2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Brain Injuries in 11 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Zileuton and LY294002 were used to inhibit expression of 5-LOX and Akt, respectively." | 1.62 | 5-Lipoxygenase inhibition reduces inflammation and neuronal apoptosis via AKT signaling after subarachnoid hemorrhage in rats. ( Chen, H; Deng, Y; Guo, Z; He, Z; Liang, Y; Liu, L; Sun, X; Zhang, P; Zhang, Z, 2021) |
| "However, its effectiveness against subarachnoid hemorrhage (SAH) is not well known." | 1.43 | Matrine alleviates early brain injury after experimental subarachnoid hemorrhage in rats: possible involvement of PI3K/Akt-mediated NF-κB inhibition and Keap1/Nrf2-dependent HO-1 inductionn. ( Hou, P; Liu, X; Liu, Z; Ma, K; Sun, B; Wang, Z; Yuan, S; Zhang, R; Zhang, X, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 9 (81.82) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, L | 1 |
| Zhang, P | 2 |
| Zhang, Z | 1 |
| Liang, Y | 1 |
| Chen, H | 1 |
| He, Z | 1 |
| Sun, X | 1 |
| Guo, Z | 1 |
| Deng, Y | 1 |
| Xie, Z | 1 |
| Enkhjargal, B | 1 |
| Wu, L | 1 |
| Zhou, K | 1 |
| Sun, C | 1 |
| Hu, X | 1 |
| Gospodarev, V | 1 |
| Tang, J | 1 |
| You, C | 1 |
| Zhang, JH | 1 |
| Ma, N | 1 |
| Zhao, ZA | 1 |
| Zhang, NN | 1 |
| Chen, HS | 1 |
| Chen, W | 1 |
| Qi, J | 1 |
| Feng, F | 1 |
| Wang, MD | 1 |
| Bao, G | 1 |
| Wang, T | 1 |
| Xiang, M | 1 |
| Xie, WF | 1 |
| Wen, XR | 2 |
| Fu, YY | 1 |
| Liu, HZ | 1 |
| Wu, J | 1 |
| Shao, XP | 1 |
| Zhang, XB | 1 |
| Tang, M | 1 |
| Shi, Y | 1 |
| Ma, K | 2 |
| Zhang, F | 1 |
| Wang, YW | 1 |
| Tang, H | 1 |
| Han, D | 2 |
| Wang, SL | 1 |
| Xu, Z | 1 |
| Song, YJ | 1 |
| Sun, N | 1 |
| Wang, H | 1 |
| Ma, L | 1 |
| Lei, P | 1 |
| Zhang, Q | 1 |
| Liu, X | 1 |
| Zhang, X | 1 |
| Zhang, R | 1 |
| Hou, P | 1 |
| Sun, B | 1 |
| Yuan, S | 1 |
| Wang, Z | 1 |
| Liu, Z | 1 |
| Li, C | 1 |
| Zong, YY | 1 |
| Yu, CZ | 1 |
| Xu, J | 1 |
| Zhang, GY | 1 |
| Lee, HT | 1 |
| Chang, YC | 1 |
| Tu, YF | 1 |
| Huang, CC | 1 |
| Chen, T | 1 |
| Zhang, L | 1 |
| Qu, Y | 1 |
| Huo, K | 1 |
| Jiang, X | 1 |
| Fei, Z | 1 |
| Chen, SF | 1 |
| Tsai, HJ | 1 |
| Hung, TH | 1 |
| Chen, CC | 1 |
| Lee, CY | 1 |
| Wu, CH | 1 |
| Wang, PY | 1 |
| Liao, NC | 1 |
11 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Brain Injuries
| Article | Year |
|---|---|
5-Lipoxygenase inhibition reduces inflammation and neuronal apoptosis via AKT signaling after subarachnoid hemorrhage in rats.
Topics: Administration, Oral; Animals; Apoptosis; Arachidonate 5-Lipoxygenase; Brain Injuries; Chromones; Di | 2021 |
Exendin-4 attenuates neuronal death via GLP-1R/PI3K/Akt pathway in early brain injury after subarachnoid hemorrhage in rats.
Topics: Animals; Apoptosis; Brain Injuries; Calcium-Binding Proteins; Chromones; Disease Models, Animal; Enz | 2018 |
Intra-arterial human urinary kallidinogenase alleviates brain injury in rats with permanent middle cerebral artery occlusion through PI3K/AKT/FoxO1 signaling pathway.
Topics: Animals; Brain Injuries; Caspase 3; Chromones; Cytokines; Disease Models, Animal; Enzyme Inhibitors; | 2018 |
Neuroprotective effect of allicin against traumatic brain injury via Akt/endothelial nitric oxide synthase pathway-mediated anti-inflammatory and anti-oxidative activities.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Brain Injuries; Chromones; Disulfides; M | 2014 |
Neuroprotection of Sevoflurane Against Ischemia/Reperfusion-Induced Brain Injury Through Inhibiting JNK3/Caspase-3 by Enhancing Akt Signaling Pathway.
Topics: Androstadienes; Animals; Apoptosis; Brain Injuries; CA1 Region, Hippocampal; Caspase 3; Chromones; E | 2016 |
Ghrelin attenuates brain injury in septic mice via PI3K/Akt signaling activation.
Topics: Animals; bcl-2-Associated X Protein; Blood-Brain Barrier; Brain Edema; Brain Injuries; Capillary Per | 2016 |
Matrine alleviates early brain injury after experimental subarachnoid hemorrhage in rats: possible involvement of PI3K/Akt-mediated NF-κB inhibition and Keap1/Nrf2-dependent HO-1 inductionn.
Topics: Alkaloids; Animals; Blood-Brain Barrier; Brain Injuries; Chromones; Disease Models, Animal; Heme Oxy | 2016 |
Dual inhibitory roles of geldanamycin on the c-Jun NH2-terminal kinase 3 signal pathway through suppressing the expression of mixed-lineage kinase 3 and attenuating the activation of apoptosis signal-regulating kinase 1 via facilitating the activation of
Topics: Analysis of Variance; Animals; Behavior, Animal; Benzoquinones; Brain Injuries; Cells, Cultured; Chr | 2008 |
CREB activation mediates VEGF-A's protection of neurons and cerebral vascular endothelial cells.
Topics: Animals; Animals, Newborn; Brain Injuries; Cell Survival; Cells, Cultured; Chromones; CREB-Binding P | 2010 |
The selective mGluR5 agonist CHPG protects against traumatic brain injury in vitro and in vivo via ERK and Akt pathway.
Topics: Animals; Brain Injuries; Cells, Cultured; Chromones; Glycine; L-Lactate Dehydrogenase; Male; Mitogen | 2012 |
Salidroside improves behavioral and histological outcomes and reduces apoptosis via PI3K/Akt signaling after experimental traumatic brain injury.
Topics: Antioxidants; Apoptosis; Brain Edema; Brain Injuries; Cells, Cultured; Cerebral Cortex; Chromones; D | 2012 |