2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Cancer of the Thyroid in 13 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
| Excerpt | Relevance | Reference |
|---|---|---|
| "The IG20/MADD gene is overexpressed in thyroid cancer tissues and cell lines, and can contribute to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) resistance." | 1.39 | Down-modulation of expression, or dephosphorylation, of IG20/MADD in tumor necrosis factor-related apoptosis-inducing ligand-resistant thyroid cancer cells makes them susceptible to treatment with this ligand. ( Jayarama, S; Li, LC; Pacini, F; Pilli, T; Prabhakar, BS; Qian, L, 2013) |
| "We recently demonstrated inhibition of thyroid cancer cells by the MEK inhibitor CI-1040." | 1.35 | Potent inhibition of thyroid cancer cells by the MEK inhibitor PD0325901 and its potentiation by suppression of the PI3K and NF-kappaB pathways. ( Liu, D; Xing, M, 2008) |
| "Medullary thyroid cancer (MTC) cells exhibit frequent activation of the PI3K pathway as evidenced by the presence of hyperactivation of Akt kinases and overexpression of neuroendocrine (NE) markers." | 1.33 | Apoptosis-mediated medullary thyroid cancer growth suppression by the PI3K inhibitor LY294002. ( Chen, H; Kunnimalaiyaan, M; Ndiaye, M, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (38.46) | 29.6817 |
| 2010's | 7 (53.85) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Lv, J | 1 |
| Liu, C | 1 |
| Chen, FK | 1 |
| Feng, ZP | 1 |
| Jia, L | 1 |
| Liu, PJ | 1 |
| Yang, ZX | 1 |
| Hou, F | 1 |
| Deng, ZY | 1 |
| Gunda, V | 1 |
| Bucur, O | 1 |
| Varnau, J | 1 |
| Vanden Borre, P | 1 |
| Bernasconi, MJ | 1 |
| Khosravi-Far, R | 1 |
| Parangi, S | 1 |
| Ingeson-Carlsson, C | 1 |
| Nilsson, M | 1 |
| Zou, M | 1 |
| Baitei, EY | 1 |
| Al-Rijjal, RA | 1 |
| Parhar, RS | 1 |
| Al-Mohanna, FA | 1 |
| Kimura, S | 1 |
| Pritchard, C | 1 |
| Binessa, HA | 1 |
| Alzahrani, AS | 1 |
| Al-Khalaf, HH | 1 |
| Hawwari, A | 1 |
| Akhtar, M | 1 |
| Assiri, AM | 1 |
| Meyer, BF | 1 |
| Shi, Y | 1 |
| Miao, X | 1 |
| Zhao, Y | 1 |
| Williamson, AJ | 1 |
| Doscas, ME | 1 |
| Ye, J | 1 |
| Heiden, KB | 1 |
| Xing, M | 2 |
| Li, Y | 1 |
| Prinz, RA | 1 |
| Xu, X | 1 |
| Liu, D | 1 |
| Kogai, T | 1 |
| Sajid-Crockett, S | 1 |
| Newmarch, LS | 1 |
| Liu, YY | 1 |
| Brent, GA | 1 |
| Burrows, N | 1 |
| Resch, J | 1 |
| Cowen, RL | 1 |
| von Wasielewski, R | 1 |
| Hoang-Vu, C | 1 |
| West, CM | 1 |
| Williams, KJ | 1 |
| Brabant, G | 1 |
| Li, LC | 1 |
| Jayarama, S | 1 |
| Pilli, T | 1 |
| Qian, L | 1 |
| Pacini, F | 1 |
| Prabhakar, BS | 1 |
| Motti, ML | 1 |
| Califano, D | 1 |
| Troncone, G | 1 |
| De Marco, C | 1 |
| Migliaccio, I | 1 |
| Palmieri, E | 1 |
| Pezzullo, L | 1 |
| Palombini, L | 1 |
| Fusco, A | 1 |
| Viglietto, G | 1 |
| Kunnimalaiyaan, M | 1 |
| Ndiaye, M | 1 |
| Chen, H | 1 |
| Furuya, F | 1 |
| Lu, C | 1 |
| Willingham, MC | 1 |
| Cheng, SY | 1 |
13 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Cancer of the Thyroid
| Article | Year |
|---|---|
M2‑like tumour‑associated macrophage‑secreted IGF promotes thyroid cancer stemness and metastasis by activating the PI3K/AKT/mTOR pathway.
Topics: Adult; Aged; Antibodies, Neutralizing; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Cell | 2021 |
Blocks to thyroid cancer cell apoptosis can be overcome by inhibition of the MAPK and PI3K/AKT pathways.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosi | 2014 |
Dual contribution of MAPK and PI3K in epidermal growth factor-induced destabilization of thyroid follicular integrity and invasion of cells into extracellular matrix.
Topics: Animals; Butadienes; Cell Movement; Cell Survival; Chromones; Enzyme Inhibitors; Epidermal Growth Fa | 2014 |
TSH overcomes Braf(V600E)-induced senescence to promote tumor progression via downregulation of p53 expression in papillary thyroid cancer.
Topics: Animals; Carcinoma; Carcinoma, Papillary; Cellular Senescence; Chromones; Disease Progression; Down- | 2016 |
ST6GalNAcII mediates tumor invasion through PI3K/Akt/NF-κB signaling pathway in follicular thyroid carcinoma.
Topics: Adenocarcinoma, Follicular; Animals; Cell Line, Tumor; Chromones; Gene Expression Regulation, Neopla | 2016 |
The sonic hedgehog signaling pathway stimulates anaplastic thyroid cancer cell motility and invasiveness by activating Akt and c-Met.
Topics: Cadherins; Cell Line, Tumor; Cell Movement; Chromones; Enzyme Activation; Epithelial-Mesenchymal Tra | 2016 |
Potent inhibition of thyroid cancer cells by the MEK inhibitor PD0325901 and its potentiation by suppression of the PI3K and NF-kappaB pathways.
Topics: Benzamides; Cell Adhesion; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromones; Diphenylamin | 2008 |
Phosphoinositide-3-kinase inhibition induces sodium/iodide symporter expression in rat thyroid cells and human papillary thyroid cancer cells.
Topics: Animals; Blotting, Western; Cell Line; Cell Line, Tumor; Chromones; Cycloheximide; Gene Expression; | 2008 |
Expression of hypoxia-inducible factor 1 alpha in thyroid carcinomas.
Topics: Adenocarcinoma, Follicular; Anaerobiosis; Antigens, Neoplasm; Carbonic Anhydrase IX; Carbonic Anhydr | 2010 |
Down-modulation of expression, or dephosphorylation, of IG20/MADD in tumor necrosis factor-related apoptosis-inducing ligand-resistant thyroid cancer cells makes them susceptible to treatment with this ligand.
Topics: Apoptosis; Cell Line, Tumor; Chromones; Death Domain Receptor Signaling Adaptor Proteins; Drug Resis | 2013 |
Complex regulation of the cyclin-dependent kinase inhibitor p27kip1 in thyroid cancer cells by the PI3K/AKT pathway: regulation of p27kip1 expression and localization.
Topics: Androstadienes; Blotting, Western; Bromodeoxyuridine; Cell Cycle Proteins; Cell Line, Tumor; Chromon | 2005 |
Apoptosis-mediated medullary thyroid cancer growth suppression by the PI3K inhibitor LY294002.
Topics: Apoptosis; Basic Helix-Loop-Helix Transcription Factors; Carcinoma, Medullary; Caspase 3; Cell Line, | 2006 |
Inhibition of phosphatidylinositol 3-kinase delays tumor progression and blocks metastatic spread in a mouse model of thyroid cancer.
Topics: Adenocarcinoma, Follicular; Animals; Apoptosis; Caspase 3; Cell Movement; Cell Proliferation; Chromo | 2007 |