2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Cancer of Liver in 53 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (1.89) | 18.2507 |
| 2000's | 15 (28.30) | 29.6817 |
| 2010's | 37 (69.81) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Melchini, A; Mithen, RF; Needs, PW; Traka, MH | 1 |
| Li, W; Wang, M; Wu, D; Zhu, Y | 1 |
| Dai, H; Li, J; Ling, S; Liu, J; Lu, D; Shan, Q; Song, P; Wen, X; Xie, H; Xu, X; Zheng, S; Zhou, L | 1 |
| Bai, PS; Kong, Y; Sun, H; Xia, N | 1 |
| Endo, H; Ito, K; Nezu, T; Okada, C; Owada, S; Shida, Y; Tatemichi, M | 1 |
| Guo, J; Ji, Y; Pang, Z; Shen, J; Wei, W; Xu, Y; Yu, H; Zhou, W; Zhu, X | 1 |
| Cao, Y; Cheng, J; He, K; Tang, L; Wang, X; Xia, J; Yu, X | 1 |
| Bai, J; Bu, X; Cheng, AB; Ma, JH; Mo, YB; Wang, JJ; Wang, YW; Xie, YX; Zhang, JW; Zhou, LJ | 1 |
| Cui, L; Li, X; Shao, J; Tan, Z; Zhang, X | 1 |
| Feng, JL; Li, GP; Liu, LX; Pu, ZJ; Wu, LF; Zhou, XT; Zhu, HC | 1 |
| Hou, Y; Jiang, X; Sun, G; Yang, J; Zhu, Z | 1 |
| Pan, D; Qin, Y; Shen, H; Wang, J; Wang, S; Wang, X; Wu, C; Xu, S; Ye, G; Ye, H | 1 |
| Du, Y; Huang, Y; Jin, Y; Meng, J; Sun, M; Tang, J; Wang, B; Wu, J; Zhang, J; Zhang, Y | 1 |
| Geng, YJ; Jin, S; Lv, GY; Ma, J; Wang, GY; Xie, SL | 1 |
| Baba, A; Kochi, T; Kubota, M; Moriwaki, H; Ohno, T; Shimizu, M; Shirakami, Y; Terakura, D; Tsurumi, H | 1 |
| Ding, X; Dong, S; Gao, J; Ke, S; Kong, F; Kong, J; Sun, W; Wang, S; Zheng, L | 1 |
| Chao, C; Djukom, C; Hellmich, MR; Mrazek, A; Porro, LJ; Townsend, CM | 1 |
| Atabey, N; Erdal, E; Karademir, S; Kunter, I; Nart, D; Sagol, O; Yilmaz, F | 1 |
| Chen, L; Ding, Y; Li, Q; Liu, T; Peng, S; Sun, Q; Wang, R; Wang, W; Yang, H; Zhang, Y; Zheng, L | 1 |
| Dong, M; Guo, B; Ke, Q; Li, F; Li, X; Zhu, G | 1 |
| Addante, A; Fabregat, I; Fernández, M; García-Álvaro, M; Herrera, B; Roncero, C; Sánchez, A | 1 |
| Li, LQ; Lu, SD; Peng, NF; Peng, YC; Xie, ZB; You, XM; Zhong, JH | 1 |
| Cai, JB; Dong, ZR; Fan, J; Gao, DM; Gao, PT; Hu, ZQ; Huang, XY; Ke, AW; Li, KS; Shen, YH; Shi, GM; Tian, MX; Zhang, C; Zhang, PF | 1 |
| Chen, L; Chen, XP; Li, GZ; Liang, HF; Zhang, BX; Zhou, HH | 1 |
| Guo, H; Khan, YH; Li, J; Qin, Y; Sui, C; Wang, H; Wang, J; Xie, F; Ye, J; Ye, L; Yuan, L; Yuan, M | 1 |
| Chen, Q; Lin, JS; Liu, ZY; Yu, Q | 1 |
| Li, LQ; Lu, SD; Pang, YB; Peng, NF; Peng, YC; Xie, ZB; You, XM; Zhong, JH; Zhu, SL | 1 |
| Fu, Z; Jia, J; Li, JP; Lu, R; Wang, L; Wang, S; Xu, HX; Xu, Q; Yao, Z; Zhu, ZF | 1 |
| Chen, KF; Chen, PJ; Cheng, AL; Hsieh, HP; Hsu, C; Hsu, CH; Lu, YS; Yeh, PY | 1 |
| Fu, Y; Liao, J; Liu, M; Luo, M; Tian, D; Wang, B; Xia, L; Yan, W; Zhu, Q | 1 |
| Cheng, C; Cui, X; Gao, S; He, S; Ke, Q; Li, P; Liu, Y; Lu, M; Shen, A; Wang, Y; Xue, W; Zhao, Y | 1 |
| Cai, X; Fan, J; Li, X; Li, Z; Liu, M; Liu, Y; Mei, C; Qiu, S; Shi, Y; Sun, L; Wang, C; Wang, L; Yang, Y; Yao, W; Zha, X | 1 |
| Buontempo, F; Capitani, S; Cetin-Atalay, R; Ersahin, T; Etro, D; Missiroli, S; Neri, ML; Ozturk, M; Senturk, S | 1 |
| Aderca, I; Adjei, AA; Hu, C; Lai, JP; Moser, CD; Murphy, LM; Roberts, LR; Sanderson, S; Sandhu, DS; Shire, AM; Yu, C | 1 |
| Cao, W; Hong, T; Liu, HY; Liu, Z; Mei, S; Ning, J; Yang, X | 1 |
| Cohen, L; Gao, Y; Gu, K; Li, HX; Meng, ZQ; Wang, P; Xu, LT; Xu, LY; Yang, PY | 1 |
| Jiao, M; Nan, KJ | 1 |
| Dekervel, J; Nevens, F; Van Cutsem, E; van Malenstein, H; van Pelt, J; Verslype, C; Windmolders, P | 1 |
| Bian, J; Chen, J; Gong, Y; Huo, X; Liu, AM; Luk, JM; Tang, C; Xu, Z; Zhang, Q | 1 |
| Deccache, Y; Demazy, C; Dumont, V; Michiels, C; Mottet, D; Ninane, N; Raes, M | 1 |
| Chen, HL; Guo, P; Ma, J; Qi, HL; Zhang, XY; Zhang, Y | 1 |
| Franklin, JL; Keeton, AB; Messina, JL; Xu, J | 1 |
| Bortoff, KD; Franklin, JL; Keeton, AB; Messina, JL | 1 |
| Bi, F; Fan, D; Liu, N; Pan, Y; Shi, Y; Xue, Y; Yao, X; Zhang, S; Zhang, X; Zheng, Y | 1 |
| Saisho, H; Tomizawa, M | 2 |
| Mistafa, O; Roudier, E; Stenius, U | 1 |
| Hashimoto, N; Miyakoshi, M; Ogawa, K; Tamakawa, S; Tanaka, H; Tokusashi, Y; Yaginuma, Y; Yamamoto, M; Yokoyama, K; Yoshie, M | 1 |
| Gu, J; Jiang, J; Liu, D; Shen, J; Wei, Y; Zhou, J; Zhou, L | 1 |
| Bácsy, E; Bander, E; Buday, L; Faragó, A; Farkas, G; Sipeki, S; Ways, DK | 1 |
| Chen, HL; Guo, HB; Huang, CX; Huang, Y; Ma, J; Shen, ZH | 1 |
| Banfi, C; Eriksson, P; Giandomenico, G; Hamsten, A; Mussoni, L; Sironi, L; Tremoli, E | 1 |
| Fujita, N; Hirohashi, S; Nakanishi, K; Sakamoto, M; Takamura, M; Todo, S; Tsuruo, T; Yasuda, J | 1 |
53 other study(ies) available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Cancer of Liver
| Article | Year |
|---|---|
Enhanced in vitro biological activity of synthetic 2-(2-pyridyl) ethyl isothiocyanate compared to natural 4-(methylsulfinyl) butyl isothiocyanate.
Topics: Anticarcinogenic Agents; Apoptosis; Biomarkers, Tumor; Blotting, Western; Brassica; Cell Proliferation; Colonic Neoplasms; Diet; Gene Expression Profiling; Humans; Isothiocyanates; Liver Neoplasms; Male; Oligonucleotide Array Sequence Analysis; Prostatic Neoplasms; Signal Transduction; Sulfoxides; Thiocyanates; Tumor Cells, Cultured | 2012 |
C-Terminus of E1A Binding Protein 1 Stimulates Malignant Phenotype in Human Hepatocellular Carcinoma.
Topics: Aged; Alcohol Oxidoreductases; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromones; DNA-Binding Proteins; Female; Humans; Liver Neoplasms; Male; Middle Aged; Morpholines; Neoplasm Invasiveness; Neoplasm Metastasis; Phenotype; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction | 2019 |
USP22 mediates the multidrug resistance of hepatocellular carcinoma via the SIRT1/AKT/MRP1 signaling pathway.
Topics: Adaptor Proteins, Signal Transducing; Analysis of Variance; Animals; Apoptosis Regulatory Proteins; ATP Binding Cassette Transporter, Subfamily B; Carcinoma, Hepatocellular; Cell Line, Tumor; Chromones; Disease Models, Animal; Down-Regulation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Enzyme Inhibitors; Humans; Liver Neoplasms; Male; Mice; Mice, Nude; Morpholines; Multidrug Resistance-Associated Proteins; Sirtuin 1; Thiolester Hydrolases; Ubiquitin Thiolesterase; Xenograft Model Antitumor Assays | 2017 |
Pleiotrophin, a target of miR-384, promotes proliferation, metastasis and lipogenesis in HBV-related hepatocellular carcinoma.
Topics: Adult; Carcinoma, Hepatocellular; Carrier Proteins; Cell Proliferation; Chromones; Cytokines; fas Receptor; Female; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Hepatitis B; Hepatitis B virus; Hepatocytes; Host-Pathogen Interactions; Humans; Lipogenesis; Liver Neoplasms; Lymphatic Metastasis; Male; Mechanistic Target of Rapamycin Complex 1; MicroRNAs; Middle Aged; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction; Sirolimus; Sterol Regulatory Element Binding Protein 1; Syndecan-3; Trans-Activators; Viral Regulatory and Accessory Proteins | 2017 |
Autophagy‑mediated adaptation of hepatocellular carcinoma cells to hypoxia‑mimicking conditions constitutes an attractive therapeutic target.
Topics: AMP-Activated Protein Kinases; Apoptosis; Autophagy; Carcinoma, Hepatocellular; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Chromones; Cobalt; Gene Knockdown Techniques; Humans; Liver Neoplasms; Macrolides; Morpholines; Oxygen; Signal Transduction | 2018 |
Elongator promotes the migration and invasion of hepatocellular carcinoma cell by the phosphorylation of AKT.
Topics: Animals; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Chromones; DNA Damage; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Hep G2 Cells; Histone Acetyltransferases; Humans; Liver Neoplasms; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Nude; Morpholines; Neoplasm Invasiveness; Neoplasm Metastasis; Nerve Tissue Proteins; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; Wound Healing | 2018 |
Baicalein and Ly294002 induces liver cancer cells apoptosis via regulating phosphatidyl inositol 3-kinase/Akt signaling pathway.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromones; Flavanones; Humans; Liver Neoplasms; Morpholines; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Signal Transduction | 2018 |
Erinacine Facilitates the Opening of the Mitochondrial Permeability Transition Pore Through the Inhibition of the PI3K/ Akt/GSK-3β Signaling Pathway in Human Hepatocellular Carcinoma.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Chromones; Diterpenes; Female; Glycogen Synthase Kinase 3 beta; Hep G2 Cells; Humans; Liver Neoplasms; Male; Membrane Potential, Mitochondrial; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Morpholines; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction | 2018 |
Docetaxel promotes cell apoptosis and decreases SOX2 expression in CD133‑expressing hepatocellular carcinoma stem cells by suppressing the PI3K/AKT signaling pathway.
Topics: AC133 Antigen; Adult; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Proliferation; Cells, Cultured; Chromones; Docetaxel; Female; Gene Expression Regulation, Neoplastic; Humans; Liver; Liver Neoplasms; Male; Middle Aged; Morpholines; Neoplastic Stem Cells; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Primary Cell Culture; Proto-Oncogene Proteins c-akt; Signal Transduction; SOXB1 Transcription Factors; Up-Regulation | 2019 |
Inhibition of autophagy enhances adenosine‑induced apoptosis in human hepatoblastoma HepG2 cells.
Topics: Adenosine; AMP-Activated Protein Kinases; Apoptosis; Autophagy; Autophagy-Related Protein-1 Homolog; Cell Survival; Chromones; Dose-Response Relationship, Drug; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; G1 Phase Cell Cycle Checkpoints; Gene Knockdown Techniques; Hep G2 Cells; Hepatoblastoma; Humans; Intracellular Signaling Peptides and Proteins; Liver Neoplasms; Morpholines; RNA, Small Interfering; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2019 |
Nuclear forkhead box O3a accumulation contributing to the proliferative suppression in liver cancer cells by PI3K/Akt signaling pathway.
Topics: Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Cell Survival; Chromones; Forkhead Box Protein O3; Humans; Liver Neoplasms; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction | 2018 |
Lamc1 promotes the Warburg effect in hepatocellular carcinoma cells by regulating PKM2 expression through AKT pathway.
Topics: Apoptosis; Carcinoma, Hepatocellular; Carrier Proteins; Chromones; Glucose; Hep G2 Cells; Humans; Laminin; Liver; Liver Neoplasms; Membrane Proteins; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Thyroid Hormone-Binding Proteins; Thyroid Hormones | 2019 |
RACK1 promotes the proliferation, migration and invasion capacity of mouse hepatocellular carcinoma cell line in vitro probably by PI3K/Rac1 signaling pathway.
Topics: Animals; Anthracenes; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Liver Neoplasms; Lymphatic Metastasis; Male; Mice; Mice, Inbred Strains; Morpholines; Neoplasm Invasiveness; Neuropeptides; Phosphatidylinositol 3-Kinases; rac1 GTP-Binding Protein; Receptors for Activated C Kinase; Signal Transduction; Transfection | 2013 |
In vitro regulation of hepatocellular carcinoma cell viability, apoptosis, invasion, and AEG-1 expression by LY294002.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Adhesion Molecules; Cell Survival; Chromones; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Membrane Proteins; Morpholines; Neoplasm Invasiveness; RNA-Binding Proteins; Tumor Cells, Cultured | 2014 |
Synergistic growth inhibition by acyclic retinoid and phosphatidylinositol 3-kinase inhibitor in human hepatoma cells.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Chromones; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Drug Synergism; Extracellular Signal-Regulated MAP Kinases; Hepatocytes; Humans; Liver Neoplasms; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Retinoid X Receptor alpha; Retinoid X Receptor beta; Tretinoin | 2013 |
Insufficient radiofrequency ablation promotes epithelial-mesenchymal transition of hepatocellular carcinoma cells through Akt and ERK signaling pathways.
Topics: Animals; Carcinoma, Hepatocellular; Catheter Ablation; Cell Line, Tumor; Chromones; Disease Progression; Epithelial-Mesenchymal Transition; Flavonoids; Humans; Liver Neoplasms; MAP Kinase Signaling System; Mice; Mice, Nude; Morpholines; Neoplasm Metastasis; Proto-Oncogene Proteins c-akt | 2013 |
Dual inhibition of PI3K and mTOR signaling pathways decreases human pancreatic neuroendocrine tumor metastatic progression.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Chromones; Disease Progression; Enzyme Inhibitors; Everolimus; Female; Humans; Immunosuppressive Agents; Liver Neoplasms; Mice; Mice, Nude; Morpholines; Neuroendocrine Tumors; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Tumor Burden; Xenograft Model Antitumor Assays | 2014 |
Active form of AKT controls cell proliferation and response to apoptosis in hepatocellular carcinoma.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Chromones; Cisplatin; Enzyme Activation; Enzyme Inhibitors; Female; G1 Phase Cell Cycle Checkpoints; Humans; Liver; Liver Neoplasms; Male; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction | 2014 |
MiR-20a Induces Cell Radioresistance by Activating the PTEN/PI3K/Akt Signaling Pathway in Hepatocellular Carcinoma.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Chromones; Humans; Liver Neoplasms; Luciferases; MicroRNAs; Morpholines; Neoplasm Proteins; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Radiation Tolerance; Real-Time Polymerase Chain Reaction; RNA, Neoplasm; Signal Transduction; Tumor Stem Cell Assay | 2015 |
PAK5-mediated E47 phosphorylation promotes epithelial-mesenchymal transition and metastasis of colon cancer.
Topics: Active Transport, Cell Nucleus; alpha Karyopherins; Animals; Cadherins; Cell Adhesion; Cell Line, Tumor; Cell Movement; Chromones; Colonic Neoplasms; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; Genes, Reporter; Hepatocyte Growth Factor; Humans; Liver Neoplasms; Mice; Mice, Nude; Morpholines; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; p21-Activated Kinases; Phenotype; Phosphorylation; Phosphoserine; Protein Binding; Protein Interaction Mapping; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Transcription Factor 3; Transcription, Genetic | 2016 |
BMP9-Induced Survival Effect in Liver Tumor Cells Requires p38MAPK Activation.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Chromones; Enzyme Activation; Growth Differentiation Factor 2; Growth Differentiation Factors; Hep G2 Cells; Humans; Liver Neoplasms; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Signal Transduction | 2015 |
Combination of 5-fluorouracil and 2-morphilino-8-phenyl-4H-chromen-4-one may inhibit liver cancer stem cell activity.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromones; Fluorouracil; Humans; Immunohistochemistry; Liver Neoplasms; Mice; Mice, Nude; Morpholines; Neoplastic Stem Cells; Polymerase Chain Reaction; Xenograft Model Antitumor Assays | 2016 |
Galectin-1 induces hepatocellular carcinoma EMT and sorafenib resistance by activating FAK/PI3K/AKT signaling.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Chromones; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Focal Adhesion Kinase 1; Galectin 1; Humans; Integrin alphaVbeta3; Liver Neoplasms; Male; Mice; Mice, Inbred C57BL; Mice, Nude; Morpholines; Neoplasm Invasiveness; Niacinamide; Phenylurea Compounds; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; RNA Interference; Signal Transduction; Sorafenib; Survival Rate | 2016 |
Smad3 Sensitizes Hepatocelluar Carcinoma Cells to Cisplatin by Repressing Phosphorylation of AKT.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Chromones; Cisplatin; Cyclin-Dependent Kinase Inhibitor p21; Drug Resistance, Neoplasm; Humans; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Morpholines; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Signal Transduction; Smad3 Protein; Transplantation, Heterologous | 2016 |
Slit2 and Robo1 induce opposing effects on metastasis of hepatocellular carcinoma Sk-hep-1 cells.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Chromones; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Intercellular Signaling Peptides and Proteins; Liver Neoplasms; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Morpholines; Neoplasm Metastasis; Neoplasm Proteins; Nerve Tissue Proteins; Phosphatidylinositol 3-Kinases; Receptors, Immunologic; Roundabout Proteins; Signal Transduction | 2016 |
Mcl-1 as a potential therapeutic target for human hepatocelluar carcinoma.
Topics: Adenoma, Liver Cell; Apoptosis; Biomarkers, Tumor; Chromones; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Liver Neoplasms; Morpholines; Myeloid Cell Leukemia Sequence 1 Protein; RNA, Small Interfering; Transfection; Tumor Suppressor Protein p53 | 2016 |
[Role of PI3K/AKT signaling pathway in clonogenicity and tumorigenicity of CD90+ stem-like cells of the hepatocellular carcinoma cell line MHCC-97H].
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Chromones; Humans; Liver Neoplasms; Mice; Mice, Nude; Morpholines; Neoplasm Transplantation; Neoplastic Stem Cells; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Thy-1 Antigens | 2016 |
Growth differentiation factor 15 induces growth and metastasis of human liver cancer stem-like cells via AKT/GSK-3β/β-catenin signaling.
Topics: Animals; beta Catenin; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Chromones; Enzyme Inhibitors; Female; Glycogen Synthase Kinase 3 beta; Growth Differentiation Factor 15; Humans; Immunohistochemistry; Liver Neoplasms; Male; Mice, Inbred NOD; Mice, SCID; Middle Aged; Morpholines; Neoplasm Metastasis; Neoplastic Stem Cells; Proto-Oncogene Proteins c-akt; RNA Interference; Signal Transduction; Spheroids, Cellular; Transplantation, Heterologous | 2017 |
Bortezomib overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells in part through the inhibition of the phosphatidylinositol 3-kinase/Akt pathway.
Topics: Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Carcinoma, Hepatocellular; Cell Line, Tumor; Chromones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Liver Neoplasms; Morpholines; NF-kappa B; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrazines; RNA, Small Interfering; TNF-Related Apoptosis-Inducing Ligand | 2009 |
PI3 kinase/Akt signaling mediates epithelial-mesenchymal transition in hypoxic hepatocellular carcinoma cells.
Topics: Carcinoma, Hepatocellular; Cell Hypoxia; Chromones; Epithelium; Humans; Liver Neoplasms; Mesoderm; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt | 2009 |
Phosphorylated p27Kip1 on Thr157 is an important prognosis in human hepatocellular carcinoma in vivo and in vitro.
Topics: Adult; Aged; Blotting, Western; Carcinoma, Hepatocellular; Cell Cycle; Chromones; Cyclin-Dependent Kinase Inhibitor p27; Female; Humans; Immunoenzyme Techniques; In Vitro Techniques; Ki-67 Antigen; Liver Neoplasms; Male; Middle Aged; Morpholines; Mutant Proteins; Mutation; Phosphorylation; Prognosis; Threonine; Tumor Cells, Cultured | 2011 |
Transcriptional and post-transcriptional control of DNA methyltransferase 3B is regulated by phosphatidylinositol 3 kinase/Akt pathway in human hepatocellular carcinoma cell lines.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Chromones; DNA (Cytosine-5-)-Methyltransferases; DNA Methyltransferase 3B; Gene Expression Regulation; Humans; Liver Neoplasms; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; RNA Processing, Post-Transcriptional; RNA Stability; RNA, Messenger; Transcription, Genetic | 2010 |
Inhibition of Akt signaling in hepatoma cells induces apoptotic cell death independent of Akt activation status.
Topics: Androstadienes; Antineoplastic Agents; Apoptosis; Benzimidazoles; Carcinoma, Hepatocellular; Cell Line, Tumor; Chromones; Humans; Inhibitory Concentration 50; Liver Neoplasms; Morpholines; Proto-Oncogene Proteins c-akt; Quinoxalines; Signal Transduction; Wortmannin | 2011 |
Sulfatase 2 protects hepatocellular carcinoma cells against apoptosis induced by the PI3K inhibitor LY294002 and ERK and JNK kinase inhibitors.
Topics: Apoptosis; bcl-Associated Death Protein; Blotting, Western; Carcinoma, Hepatocellular; Caspase 3; Caspase 7; Cell Line, Tumor; Cell Survival; Chromones; Cyclin D1; Extracellular Signal-Regulated MAP Kinases; Humans; Immunohistochemistry; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Signal Transduction; Sulfatases; Sulfotransferases; Transfection | 2010 |
Insulin and insulin signaling play a critical role in fat induction of insulin resistance in mouse.
Topics: Acyl Coenzyme A; Adenosine Diphosphate; Adenosine Triphosphate; Adipose Tissue; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Chromones; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Fatty Acids; Hepatocytes; Insulin; Insulin Resistance; Liver Neoplasms; Mice; Mice, Inbred C57BL; Mitochondria; Morpholines; Obesity; Receptor, Insulin; RNA, Small Interfering; Signal Transduction | 2011 |
Bufalin enhances the anti-proliferative effect of sorafenib on human hepatocellular carcinoma cells through downregulation of ERK.
Topics: Antineoplastic Agents; Benzenesulfonates; Blotting, Western; Bufanolides; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Chromones; Drug Synergism; Gene Expression Regulation, Enzymologic; Humans; Liver Neoplasms; Microscopy, Electron, Transmission; Morpholines; Niacinamide; Phenylurea Compounds; Pyridines; Sorafenib | 2012 |
Activation of PI3 kinase/Akt/HIF-1α pathway contributes to hypoxia-induced epithelial-mesenchymal transition and chemoresistance in hepatocellular carcinoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Hepatocellular; Cell Hypoxia; Cell Movement; Cell Survival; Chromones; Cisplatin; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Gene Expression; Genes, MDR; Hep G2 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Liver Neoplasms; Male; Mice; Mice, Nude; Morpholines; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Xenograft Model Antitumor Assays | 2012 |
Long-term exposure to sorafenib of liver cancer cells induces resistance with epithelial-to-mesenchymal transition, increased invasion and risk of rebound growth.
Topics: Anilides; Antineoplastic Agents; Cadherins; Carcinoma, Hepatocellular; Cell Line, Tumor; Chromones; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Keratin-19; Liver Neoplasms; Morpholines; Niacinamide; Phenylurea Compounds; Proto-Oncogene Proteins c-akt; Pyridines; Sorafenib; Vimentin | 2013 |
Overexpression of Yes-associated protein confers doxorubicin resistance in hepatocellullar carcinoma.
Topics: Adaptor Proteins, Signal Transducing; Antibiotics, Antineoplastic; Apoptosis; bcl-X Protein; Butadienes; Carcinoma, Hepatocellular; Cell Line, Tumor; Chromones; Doxorubicin; Drug Resistance, Neoplasm; Humans; Liver Neoplasms; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Nitriles; Phosphoproteins; Phosphorylation; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-akt; RNA Interference; Signal Transduction; Transcription Factors; YAP-Signaling Proteins | 2013 |
Regulation of hypoxia-inducible factor-1alpha protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta pathway in HepG2 cells.
Topics: Adjuvants, Immunologic; Carcinoma, Hepatocellular; Chromones; DNA-Binding Proteins; Enzyme Inhibitors; Gene Expression; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Lithium Chloride; Liver Neoplasms; Morpholines; Nuclear Proteins; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Transcription Factors; Tumor Cells, Cultured | 2003 |
Insulin/protein kinase B signalling pathway upregulates metastasis-related phenotypes and molecules in H7721 human hepatocarcinoma cell line.
Topics: Antibodies, Monoclonal; Carcinoma, Hepatocellular; Cell Adhesion; Cell Movement; Cells, Cultured; Chromones; DNA, Complementary; Endothelium, Vascular; Fucosyltransferases; Humans; Insulin; Laminin; Liver Neoplasms; Morpholines; Neoplasm Metastasis; Oligosaccharides; Phenotype; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Sialyl Lewis X Antigen; Signal Transduction; Transfection; Up-Regulation | 2003 |
Regulation of Gene33 expression by insulin requires MEK-ERK activation.
Topics: Adaptor Proteins, Signal Transducing; Androstadienes; Animals; Carcinoma, Hepatocellular; Carrier Proteins; Chromones; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Humans; Immune Sera; Insulin; Intracellular Signaling Peptides and Proteins; Liver Neoplasms; MAP Kinase Kinase Kinase 1; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Recombinant Fusion Proteins; Signal Transduction; Transcription, Genetic; Tretinoin; Tumor Cells, Cultured; Tumor Suppressor Proteins; Wortmannin | 2004 |
Blockade of rapid versus prolonged extracellularly regulated kinase 1/2 activation has differential effects on insulin-induced gene expression.
Topics: Activating Transcription Factor 3; Androstadienes; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Chromones; Enzyme Activation; Enzyme Inhibitors; Gene Expression; Hypoglycemic Agents; Insulin; Intracellular Signaling Peptides and Proteins; Liver Neoplasms; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors; Proteins; Rats; Signal Transduction; Transcription Factors; Wortmannin | 2005 |
Role of Rac1 and Cdc42 in hypoxia induced p53 and von Hippel-Lindau suppression and HIF1alpha activation.
Topics: Blotting, Western; Carcinoma, Hepatocellular; cdc42 GTP-Binding Protein; Cell Hypoxia; Cell Line, Tumor; Chromones; Down-Regulation; Endothelial Cells; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Genistein; GTP Phosphohydrolases; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Morpholines; Neovascularization, Pathologic; Phosphoinositide-3 Kinase Inhibitors; Protein-Tyrosine Kinases; rac1 GTP-Binding Protein; Reverse Transcriptase Polymerase Chain Reaction; Stomach Neoplasms; Transfection; Tumor Suppressor Protein p53; Up-Regulation; Vascular Endothelial Growth Factor A; Von Hippel-Lindau Tumor Suppressor Protein | 2006 |
Signaling pathway of insulin-like growth factor-II as a target of molecular therapy for hepatoblastoma.
Topics: Androstadienes; Apoptosis; Cell Line, Tumor; Cell Proliferation; Chromones; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Hepatoblastoma; Humans; Insulin-Like Growth Factor II; Liver Neoplasms; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Receptor, IGF Type 1; Signal Transduction; Wortmannin | 2006 |
Statins induce mammalian target of rapamycin (mTOR)-mediated inhibition of Akt signaling and sensitize p53-deficient cells to cytostatic drugs.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Atorvastatin; Carcinoma, Hepatocellular; Cell Proliferation; Chromones; Dose-Response Relationship, Drug; Etoposide; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver Neoplasms; Morpholines; Phosphorylation; Pravastatin; Protein Kinases; Proto-Oncogene Proteins c-akt; Pyrroles; Signal Transduction; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53 | 2006 |
Hypoxia-independent overexpression of hypoxia-inducible factor 1alpha as an early change in mouse hepatocarcinogenesis.
Topics: Animals; Blotting, Western; Cell Line, Tumor; Chromones; Disease Progression; Enzyme Inhibitors; Gene Expression; Glucose Transporter Type 1; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Insulin-Like Growth Factor II; Liver Neoplasms; Male; Mice; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Precancerous Conditions; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-met; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Time Factors; Vascular Endothelial Growth Factor A | 2006 |
Insulin-like growth factor (IGF)-II regulates CCAAT/enhancer binding protein alpha expression via phosphatidyl-inositol 3 kinase in human hepatoblastoma cell lines.
Topics: Androstadienes; CCAAT-Binding Factor; Cell Line, Tumor; Cell Proliferation; Chromones; Enzyme Inhibitors; Hepatoblastoma; Hepatocytes; Humans; Insulin-Like Growth Factor II; Liver Neoplasms; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Promoter Regions, Genetic; RNA Stability; Up-Regulation; Wortmannin | 2007 |
Two specific inhibitors of the phosphatidylinositol 3-kinase LY294002 and wortmannin up-regulate beta1,4-galactosyltransferase I and thus sensitize SMMC-7721 human hepatocarcinoma cells to cycloheximide-induced apoptosis.
Topics: Androstadienes; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Chromones; Cycloheximide; Drug Evaluation, Preclinical; Drug Synergism; Galactosyltransferases; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Morpholines; Phosphatidylinositol 3-Kinases; Substrate Specificity; Up-Regulation; Wortmannin | 2007 |
Phosphatidylinositol 3-kinase contributes to Erk1/Erk2 MAP kinase activation associated with hepatocyte growth factor-induced cell scattering.
Topics: Carcinoma, Hepatocellular; Cell Movement; Chromones; Cycloheximide; Enzyme Inhibitors; Flavonoids; Hepatocyte Growth Factor; Humans; Liver Neoplasms; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Ubiquitin-Protein Ligases | 1999 |
Modulation of the basal activity of phosphatidylinositol-3-kinase/protein kinase B signaling pathway in human hepatocarcinoma cells.
Topics: Antibodies, Monoclonal; Carcinoma, Hepatocellular; Chromones; DNA, Antisense; Enzyme Activation; Enzyme Inhibitors; Genes, ras; Humans; Liver Neoplasms; MAP Kinase Kinase Kinase 1; Morpholines; N-Acetylglucosaminyltransferases; Phosphatidylcholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phospholipid Ethers; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-raf; Signal Transduction; Transfection; Tumor Cells, Cultured | 2000 |
Transcriptional regulation of plasminogen activator inhibitor type 1 gene by insulin: insights into the signaling pathway.
Topics: Base Sequence; Carcinoma, Hepatocellular; Chromones; Chromosome Mapping; Enzyme Inhibitors; Humans; Insulin; Liver Neoplasms; Molecular Sequence Data; Morpholines; Plasminogen Activator Inhibitor 1; Promoter Regions, Genetic; Protein Kinase C; ras Proteins; Ribosomal Protein S6 Kinases; Signal Transduction; Transcription, Genetic; Tumor Cells, Cultured | 2001 |
Critical involvement of the phosphatidylinositol 3-kinase/Akt pathway in anchorage-independent growth and hematogeneous intrahepatic metastasis of liver cancer.
Topics: Animals; Carcinoma, Hepatocellular; Cell Adhesion; Cell Division; Chromones; Enzyme Activation; Enzyme Inhibitors; Humans; Liver Neoplasms; Male; Mice; Mice, SCID; Morpholines; Neoplasm Transplantation; Neoplastic Cells, Circulating; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Signal Transduction; Tumor Cells, Cultured | 2002 |