Compounds > 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one
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2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Carcinoid Tumor

2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Carcinoid Tumor in 2 studies

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source

Carcinoid Tumor: A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182)

Research Excerpts

ExcerptRelevanceReference
"Human carcinoid BON cells were treated in vitro with LY294002, a PI3-kinase inhibitor, or transfected with Akt1 siRNA."1.35Inhibition of phosphatidylinositol 3-kinase/Akt signaling suppresses tumor cell proliferation and neuroendocrine marker expression in GI carcinoid tumors. ( Chen, H; Kunnimalaiyaan, M; Pitt, SC, 2009)
"Human pulmonary carcinoid NCI-H727 cells were treated with LY294002 (0 to 100 microM), a well-known PI3K inhibitor, or transfected with Akt1 small interfering RNA (75 nM)."1.35Phosphatidylinositol 3-kinase-Akt signaling in pulmonary carcinoid cells. ( Chen, H; Kunnimalaiyaan, M; Pitt, SC, 2009)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Pitt, SC2
Chen, H2
Kunnimalaiyaan, M2

Other Studies

2 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Carcinoid Tumor

ArticleYear
Inhibition of phosphatidylinositol 3-kinase/Akt signaling suppresses tumor cell proliferation and neuroendocrine marker expression in GI carcinoid tumors.
    Annals of surgical oncology, 2009, Volume: 16, Issue:10

    Topics: Biomarkers, Tumor; Blotting, Western; Carcinoid Tumor; Cell Proliferation; Chromogranin A; Chromones

2009
Phosphatidylinositol 3-kinase-Akt signaling in pulmonary carcinoid cells.
    Journal of the American College of Surgeons, 2009, Volume: 209, Issue:1

    Topics: Apoptosis; Blotting, Western; Carcinoid Tumor; Cell Line, Tumor; Cell Proliferation; Chromones; Dose

2009