2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Cancer of Kidney in 14 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clear cell renal cell carcinoma (ccRCC) has been associated with one of the highest mortality rates among all cancers." | 1.51 | FABP5 regulates the proliferation of clear cell renal cell carcinoma cells via the PI3K/AKT signaling pathway. ( Ding, Q; Han, X; Le, W; Li, H; Lv, Q; Ma, C; Wang, G; Wang, P; Zhang, M; Zhang, Y, 2019) |
| "Metastatic renal cell carcinoma is resistant to current therapies." | 1.33 | The phosphoinositide 3-kinase/Akt pathway: a new target in human renal cell carcinoma therapy. ( Agouni, A; Danilin, S; Helwig, JJ; Jacqmin, D; Lang, H; Lindner, V; Massfelder, T; Rothhut, S; Schordan, E; Sourbier, C, 2006) |
| "A panel of breast cancer cell lines reflecting the different genetic changes occurring in human breast cancer was analyzed." | 1.31 | Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3'-kinase/Akt signaling pathway. ( Blancher, C; Harris, AL; Moore, JW; Robertson, N, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (42.86) | 29.6817 |
| 2010's | 8 (57.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lv, Q | 1 |
| Wang, G | 1 |
| Zhang, Y | 1 |
| Han, X | 1 |
| Li, H | 1 |
| Le, W | 1 |
| Zhang, M | 1 |
| Ma, C | 1 |
| Wang, P | 1 |
| Ding, Q | 1 |
| Benzonana, LL | 1 |
| Perry, NJ | 1 |
| Watts, HR | 1 |
| Yang, B | 1 |
| Perry, IA | 1 |
| Coombes, C | 1 |
| Takata, M | 1 |
| Ma, D | 1 |
| Harada, K | 1 |
| Miyake, H | 1 |
| Kumano, M | 1 |
| Fujisawa, M | 1 |
| Weissinger, D | 1 |
| Tagscherer, KE | 1 |
| Macher-Göppinger, S | 1 |
| Haferkamp, A | 1 |
| Wagener, N | 1 |
| Roth, W | 1 |
| Ito, H | 1 |
| Ichiyanagi, O | 1 |
| Naito, S | 1 |
| Bilim, VN | 1 |
| Tomita, Y | 1 |
| Kato, T | 1 |
| Nagaoka, A | 1 |
| Tsuchiya, N | 1 |
| Elfiky, AA | 1 |
| Aziz, SA | 1 |
| Conrad, PJ | 1 |
| Siddiqui, S | 1 |
| Hackl, W | 1 |
| Maira, M | 1 |
| Robert, CL | 1 |
| Kluger, HM | 1 |
| Ho, MY | 1 |
| Tang, SJ | 1 |
| Chuang, MJ | 1 |
| Cha, TL | 1 |
| Li, JY | 1 |
| Sun, GH | 1 |
| Sun, KH | 1 |
| Zhu, S | 1 |
| Cohen, MB | 1 |
| Bjorge, JD | 1 |
| Mier, JW | 1 |
| Cho, DC | 1 |
| Miyata, Y | 1 |
| Ashida, S | 1 |
| Nakamura, T | 1 |
| Mochizuki, Y | 1 |
| Koga, S | 1 |
| Kanetake, H | 1 |
| Shuin, T | 1 |
| Kanda, S | 1 |
| Kolb, TM | 1 |
| Duan, L | 1 |
| Davis, MA | 1 |
| Pflug, BR | 1 |
| Zheng, H | 1 |
| Udan, MS | 1 |
| D'Antonio, JM | 1 |
| Marshall, FF | 1 |
| Brooks, JD | 1 |
| Nelson, JB | 1 |
| Sourbier, C | 1 |
| Lindner, V | 1 |
| Lang, H | 1 |
| Agouni, A | 1 |
| Schordan, E | 1 |
| Danilin, S | 1 |
| Rothhut, S | 1 |
| Jacqmin, D | 1 |
| Helwig, JJ | 1 |
| Massfelder, T | 1 |
| Bussolati, B | 1 |
| Assenzio, B | 1 |
| Deregibus, MC | 1 |
| Camussi, G | 1 |
| Blancher, C | 1 |
| Moore, JW | 1 |
| Robertson, N | 1 |
| Harris, AL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Impact of Inhalational Versus Intravenous Anesthesia Maintenance Methods on Long-term Survival in Elderly Patients After Cancer Surgery: a Randomized Controlled Trial[NCT02660411] | 1,228 participants (Actual) | Interventional | 2015-04-01 | Completed | |||
| Impact of Inhalational Versus Intravenous Anesthesia Maintenance Methods on 5-year Survival in Elderly Patients After Cancer Surgery: a Randomized Controlled Trial[NCT05343260] | 1,228 participants (Actual) | Interventional | 2015-04-01 | Active, not recruiting | |||
| The Effects of Propofol Based Intravenous vs Sevoflurane Inhalation Anaesthesia on Inflammation and Circulating Tumor Cells in Paediatric Tumor Surgery - a Pilot Study[NCT04475705] | Phase 4 | 100 participants (Anticipated) | Interventional | 2021-01-11 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
14 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Cancer of Kidney
| Article | Year |
|---|---|
FABP5 regulates the proliferation of clear cell renal cell carcinoma cells via the PI3K/AKT signaling pathway.
Topics: Animals; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Proliferation; Chromones; Computational Biolo | 2019 |
Isoflurane, a commonly used volatile anesthetic, enhances renal cancer growth and malignant potential via the hypoxia-inducible factor cellular signaling pathway in vitro.
Topics: Anesthetics, Inhalation; Basic Helix-Loop-Helix Transcription Factors; Cell Movement; Cell Prolifera | 2013 |
Isoflurane, a commonly used volatile anesthetic, enhances renal cancer growth and malignant potential via the hypoxia-inducible factor cellular signaling pathway in vitro.
Topics: Anesthetics, Inhalation; Basic Helix-Loop-Helix Transcription Factors; Cell Movement; Cell Prolifera | 2013 |
Isoflurane, a commonly used volatile anesthetic, enhances renal cancer growth and malignant potential via the hypoxia-inducible factor cellular signaling pathway in vitro.
Topics: Anesthetics, Inhalation; Basic Helix-Loop-Helix Transcription Factors; Cell Movement; Cell Prolifera | 2013 |
Isoflurane, a commonly used volatile anesthetic, enhances renal cancer growth and malignant potential via the hypoxia-inducible factor cellular signaling pathway in vitro.
Topics: Anesthetics, Inhalation; Basic Helix-Loop-Helix Transcription Factors; Cell Movement; Cell Prolifera | 2013 |
Isoflurane, a commonly used volatile anesthetic, enhances renal cancer growth and malignant potential via the hypoxia-inducible factor cellular signaling pathway in vitro.
Topics: Anesthetics, Inhalation; Basic Helix-Loop-Helix Transcription Factors; Cell Movement; Cell Prolifera | 2013 |
Isoflurane, a commonly used volatile anesthetic, enhances renal cancer growth and malignant potential via the hypoxia-inducible factor cellular signaling pathway in vitro.
Topics: Anesthetics, Inhalation; Basic Helix-Loop-Helix Transcription Factors; Cell Movement; Cell Prolifera | 2013 |
Isoflurane, a commonly used volatile anesthetic, enhances renal cancer growth and malignant potential via the hypoxia-inducible factor cellular signaling pathway in vitro.
Topics: Anesthetics, Inhalation; Basic Helix-Loop-Helix Transcription Factors; Cell Movement; Cell Prolifera | 2013 |
Isoflurane, a commonly used volatile anesthetic, enhances renal cancer growth and malignant potential via the hypoxia-inducible factor cellular signaling pathway in vitro.
Topics: Anesthetics, Inhalation; Basic Helix-Loop-Helix Transcription Factors; Cell Movement; Cell Prolifera | 2013 |
Isoflurane, a commonly used volatile anesthetic, enhances renal cancer growth and malignant potential via the hypoxia-inducible factor cellular signaling pathway in vitro.
Topics: Anesthetics, Inhalation; Basic Helix-Loop-Helix Transcription Factors; Cell Movement; Cell Prolifera | 2013 |
Acquired resistance to temsirolimus in human renal cell carcinoma cells is mediated by the constitutive activation of signal transduction pathways through mTORC2.
Topics: Animals; Apoptosis; Butadienes; Carcinoma, Renal Cell; Cell Line, Tumor; Chromones; Drug Resistance, | 2013 |
The soluble Decoy Receptor 3 is regulated by a PI3K-dependent mechanism and promotes migration and invasion in renal cell carcinoma.
Topics: Carcinoma, Renal Cell; Cell Adhesion; Cell Line, Tumor; Cell Movement; Chromones; Fibronectins; Gene | 2013 |
GSK-3 directly regulates phospho-4EBP1 in renal cell carcinoma cell-line: an intrinsic subcellular mechanism for resistance to mTORC1 inhibition.
Topics: Adaptor Proteins, Signal Transducing; Carcinoma, Renal Cell; Cell Cycle Proteins; Cell Line, Tumor; | 2016 |
Characterization and targeting of phosphatidylinositol-3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in renal cell cancer.
Topics: Apoptosis; Automation; Biomarkers, Tumor; Carcinoma, Renal Cell; Cell Line, Tumor; Chromones; Drug S | 2011 |
TNF-α induces epithelial-mesenchymal transition of renal cell carcinoma cells via a GSK3β-dependent mechanism.
Topics: Animals; Cadherins; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Transformation, Neoplastic; Chromo | 2012 |
PI3K inhibition potentiates Bcl-2-dependent apoptosis in renal carcinoma cells.
Topics: Apoptosis; Biphenyl Compounds; Blotting, Western; Carcinoma, Renal Cell; Caspase 3; Caspase 8; Cell | 2013 |
Overexpression of hepatocyte growth factor receptor in renal carcinoma cells indirectly stimulates tumor growth in vivo.
Topics: Animals; Chromones; Endothelial Growth Factors; Enzyme Inhibitors; Humans; Kidney Neoplasms; Mice; M | 2003 |
Tsc2 expression increases the susceptibility of renal tumor cells to apoptosis.
Topics: Animals; Apoptosis; Carcinoma, Renal Cell; Caspase 3; Caspases; Cell Adhesion; Cell Line, Tumor; Cel | 2005 |
Endothelin-1 promotes cell survival in renal cell carcinoma through the ET(A) receptor.
Topics: Androstadienes; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Renal Cell; Cell Line, Tumo | 2007 |
The phosphoinositide 3-kinase/Akt pathway: a new target in human renal cell carcinoma therapy.
Topics: Animals; Carcinoma, Renal Cell; Cell Growth Processes; Cell Line, Tumor; Chromones; Enzyme Inhibitor | 2006 |
The proangiogenic phenotype of human tumor-derived endothelial cells depends on thrombospondin-1 downregulation via phosphatidylinositol 3-kinase/Akt pathway.
Topics: Adult; Androstadienes; Apoptosis; Blotting, Western; Carcinoma, Renal Cell; Cell Line; Chromones; Do | 2006 |
Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3'-kinase/Akt signaling pathway.
Topics: Basic Helix-Loop-Helix Transcription Factors; Blotting, Western; Breast Neoplasms; Carcinoma, Renal | 2001 |