2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Bone Neoplasms in 14 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
Bone Neoplasms: Tumors or cancer located in bone tissue or specific BONES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diallyl trisulfide (DATS) is a natural organosulfur compound isolated from garlic, and has been reported to possess anticancer activities." | 5.43 | Diallyl trisulfide induces osteosarcoma cell apoptosis through reactive oxygen species-mediated downregulation of the PI3K/Akt pathway. ( Li, J; Li, K; Li, X; Sun, N; Tian, J; Wang, H, 2016) |
| "Osteosarcoma is a primary bone tumor that mainly occurs in children and adolescents." | 1.72 | AIM2 inhibits the proliferation, invasion and migration, and promotes the apoptosis of osteosarcoma cells by inactivating the PI3K/AKT/mTOR signaling pathway. ( Liu, C; Shi, J; Wang, X; Wen, K; Zheng, J, 2022) |
| "Diallyl trisulfide (DATS) is a natural organosulfur compound isolated from garlic, and has been reported to possess anticancer activities." | 1.43 | Diallyl trisulfide induces osteosarcoma cell apoptosis through reactive oxygen species-mediated downregulation of the PI3K/Akt pathway. ( Li, J; Li, K; Li, X; Sun, N; Tian, J; Wang, H, 2016) |
| "Osteosarcoma is a common malignant bone tumor." | 1.38 | Inhibition of c-Met activation sensitizes osteosarcoma cells to cisplatin via suppression of the PI3K-Akt signaling. ( Li, Y; Liu, C; Wang, K; Zhuang, Y, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (28.57) | 29.6817 |
| 2010's | 8 (57.14) | 24.3611 |
| 2020's | 2 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Zheng, J | 1 |
| Liu, C | 2 |
| Shi, J | 1 |
| Wen, K | 1 |
| Wang, X | 1 |
| Zhao, J | 2 |
| Yan, Y | 1 |
| Zhen, S | 1 |
| Yu, L | 1 |
| Ding, J | 1 |
| Tang, Q | 1 |
| Liu, L | 1 |
| Zhu, H | 1 |
| Xie, M | 1 |
| Shats, I | 1 |
| Gatza, ML | 1 |
| Liu, B | 1 |
| Angus, SP | 1 |
| You, L | 1 |
| Nevins, JR | 1 |
| Long, XH | 2 |
| Zhong, ZH | 1 |
| Peng, AF | 2 |
| Zhu, LB | 2 |
| Wang, H | 2 |
| Zhang, GM | 1 |
| Liu, ZL | 2 |
| Zhou, Y | 1 |
| Wang, TF | 1 |
| Gao, S | 1 |
| Zhou, RP | 1 |
| Jin, D | 1 |
| Yang, JP | 1 |
| Hu, JH | 1 |
| Wang, LN | 1 |
| Zuo, JL | 1 |
| Sun, N | 1 |
| Li, X | 1 |
| Li, K | 1 |
| Tian, J | 1 |
| Li, J | 1 |
| Yamamoto, T | 1 |
| Ohno, T | 1 |
| Wakahara, K | 1 |
| Nagano, A | 1 |
| Kawai, G | 1 |
| Saitou, M | 1 |
| Takigami, I | 1 |
| Matsuhashi, A | 1 |
| Yamada, K | 1 |
| Shimizu, K | 1 |
| Harisi, R | 1 |
| Kenessey, I | 1 |
| Olah, JN | 1 |
| Timar, F | 1 |
| Babo, I | 1 |
| Pogany, G | 1 |
| Paku, S | 1 |
| Jeney, A | 1 |
| Wang, K | 1 |
| Zhuang, Y | 1 |
| Li, Y | 1 |
| Gong, C | 1 |
| Liao, H | 1 |
| Wang, J | 1 |
| Lin, Y | 1 |
| Qi, J | 1 |
| Qin, L | 1 |
| Tian, LQ | 1 |
| Guo, FJ | 1 |
| Zhao, G | 1 |
| Cai, C | 1 |
| Yang, T | 1 |
| Qiu, X | 1 |
| Liao, B | 1 |
| Li, W | 1 |
| Ji, Z | 1 |
| Zhao, H | 1 |
| Guo, M | 1 |
| Ma, Q | 1 |
| Xiao, C | 1 |
| Fan, Q | 1 |
| Ma, B | 1 |
| Lekmine, F | 1 |
| Sassano, A | 1 |
| Uddin, S | 1 |
| Smith, J | 1 |
| Majchrzak, B | 1 |
| Brachmann, SM | 1 |
| Hay, N | 1 |
| Fish, EN | 1 |
| Platanias, LC | 1 |
| Lawlor, ER | 1 |
| Scheel, C | 1 |
| Irving, J | 1 |
| Sorensen, PH | 1 |
14 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Bone Neoplasms
| Article | Year |
|---|---|
AIM2 inhibits the proliferation, invasion and migration, and promotes the apoptosis of osteosarcoma cells by inactivating the PI3K/AKT/mTOR signaling pathway.
Topics: Bone Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromones; Computational Biolog | 2022 |
LY294002 alleviates bone cancer pain by reducing mitochondrial dysfunction and the inflammatory response.
Topics: Animals; Bone Neoplasms; Cancer Pain; Disabled Persons; Humans; Mitochondria; Motor Disorders; Neura | 2023 |
FOXO transcription factors control E2F1 transcriptional specificity and apoptotic function.
Topics: Apoptosis; Biomarkers, Tumor; Blotting, Western; Bone Neoplasms; Breast Neoplasms; Cell Proliferatio | 2013 |
LY294002 suppresses the malignant phenotype and sensitizes osteosarcoma cells to pirarubicin chemotherapy.
Topics: Antineoplastic Agents; Apoptosis; Bone Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferatio | 2014 |
LY294002 inhibits the malignant phenotype of osteosarcoma cells by modulating the phosphatidylinositol 3‑kinase/Akt/fatty acid synthase signaling pathway in vitro.
Topics: Bone Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromones; Down-Regulation; Enz | 2015 |
MCP-1 stimulates spinal microglia via PI3K/Akt pathway in bone cancer pain.
Topics: Animals; Bone Neoplasms; Carcinoma, Ductal, Breast; Cell Line, Tumor; Chemokine CCL2; Chromones; Enz | 2015 |
Diallyl trisulfide induces osteosarcoma cell apoptosis through reactive oxygen species-mediated downregulation of the PI3K/Akt pathway.
Topics: Acetylcysteine; Allyl Compounds; Antineoplastic Agents; Antioxidants; Apoptosis; Bone Neoplasms; Cel | 2016 |
Simultaneous inhibition of mitogen-activated protein kinase and phosphatidylinositol 3-kinase pathways augment the sensitivity to actinomycin D in Ewing sarcoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Bone Neoplasms; Butadienes; Cell | 2009 |
Differential inhibition of single and cluster type tumor cell migration.
Topics: Adolescent; Bone Neoplasms; Cell Culture Techniques; Cell Movement; Cell Proliferation; Chromones; D | 2009 |
Inhibition of c-Met activation sensitizes osteosarcoma cells to cisplatin via suppression of the PI3K-Akt signaling.
Topics: Antineoplastic Agents; Bone Neoplasms; Cell Line, Tumor; Cell Survival; Chromones; Cisplatin; Enzyme | 2012 |
LY294002 induces G0/G1 cell cycle arrest and apoptosis of cancer stem-like cells from human osteosarcoma via down-regulation of PI3K activity.
Topics: Apoptosis; Bone Neoplasms; Caspase 3; Caspase 9; Cell Line, Tumor; Chromones; Down-Regulation; Enzym | 2012 |
MicroRNA-221 induces cell survival and cisplatin resistance through PI3K/Akt pathway in human osteosarcoma.
Topics: 3' Untranslated Regions; Antineoplastic Agents; Apoptosis; Bone Neoplasms; Cell Cycle; Cell Line, Tu | 2013 |
Interferon-gamma engages the p70 S6 kinase to regulate phosphorylation of the 40S S6 ribosomal protein.
Topics: Bone Neoplasms; Cell Line, Tumor; Chromones; Enzyme Activation; Enzyme Inhibitors; Humans; Interfero | 2004 |
Anchorage-independent multi-cellular spheroids as an in vitro model of growth signaling in Ewing tumors.
Topics: Artificial Gene Fusion; Bone Neoplasms; Butadienes; Cell Adhesion; Cell Division; Chromones; DNA-Bin | 2002 |