2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Carcinoma, Epidermoid in 27 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cutaneous squamous cell carcinomas (cSCCs) account for about 20% of keratinocyte carcinomas, the most common cancer in the UK." | 1.62 | Growth and Viability of Cutaneous Squamous Cell Carcinoma Cell Lines Display Different Sensitivities to Isoform-Specific Phosphoinositide 3-Kinase Inhibitors. ( Ali, T; Bergamaschi, D; Boehm, K; Celik, S; El Hasnaouy, M; Harwood, CA; Kafaei Golahmadi, D; Kaffa, A; Leigh, IM; Lyu, Y; Maffucci, T; Mannella, V; Mirza, AN, 2021) |
| "The esophageal squamous cell carcinoma (ESCC) subtype with STMN1 overexpression has a high likelihood of lymphatic metastatic recurrence." | 1.48 | STMN1, a prognostic predictor of esophageal squamous cell carcinoma, is a marker of the activation of the PI3K pathway. ( Huang, S; Jiang, W; Song, L; Wang, Z, 2018) |
| "(MEIB) and related mechanisms in human oral squamous cell carcinoma (OSCC) cells have been systematically investigated." | 1.42 | Down-regulation of Akt by methanol extracts of Impatiens balsamina L. promotes apoptosis in human oral squamous cell carcinoma cell lines. ( Cho, SD; Choi, B; Kwon, KH; Ryu, MH; Shin, JA, 2015) |
| "Head and neck squamous cell carcinoma (HNSCC) is frequently characterized by high resistance to radiotherapy, which critically depends on both altered signaling pathways within tumor cells and their dynamic interaction with the tumor microenvironment." | 1.42 | Phosphorylation of AKT(Ser473) serves as an independent prognostic marker for radiosensitivity in advanced head and neck squamous cell carcinoma. ( Dyckhoff, G; Freier, K; Freudlsperger, C; Grabe, N; Hess, J; Hoffmann, J; Horn, D; Plinkert, P; Saure, D; Sharma, S; Weber, KJ; Weichert, W; Weißfuß, S, 2015) |
| "Epidemiological association of head and neck cancer with smokeless tobacco (ST) emphasizes the need to unravel the molecular mechanisms implicated in cancer development, and identify pharmacologically safe agents for early intervention and prevention of disease recurrence." | 1.37 | Guggulsterone targets smokeless tobacco induced PI3K/Akt pathway in head and neck cancer cells. ( Chauhan, SS; Macha, MA; Matta, A; Ralhan, R; Siu, KW, 2011) |
| "Metastatic squamous cell carcinoma (SCC) of the head and neck expresses chemokine receptor 7 (CCR7), which activates phosphoinositide-3 kinase (PI3K) to promote invasion and survival of SCC cells in the head and neck." | 1.36 | Mammalian target of rapamycin (mTOR) is involved in the survival of cells mediated by chemokine receptor 7 through PI3K/Akt in metastatic squamous cell carcinoma of the head and neck. ( Ding, X; Li, P; Liu, FY; Sun, CF; Zhao, ZJ; Zong, ZH, 2010) |
| "In general, oral squamous cell carcinoma (OSCC) cells are relatively resistant to Fas-mediated apoptosis during in vitro culture." | 1.33 | Enhancement of susceptibility to Fas-mediated apoptosis in oral squamous cell carcinoma cells by phosphatidylinositol 3-kinase inhibitor. ( Iwase, M; Kondo, G; Nagumo, M; Ohashi, M; Takaoka, S; Uchida, M; Watanabe, H, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (25.93) | 29.6817 |
| 2010's | 19 (70.37) | 24.3611 |
| 2020's | 1 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Duarte, A | 1 |
| Silveira, GG | 1 |
| Soave, DF | 1 |
| Costa, JPO | 1 |
| Silva, AR | 1 |
| Mannella, V | 1 |
| Boehm, K | 1 |
| Celik, S | 1 |
| Ali, T | 1 |
| Mirza, AN | 1 |
| El Hasnaouy, M | 1 |
| Kaffa, A | 1 |
| Lyu, Y | 1 |
| Kafaei Golahmadi, D | 1 |
| Leigh, IM | 1 |
| Bergamaschi, D | 1 |
| Harwood, CA | 1 |
| Maffucci, T | 1 |
| Wang, H | 1 |
| Deng, X | 1 |
| Zhang, J | 1 |
| Ou, Z | 1 |
| Mai, J | 1 |
| Ding, S | 1 |
| Huo, S | 1 |
| Jiang, W | 1 |
| Huang, S | 1 |
| Song, L | 1 |
| Wang, Z | 1 |
| Gen, Y | 1 |
| Yasui, K | 1 |
| Nishikawa, T | 1 |
| Yoshikawa, T | 1 |
| Islam, MR | 1 |
| Jones, SJ | 1 |
| Macluskey, M | 1 |
| Ellis, IR | 1 |
| Shin, JA | 1 |
| Ryu, MH | 1 |
| Kwon, KH | 1 |
| Choi, B | 1 |
| Cho, SD | 1 |
| Freudlsperger, C | 1 |
| Horn, D | 1 |
| Weißfuß, S | 1 |
| Weichert, W | 1 |
| Weber, KJ | 1 |
| Saure, D | 1 |
| Sharma, S | 1 |
| Dyckhoff, G | 1 |
| Grabe, N | 1 |
| Plinkert, P | 1 |
| Hoffmann, J | 1 |
| Freier, K | 1 |
| Hess, J | 1 |
| Hu, FW | 1 |
| Lee, SS | 1 |
| Yang, LC | 1 |
| Tsai, CH | 1 |
| Wang, TH | 1 |
| Chou, MY | 1 |
| Yu, CC | 1 |
| Gao, CL | 1 |
| Li, KN | 1 |
| Zhou, L | 1 |
| Tao, L | 1 |
| Zhang, M | 1 |
| Xi, R | 1 |
| Pan, S | 1 |
| Chen, X | 1 |
| Hui, B | 1 |
| Zhang, L | 1 |
| Fu, S | 1 |
| Li, X | 1 |
| Zhang, X | 2 |
| Gong, T | 1 |
| Guo, J | 1 |
| Che, S | 1 |
| Liu, FY | 1 |
| Zhao, ZJ | 1 |
| Li, P | 1 |
| Ding, X | 1 |
| Zong, ZH | 1 |
| Sun, CF | 1 |
| Han, W | 1 |
| Pan, H | 1 |
| Jiang, L | 1 |
| Wei, K | 1 |
| Zou, D | 1 |
| Zhang, Z | 2 |
| Macha, MA | 1 |
| Matta, A | 1 |
| Chauhan, SS | 1 |
| Siu, KW | 1 |
| Ralhan, R | 1 |
| Li, H | 1 |
| Gao, Q | 1 |
| Guo, L | 1 |
| Lu, SH | 1 |
| Tarquinio, SB | 1 |
| Neiva, KG | 1 |
| Polverini, PJ | 1 |
| Nör, JE | 1 |
| Tonoike, Y | 1 |
| Matsushita, K | 1 |
| Tomonaga, T | 1 |
| Katada, K | 1 |
| Tanaka, N | 1 |
| Shimada, H | 1 |
| Nakatani, Y | 1 |
| Okamoto, Y | 1 |
| Nomura, F | 1 |
| Zare, M | 1 |
| Jazii, FR | 1 |
| Soheili, ZS | 1 |
| Moghanibashi, MM | 1 |
| Ou, Y | 1 |
| Ma, L | 2 |
| Huang, Z | 1 |
| Zhou, W | 1 |
| Zhao, C | 1 |
| Zhang, B | 1 |
| Song, Y | 1 |
| Yu, C | 1 |
| Zhan, Q | 1 |
| Ko, SC | 1 |
| Huang, CR | 1 |
| Shieh, JM | 1 |
| Yang, JH | 1 |
| Chang, WC | 1 |
| Chen, BK | 1 |
| Kim, YN | 1 |
| Dam, P | 1 |
| Bertics, PJ | 1 |
| Maruya, SI | 1 |
| Myers, JN | 1 |
| Weber, RS | 2 |
| Rosenthal, DI | 2 |
| Lotan, R | 1 |
| El-Naggar, AK | 1 |
| Kondo, G | 1 |
| Iwase, M | 1 |
| Watanabe, H | 1 |
| Uchida, M | 1 |
| Takaoka, S | 1 |
| Ohashi, M | 1 |
| Nagumo, M | 1 |
| Kaneda, Y | 1 |
| Shimamoto, H | 1 |
| Matsumura, K | 1 |
| Arvind, R | 1 |
| Zhang, S | 1 |
| Sakai, E | 1 |
| Omura, K | 1 |
| Tsuchida, N | 1 |
| Mori, R | 1 |
| Ishiguro, H | 1 |
| Kimura, M | 1 |
| Mitsui, A | 1 |
| Sasaki, H | 1 |
| Tomoda, K | 1 |
| Mori, Y | 1 |
| Ogawa, R | 1 |
| Katada, T | 1 |
| Kawano, O | 1 |
| Harada, K | 1 |
| Fujii, Y | 1 |
| Kuwabara, Y | 1 |
| Lin, CY | 1 |
| Jeng, YM | 1 |
| Chou, HY | 1 |
| Hsu, HC | 1 |
| Yuan, RH | 1 |
| Chiang, CP | 1 |
| Kuo, MY | 1 |
| Gupta, AK | 1 |
| McKenna, WG | 1 |
| Weber, CN | 1 |
| Feldman, MD | 1 |
| Goldsmith, JD | 1 |
| Mick, R | 1 |
| Machtay, M | 1 |
| Bakanauskas, VJ | 1 |
| Cerniglia, GJ | 1 |
| Bernhard, EJ | 1 |
| Muschel, RJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase III Randomized Clinical Trial to Study the Radiosensitizing Effect of Nelfinavir in Locally Advanced Carcinoma of Uterine Cervix.[NCT03256916] | Phase 3 | 348 participants (Anticipated) | Interventional | 2018-01-16 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Carcinoma, Epidermoid
| Article | Year |
|---|---|
Local recurrence in head and neck cancer: relationship to radiation resistance and signal transduction.
Topics: Adult; Aged; Aged, 80 and over; Blotting, Western; Carcinoma, Squamous Cell; Cell Division; Chromone | 2002 |
26 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Carcinoma, Epidermoid
| Article | Year |
|---|---|
The Role of the LY294002 - A Non-Selective Inhibitor of Phosphatidylinositol 3-Kinase (PI3K) Pathway- in Cell Survival and Proliferation in Cell Line SCC-25.
Topics: Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chromones; | 2019 |
Growth and Viability of Cutaneous Squamous Cell Carcinoma Cell Lines Display Different Sensitivities to Isoform-Specific Phosphoinositide 3-Kinase Inhibitors.
Topics: Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Survival; Chromones; Humans; Imidazoles; Isoenzymes | 2021 |
Elevated Expression of Zinc Finger Protein 703 Promotes Cell Proliferation and Metastasis through PI3K/AKT/GSK-3β Signalling in Oral Squamous Cell Carcinoma.
Topics: Animals; Carcinoma, Squamous Cell; Carrier Proteins; Cell Cycle Checkpoints; Cell Line, Tumor; Cell | 2017 |
STMN1, a prognostic predictor of esophageal squamous cell carcinoma, is a marker of the activation of the PI3K pathway.
Topics: Carcinoma, Squamous Cell; Cell Line, Tumor; Chromones; Esophageal Neoplasms; Esophageal Squamous Cel | 2018 |
SOX2 promotes tumor growth of esophageal squamous cell carcinoma through the AKT/mammalian target of rapamycin complex 1 signaling pathway.
Topics: Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chromones; E | 2013 |
Is there a pAkt between VEGF and oral cancer cell migration?
Topics: Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Chromones; Furans; Humans; Morpholines; M | 2014 |
Down-regulation of Akt by methanol extracts of Impatiens balsamina L. promotes apoptosis in human oral squamous cell carcinoma cell lines.
Topics: Adult; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Chr | 2015 |
Phosphorylation of AKT(Ser473) serves as an independent prognostic marker for radiosensitivity in advanced head and neck squamous cell carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Squamous Cell; Chromones; Enzyme Inhib | 2015 |
Knockdown of S100A4 impairs arecoline-induced invasiveness of oral squamous cell carcinomas.
Topics: Anthracenes; Areca; Carcinoma, Squamous Cell; Chromones; Enzyme Inhibitors; Female; Humans; Lymphati | 2015 |
[A dual PI3K/mTOR inhibitor, PI-103, cooperates with TRAIL in laryngeal squamous carcinoma cells in vitro].
Topics: Animals; Apoptosis; Carcinoma, Squamous Cell; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chro | 2016 |
HPV16 E6-E7 induces cancer stem-like cells phenotypes in esophageal squamous cell carcinoma through the activation of PI3K/Akt signaling pathway in vitro and in vivo.
Topics: Animals; Carcinoma, Squamous Cell; Cell Cycle; Cell Movement; Cell Survival; Chromones; Enzyme Activ | 2016 |
Mammalian target of rapamycin (mTOR) is involved in the survival of cells mediated by chemokine receptor 7 through PI3K/Akt in metastatic squamous cell carcinoma of the head and neck.
Topics: Antibodies, Monoclonal; Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Squamous Cel | 2010 |
A novel approach to rescue immune escape in oral squamous cell carcinoma: Combined use of interferon-γ and LY294002.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; ATP Bindi | 2011 |
Guggulsterone targets smokeless tobacco induced PI3K/Akt pathway in head and neck cancer cells.
Topics: bcl-2-Associated X Protein; bcl-Associated Death Protein; Carcinoma, Squamous Cell; Chromones; Dose- | 2011 |
The PTEN/PI3K/Akt pathway regulates stem-like cells in primary esophageal carcinoma cells.
Topics: Antineoplastic Agents; ATP-Binding Cassette Transporters; Carcinoma, Squamous Cell; Cell Proliferati | 2011 |
Endothelial cell Bcl-2 and lymph node metastasis in patients with oral squamous cell carcinoma.
Topics: Biomarkers, Tumor; Blotting, Western; Carcinoma, Squamous Cell; Cells, Cultured; Chromones; Endothel | 2012 |
Adhesion molecule periplakin is involved in cellular movement and attachment in pharyngeal squamous cancer cells.
Topics: Carcinoma, Squamous Cell; Cell Adhesion; Cell Cycle; Cell Growth Processes; Cell Line, Tumor; Cell M | 2011 |
Downregulation of tropomyosin-1 in squamous cell carcinoma of esophagus, the role of Ras signaling and methylation.
Topics: Carcinoma, Squamous Cell; Cell Movement; Chromones; Down-Regulation; Enzyme Inhibitors; Esophageal N | 2012 |
Overexpression of cyclin B1 antagonizes chemotherapeutic-induced apoptosis through PTEN/Akt pathway in human esophageal squamous cell carcinoma cells.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Caspases; Cell Line, Tumor; Cell Surviva | 2013 |
Epidermal growth factor protects squamous cell carcinoma against cisplatin-induced cytotoxicity through increased interleukin-1β expression.
Topics: Biomarkers, Tumor; Blotting, Western; Carcinoma, Squamous Cell; Chromones; Cisplatin; Cytotoxins; DN | 2013 |
Caveolin-1 phosphorylation in human squamous and epidermoid carcinoma cells: dependence on ErbB1 expression and Src activation.
Topics: Androstadienes; Carcinoma, Squamous Cell; Caveolae; Caveolin 1; Caveolins; Cell Line; Chromones; Col | 2002 |
ICAM-5 (telencephalin) gene expression in head and neck squamous carcinoma tumorigenesis and perineural invasion!
Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Cell Adhesion Molecules; Cell Transformati | 2005 |
Enhancement of susceptibility to Fas-mediated apoptosis in oral squamous cell carcinoma cells by phosphatidylinositol 3-kinase inhibitor.
Topics: Androstadienes; Apoptosis; Carcinoma, Squamous Cell; CASP8 and FADD-Like Apoptosis Regulating Protei | 2006 |
Role of caspase 8 as a determinant in chemosensitivity of p53-mutated head and neck squamous cell carcinoma cell lines.
Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Carcinoma, Squamous Cell; Caspase 8 | 2006 |
PIK3CA mutation status in Japanese esophageal squamous cell carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Asian People; Carcinoma, Squamous Cell; Cell Division; Cell Line, Tu | 2008 |
Nuclear localization of annexin A1 is a prognostic factor in oral squamous cell carcinoma.
Topics: Annexin A1; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Membrane; Cell Nucleus; Chromones; Cyt | 2008 |