2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Carcinoma, Anaplastic in 26 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ovarian cancer has the highest mortality rate among gynecologic malignant tumors." | 5.46 | Cepharanthine hydrochloride reverses P‑glycoprotein-mediated multidrug resistance in human ovarian carcinoma A2780/Taxol cells by inhibiting the PI3K/Akt signaling pathway. ( Huang, CZ; Jiang, JH; Liu, YX; Ma, F; Peng, YM; Wang, QD; Wang, YF; Zhang, Y, 2017) |
| "Ovarian cancer has the highest mortality rate among gynecologic malignant tumors." | 1.46 | Cepharanthine hydrochloride reverses P‑glycoprotein-mediated multidrug resistance in human ovarian carcinoma A2780/Taxol cells by inhibiting the PI3K/Akt signaling pathway. ( Huang, CZ; Jiang, JH; Liu, YX; Ma, F; Peng, YM; Wang, QD; Wang, YF; Zhang, Y, 2017) |
| "While in vitro, following release of breast cancer cell lines from serum starvation, the expression of Jab1, phosphor-Akt (p-Akt) was up-regulated, whereas BRSK1 and p27(Kip1) were decreased." | 1.40 | Decreased expression and prognostic role of cytoplasmic BRSK1 in human breast carcinoma: correlation with Jab1 stability and PI3K/Akt pathway. ( Chen, JH; Chen, JP; Liu, XB; Ni, QC; Sheng, CY; Wang, H; Wang, QQ; Xu, JF, 2014) |
| "PC3 and LNCaP prostate cancer cells were also sensitive to treatment with the PI3K inhibitor LY294002." | 1.36 | The Akt-inhibitor Erufosine induces apoptotic cell death in prostate cancer cells and increases the short term effects of ionizing radiation. ( Belka, C; Eibl, HJ; Handrick, R; Jendrossek, V; Rudner, J; Ruiner, CE, 2010) |
| "Human cervical cancer cell lines C-33A and HeLa were transiently cotransfected with pSG5-HPV-16 E6 or 16 E7 constructs along with HIF-1 alpha small interfering RNA (siRNA) or nonspecific siRNA." | 1.34 | Overexpression of human papillomavirus type 16 oncoproteins enhances hypoxia-inducible factor 1 alpha protein accumulation and vascular endothelial growth factor expression in human cervical carcinoma cells. ( Brown, J; Le, AD; Nishitani, J; Shi, S; Tang, X; Zhang, Q, 2007) |
| "HER-2/neu-overexpressing breast cancer cell lines were resistant to apoptosis induced by UV treatment and hypoxia, which was suppressed in the presence of the phosphatidylinositol 3-kinase inhibitors LY294002 and wortmannin, indicating a link between AKT activation and stress resistance in HER-2/neu-overexpressing cells." | 1.31 | AKT2 is frequently upregulated in HER-2/neu-positive breast cancers and may contribute to tumor aggressiveness by enhancing cell survival. ( Altomare, DA; Bacus, SS; Chin, DM; Farrell, MP; Gudkov, A; Gurova, K; Lyass, L; Testa, JR, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (3.85) | 18.2507 |
| 2000's | 10 (38.46) | 29.6817 |
| 2010's | 15 (57.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, CZ | 1 |
| Wang, YF | 1 |
| Zhang, Y | 2 |
| Peng, YM | 1 |
| Liu, YX | 1 |
| Ma, F | 1 |
| Jiang, JH | 1 |
| Wang, QD | 1 |
| Lo, MC | 1 |
| Yip, TC | 1 |
| Ngan, KC | 1 |
| Cheng, WW | 1 |
| Law, CK | 1 |
| Chan, PS | 1 |
| Chan, KC | 1 |
| Wong, CK | 1 |
| Wong, RN | 1 |
| Lo, KW | 1 |
| Ng, WT | 1 |
| Lee, WM | 1 |
| Tsao, SW | 1 |
| Kwong, LW | 1 |
| Lung, ML | 1 |
| Mak, NK | 1 |
| Wang, H | 1 |
| Liu, XB | 1 |
| Chen, JH | 1 |
| Wang, QQ | 1 |
| Chen, JP | 1 |
| Xu, JF | 1 |
| Sheng, CY | 1 |
| Ni, QC | 1 |
| Wang, YH | 1 |
| Zhou, ZB | 1 |
| Guo, CA | 1 |
| Zhai, J | 1 |
| Qi, FM | 1 |
| Li, HL | 1 |
| Zou, M | 1 |
| Baitei, EY | 1 |
| Al-Rijjal, RA | 1 |
| Parhar, RS | 1 |
| Al-Mohanna, FA | 1 |
| Kimura, S | 1 |
| Pritchard, C | 1 |
| Binessa, HA | 1 |
| Alzahrani, AS | 1 |
| Al-Khalaf, HH | 1 |
| Hawwari, A | 1 |
| Akhtar, M | 1 |
| Assiri, AM | 1 |
| Meyer, BF | 1 |
| Shi, Y | 1 |
| Habashy, HO | 1 |
| Powe, DG | 1 |
| Staka, CM | 1 |
| Rakha, EA | 1 |
| Ball, G | 1 |
| Green, AR | 1 |
| Aleskandarany, M | 1 |
| Paish, EC | 1 |
| Douglas Macmillan, R | 1 |
| Nicholson, RI | 1 |
| Ellis, IO | 1 |
| Gee, JM | 1 |
| Burrows, N | 1 |
| Resch, J | 1 |
| Cowen, RL | 1 |
| von Wasielewski, R | 1 |
| Hoang-Vu, C | 1 |
| West, CM | 1 |
| Williams, KJ | 1 |
| Brabant, G | 1 |
| Han, F | 1 |
| Zhu, HG | 1 |
| Jiang, H | 1 |
| Fan, D | 1 |
| Zhou, G | 1 |
| Li, X | 1 |
| Deng, H | 1 |
| Zhang, XT | 1 |
| Kang, LG | 1 |
| Ding, L | 1 |
| Vranic, S | 1 |
| Gatalica, Z | 1 |
| Wang, ZY | 1 |
| Rudner, J | 1 |
| Ruiner, CE | 1 |
| Handrick, R | 1 |
| Eibl, HJ | 1 |
| Belka, C | 1 |
| Jendrossek, V | 1 |
| Henken, FE | 1 |
| Banerjee, NS | 1 |
| Snijders, PJ | 1 |
| Meijer, CJ | 1 |
| De-Castro Arce, J | 1 |
| Rösl, F | 1 |
| Broker, TR | 1 |
| Chow, LT | 1 |
| Steenbergen, RD | 1 |
| Li, SS | 1 |
| Tang, QL | 1 |
| Wang, SH | 1 |
| Chen, YH | 1 |
| Liu, JJ | 1 |
| Wang, S | 2 |
| Yang, XM | 1 |
| Xiang, L | 1 |
| Xie, G | 1 |
| Ou, J | 1 |
| Wei, X | 1 |
| Pan, F | 1 |
| Liang, H | 1 |
| Li, A | 1 |
| Lu, D | 1 |
| Li, J | 1 |
| Fang, Y | 1 |
| Li, F | 1 |
| Sun, J | 1 |
| Sordat, I | 1 |
| Decraene, C | 1 |
| Silvestre, T | 1 |
| Petermann, O | 1 |
| Auffray, C | 1 |
| Piétu, G | 1 |
| Sordat, B | 1 |
| Bondar, VM | 1 |
| Sweeney-Gotsch, B | 1 |
| Andreeff, M | 1 |
| Mills, GB | 1 |
| McConkey, DJ | 1 |
| Osaki, M | 1 |
| Kase, S | 1 |
| Adachi, K | 1 |
| Takeda, A | 1 |
| Hashimoto, K | 1 |
| Ito, H | 1 |
| Rieger-Christ, KM | 1 |
| Lee, P | 1 |
| Zagha, R | 1 |
| Kosakowski, M | 1 |
| Moinzadeh, A | 1 |
| Stoffel, J | 1 |
| Ben-Ze'ev, A | 1 |
| Libertino, JA | 1 |
| Summerhayes, IC | 1 |
| Lynch, L | 1 |
| Vodyanik, PI | 1 |
| Boettiger, D | 1 |
| Guvakova, MA | 1 |
| Kim, IA | 1 |
| Bae, SS | 1 |
| Fernandes, A | 1 |
| Wu, J | 1 |
| Muschel, RJ | 1 |
| McKenna, WG | 1 |
| Birnbaum, MJ | 1 |
| Bernhard, EJ | 1 |
| Blanco-Aparicio, C | 1 |
| Pequeño, B | 1 |
| Moneo, V | 1 |
| Romero, L | 1 |
| Leal, JF | 1 |
| Velasco, J | 1 |
| Fominaya, J | 1 |
| Carnero, A | 1 |
| Toulany, M | 1 |
| Kasten-Pisula, U | 1 |
| Brammer, I | 1 |
| Chen, J | 1 |
| Dittmann, K | 1 |
| Baumann, M | 1 |
| Dikomey, E | 1 |
| Rodemann, HP | 1 |
| Tang, X | 1 |
| Zhang, Q | 1 |
| Nishitani, J | 1 |
| Brown, J | 1 |
| Shi, S | 1 |
| Le, AD | 1 |
| Xue, LY | 1 |
| Qiu, Y | 1 |
| He, J | 1 |
| Kung, HJ | 1 |
| Oleinick, NL | 1 |
| Bacus, SS | 1 |
| Altomare, DA | 1 |
| Lyass, L | 1 |
| Chin, DM | 1 |
| Farrell, MP | 1 |
| Gurova, K | 1 |
| Gudkov, A | 1 |
| Testa, JR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase III Randomized Clinical Trial to Study the Radiosensitizing Effect of Nelfinavir in Locally Advanced Carcinoma of Uterine Cervix.[NCT03256916] | Phase 3 | 348 participants (Anticipated) | Interventional | 2018-01-16 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
26 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Carcinoma, Anaplastic
| Article | Year |
|---|---|
Cepharanthine hydrochloride reverses P‑glycoprotein-mediated multidrug resistance in human ovarian carcinoma A2780/Taxol cells by inhibiting the PI3K/Akt signaling pathway.
Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member | 2017 |
Role of MIF/CXCL8/CXCR2 signaling in the growth of nasopharyngeal carcinoma tumor spheres.
Topics: Carcinoma; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromones; Gene Expression; Gene Kno | 2013 |
Decreased expression and prognostic role of cytoplasmic BRSK1 in human breast carcinoma: correlation with Jab1 stability and PI3K/Akt pathway.
Topics: Adult; Biomarkers, Tumor; Breast Neoplasms; Carcinoma; Chromones; COP9 Signalosome Complex; Cytoplas | 2014 |
Role of mimic of manganese superoxide dismutase in proliferation and apoptosis of gastric carcinoma BGC-823 cells in vitro and in vivo.
Topics: Animals; Apoptosis; Carcinoma; Caspases; Cell Line, Tumor; Chromones; Gene Expression Regulation; Hu | 2015 |
TSH overcomes Braf(V600E)-induced senescence to promote tumor progression via downregulation of p53 expression in papillary thyroid cancer.
Topics: Animals; Carcinoma; Carcinoma, Papillary; Cellular Senescence; Chromones; Disease Progression; Down- | 2016 |
Transferrin receptor (CD71) is a marker of poor prognosis in breast cancer and can predict response to tamoxifen.
Topics: Adult; Antigens, CD; Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Breast Neoplasms; Carcinoma | 2010 |
Expression of hypoxia-inducible factor 1 alpha in thyroid carcinomas.
Topics: Adenocarcinoma, Follicular; Anaerobiosis; Antigens, Neoplasm; Carbonic Anhydrase IX; Carbonic Anhydr | 2010 |
Caveolin-1 regulating the invasion and expression of matrix metalloproteinase (MMPs) in pancreatic carcinoma cells.
Topics: Carcinoma; Caveolin 1; Cell Line, Tumor; Chromones; Epithelial Cells; Extracellular Signal-Regulated | 2010 |
Phosphatidylinositol 3-kinase inhibitor(LY294002) induces apoptosis of human nasopharyngeal carcinoma in vitro and in vivo.
Topics: Animals; Apoptosis; Carcinoma; Caspase 9; Cell Line, Tumor; Chromones; Enzyme Inhibitors; Gene Expre | 2010 |
A positive feedback loop of ER-α36/EGFR promotes malignant growth of ER-negative breast cancer cells.
Topics: Animals; Antineoplastic Agents, Hormonal; Breast Neoplasms; Carcinoma; Cell Line, Tumor; Cell Prolif | 2011 |
The Akt-inhibitor Erufosine induces apoptotic cell death in prostate cancer cells and increases the short term effects of ionizing radiation.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma; Cell Death; Cell Line, Tumor; Chromones; Humans; Male; | 2010 |
PIK3CA-mediated PI3-kinase signalling is essential for HPV-induced transformation in vitro.
Topics: Alphapapillomavirus; Carcinoma; Cell Differentiation; Cell Line, Transformed; Cell Movement; Cell Pr | 2011 |
[Effects of combining tumor necrosis factor related apoptosis-inducing ligand with PI3-K-Akt inhibition on nasopharyngeal carcinoma cell].
Topics: Apoptosis; Carcinoma; Caspases; Cell Line, Tumor; Chromones; Humans; Morpholines; Nasopharyngeal Car | 2011 |
The extra domain A of fibronectin increases VEGF-C expression in colorectal carcinoma involving the PI3K/AKT signaling pathway.
Topics: Aged; Animals; Carcinoma; Cell Line, Tumor; Cells, Cultured; Chromones; Colorectal Neoplasms; Enzyme | 2012 |
Critical role of aquaporin-3 in epidermal growth factor-induced migration of colorectal carcinoma cells and its clinical significance.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Aquaporin 3; Butadienes; Carcinoma; Cell Movem | 2013 |
Complementary DNA arrays identify CD63 tetraspanin and alpha3 integrin chain as differentially expressed in low and high metastatic human colon carcinoma cells.
Topics: Antibodies, Blocking; Antigens, CD; Carcinoma; Cell Adhesion; Cell Adhesion Molecules; Cell Movement | 2002 |
Inhibition of the phosphatidylinositol 3'-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo.
Topics: Androstadienes; Animals; Apoptosis; Carcinoma; Chromones; Collagen; Dose-Response Relationship, Drug | 2002 |
Inhibition of the PI3K-Akt signaling pathway enhances the sensitivity of Fas-mediated apoptosis in human gastric carcinoma cell line, MKN-45.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma; Cell Line, Tumor; Chromones; Enzyme | 2004 |
Novel expression of N-cadherin elicits in vitro bladder cell invasion via the Akt signaling pathway.
Topics: Blotting, Western; Cadherins; Carcinoma; Cell Line, Tumor; Chromones; Clone Cells; Collagen; Drug Co | 2004 |
Insulin-like growth factor I controls adhesion strength mediated by alpha5beta1 integrins in motile carcinoma cells.
Topics: Actins; Amides; Blotting, Western; Breast Neoplasms; Butadienes; Carcinoma; Catalysis; Cell Adhesion | 2005 |
Selective inhibition of Ras, phosphoinositide 3 kinase, and Akt isoforms increases the radiosensitivity of human carcinoma cell lines.
Topics: Animals; Carcinoma; Cell Survival; Chromones; Colonic Neoplasms; Enzyme Inhibitors; Flavonoids; Huma | 2005 |
Inhibition of phosphatidylinositol-3-kinase synergizes with gemcitabine in low-passage tumor cell lines correlating with Bax translocation to the mitochondria.
Topics: bcl-2-Associated X Protein; bcl-X Protein; Carcinoma; Cell Line, Tumor; Cell Proliferation; Cell Sur | 2005 |
Blockage of epidermal growth factor receptor-phosphatidylinositol 3-kinase-AKT signaling increases radiosensitivity of K-RAS mutated human tumor cells in vitro by affecting DNA repair.
Topics: Carcinoma; Cell Line, Tumor; Chromones; DNA Repair; Dose-Response Relationship, Drug; Ellipticines; | 2006 |
Overexpression of human papillomavirus type 16 oncoproteins enhances hypoxia-inducible factor 1 alpha protein accumulation and vascular endothelial growth factor expression in human cervical carcinoma cells.
Topics: Anticarcinogenic Agents; Carcinoma; Chromones; Female; Flavonoids; HeLa Cells; Humans; Hypoxia-Induc | 2007 |
Etk/Bmx, a PH-domain containing tyrosine kinase, protects prostate cancer cells from apoptosis induced by photodynamic therapy or thapsigargin.
Topics: Apoptosis; Carcinoma; Cell Survival; Chromones; DNA Fragmentation; Enzyme Inhibitors; Humans; Male; | 1999 |
AKT2 is frequently upregulated in HER-2/neu-positive breast cancers and may contribute to tumor aggressiveness by enhancing cell survival.
Topics: Androstadienes; Apoptosis; Breast Neoplasms; Carcinoma; Cell Hypoxia; Cell Survival; Chromones; Enzy | 2002 |