2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Cell Transformation, Neoplastic in 43 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| "As EBV-associated gastric cancer has unique features that are different from EBV (-) gastric cancer, EBV is considered to have a key role in gastric carcinogenesis." | 1.36 | LY294002 may overcome 5-FU resistance via down-regulation of activated p-AKT in Epstein-Barr virus-positive gastric cancer cells. ( Chae, HS; Kang, JH; Kim, JO; Lee, SK; Shin, JY, 2010) |
| "Refined cancer models are required if researchers are to assess the burgeoning number of potential targets for cancer therapeutics in a clinically relevant context that allows a fast turnaround." | 1.36 | Invasive three-dimensional organotypic neoplasia from multiple normal human epithelia. ( Chow, JM; Khavari, PA; Ridky, TW; Wong, DJ, 2010) |
| "Because many melanomas have (V600E)B-Raf and active Akt3, it is possible that these proteins cooperatively facilitate melanocyte transformation." | 1.35 | Akt3 and mutant V600E B-Raf cooperate to promote early melanoma development. ( Cheung, M; Madhunapantula, SV; Robertson, GP; Sharma, A, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (9.30) | 18.2507 |
| 2000's | 24 (55.81) | 29.6817 |
| 2010's | 15 (34.88) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rho, O | 1 |
| Kiguchi, K | 1 |
| Jiang, G | 1 |
| DiGiovanni, J | 1 |
| Sun, J | 2 |
| Mohlin, S | 1 |
| Lundby, A | 1 |
| Kazi, JU | 2 |
| Hellman, U | 1 |
| Påhlman, S | 1 |
| Olsen, JV | 1 |
| Rönnstrand, L | 3 |
| Rao, W | 1 |
| Xie, G | 1 |
| Zhang, Y | 1 |
| Wang, S | 1 |
| Wang, Y | 1 |
| Zhang, H | 1 |
| Song, F | 1 |
| Zhang, R | 1 |
| Yin, Q | 1 |
| Shen, L | 1 |
| Ge, H | 1 |
| Ohoka, A | 1 |
| Kajita, M | 1 |
| Ikenouchi, J | 1 |
| Yako, Y | 1 |
| Kitamoto, S | 1 |
| Kon, S | 1 |
| Ikegawa, M | 1 |
| Shimada, T | 1 |
| Ishikawa, S | 1 |
| Fujita, Y | 1 |
| Lindblad, O | 1 |
| Geletu, M | 1 |
| Guy, S | 1 |
| Greer, S | 1 |
| Raptis, L | 1 |
| García-Álvaro, M | 1 |
| Addante, A | 1 |
| Roncero, C | 1 |
| Fernández, M | 1 |
| Fabregat, I | 1 |
| Sánchez, A | 1 |
| Herrera, B | 1 |
| van Gorp, AG | 1 |
| van der Vos, KE | 1 |
| Brenkman, AB | 1 |
| Bremer, A | 1 |
| van den Broek, N | 1 |
| Zwartkruis, F | 1 |
| Hershey, JW | 1 |
| Burgering, BM | 1 |
| Calkhoven, CF | 1 |
| Coffer, PJ | 1 |
| Chu, JH | 1 |
| Yu, S | 1 |
| Hayward, SW | 1 |
| Chan, FL | 1 |
| Vitolo, MI | 1 |
| Weiss, MB | 1 |
| Szmacinski, M | 1 |
| Tahir, K | 1 |
| Waldman, T | 1 |
| Park, BH | 1 |
| Martin, SS | 1 |
| Weber, DJ | 1 |
| Bachman, KE | 1 |
| Shin, JY | 1 |
| Kim, JO | 1 |
| Lee, SK | 1 |
| Chae, HS | 1 |
| Kang, JH | 1 |
| Ridky, TW | 1 |
| Chow, JM | 1 |
| Wong, DJ | 1 |
| Khavari, PA | 1 |
| Kamishimoto, J | 1 |
| Tago, K | 1 |
| Kasahara, T | 1 |
| Funakoshi-Tago, M | 1 |
| Henken, FE | 1 |
| Banerjee, NS | 1 |
| Snijders, PJ | 1 |
| Meijer, CJ | 1 |
| De-Castro Arce, J | 1 |
| Rösl, F | 1 |
| Broker, TR | 1 |
| Chow, LT | 1 |
| Steenbergen, RD | 1 |
| Chae, JI | 1 |
| Cho, JH | 1 |
| Kim, DJ | 1 |
| Lee, KA | 1 |
| Cho, MK | 1 |
| Nam, HS | 1 |
| Woo, KM | 1 |
| Lee, SH | 1 |
| Shim, JH | 1 |
| Ho, MY | 1 |
| Tang, SJ | 1 |
| Chuang, MJ | 1 |
| Cha, TL | 2 |
| Li, JY | 1 |
| Sun, GH | 1 |
| Sun, KH | 1 |
| Berglund, FM | 1 |
| Weerasinghe, NR | 1 |
| Davidson, L | 1 |
| Lim, JC | 1 |
| Eickholt, BJ | 1 |
| Leslie, NR | 1 |
| Polzer, H | 1 |
| Janke, H | 1 |
| Schmid, D | 1 |
| Hiddemann, W | 1 |
| Spiekermann, K | 1 |
| Lewandowski, D | 1 |
| Linassier, C | 1 |
| Iochmann, S | 1 |
| Degenne, M | 1 |
| Domenech, J | 1 |
| Colombat, P | 1 |
| Binet, C | 1 |
| Hérault, O | 1 |
| Agazie, YM | 1 |
| Movilla, N | 1 |
| Ischenko, I | 1 |
| Hayman, MJ | 1 |
| Tchernitsa, OI | 1 |
| Sers, C | 1 |
| Zuber, J | 1 |
| Hinzmann, B | 1 |
| Grips, M | 1 |
| Schramme, A | 1 |
| Lund, P | 1 |
| Schwendel, A | 1 |
| Rosenthal, A | 1 |
| Schäfer, R | 1 |
| Slupianek, A | 1 |
| Skorski, T | 1 |
| Maruya, SI | 1 |
| Myers, JN | 1 |
| Weber, RS | 1 |
| Rosenthal, DI | 1 |
| Lotan, R | 1 |
| El-Naggar, AK | 1 |
| Chen, YC | 1 |
| Su, YN | 1 |
| Chou, PC | 1 |
| Chiang, WC | 1 |
| Chang, MC | 1 |
| Wang, LS | 1 |
| Teng, SC | 1 |
| Wu, KJ | 1 |
| Blázquez-Domingo, M | 1 |
| Grech, G | 1 |
| von Lindern, M | 1 |
| Zhou, BP | 1 |
| Xia, W | 1 |
| Wu, Y | 1 |
| Yang, CC | 1 |
| Chen, CT | 1 |
| Ping, B | 1 |
| Otte, AP | 1 |
| Hung, MC | 1 |
| Langenfeld, EM | 1 |
| Kong, Y | 1 |
| Langenfeld, J | 1 |
| Liang, J | 1 |
| Pan, Y | 1 |
| Zhang, D | 1 |
| Guo, C | 1 |
| Shi, Y | 1 |
| Wang, J | 1 |
| Chen, Y | 1 |
| Wang, X | 1 |
| Liu, J | 1 |
| Guo, X | 1 |
| Chen, Z | 1 |
| Qiao, T | 1 |
| Fan, D | 1 |
| Cheung, M | 1 |
| Sharma, A | 1 |
| Madhunapantula, SV | 1 |
| Robertson, GP | 1 |
| Huang, C | 2 |
| Ma, WY | 2 |
| Dong, Z | 2 |
| Schmid, PC | 1 |
| Schmid, HH | 1 |
| Grossi, M | 1 |
| La Rocca, SA | 1 |
| Pierluigi, G | 1 |
| Vannucchi, S | 1 |
| Ruaro, EM | 1 |
| Schneider, C | 1 |
| Tatò, F | 1 |
| Rosen, K | 1 |
| Rak, J | 2 |
| Jin, J | 1 |
| Kerbel, RS | 2 |
| Newman, MJ | 1 |
| Filmus, J | 2 |
| Mitsuhashi, Y | 1 |
| Sheehan, C | 1 |
| Tamir, A | 1 |
| Viloria-Petit, A | 1 |
| Mansour, SJ | 1 |
| Ahn, NG | 1 |
| Cristofanelli, B | 1 |
| Valentinis, B | 1 |
| Soddu, S | 1 |
| Rizzo, MG | 1 |
| Marchetti, A | 1 |
| Bossi, G | 1 |
| Morena, AR | 1 |
| Dews, M | 1 |
| Baserga, R | 1 |
| Sacchi, A | 1 |
| Nguyen, KT | 2 |
| Wang, WJ | 1 |
| Chan, JL | 2 |
| Wang, LH | 2 |
| Bai, RY | 1 |
| Ouyang, T | 1 |
| Miething, C | 1 |
| Morris, SW | 1 |
| Peschel, C | 1 |
| Duyster, J | 1 |
| Sheng, H | 1 |
| Shao, J | 1 |
| DuBois, RN | 1 |
| Clarke, K | 1 |
| Smith, K | 1 |
| Gullick, WJ | 1 |
| Harris, AL | 1 |
| Rosenmüller, T | 1 |
| Rydh, K | 1 |
| Nånberg, E | 1 |
| Chian, R | 1 |
| Young, S | 1 |
| Danilkovitch-Miagkova, A | 1 |
| Leonard, E | 1 |
| Ferrao, P | 1 |
| Ashman, L | 1 |
| Linnekin, D | 1 |
| Tenzer, A | 1 |
| Zingg, D | 1 |
| Rocha, S | 1 |
| Hemmings, B | 1 |
| Fabbro, D | 1 |
| Glanzmann, C | 1 |
| Schubiger, PA | 1 |
| Bodis, S | 1 |
| Pruschy, M | 1 |
| Zong, CS | 1 |
| Uttamsingh, S | 1 |
| Sachdev, P | 1 |
| Bhanot, M | 1 |
| Le, MT | 1 |
43 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Impact of mTORC1 inhibition on keratinocyte proliferation during skin tumor promotion in wild-type and BK5.AktWT mice.
Topics: Animals; Antibiotics, Antineoplastic; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell | 2014 |
The PI3-kinase isoform p110δ is essential for cell transformation induced by the D816V mutant of c-Kit in a lipid-kinase-independent manner.
Topics: Adenine; Animals; Binding Sites; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Proliferation; | 2014 |
OVA66, a tumor associated protein, induces oncogenic transformation of NIH3T3 cells.
Topics: Animals; Antigens, Neoplasm; Cell Transformation, Neoplastic; Chromones; Flavonoids; HeLa Cells; Hum | 2014 |
EPLIN is a crucial regulator for extrusion of RasV12-transformed cells.
Topics: Animals; Butadienes; Caveolae; Caveolin 1; Cell Line; Cell Transformation, Neoplastic; Chromones; Co | 2015 |
PI3 kinase is indispensable for oncogenic transformation by the V560D mutant of c-Kit in a kinase-independent manner.
Topics: Animals; Blotting, Western; Cell Line; Cell Proliferation; Cell Survival; Cell Transformation, Neopl | 2015 |
Differential effects of polyoma virus middle tumor antigen mutants upon gap junctional, intercellular communication.
Topics: Androstadienes; Animals; Antigens, Polyomavirus Transforming; Binding Sites; Catalytic Domain; Cell | 2015 |
BMP9-Induced Survival Effect in Liver Tumor Cells Requires p38MAPK Activation.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cell Tran | 2015 |
AGC kinases regulate phosphorylation and activation of eukaryotic translation initiation factor 4B.
Topics: Amino Acid Sequence; Animals; Cell Line; Cell Transformation, Neoplastic; Chromones; Eukaryotic Init | 2009 |
Development of a three-dimensional culture model of prostatic epithelial cells and its use for the study of epithelial-mesenchymal transition and inhibition of PI3K pathway in prostate cancer.
Topics: Cell Differentiation; Cell Line; Cell Transformation, Neoplastic; Chromones; Collagen; Culture Techn | 2009 |
Deletion of PTEN promotes tumorigenic signaling, resistance to anoikis, and altered response to chemotherapeutic agents in human mammary epithelial cells.
Topics: Anoikis; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Wester | 2009 |
LY294002 may overcome 5-FU resistance via down-regulation of activated p-AKT in Epstein-Barr virus-positive gastric cancer cells.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Blotting, Western; Cell Cycle; Cell Proliferation; Cell | 2010 |
Invasive three-dimensional organotypic neoplasia from multiple normal human epithelia.
Topics: Basement Membrane; Butadienes; Cell Transformation, Neoplastic; Chromones; Epithelial Cells; Gene Ex | 2010 |
Akt activation through the phosphorylation of erythropoietin receptor at tyrosine 479 is required for myeloproliferative disorder-associated JAK2 V617F mutant-induced cellular transformation.
Topics: Amino Acid Substitution; Animals; bcl-X Protein; Cell Transformation, Neoplastic; Chromones; CREB-Bi | 2011 |
PIK3CA-mediated PI3-kinase signalling is essential for HPV-induced transformation in vitro.
Topics: Alphapapillomavirus; Carcinoma; Cell Differentiation; Cell Line, Transformed; Cell Movement; Cell Pr | 2011 |
Phosphoinositol 3-kinase, a novel target molecule for the inhibitory effects of juglone on TPA-induced cell transformation.
Topics: Androstadienes; Animals; Cell Line; Cell Transformation, Neoplastic; Chromones; Cyclooxygenase 2; Cy | 2012 |
TNF-α induces epithelial-mesenchymal transition of renal cell carcinoma cells via a GSK3β-dependent mechanism.
Topics: Animals; Cadherins; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Transformation, Neoplastic; Chromo | 2012 |
Disruption of epithelial architecture caused by loss of PTEN or by oncogenic mutant p110α/PIK3CA but not by HER2 or mutant AKT1.
Topics: Breast Neoplasms; Cell Transformation, Neoplastic; Chromones; Class Ia Phosphatidylinositol 3-Kinase | 2013 |
Casitas B-lineage lymphoma mutants activate AKT to induce transformation in cooperation with class III receptor tyrosine kinases.
Topics: Animals; Apoptosis; Benzothiazoles; Binding Sites; Blotting, Western; Cell Line; Cell Line, Tumor; C | 2013 |
Phosphatidylinositol 3-kinases are involved in the all-trans retinoic acid-induced upregulation of CD38 antigen on human haematopoietic cells.
Topics: ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Androstadienes; Antigens, CD; Antigens, Differentiation; | 2002 |
The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Animals; Calcium-Calmodulin-Dependent Protein Kinas | 2003 |
Transcriptional basis of KRAS oncogene-mediated cellular transformation in ovarian epithelial cells.
Topics: Animals; Cell Transformation, Neoplastic; Chromones; Enzyme Inhibitors; Epithelial Cells; Female; Fl | 2004 |
NPM/ALK downregulates p27Kip1 in a PI-3K-dependent manner.
Topics: B-Lymphocytes; Blotting, Western; Carrier Proteins; Cell Line, Transformed; Cell Line, Tumor; Cell N | 2004 |
ICAM-5 (telencephalin) gene expression in head and neck squamous carcinoma tumorigenesis and perineural invasion!
Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Cell Adhesion Molecules; Cell Transformati | 2005 |
Overexpression of NBS1 contributes to transformation through the activation of phosphatidylinositol 3-kinase/Akt.
Topics: Agar; Animals; Blotting, Western; Cell Cycle Proteins; Cell Line, Tumor; Cell Transformation, Neopla | 2005 |
Translation initiation factor 4E inhibits differentiation of erythroid progenitors.
Topics: 5' Untranslated Regions; Animals; Blotting, Western; Cell Differentiation; Cell Line; Cell Transform | 2005 |
Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3.
Topics: 3T3 Cells; Animals; Cell Line; Cell Transformation, Neoplastic; Chlorocebus aethiops; Chromones; COS | 2005 |
Bone morphogenetic protein-2-induced transformation involves the activation of mammalian target of rapamycin.
Topics: Androstadienes; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Cell Line, Tumor; Cell Tr | 2005 |
Cellular prion protein promotes proliferation and G1/S transition of human gastric cancer cells SGC7901 and AGS.
Topics: Animals; Cell Division; Cell Line, Tumor; Cell Transformation, Neoplastic; Chromones; Cyclin D; Cycl | 2007 |
Akt3 and mutant V600E B-Raf cooperate to promote early melanoma development.
Topics: Animals; Cell Adhesion; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Chromo | 2008 |
Requirement for phosphatidylinositol 3-kinase in epidermal growth factor-induced AP-1 transactivation and transformation in JB6 P+ cells.
Topics: Androstadienes; Animals; Cell Line; Cell Transformation, Neoplastic; Chromones; Enzyme Induction; En | 1996 |
Phosphatidylinositol-3 kinase is necessary for 12-O-tetradecanoylphorbol-13-acetate-induced cell transformation and activated protein 1 activation.
Topics: Androstadienes; Animals; Cell Line; Cell Transformation, Neoplastic; Chromones; Drug Interactions; E | 1997 |
Role of Gas1 down-regulation in mitogenic stimulation of quiescent NIH3T3 cells by v-Src.
Topics: 3T3 Cells; Animals; Cell Cycle Proteins; Cell Division; Cell Transformation, Neoplastic; Chromones; | 1998 |
Downregulation of the pro-apoptotic protein Bak is required for the ras-induced transformation of intestinal epithelial cells.
Topics: Animals; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; Cell Transformation, Neoplastic; Chr | 1998 |
Oncogenes and tumor angiogenesis: differential modes of vascular endothelial growth factor up-regulation in ras-transformed epithelial cells and fibroblasts.
Topics: 3T3 Cells; Animals; Cell Division; Cell Line; Cell Transformation, Neoplastic; Chromones; Endothelia | 2000 |
Cooperative transformation of 32D cells by the combined expression of IRS-1 and V-Ha-Ras.
Topics: Androstadienes; Animals; Cell Differentiation; Cell Survival; Cell Transformation, Neoplastic; Chrom | 2000 |
Differential requirements of the MAP kinase and PI3 kinase signaling pathways in Src- versus insulin and IGF-1 receptors-induced growth and transformation of rat intestinal epithelial cells.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Line, Tra | 2000 |
Nucleophosmin-anaplastic lymphoma kinase associated with anaplastic large-cell lymphoma activates the phosphatidylinositol 3-kinase/Akt antiapoptotic signaling pathway.
Topics: Amino Acid Substitution; Androstadienes; Animals; Apoptosis; bcl-Associated Death Protein; Binding S | 2000 |
Akt/PKB activity is required for Ha-Ras-mediated transformation of intestinal epithelial cells.
Topics: Androstadienes; Animals; Apoptosis; Blotting, Northern; Blotting, Western; Cell Cycle; Cell Division | 2001 |
Mutant epidermal growth factor receptor enhances induction of vascular endothelial growth factor by hypoxia and insulin-like growth factor-1 via a PI3 kinase dependent pathway.
Topics: 3T3 Cells; Androstadienes; Animals; Cell Division; Cell Hypoxia; Cell Transformation, Neoplastic; Ch | 2001 |
Role of phosphoinositide 3OH-kinase in autocrine transformation by PDGF-BB.
Topics: Animals; Autocrine Communication; Becaplermin; Cell Line; Cell Movement; Cell Surface Extensions; Ce | 2001 |
Phosphatidylinositol 3 kinase contributes to the transformation of hematopoietic cells by the D816V c-Kit mutant.
Topics: Amino Acid Substitution; Animals; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; C | 2001 |
The phosphatidylinositide 3'-kinase/Akt survival pathway is a target for the anticancer and radiosensitizing agent PKC412, an inhibitor of protein kinase C.
Topics: Animals; Cell Line, Transformed; Cell Transformation, Neoplastic; Chromones; Down-Regulation; Enzyme | 2001 |
The role of phosphatidylinositol 3-kinase, rho family GTPases, and STAT3 in Ros-induced cell transformation.
Topics: Animals; Cell Adhesion; Cell Division; Cell Line; Cell Transformation, Neoplastic; Chick Embryo; Chr | 2002 |