2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Brain Neoplasms in 25 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Glioblastoma is a high-grade glioma with poor prognosis even after surgery and standard therapy." | 5.51 | Carnosine inhibits glioblastoma growth independent from PI3K/Akt/mTOR signaling. ( Faust, H; Gaunitz, F; Meixensberger, J; Oppermann, H; Yamanishi, U, 2019) |
| " This includes less toxic drugs, more selective towards tumor cells, causing less damage to the patient." | 5.43 | Phosphatidylinositol 3-Kinase/AKT Pathway Inhibition by Doxazosin Promotes Glioblastoma Cells Death, Upregulation of p53 and Triggers Low Neurotoxicity. ( Battastini, AM; Coelho, BP; de Quadros, AH; Gaelzer, MM; Gonçalves, CA; Guerra, MC; Guma, FC; Hoppe, JB; Salbego, CG; Setton-Avruj, P; Terra, SR; Usach, V, 2016) |
| "Ginsenoside Rh2 (GRh2) has been reported to have a therapeutic effect on some tumors, and we recently reported its inhibitory effect on GBM growth in vitro and in vivo, possibly through an epidermal growth factor receptor (EGFR) signaling pathway." | 5.42 | Ginsenoside Rh2 inhibits growth of glioblastoma multiforme through mTor. ( Gao, Y; Guo, W; Li, S; Liu, Y, 2015) |
| "Leptin plays a role in glioma invasion, however, whether and how leptin contributes to the biological properties of glioma stem-like cells, such as invasion, remains to be explored." | 5.40 | Leptin enhances the invasive ability of glioma stem-like cells depending on leptin receptor expression. ( Han, G; Hu, X; Li, Y; Liu, J; Wang, L; Yue, Z; Zhao, R; Zhao, W; Zhou, X, 2014) |
| " Dose-response studies with SH-6 administered to glioma cell lines were performed using a luminescent cell-viability assay (0." | 5.33 | Cotreatment with a novel phosphoinositide analogue inhibitor and carmustine enhances chemotherapeutic efficacy by attenuating AKT activity in gliomas. ( Broaddus, WC; Cash, D; Fillmore, H; Van Meter, TE, 2006) |
| "Glioma is a malignant brain cancer that exhibits high invasive ability and poor prognosis." | 1.56 | miR‑181d promotes cell proliferation via the IGF1/PI3K/AKT axis in glioma. ( Chen, Q; Gao, W; Ge, J; Liu, B; Liu, J; Tang, D; Yang, J; Zhao, J, 2020) |
| "Glioblastoma is a high-grade glioma with poor prognosis even after surgery and standard therapy." | 1.51 | Carnosine inhibits glioblastoma growth independent from PI3K/Akt/mTOR signaling. ( Faust, H; Gaunitz, F; Meixensberger, J; Oppermann, H; Yamanishi, U, 2019) |
| " This includes less toxic drugs, more selective towards tumor cells, causing less damage to the patient." | 1.43 | Phosphatidylinositol 3-Kinase/AKT Pathway Inhibition by Doxazosin Promotes Glioblastoma Cells Death, Upregulation of p53 and Triggers Low Neurotoxicity. ( Battastini, AM; Coelho, BP; de Quadros, AH; Gaelzer, MM; Gonçalves, CA; Guerra, MC; Guma, FC; Hoppe, JB; Salbego, CG; Setton-Avruj, P; Terra, SR; Usach, V, 2016) |
| "Ginsenoside Rh2 (GRh2) has been reported to have a therapeutic effect on some tumors, and we recently reported its inhibitory effect on GBM growth in vitro and in vivo, possibly through an epidermal growth factor receptor (EGFR) signaling pathway." | 1.42 | Ginsenoside Rh2 inhibits growth of glioblastoma multiforme through mTor. ( Gao, Y; Guo, W; Li, S; Liu, Y, 2015) |
| "Leptin plays a role in glioma invasion, however, whether and how leptin contributes to the biological properties of glioma stem-like cells, such as invasion, remains to be explored." | 1.40 | Leptin enhances the invasive ability of glioma stem-like cells depending on leptin receptor expression. ( Han, G; Hu, X; Li, Y; Liu, J; Wang, L; Yue, Z; Zhao, R; Zhao, W; Zhou, X, 2014) |
| "Glioblastoma (GBM) is the most common brain cancer and is highly lethal in both adults and children." | 1.40 | PTEN status mediates 2ME2 anti-tumor efficacy in preclinical glioblastoma models: role of HIF1α suppression. ( Durden, DL; Joshi, S; Kesari, S; Makale, MT; Muh, CR; Singh, AR, 2014) |
| "Gliomas are primary brain tumors with poor prognosis that exhibit frequent abnormalities in phosphatidylinositol 3-kinase (PI3 kinase) signaling." | 1.35 | Molecular pharmacology of phosphatidylinositol 3-kinase inhibition in human glioma. ( Bjerke, L; Clarke, PA; Eccles, SA; Guillard, S; Mohri, Z; Raynaud, F; Te Poele, R; Valenti, M; Workman, P, 2009) |
| " Dose-response studies with SH-6 administered to glioma cell lines were performed using a luminescent cell-viability assay (0." | 1.33 | Cotreatment with a novel phosphoinositide analogue inhibitor and carmustine enhances chemotherapeutic efficacy by attenuating AKT activity in gliomas. ( Broaddus, WC; Cash, D; Fillmore, H; Van Meter, TE, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (40.00) | 29.6817 |
| 2010's | 13 (52.00) | 24.3611 |
| 2020's | 2 (8.00) | 2.80 |
| Authors | Studies |
|---|---|
| Seifert, C | 1 |
| Balz, E | 1 |
| Herzog, S | 2 |
| Korolev, A | 1 |
| Gaßmann, S | 1 |
| Paland, H | 1 |
| Fink, MA | 2 |
| Grube, M | 1 |
| Marx, S | 1 |
| Jedlitschky, G | 1 |
| Tzvetkov, MV | 1 |
| Rauch, BH | 1 |
| Schroeder, HWS | 1 |
| Bien-Möller, S | 2 |
| Tang, D | 1 |
| Gao, W | 1 |
| Yang, J | 1 |
| Liu, J | 2 |
| Zhao, J | 1 |
| Ge, J | 1 |
| Chen, Q | 1 |
| Liu, B | 1 |
| Gupta, P | 1 |
| Singh, P | 1 |
| Pandey, HS | 1 |
| Seth, P | 1 |
| Mukhopadhyay, CK | 1 |
| Oppermann, H | 1 |
| Faust, H | 1 |
| Yamanishi, U | 1 |
| Meixensberger, J | 1 |
| Gaunitz, F | 1 |
| Friedman, MD | 1 |
| Jeevan, DS | 1 |
| Tobias, M | 1 |
| Murali, R | 1 |
| Jhanwar-Uniyal, M | 1 |
| Han, G | 1 |
| Zhao, W | 1 |
| Wang, L | 1 |
| Yue, Z | 1 |
| Zhao, R | 1 |
| Li, Y | 1 |
| Zhou, X | 1 |
| Hu, X | 1 |
| Muh, CR | 1 |
| Joshi, S | 1 |
| Singh, AR | 1 |
| Kesari, S | 1 |
| Durden, DL | 2 |
| Makale, MT | 1 |
| Weitmann, K | 1 |
| Friedel, C | 1 |
| Hadlich, S | 1 |
| Langner, S | 1 |
| Kindermann, K | 1 |
| Holm, T | 1 |
| Böhm, A | 1 |
| Eskilsson, E | 1 |
| Miletic, H | 1 |
| Hildner, M | 1 |
| Fritsch, M | 1 |
| Vogelgesang, S | 1 |
| Havemann, C | 1 |
| Ritter, CA | 1 |
| Meyer zu Schwabedissen, HE | 1 |
| Rauch, B | 1 |
| Hoffmann, W | 1 |
| Kroemer, HK | 1 |
| Schroeder, H | 1 |
| Gwak, HS | 1 |
| Park, MJ | 1 |
| Park, IC | 1 |
| Woo, SH | 1 |
| Jin, HO | 1 |
| Rhee, CH | 1 |
| Jung, HW | 1 |
| Li, S | 1 |
| Guo, W | 1 |
| Gao, Y | 1 |
| Liu, Y | 1 |
| Gaelzer, MM | 1 |
| Coelho, BP | 1 |
| de Quadros, AH | 1 |
| Hoppe, JB | 1 |
| Terra, SR | 1 |
| Guerra, MC | 1 |
| Usach, V | 1 |
| Guma, FC | 1 |
| Gonçalves, CA | 1 |
| Setton-Avruj, P | 1 |
| Battastini, AM | 1 |
| Salbego, CG | 1 |
| Cai, RP | 1 |
| Xue, YX | 1 |
| Huang, J | 1 |
| Wang, JH | 2 |
| Zhao, SY | 1 |
| Guan, TT | 1 |
| Zhang, Z | 1 |
| Gu, YT | 1 |
| Pandher, R | 1 |
| Ducruix, C | 1 |
| Eccles, SA | 2 |
| Raynaud, FI | 1 |
| Guillard, S | 1 |
| Clarke, PA | 1 |
| Te Poele, R | 1 |
| Mohri, Z | 1 |
| Bjerke, L | 1 |
| Valenti, M | 1 |
| Raynaud, F | 1 |
| Workman, P | 1 |
| Aziz, SA | 1 |
| Davies, M | 1 |
| Pick, E | 1 |
| Zito, C | 1 |
| Jilaveanu, L | 1 |
| Camp, RL | 1 |
| Rimm, DL | 1 |
| Kluger, Y | 1 |
| Kluger, HM | 1 |
| Johannessen, TC | 1 |
| Wang, J | 1 |
| Skaftnesmo, KO | 1 |
| Sakariassen, PØ | 1 |
| Enger, PØ | 1 |
| Petersen, K | 1 |
| Øyan, AM | 1 |
| Kalland, KH | 1 |
| Bjerkvig, R | 1 |
| Tysnes, BB | 1 |
| Shi, J | 1 |
| Zhang, L | 1 |
| Shen, A | 1 |
| Zhang, J | 1 |
| Wang, Y | 1 |
| Zhao, Y | 1 |
| Zou, L | 1 |
| Ke, Q | 1 |
| He, F | 1 |
| Wang, P | 1 |
| Cheng, C | 1 |
| Shi, G | 1 |
| Zhang, LH | 1 |
| Yang, XL | 1 |
| Zhang, X | 1 |
| Cheng, JX | 1 |
| Zhang, W | 1 |
| Zhong, D | 1 |
| Ran, JH | 1 |
| Tang, WY | 1 |
| Zhang, XD | 1 |
| Tan, Y | 1 |
| Chen, GJ | 1 |
| Li, XS | 1 |
| Yan, Y | 1 |
| Su, JD | 1 |
| Mayo, LD | 1 |
| Donner, DB | 1 |
| Yanamandra, N | 1 |
| Gumidyala, KV | 1 |
| Waldron, KG | 1 |
| Gujrati, M | 1 |
| Olivero, WC | 1 |
| Dinh, DH | 1 |
| Rao, JS | 1 |
| Mohanam, S | 1 |
| Aeder, SE | 1 |
| Martin, PM | 1 |
| Soh, JW | 1 |
| Hussaini, IM | 1 |
| Zhan, Y | 1 |
| O'Rourke, DM | 1 |
| Nakamura, JL | 1 |
| Karlsson, A | 1 |
| Arvold, ND | 1 |
| Gottschalk, AR | 1 |
| Pieper, RO | 1 |
| Stokoe, D | 1 |
| Haas-Kogan, DA | 1 |
| Van Meter, TE | 1 |
| Broaddus, WC | 1 |
| Cash, D | 1 |
| Fillmore, H | 1 |
25 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Brain Neoplasms
| Article | Year |
|---|---|
PIM1 Inhibition Affects Glioblastoma Stem Cell Behavior and Kills Glioblastoma Stem-like Cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Survival; Chromones; Drug Screening | 2021 |
miR‑181d promotes cell proliferation via the IGF1/PI3K/AKT axis in glioma.
Topics: Animals; Apoptosis; Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromones; Gl | 2020 |
Phosphoinositide-3-kinase inhibition elevates ferritin level resulting depletion of labile iron pool and blocking of glioma cell proliferation.
Topics: Adenine; Animals; Brain Neoplasms; Cell Proliferation; Cells, Cultured; Chromones; Down-Regulation; | 2019 |
Carnosine inhibits glioblastoma growth independent from PI3K/Akt/mTOR signaling.
Topics: Brain Neoplasms; Carnosine; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chromones; Drug Scr | 2019 |
Targeting cancer stem cells in glioblastoma multiforme using mTOR inhibitors and the differentiating agent all-trans retinoic acid.
Topics: Antibiotics, Antineoplastic; Brain Neoplasms; Butadienes; Cell Differentiation; Cell Line, Tumor; Ce | 2013 |
Leptin enhances the invasive ability of glioma stem-like cells depending on leptin receptor expression.
Topics: AC133 Antigen; Antigens, CD; Brain Neoplasms; Cell Movement; Chromones; Colony-Forming Units Assay; | 2014 |
PTEN status mediates 2ME2 anti-tumor efficacy in preclinical glioblastoma models: role of HIF1α suppression.
Topics: 2-Methoxyestradiol; Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Hypoxia; Cell L | 2014 |
Pim1 kinase is upregulated in glioblastoma multiforme and mediates tumor cell survival.
Topics: Animals; Apoptosis; Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Survival; Chromones; ErbB Re | 2015 |
Tetraarsenic oxide-induced inhibition of malignant glioma cell invasion in vitro via a decrease in matrix metalloproteinase secretion and protein kinase B phosphorylation.
Topics: Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Brain Neoplasms; Cell Line, Tumor; C | 2014 |
Ginsenoside Rh2 inhibits growth of glioblastoma multiforme through mTor.
Topics: Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Chromones; ErbB Receptors; Ginsenosides; Glio | 2015 |
Phosphatidylinositol 3-Kinase/AKT Pathway Inhibition by Doxazosin Promotes Glioblastoma Cells Death, Upregulation of p53 and Triggers Low Neurotoxicity.
Topics: Animals; Antineoplastic Agents; Apoptosis; Astrocytes; Brain Neoplasms; Caspase 3; Cell Line, Tumor; | 2016 |
NS1619 regulates the expression of caveolin-1 protein in a time-dependent manner via ROS/PI3K/PKB/FoxO1 signaling pathway in brain tumor microvascular endothelial cells.
Topics: Animals; Antineoplastic Agents; Benzimidazoles; Brain Neoplasms; Carotid Arteries; Caveolin 1; Cell | 2016 |
Cross-platform Q-TOF validation of global exo-metabolomic analysis: application to human glioblastoma cells treated with the standard PI 3-Kinase inhibitor LY294002.
Topics: Brain Neoplasms; Cell Line, Tumor; Chromones; Enzyme Inhibitors; Glioblastoma; Humans; Morpholines; | 2009 |
Molecular pharmacology of phosphatidylinositol 3-kinase inhibition in human glioma.
Topics: Animals; Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Chromones; Enzyme Inhibitors; Furans; Gene E | 2009 |
Phosphatidylinositol-3-kinase as a therapeutic target in melanoma.
Topics: Brain Neoplasms; Cell Proliferation; Chromones; Enzyme Inhibitors; Humans; Immunoblotting; Immunoenz | 2009 |
Highly infiltrative brain tumours show reduced chemosensitivity associated with a stem cell-like phenotype.
Topics: Animals; Antineoplastic Agents; Brain; Brain Neoplasms; Chromones; Doxorubicin; Enzyme Inhibitors; G | 2009 |
Clinical and biological significance of forkhead class box O 3a expression in glioma: mediation of glioma malignancy by transcriptional regulation of p27kip1.
Topics: Adult; Aged; Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Chromones; Cyclin-Dependent Kinase Inhib | 2010 |
Association of elevated GRP78 expression with increased astrocytoma malignancy via Akt and ERK pathways.
Topics: Antibodies, Neutralizing; Astrocytoma; Brain Neoplasms; Cell Division; Chromones; Endoplasmic Reticu | 2011 |
Mda-9/syntenin promotes human brain glioma migration through focal adhesion kinase (FAK)-JNK and FAK-AKT signaling.
Topics: Anthracenes; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Chromones; Focal Adhesion Protein-Tyr | 2012 |
PTEN and phosphatidylinositol 3'-kinase inhibitors up-regulate p53 and block tumor-induced angiogenesis: evidence for an effect on the tumor and endothelial compartment.
Topics: Angiogenesis Inhibitors; Brain Neoplasms; Cell Division; Cell Line; Cell Survival; Cerebrovascular C | 2003 |
Blockade of cathepsin B expression in human glioblastoma cells is associated with suppression of angiogenesis.
Topics: Angiogenesis Inhibitors; Animals; Biological Assay; Brain Neoplasms; Cathepsin B; Cell Line, Tumor; | 2004 |
PKC-eta mediates glioblastoma cell proliferation through the Akt and mTOR signaling pathways.
Topics: Brain Neoplasms; Cell Cycle; Chromones; Enzyme Inhibitors; Glioblastoma; Humans; Morpholines; Protei | 2004 |
SHP-2-dependent mitogen-activated protein kinase activation regulates EGFRvIII but not wild-type epidermal growth factor receptor phosphorylation and glioblastoma cell survival.
Topics: Brain Neoplasms; Cell Line, Tumor; Chromones; Enzyme Activation; ErbB Receptors; Flavonoids; Gliobla | 2004 |
PKB/Akt mediates radiosensitization by the signaling inhibitor LY294002 in human malignant gliomas.
Topics: Agammaglobulinaemia Tyrosine Kinase; Analysis of Variance; Antibiotics, Antineoplastic; Brain Neopla | 2005 |
Cotreatment with a novel phosphoinositide analogue inhibitor and carmustine enhances chemotherapeutic efficacy by attenuating AKT activity in gliomas.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Carmustine; Caspases; Cell Survival; Chemotherap | 2006 |