2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Carcinoma, Ductal, Pancreatic in 4 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
| Excerpt | Relevance | Reference |
|---|---|---|
| " The effects of PD98059, LY294002, rapamycin and its analogue CCI-779 were tested in dose-response experiments." | 1.33 | Inhibition of different intracellular signal cascades in human pancreatic cancer cells. ( Axelson, J; Hörlin, K; Lindell, M; Ohlsson, B, 2005) |
| "In PK-45H pancreatic cancer cells, the growth-inhibitory and apoptosis-inducing effects of LY294002, a PI3K inhibitor, were detected in a concentration-dependent manner, followed by the reduction of phosphorylated Akt levels." | 1.32 | Phosphorylated Akt/PKB controls cell growth and apoptosis in intraductal papillary-mucinous tumor and invasive ductal adenocarcinoma of the pancreas. ( Kimura, W; Moriya, T; Semba, S; Yamakawa, M, 2003) |
| "Flow cytometric analysis revealed that pancreatic cancer cells treated with 50 micromol/L LY294002 underwent G1 arrest, which was associated with dephosphorylation of the ppRB protein, a decrease in the protein expression of cyclin D and E, and their activating partners Cdk2, 4, and 6 with simultaneous accumulation of P27/Kip1." | 1.32 | Role of the phosphatidylinositol 3'-kinase-Akt signal pathway in the proliferation of human pancreatic ductal carcinoma cell lines. ( Adachi, K; Honjo, S; Ito, H; Osaki, M; Takeda, A, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Semba, S | 1 |
| Moriya, T | 1 |
| Kimura, W | 1 |
| Yamakawa, M | 1 |
| Takeda, A | 1 |
| Osaki, M | 1 |
| Adachi, K | 1 |
| Honjo, S | 1 |
| Ito, H | 1 |
| Axelson, J | 1 |
| Lindell, M | 1 |
| Hörlin, K | 1 |
| Ohlsson, B | 1 |
| Reichert, M | 1 |
| Saur, D | 1 |
| Hamacher, R | 1 |
| Schmid, RM | 1 |
| Schneider, G | 1 |
4 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Carcinoma, Ductal, Pancreatic
| Article | Year |
|---|---|
Phosphorylated Akt/PKB controls cell growth and apoptosis in intraductal papillary-mucinous tumor and invasive ductal adenocarcinoma of the pancreas.
Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Aged; Apoptosis; Carcinoma, Pancreatic Ductal; Carcinoma, | 2003 |
Role of the phosphatidylinositol 3'-kinase-Akt signal pathway in the proliferation of human pancreatic ductal carcinoma cell lines.
Topics: Apoptosis; Carcinoma, Pancreatic Ductal; Cell Cycle; Cell Cycle Proteins; Cell Division; Cell Line, | 2004 |
Inhibition of different intracellular signal cascades in human pancreatic cancer cells.
Topics: Antibiotics, Antineoplastic; Carcinoma, Pancreatic Ductal; Cell Division; Chromones; Culture Media, | 2005 |
Phosphoinositide-3-kinase signaling controls S-phase kinase-associated protein 2 transcription via E2F1 in pancreatic ductal adenocarcinoma cells.
Topics: Carcinoma, Pancreatic Ductal; Cell Cycle; Cell Growth Processes; Chromones; E2F1 Transcription Facto | 2007 |