2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Bone Loss, Osteoclastic in 7 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
| Excerpt | Relevance | Reference |
|---|---|---|
| "Inhibitors of bone resorption, such as alendronate, bafilomycin A1, and the PI3K inhibitor LY294002, suppressed the expression of Pmepa1 in osteoclasts." | 1.51 | Prostate transmembrane protein androgen induced 1 is induced by activation of osteoclasts and regulates bone resorption. ( Hirata, H; Kamohara, A; Kukita, A; Kukita, T; Miyamoto, H; Nishioka, K; Shiraki, M; Xu, X, 2019) |
| "Individuals with neurofibromatosis type 1 (NF1) have a high incidence of osteoporosis and osteopenia." | 1.33 | Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions. ( Chen, S; Clapp, DW; Hock, J; Ingram, DA; Li, X; Morgan, T; Nebesio, TD; Robling, AG; Yan, J; Yang, FC; Yu, X; Yuan, J, 2006) |
| "The inhibitory effects of WT and HWT on bone resorption may be due, in part, to impairment of osteoclast motility." | 1.30 | Wortmannin inhibits spreading and chemotaxis of rat osteoclasts in vitro. ( Dixon, SJ; Pilkington, MF; Sims, SM, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xu, X | 1 |
| Hirata, H | 1 |
| Shiraki, M | 1 |
| Kamohara, A | 1 |
| Nishioka, K | 1 |
| Miyamoto, H | 1 |
| Kukita, T | 1 |
| Kukita, A | 1 |
| Shugg, RP | 1 |
| Thomson, A | 1 |
| Tanabe, N | 1 |
| Kashishian, A | 1 |
| Steiner, BH | 1 |
| Puri, KD | 1 |
| Pereverzev, A | 1 |
| Lannutti, BJ | 1 |
| Jirik, FR | 1 |
| Dixon, SJ | 2 |
| Sims, SM | 2 |
| Adapala, NS | 1 |
| Barbe, MF | 1 |
| Tsygankov, AY | 1 |
| Lorenzo, JA | 1 |
| Sanjay, A | 1 |
| Chen, SH | 1 |
| Bubb, MR | 1 |
| Yarmola, EG | 1 |
| Zuo, J | 1 |
| Jiang, J | 1 |
| Lee, BS | 1 |
| Lu, M | 1 |
| Gluck, SL | 1 |
| Hurst, IR | 1 |
| Holliday, LS | 1 |
| Fukuda, A | 1 |
| Hikita, A | 1 |
| Wakeyama, H | 1 |
| Akiyama, T | 1 |
| Oda, H | 1 |
| Nakamura, K | 1 |
| Tanaka, S | 1 |
| Yang, FC | 1 |
| Chen, S | 1 |
| Robling, AG | 1 |
| Yu, X | 1 |
| Nebesio, TD | 1 |
| Yan, J | 1 |
| Morgan, T | 1 |
| Li, X | 1 |
| Yuan, J | 1 |
| Hock, J | 1 |
| Ingram, DA | 1 |
| Clapp, DW | 1 |
| Pilkington, MF | 1 |
7 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
Prostate transmembrane protein androgen induced 1 is induced by activation of osteoclasts and regulates bone resorption.
Topics: Animals; Arthritis, Experimental; Bone Resorption; Calcimycin; Cell Adhesion; Cell Culture Technique | 2019 |
Effects of isoform-selective phosphatidylinositol 3-kinase inhibitors on osteoclasts: actions on cytoskeletal organization, survival, and resorption.
Topics: Adenine; Androstadienes; Animals; Bone Resorption; Cell Survival; Chromones; Cytoskeleton; Indazoles | 2013 |
Loss of Cbl-PI3K interaction enhances osteoclast survival due to p21-Ras mediated PI3K activation independent of Cbl-b.
Topics: Adaptor Proteins, Signal Transducing; Animals; Bone Density; Bone Remodeling; Bone Resorption; Cell | 2014 |
Vacuolar H+-ATPase binding to microfilaments: regulation in response to phosphatidylinositol 3-kinase activity and detailed characterization of the actin-binding site in subunit B.
Topics: Actin Cytoskeleton; Actins; Animals; Binding Sites; Binding, Competitive; Bone Resorption; Chromones | 2004 |
Regulation of osteoclast apoptosis and motility by small GTPase binding protein Rac1.
Topics: Actins; Adenoviridae; Androstadienes; Animals; Animals, Newborn; Apoptosis; Bone Marrow Cells; Bone | 2005 |
Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions.
Topics: Animals; Bone Resorption; Cell Differentiation; Cell Nucleus; Cell Survival; Cells, Cultured; Chromo | 2006 |
Wortmannin inhibits spreading and chemotaxis of rat osteoclasts in vitro.
Topics: Androstadienes; Animals; Bone Resorption; Cell Movement; Cell Size; Chemotaxis; Chromones; Femur; Ma | 1998 |