2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Carcinoma, Renal Cell in 14 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
Carcinoma, Renal Cell: A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clear cell renal cell carcinoma (ccRCC) has been associated with one of the highest mortality rates among all cancers." | 1.51 | FABP5 regulates the proliferation of clear cell renal cell carcinoma cells via the PI3K/AKT signaling pathway. ( Ding, Q; Han, X; Le, W; Li, H; Lv, Q; Ma, C; Wang, G; Wang, P; Zhang, M; Zhang, Y, 2019) |
| "Metastatic renal cell carcinoma is resistant to current therapies." | 1.33 | The phosphoinositide 3-kinase/Akt pathway: a new target in human renal cell carcinoma therapy. ( Agouni, A; Danilin, S; Helwig, JJ; Jacqmin, D; Lang, H; Lindner, V; Massfelder, T; Rothhut, S; Schordan, E; Sourbier, C, 2006) |
| "A panel of breast cancer cell lines reflecting the different genetic changes occurring in human breast cancer was analyzed." | 1.31 | Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3'-kinase/Akt signaling pathway. ( Blancher, C; Harris, AL; Moore, JW; Robertson, N, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (35.71) | 29.6817 |
| 2010's | 8 (57.14) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, DE | 1 |
| Lee, J | 1 |
| Park, JW | 1 |
| Kang, H | 1 |
| Nam, YR | 1 |
| Kwon, TK | 1 |
| Kim, KS | 1 |
| Kim, S | 1 |
| Lv, Q | 1 |
| Wang, G | 1 |
| Zhang, Y | 1 |
| Han, X | 1 |
| Li, H | 1 |
| Le, W | 1 |
| Zhang, M | 1 |
| Ma, C | 1 |
| Wang, P | 1 |
| Ding, Q | 1 |
| Yamada, T | 1 |
| Horinaka, M | 1 |
| Shinnoh, M | 1 |
| Yoshioka, T | 1 |
| Miki, T | 1 |
| Sakai, T | 1 |
| Harada, K | 1 |
| Miyake, H | 1 |
| Kumano, M | 1 |
| Fujisawa, M | 1 |
| Weissinger, D | 1 |
| Tagscherer, KE | 1 |
| Macher-Göppinger, S | 1 |
| Haferkamp, A | 1 |
| Wagener, N | 1 |
| Roth, W | 1 |
| Ito, H | 1 |
| Ichiyanagi, O | 1 |
| Naito, S | 1 |
| Bilim, VN | 1 |
| Tomita, Y | 1 |
| Kato, T | 1 |
| Nagaoka, A | 1 |
| Tsuchiya, N | 1 |
| Elfiky, AA | 1 |
| Aziz, SA | 1 |
| Conrad, PJ | 1 |
| Siddiqui, S | 1 |
| Hackl, W | 1 |
| Maira, M | 1 |
| Robert, CL | 1 |
| Kluger, HM | 1 |
| Ho, MY | 1 |
| Tang, SJ | 1 |
| Chuang, MJ | 1 |
| Cha, TL | 1 |
| Li, JY | 1 |
| Sun, GH | 1 |
| Sun, KH | 1 |
| Zhu, S | 1 |
| Cohen, MB | 1 |
| Bjorge, JD | 1 |
| Mier, JW | 1 |
| Cho, DC | 1 |
| Kolb, TM | 1 |
| Duan, L | 1 |
| Davis, MA | 1 |
| Pflug, BR | 1 |
| Zheng, H | 1 |
| Udan, MS | 1 |
| D'Antonio, JM | 1 |
| Marshall, FF | 1 |
| Brooks, JD | 1 |
| Nelson, JB | 1 |
| Sourbier, C | 1 |
| Lindner, V | 1 |
| Lang, H | 1 |
| Agouni, A | 1 |
| Schordan, E | 1 |
| Danilin, S | 1 |
| Rothhut, S | 1 |
| Jacqmin, D | 1 |
| Helwig, JJ | 1 |
| Massfelder, T | 1 |
| Bussolati, B | 1 |
| Assenzio, B | 1 |
| Deregibus, MC | 1 |
| Camussi, G | 1 |
| Blancher, C | 1 |
| Moore, JW | 1 |
| Robertson, N | 1 |
| Harris, AL | 1 |
14 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Carcinoma, Renal Cell
| Article | Year |
|---|---|
Cyclin-Dependent Kinase Inhibitor BMI-1026 Induces Apoptosis by Downregulating Mcl-1 (L) and c-FLIP (L) and Inactivating p-Akt in Human Renal Carcinoma Cells.
Topics: Apoptosis; Blotting, Western; Carcinoma, Renal Cell; CASP8 and FADD-Like Apoptosis Regulating Protei | 2021 |
FABP5 regulates the proliferation of clear cell renal cell carcinoma cells via the PI3K/AKT signaling pathway.
Topics: Animals; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Proliferation; Chromones; Computational Biolo | 2019 |
A novel HDAC inhibitor OBP-801 and a PI3K inhibitor LY294002 synergistically induce apoptosis via the suppression of survivin and XIAP in renal cell carcinoma.
Topics: Apoptosis; Carcinoma, Renal Cell; Caspase 3; Cell Line, Tumor; Chromones; Drug Synergism; Enzyme Inh | 2013 |
Acquired resistance to temsirolimus in human renal cell carcinoma cells is mediated by the constitutive activation of signal transduction pathways through mTORC2.
Topics: Animals; Apoptosis; Butadienes; Carcinoma, Renal Cell; Cell Line, Tumor; Chromones; Drug Resistance, | 2013 |
The soluble Decoy Receptor 3 is regulated by a PI3K-dependent mechanism and promotes migration and invasion in renal cell carcinoma.
Topics: Carcinoma, Renal Cell; Cell Adhesion; Cell Line, Tumor; Cell Movement; Chromones; Fibronectins; Gene | 2013 |
GSK-3 directly regulates phospho-4EBP1 in renal cell carcinoma cell-line: an intrinsic subcellular mechanism for resistance to mTORC1 inhibition.
Topics: Adaptor Proteins, Signal Transducing; Carcinoma, Renal Cell; Cell Cycle Proteins; Cell Line, Tumor; | 2016 |
Characterization and targeting of phosphatidylinositol-3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in renal cell cancer.
Topics: Apoptosis; Automation; Biomarkers, Tumor; Carcinoma, Renal Cell; Cell Line, Tumor; Chromones; Drug S | 2011 |
TNF-α induces epithelial-mesenchymal transition of renal cell carcinoma cells via a GSK3β-dependent mechanism.
Topics: Animals; Cadherins; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Transformation, Neoplastic; Chromo | 2012 |
PI3K inhibition potentiates Bcl-2-dependent apoptosis in renal carcinoma cells.
Topics: Apoptosis; Biphenyl Compounds; Blotting, Western; Carcinoma, Renal Cell; Caspase 3; Caspase 8; Cell | 2013 |
Tsc2 expression increases the susceptibility of renal tumor cells to apoptosis.
Topics: Animals; Apoptosis; Carcinoma, Renal Cell; Caspase 3; Caspases; Cell Adhesion; Cell Line, Tumor; Cel | 2005 |
Endothelin-1 promotes cell survival in renal cell carcinoma through the ET(A) receptor.
Topics: Androstadienes; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Renal Cell; Cell Line, Tumo | 2007 |
The phosphoinositide 3-kinase/Akt pathway: a new target in human renal cell carcinoma therapy.
Topics: Animals; Carcinoma, Renal Cell; Cell Growth Processes; Cell Line, Tumor; Chromones; Enzyme Inhibitor | 2006 |
The proangiogenic phenotype of human tumor-derived endothelial cells depends on thrombospondin-1 downregulation via phosphatidylinositol 3-kinase/Akt pathway.
Topics: Adult; Androstadienes; Apoptosis; Blotting, Western; Carcinoma, Renal Cell; Cell Line; Chromones; Do | 2006 |
Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3'-kinase/Akt signaling pathway.
Topics: Basic Helix-Loop-Helix Transcription Factors; Blotting, Western; Breast Neoplasms; Carcinoma, Renal | 2001 |