N | 1 |
| Ito, M | 1 |
| Harada, M | 1 |
| Yamakawa, M | 1 |
1 trial available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Colonic Neoplasms
| Article | Year |
|---|---|
Survivin down-regulation plays a crucial role in 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor-induced apoptosis in cancer.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Cell Line, Tumor; Cholesterol; Colonic Neoplasms; Diterpen | 2007 |
42 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Colonic Neoplasms
| Article | Year |
|---|---|
Biological evaluation and docking studies of recently identified inhibitors of phosphoinositide-3-kinases.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Colonic Neoplasms; Dose-Response Relationship, D | 2012 |
Enhanced in vitro biological activity of synthetic 2-(2-pyridyl) ethyl isothiocyanate compared to natural 4-(methylsulfinyl) butyl isothiocyanate.
Topics: Anticarcinogenic Agents; Apoptosis; Biomarkers, Tumor; Blotting, Western; Brassica; Cell Proliferati | 2012 |
N-Phenyl-4-hydroxy-2-quinolone-3-carboxamides as selective inhibitors of mutant H1047R phosphoinositide-3-kinase (PI3Kα).
Topics: Antineoplastic Agents; Colonic Neoplasms; Drug Screening Assays, Antitumor; HCT116 Cells; Humans; Mo | 2012 |
Collective cancer cell invasion in contact with fibroblasts through integrin-α5β1/fibronectin interaction in collagen matrix.
Topics: A549 Cells; Adenocarcinoma; Amides; Benzamides; Cancer-Associated Fibroblasts; Cell Adhesion; Cell L | 2020 |
Upregulation of miR-542-3p inhibits the growth and invasion of human colon cancer cells through PI3K/AKT/survivin signaling.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Chromones; Colonic Neoplasms; Female; Gene Expressi | 2017 |
Down-regulated paxillin suppresses cell proliferation and invasion by inhibiting M2 macrophage polarization in colon cancer.
Topics: Animals; Cell Polarity; Cell Proliferation; Cells, Cultured; Chromones; Colonic Neoplasms; Down-Regu | 2018 |
[Experiment on Jianpi Qingre Huoxue Decoction Drug Serum Regulates SW480 Cell Proliferation,Apoptosis,Cycle and the Expression of β-Catenin by Altering PI3K/Akt Signal Pathway].
Topics: Apoptosis; beta Catenin; Cell Cycle; Cell Division; Cell Line, Tumor; Cell Proliferation; Chromones; | 2016 |
Regulation of YAP through an Akt-dependent process by 3, 3'-diindolylmethane in human colon cancer cells.
Topics: Anticarcinogenic Agents; Apoptosis; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Chrom | 2013 |
ERBB3 knockdown induces cell cycle arrest and activation of Bak and Bax-dependent apoptosis in colon cancer cells.
Topics: Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Blotting, Western | 2014 |
Synergism of PI3K/Akt inhibition and Fas activation on colon cancer cell death.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Chromones; Colonic Neop | 2014 |
CXCL13-CXCR5 axis promotes the growth and invasion of colon cancer cells via PI3K/AKT pathway.
Topics: Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Chemokine CXCL13; Chromones; Colonic Neopla | 2015 |
PAK5-mediated E47 phosphorylation promotes epithelial-mesenchymal transition and metastasis of colon cancer.
Topics: Active Transport, Cell Nucleus; alpha Karyopherins; Animals; Cadherins; Cell Adhesion; Cell Line, Tu | 2016 |
The interplay between GRP78 expression and Akt activation in human colon cancer cells under celecoxib treatment.
Topics: Antineoplastic Agents; Apoptosis; Celecoxib; Cell Line, Tumor; Chromones; Colonic Neoplasms; Endopla | 2015 |
Reactive oxygen species mediate oxaliplatin-induced epithelial-mesenchymal transition and invasive potential in colon cancer.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Chromones; Colonic Neoplasms; E | 2016 |
Resveratrol analogue, HS-1793, induces apoptotic cell death and cell cycle arrest through downregulation of AKT in human colon cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Proliferation; Chromones; Colonic Neo | 2017 |
Hyperosmotic stress up-regulates the expression of major vault protein in SW620 human colon cancer cells.
Topics: Animals; Cell Line, Tumor; Cell Survival; Chromones; Colonic Neoplasms; Enzyme Inhibitors; Gene Expr | 2008 |
Src activity alters alpha3 integrin expression in colon tumor cells.
Topics: Cell Adhesion; Cell Line, Tumor; Cell Movement; Chromones; Colonic Neoplasms; Down-Regulation; Extra | 2009 |
Akt-dependent NF-kappaB activation is required for bile acids to rescue colon cancer cells from stress-induced apoptosis.
Topics: Active Transport, Cell Nucleus; Apoptosis; Bile Acids and Salts; Cell Line, Tumor; Cell Nucleus; Cel | 2009 |
LY294002 enhances boswellic acid-induced apoptosis in colon cancer cells.
Topics: Anti-Inflammatory Agents; Apoptosis; Blotting, Western; Boswellia; Cell Proliferation; Chromones; Co | 2009 |
Activation of FOXO3a is sufficient to reverse mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor chemoresistance in human cancer.
Topics: Animals; Apoptosis; Benzimidazoles; Breast Neoplasms; Cell Growth Processes; Cell Line, Tumor; Chlor | 2010 |
The PI3K-Akt mediates oncogenic Met-induced centrosome amplification and chromosome instability.
Topics: 1-Phosphatidylinositol 4-Kinase; Blotting, Western; Cell Cycle; Cell Proliferation; Centrosome; Chro | 2010 |
WITHDRAWN: Restoration of transforming growth factor-beta receptor II expression in colon cancer cells with microsatellite instability increases metastatic potential in vivo.
Topics: Animals; Cell Line, Tumor; Cell Movement; Cell Survival; Chromones; Colonic Neoplasms; Enzyme Activa | 2011 |
Insulin decreases therapeutic efficacy in colon cancer cell line HT29 via the activation of the PI3K/Akt pathway.
Topics: Antineoplastic Agents; Cell Survival; Chromones; Colonic Neoplasms; Cycloheximide; Dose-Response Rel | 2011 |
Survival advantages conferred to colon cancer cells by E-selectin-induced activation of the PI3K-NFκB survival axis downstream of Death receptor-3.
Topics: Amino Acid Sequence; Apoptosis; Cell Adhesion; Cell Survival; Chromones; Colonic Neoplasms; E-Select | 2011 |
Oncogenic KRAS regulates BMP4 expression in colon cancer cell lines.
Topics: Bone Morphogenetic Protein 4; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line, Tumor; Cell P | 2012 |
HT-29 human colon cancer cell proliferation is regulated by cytosolic phospholipase A(2)α dependent PGE(2)via both PKA and PKB pathways.
Topics: Active Transport, Cell Nucleus; beta Catenin; Caco-2 Cells; Cadherins; Cell Line, Tumor; Cell Nucleu | 2012 |
Src activation regulates anoikis in human colon tumor cell lines.
Topics: Adenocarcinoma; Amino Acid Substitution; Anoikis; Apoptosis; bcl-X Protein; Caspase 3; Caspases; Cel | 2002 |
Complementary DNA arrays identify CD63 tetraspanin and alpha3 integrin chain as differentially expressed in low and high metastatic human colon carcinoma cells.
Topics: Antibodies, Blocking; Antigens, CD; Carcinoma; Cell Adhesion; Cell Adhesion Molecules; Cell Movement | 2002 |
Integrin alpha2 and extracellular signal-regulated kinase are functionally linked in highly malignant autocrine transforming growth factor-alpha-driven colon cancer cells.
Topics: Butadienes; Chromones; Colonic Neoplasms; Enzyme Inhibitors; Flavonoids; Humans; Integrin alpha2; Mi | 2003 |
Interleukin-4 enhances prostate-specific antigen expression by activation of the androgen receptor and Akt pathway.
Topics: Androgen Antagonists; Cell Nucleus; Chromones; Colonic Neoplasms; Enzyme Inhibitors; Flutamide; Gene | 2003 |
Survivin enhances telomerase activity via up-regulation of specificity protein 1- and c-Myc-mediated human telomerase reverse transcriptase gene transcription.
Topics: Chromones; Colonic Neoplasms; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Humans; | 2005 |
Agonists of an ecdysone-inducible mammalian expression system inhibit Fas Ligand- and TRAIL-induced apoptosis in the human colon carcinoma cell line RKO.
Topics: Androstadienes; Apoptosis; Apoptosis Regulatory Proteins; bcl-X Protein; Caspase 8; Caspases; Cell C | 2006 |
Selective inhibition of Ras, phosphoinositide 3 kinase, and Akt isoforms increases the radiosensitivity of human carcinoma cell lines.
Topics: Animals; Carcinoma; Cell Survival; Chromones; Colonic Neoplasms; Enzyme Inhibitors; Flavonoids; Huma | 2005 |
The PI3K inhibitor LY294002 blocks drug export from resistant colon carcinoma cells overexpressing MRP1.
Topics: Antibiotics, Antineoplastic; Apoptosis; Biological Transport; Blotting, Western; Cell Line, Tumor; C | 2006 |
Glycine-extended gastrin inhibits apoptosis in colon cancer cells via separate activation of Akt and JNK pathways.
Topics: Anthracenes; Apoptosis; Celecoxib; Cell Line, Tumor; Cell Survival; Chromones; Colonic Neoplasms; Ga | 2006 |
Caveolin-1-mediated expression and secretion of kallikrein 6 in colon cancer cells.
Topics: Caveolin 1; Cell Line, Tumor; Chromones; Colonic Neoplasms; Gene Expression Regulation, Neoplastic; | 2008 |
Inhibition by platelet-activating factor of Src- and hepatocyte growth factor-dependent invasiveness of intestinal and kidney epithelial cells. Phosphatidylinositol 3'-kinase is a critical mediator of tumor invasion.
Topics: Androstadienes; Animals; Azepines; Cell Adhesion Molecules; Cell Movement; Chromones; Colonic Neopla | 1998 |
A novel mitogenic signaling pathway of bradykinin in the human colon carcinoma cell line SW-480 involves sequential activation of a Gq/11 protein, phosphatidylinositol 3-kinase beta, and protein kinase Cepsilon.
Topics: Bradykinin; Calcium-Calmodulin-Dependent Protein Kinases; Chromones; Colonic Neoplasms; Dimerization | 1998 |
Activated Ki-Ras suppresses 12-O-tetradecanoylphorbol-13-acetate-induced activation of the c-Jun NH2-terminal kinase pathway in human colon cancer cells.
Topics: Alleles; Amino Acid Substitution; Calcium-Calmodulin-Dependent Protein Kinases; Chromones; Colonic N | 1999 |
Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells.
Topics: Adenocarcinoma; Androstadienes; Autophagy; Chromones; Colonic Neoplasms; Enzyme Inhibitors; Homeosta | 2000 |
Autocrine heregulin generates growth factor independence and blocks apoptosis in colon cancer cells.
Topics: Adenocarcinoma; Apoptosis; Autocrine Communication; Cell Cycle; Chromones; Colonic Neoplasms; Cultur | 2002 |
The in vitro and in vivo effects of 2-(4-morpholinyl)-8-phenyl-chromone (LY294002), a specific inhibitor of phosphatidylinositol 3'-kinase, in human colon cancer cells.
Topics: Animals; Apoptosis; Blotting, Western; Caspases; Cell Division; Chromones; Colonic Neoplasms; Enzyme | 2002 |