2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Benign Neoplasms in 48 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
Excerpt | Relevance | Reference |
---|---|---|
" In GS-2 glioblastoma cells, PI3K inhibition by LY294002 or everolimus caused hyperpolarized lactate to drop to 42 +/- 12% and to 76 +/- 5%, respectively." | 3.76 | Noninvasive detection of target modulation following phosphatidylinositol 3-kinase inhibition using hyperpolarized 13C magnetic resonance spectroscopy. ( Brandes, AH; Chaumeil, MM; Dafni, H; Haas-Kogan, DA; James, CD; Kurhanewicz, J; Nelson, SJ; Ronen, SM; Sukumar, S; Vancriekinge, M; Venkatesh, HS; Vigneron, DB; Ward, CS, 2010) |
"Presently cancer is a grave health issue with predominance beyond restrictions." | 2.72 | Therapeutic progression of quinazolines as targeted chemotherapeutic agents. ( Bansal, R; Malhotra, A, 2021) |
"Some of them revealed potent anticancer efficacy and are now undergoing clinical trials." | 2.44 | Phosphatidylinositol 3-kinase inhibitors: promising drug candidates for cancer therapy. ( Kong, D; Yamori, T, 2008) |
"During the irradiation, the cancer cells treated with 0." | 1.43 | Invention of a novel photodynamic therapy for tumors using a photosensitizing PI3K inhibitor. ( Araki, N; Hayashida, Y; Ikeda, Y; Kakehi, Y; Kato, T; Kawai, K; Sawada, K, 2016) |
"Side population (SP) cells within tumors are a small fraction of cancer cells with stem-like properties that can be identified by flow cytometry analysis based on their high ability to export certain compounds such as Hoechst 33342 and chemotherapeutic agents." | 1.40 | Metabolic regulation of cancer cell side population by glucose through activation of the Akt pathway. ( Hu, Y; Huang, P; Ju, HQ; Liao, J; Liu, PP; Tang, ZJ; Wang, P; Wu, WJ; Xu, RH; Yang, J; Zeng, ZL, 2014) |
"A key modality of non-surgical cancer management is DNA damaging therapy that causes DNA double-strand breaks that are preferentially toxic to rapidly dividing cancer cells." | 1.39 | Single-cell microarray enables high-throughput evaluation of DNA double-strand breaks and DNA repair inhibitors. ( Engelward, BP; Floyd, S; Ge, J; Huang, Q; Mutamba, JT; Rowland, EA; Weingeist, DM; Wood, DK; Yaffe, MB, 2013) |
"We optimized the conditions for the cancer cell xenograft in terms of injected cell numbers, incubation temperature and time." | 1.38 | A novel zebrafish human tumor xenograft model validated for anti-cancer drug screening. ( Chang, YT; Choi, SY; Jung, DW; Kim, CH; Oh, ES; Park, SH; Williams, DR, 2012) |
"Survivin expression is elevated in cancer cells, and induced by some growth factors through PI3K activation." | 1.36 | Regulation of survivin by PI3K/Akt/p70S6K1 pathway. ( Jiang, BH; Liu, LZ; Liu, N; Meng, Q; You, YP; Zhao, P, 2010) |
"In AZD6244-resistant cancer cells, we observed the impaired nuclear localization of FOXO3a, reduced FOXO3a-mediated transcriptional activity, and decreased the expression of FOXO3a target gene Bim after cell treatment with AZD6244." | 1.36 | Activation of FOXO3a is sufficient to reverse mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor chemoresistance in human cancer. ( Andreeff, M; Chang, CJ; Du, Y; Engelman, JA; Hortobagyi, GN; Hung, MC; Wang, Y; Wong, KK; Xia, W; Yang, JY, 2010) |
"In addition, treating Z12 or cancer cell lines with either of these 2 inhibitors significantly decreased their secretion of TGFβ2." | 1.36 | Activation of cAMP-responsive-element-binding protein by PI3 kinase and p38 MAPK is essential for elevated expression of transforming growth factor β2 in cancer cells. ( Kolattukudy, S; Lu, T; Stark, GR; Wan, Y; Yang, M, 2010) |
"The metastasis suppressor breast cancer metastasis suppressor 1 (BRMS1) upregulates GJIC and decreases phosphoinositide-3-kinase (PI3K) signaling." | 1.36 | Homotypic gap junctional communication associated with metastasis suppression increases with PKA activity and is unaffected by PI3K inhibition. ( Beck, BH; Bodenstine, TM; Cook, LM; Diers, AR; Ismail, A; Landar, A; Vaidya, KS; Welch, DR, 2010) |
"Refined cancer models are required if researchers are to assess the burgeoning number of potential targets for cancer therapeutics in a clinically relevant context that allows a fast turnaround." | 1.36 | Invasive three-dimensional organotypic neoplasia from multiple normal human epithelia. ( Chow, JM; Khavari, PA; Ridky, TW; Wong, DJ, 2010) |
"Thus, CQ is a very effective and cancer-specific chemosensitizer when used in combination with Akt inhibitors." | 1.35 | The efficacy and selectivity of tumor cell killing by Akt inhibitors are substantially increased by chloroquine. ( Hu, C; Lee, H; Solomon, VR; Ulibarri, G, 2008) |
"We report here that both of these cancer cell lines express highly elevated levels of PLD activity and that the PLD activity is dependent upon Ras." | 1.34 | Phospholipase D provides a survival signal in human cancer cells with activated H-Ras or K-Ras. ( Foster, DA; Garcia, A; Shi, M; Xu, L; Zheng, Y, 2007) |
"Fifteen breast cancer cell lines and 92 primary breast tumors (33 with matched normal tissue) were used to check somatic mutation and gene copy number of PIK3CA." | 1.33 | Somatic mutation and gain of copy number of PIK3CA in human breast cancer. ( Chatterjee, A; Goldenberg, D; Gollin, SM; Guo, Z; Huang, X; Liu, J; Mambo, E; Sidransky, D; Sukumar, S; Trink, B; Wu, G; Xing, M, 2005) |
"A COMPARE analysis of the National Cancer Institute chemical screening database revealed that the patterns of activity of PIAs correlated best with patterns of activity of other lipid-based compounds." | 1.33 | Spectrum of activity and molecular correlates of response to phosphatidylinositol ether lipid analogues, novel lipid-based inhibitors of Akt. ( Dennis, PA; Gills, JJ; Hewitt, SM; Holbeck, S; Hollingshead, M; Kozikowski, AP, 2006) |
"Antiapoptotic activity of NF-kappaB in tumors contributes to acquisition of resistance to chemotherapy." | 1.32 | IkappaB kinase-independent IkappaBalpha degradation pathway: functional NF-kappaB activity and implications for cancer therapy. ( Bottero, V; Ikawa, M; Li, Q; Tergaonkar, V; Verma, IM, 2003) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 19 (39.58) | 29.6817 |
2010's | 27 (56.25) | 24.3611 |
2020's | 2 (4.17) | 2.80 |
Authors | Studies |
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Diamandis, P | 1 |
Wildenhain, J | 1 |
Clarke, ID | 1 |
Sacher, AG | 1 |
Graham, J | 1 |
Bellows, DS | 1 |
Ling, EK | 1 |
Ward, RJ | 1 |
Jamieson, LG | 1 |
Tyers, M | 1 |
Dirks, PB | 1 |
Hu, C | 1 |
Solomon, VR | 1 |
Ulibarri, G | 1 |
Lee, H | 1 |
Xia, Z | 1 |
Knaak, C | 1 |
Ma, J | 1 |
Beharry, ZM | 1 |
McInnes, C | 1 |
Wang, W | 1 |
Kraft, AS | 1 |
Smith, CD | 1 |
Finlay, MR | 1 |
Griffin, RJ | 1 |
Morrison, R | 1 |
Al-Rawi, JM | 1 |
Jennings, IG | 1 |
Thompson, PE | 1 |
Angove, MJ | 1 |
Li, Y | 2 |
Xiao, J | 1 |
Zhang, Q | 1 |
Yu, W | 1 |
Liu, M | 1 |
Guo, Y | 1 |
He, J | 1 |
Liu, Y | 1 |
Myers, SH | 1 |
Ortega, JA | 1 |
Cavalli, A | 1 |
Bansal, R | 1 |
Malhotra, A | 1 |
Song, L | 1 |
Dong, X | 1 |
Zhu, S | 1 |
Zhang, C | 1 |
Yin, W | 1 |
Zhang, X | 1 |
Liu, X | 1 |
Gu, Z | 1 |
Yu, G | 1 |
Wang, C | 1 |
Song, X | 1 |
Liu, S | 1 |
Zhang, Y | 2 |
Fan, L | 1 |
Yang, Y | 1 |
Huang, Y | 2 |
Song, J | 1 |
Weingeist, DM | 1 |
Ge, J | 1 |
Wood, DK | 1 |
Mutamba, JT | 1 |
Huang, Q | 1 |
Rowland, EA | 1 |
Yaffe, MB | 1 |
Floyd, S | 1 |
Engelward, BP | 1 |
Liu, PP | 1 |
Liao, J | 1 |
Tang, ZJ | 1 |
Wu, WJ | 1 |
Yang, J | 1 |
Zeng, ZL | 1 |
Hu, Y | 1 |
Wang, P | 1 |
Ju, HQ | 1 |
Xu, RH | 1 |
Huang, P | 1 |
Rybalkina, EIu | 1 |
Stromskaia, TP | 1 |
Ovchinnikov, LP | 1 |
Stavrovskaia, AA | 1 |
Noh, KH | 1 |
Kim, SH | 1 |
Kim, JH | 1 |
Song, KH | 1 |
Lee, YH | 1 |
Kang, TH | 1 |
Han, HD | 1 |
Sood, AK | 1 |
Ng, J | 1 |
Kim, K | 1 |
Sonn, CH | 1 |
Kumar, V | 1 |
Yee, C | 1 |
Lee, KM | 1 |
Kim, TW | 1 |
Ohoka, A | 1 |
Kajita, M | 1 |
Ikenouchi, J | 1 |
Yako, Y | 1 |
Kitamoto, S | 1 |
Kon, S | 1 |
Ikegawa, M | 1 |
Shimada, T | 1 |
Ishikawa, S | 1 |
Fujita, Y | 2 |
Wang, Q | 1 |
Tan, R | 1 |
Zhu, X | 1 |
Tan, Z | 1 |
Su, B | 1 |
Hayashida, Y | 1 |
Ikeda, Y | 1 |
Sawada, K | 1 |
Kawai, K | 1 |
Kato, T | 1 |
Kakehi, Y | 1 |
Araki, N | 1 |
Tsvetkov, D | 1 |
Shymanets, A | 1 |
Bucher, K | 1 |
Piekorz, R | 1 |
Hirsch, E | 1 |
Beer-Hammer, S | 1 |
Harteneck, C | 1 |
Gollasch, M | 1 |
Nürnberg, B | 1 |
Zhang, XF | 1 |
Sun, RQ | 1 |
Jia, YF | 1 |
Chen, Q | 1 |
Tu, RF | 1 |
Li, KK | 1 |
Zhang, XD | 1 |
Du, RL | 1 |
Cao, RH | 1 |
Kong, D | 2 |
Yamori, T | 3 |
Matsumoto, K | 1 |
Arao, T | 1 |
Tanaka, K | 1 |
Kaneda, H | 1 |
Kudo, K | 1 |
Tamura, D | 1 |
Aomatsu, K | 1 |
Tamura, T | 1 |
Yamada, Y | 1 |
Saijo, N | 1 |
Nishio, K | 1 |
Dan, S | 1 |
Yamazaki, K | 1 |
Ward, CS | 1 |
Venkatesh, HS | 1 |
Chaumeil, MM | 1 |
Brandes, AH | 1 |
Vancriekinge, M | 1 |
Dafni, H | 1 |
Sukumar, S | 2 |
Nelson, SJ | 1 |
Vigneron, DB | 1 |
Kurhanewicz, J | 1 |
James, CD | 1 |
Haas-Kogan, DA | 1 |
Ronen, SM | 1 |
David-Pfeuty, T | 1 |
Legraverend, M | 1 |
Ludwig, O | 1 |
Grierson, DS | 1 |
Zhao, P | 1 |
Meng, Q | 1 |
Liu, LZ | 1 |
You, YP | 1 |
Liu, N | 1 |
Jiang, BH | 1 |
Mireuta, M | 1 |
Darnel, A | 1 |
Pollak, M | 1 |
Knight, ZA | 1 |
Yang, JY | 1 |
Chang, CJ | 1 |
Xia, W | 1 |
Wang, Y | 1 |
Wong, KK | 1 |
Engelman, JA | 1 |
Du, Y | 1 |
Andreeff, M | 1 |
Hortobagyi, GN | 1 |
Hung, MC | 1 |
Wan, Y | 1 |
Yang, M | 1 |
Kolattukudy, S | 1 |
Stark, GR | 1 |
Lu, T | 1 |
Bodenstine, TM | 1 |
Vaidya, KS | 1 |
Ismail, A | 1 |
Beck, BH | 1 |
Cook, LM | 1 |
Diers, AR | 1 |
Landar, A | 1 |
Welch, DR | 1 |
Ridky, TW | 1 |
Chow, JM | 1 |
Wong, DJ | 1 |
Khavari, PA | 1 |
Zhuang, L | 1 |
Cao, Y | 1 |
Xiong, H | 1 |
Gao, Q | 1 |
Cao, Z | 1 |
Liu, F | 1 |
Qiu, H | 1 |
Yu, S | 1 |
Huang, X | 2 |
Jung, DW | 1 |
Oh, ES | 1 |
Park, SH | 1 |
Chang, YT | 1 |
Kim, CH | 1 |
Choi, SY | 1 |
Williams, DR | 1 |
Beltran, L | 1 |
Casado, P | 1 |
Rodríguez-Prados, JC | 1 |
Cutillas, PR | 1 |
Nicholson, KM | 1 |
Quinn, DM | 1 |
Kellett, GL | 1 |
Warr, JR | 1 |
Tergaonkar, V | 1 |
Bottero, V | 1 |
Ikawa, M | 1 |
Li, Q | 1 |
Verma, IM | 1 |
Yanamandra, N | 1 |
Gumidyala, KV | 1 |
Waldron, KG | 1 |
Gujrati, M | 1 |
Olivero, WC | 1 |
Dinh, DH | 1 |
Rao, JS | 1 |
Mohanam, S | 1 |
DeFeo-Jones, D | 1 |
Barnett, SF | 1 |
Fu, S | 1 |
Hancock, PJ | 1 |
Haskell, KM | 1 |
Leander, KR | 1 |
McAvoy, E | 1 |
Robinson, RG | 1 |
Duggan, ME | 1 |
Lindsley, CW | 1 |
Zhao, Z | 1 |
Huber, HE | 1 |
Jones, RE | 1 |
Coffey, JC | 1 |
Wang, JH | 1 |
Smith, MJ | 1 |
Laing, A | 1 |
Bouchier-Hayes, D | 1 |
Cotter, TG | 1 |
Redmond, HP | 1 |
Strickland, LA | 1 |
Jubb, AM | 1 |
Hongo, JA | 1 |
Zhong, F | 1 |
Burwick, J | 1 |
Fu, L | 1 |
Frantz, GD | 1 |
Koeppen, H | 1 |
Blanco-Aparicio, C | 1 |
Pequeño, B | 1 |
Moneo, V | 1 |
Romero, L | 1 |
Leal, JF | 1 |
Velasco, J | 1 |
Fominaya, J | 1 |
Carnero, A | 1 |
Wu, G | 1 |
Xing, M | 1 |
Mambo, E | 1 |
Liu, J | 1 |
Guo, Z | 1 |
Chatterjee, A | 1 |
Goldenberg, D | 1 |
Gollin, SM | 1 |
Trink, B | 1 |
Sidransky, D | 1 |
Gills, JJ | 1 |
Holbeck, S | 1 |
Hollingshead, M | 1 |
Hewitt, SM | 1 |
Kozikowski, AP | 1 |
Dennis, PA | 1 |
Akashi, T | 1 |
Nishimura, Y | 1 |
Wakatabe, R | 1 |
Shiwa, M | 1 |
Fujiwara, Y | 1 |
Hosokawa, Y | 1 |
Watanabe, K | 1 |
Tanimura, S | 1 |
Ozaki, K | 1 |
Kohno, M | 1 |
Bowers, RK | 1 |
Marder, P | 1 |
Green, LJ | 1 |
Horn, CL | 1 |
Faber, AL | 1 |
Thomas, JE | 1 |
Shi, M | 1 |
Zheng, Y | 1 |
Garcia, A | 1 |
Xu, L | 1 |
Foster, DA | 1 |
Berrie, CP | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
A Single-Arm, Open-Label, Multi-Center, Phase I Study of YY-20394 in Patients With Advanced Solid Tumors[NCT04049929] | Phase 1 | 50 participants (Anticipated) | Interventional | 2019-08-31 | Not yet recruiting | ||
A Phase I Study of YY-20394 Given Orally to Patients With Relapsed or Refractory B Cell Hematologic Malignancies[NCT03757000] | Phase 1 | 42 participants (Anticipated) | Interventional | 2017-12-25 | Recruiting | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
7 reviews available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Benign Neoplasms
Article | Year |
---|---|
Modulation of DNA repair by pharmacological inhibitors of the PIKK protein kinase family.
Topics: Animals; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; DNA; DNA Repair; DNA-Activated | 2012 |
The association between anti-tumor potency and structure-activity of protein-kinases inhibitors based on quinazoline molecular skeleton.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Humans; Neoplasms; Protein Kinase Inhibitors; Pr | 2019 |
Synthetic Lethality through the Lens of Medicinal Chemistry.
Topics: Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cyclin-Dependent Kinases; DNA-Activated | 2020 |
Therapeutic progression of quinazolines as targeted chemotherapeutic agents.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Enzyme Inhibitors; Humans; Molecular Structure; | 2021 |
Phosphatidylinositol 3-kinase inhibitors: promising drug candidates for cancer therapy.
Topics: Androstadienes; Angiogenesis Inhibitors; Antineoplastic Agents; Cell Proliferation; Chromones; Combi | 2008 |
Phosphatidylinositol 3-kinase inhibitors: promising drug candidates for cancer therapy.
Topics: Androstadienes; Angiogenesis Inhibitors; Antineoplastic Agents; Cell Proliferation; Chromones; Combi | 2008 |
Phosphatidylinositol 3-kinase inhibitors: promising drug candidates for cancer therapy.
Topics: Androstadienes; Angiogenesis Inhibitors; Antineoplastic Agents; Cell Proliferation; Chromones; Combi | 2008 |
Phosphatidylinositol 3-kinase inhibitors: promising drug candidates for cancer therapy.
Topics: Androstadienes; Angiogenesis Inhibitors; Antineoplastic Agents; Cell Proliferation; Chromones; Combi | 2008 |
Small molecule inhibitors of the PI3-kinase family.
Topics: Adenine; Androstadienes; Animals; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Chrom | 2010 |
Phosphoinositide 3-kinase inhibition in cancer treatment.
Topics: Androstadienes; Animals; Chromones; Enzyme Inhibitors; Humans; Morpholines; Neoplasms; Phosphatidyli | 2001 |
41 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Benign Neoplasms
Article | Year |
---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic | 2007 |
The efficacy and selectivity of tumor cell killing by Akt inhibitors are substantially increased by chloroquine.
Topics: Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; Cell Line, Tumor; Cell Proliferation | 2008 |
Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell-Free System; Combinatorial Chemistry Techniques; Fem | 2009 |
Synthesis, structure elucidation, DNA-PK and PI3K and anti-cancer activity of 8- and 6-aryl-substituted-1-3-benzoxazines.
Topics: Antineoplastic Agents; Benzoxazines; Cell Line, Tumor; Cell Proliferation; DNA-Activated Protein Kin | 2016 |
Bi
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Bismuth; Cell Line, Tumor; Cell Survival; Chromones; | 2018 |
Formaldehyde induces the apoptosis of BMCs of BALB/c mice via the PTEN/PI3K/Akt signal transduction pathway.
Topics: Animals; Apoptosis; Bone Marrow Cells; Cell Cycle Checkpoints; Cell Proliferation; Cell Survival; Ch | 2019 |
Single-cell microarray enables high-throughput evaluation of DNA double-strand breaks and DNA repair inhibitors.
Topics: Animals; Cell Line; CHO Cells; Chromones; Cricetinae; DNA Breaks, Double-Stranded; DNA Damage; DNA R | 2013 |
Metabolic regulation of cancer cell side population by glucose through activation of the Akt pathway.
Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Sub | 2014 |
[Connection of intracellular protein YB-1 localization in cell cultures of human tumors with multidrug resistance].
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transport | 2013 |
API5 confers tumoral immune escape through FGF2-dependent cell survival pathway.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; CD8-Positive T-Lymphocytes | 2014 |
EPLIN is a crucial regulator for extrusion of RasV12-transformed cells.
Topics: Animals; Butadienes; Caveolae; Caveolin 1; Cell Line; Cell Transformation, Neoplastic; Chromones; Co | 2015 |
Oncogenic K-ras confers SAHA resistance by up-regulating HDAC6 and c-myc expression.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line; Cell Line, Tumor; Chromones; Dru | 2016 |
Invention of a novel photodynamic therapy for tumors using a photosensitizing PI3K inhibitor.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Chromones; Dose-Response Relationship, | 2016 |
Better Understanding of Phosphoinositide 3-Kinase (PI3K) Pathways in Vasculature: Towards Precision Therapy Targeting Angiogenesis and Tumor Blood Supply.
Topics: Androstadienes; Animals; Chromones; Class I Phosphatidylinositol 3-Kinases; Class Ib Phosphatidylino | 2016 |
Synthesis and mechanisms of action of novel harmine derivatives as potential antitumor agents.
Topics: A549 Cells; Animals; Antineoplastic Agents; Chromones; Harmine; HeLa Cells; Hep G2 Cells; Humans; Mi | 2016 |
mTOR signal and hypoxia-inducible factor-1 alpha regulate CD133 expression in cancer cells.
Topics: AC133 Antigen; Antigens, CD; Cell Line, Tumor; Chromones; Colorectal Neoplasms; Down-Regulation; Gly | 2009 |
Inhibition profiles of phosphatidylinositol 3-kinase inhibitors against PI3K superfamily and human cancer cell line panel JFCR39.
Topics: Algorithms; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Chromones; Drug Screenin | 2010 |
Noninvasive detection of target modulation following phosphatidylinositol 3-kinase inhibition using hyperpolarized 13C magnetic resonance spectroscopy.
Topics: Animals; Carbon Isotopes; Chromones; Drug Delivery Systems; Enzyme Inhibitors; Everolimus; Glioblast | 2010 |
Targeting the cell cycle and the PI3K pathway: a possible universal strategy to reactivate innate tumor suppressor programmes in cancer cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Cycle; Cell Survival; Chromones; Cyc | 2010 |
Regulation of survivin by PI3K/Akt/p70S6K1 pathway.
Topics: Animals; Apoptosis; Cell Line, Tumor; Chick Embryo; Chromones; Enzyme Inhibitors; Gene Knockdown Tec | 2010 |
IGFBP-2 expression in MCF-7 cells is regulated by the PI3K/AKT/mTOR pathway through Sp1-induced increase in transcription.
Topics: Blotting, Western; Cell Line, Tumor; Chromones; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked I | 2010 |
Activation of FOXO3a is sufficient to reverse mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor chemoresistance in human cancer.
Topics: Animals; Apoptosis; Benzimidazoles; Breast Neoplasms; Cell Growth Processes; Cell Line, Tumor; Chlor | 2010 |
Activation of cAMP-responsive-element-binding protein by PI3 kinase and p38 MAPK is essential for elevated expression of transforming growth factor β2 in cancer cells.
Topics: Cell Line, Tumor; Chromones; CREB-Binding Protein; Cyclic AMP; Female; Humans; Imidazoles; Male; Mor | 2010 |
Homotypic gap junctional communication associated with metastasis suppression increases with PKA activity and is unaffected by PI3K inhibition.
Topics: Androstadienes; Cell Communication; Cell Line, Tumor; Cell Membrane; Chromones; Connexin 43; Cyclic | 2010 |
Invasive three-dimensional organotypic neoplasia from multiple normal human epithelia.
Topics: Basement Membrane; Butadienes; Cell Transformation, Neoplastic; Chromones; Epithelial Cells; Gene Ex | 2010 |
Suppression of DNA-PKcs and Ku80 individually and in combination: Different effects of radiobiology in HeLa cells.
Topics: Antigens, Nuclear; Cell Cycle; Cell Line, Tumor; Chromones; DNA-Activated Protein Kinase; DNA-Bindin | 2011 |
A novel zebrafish human tumor xenograft model validated for anti-cancer drug screening.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Chromones; Dose-Response Relationsh | 2012 |
Global profiling of protein kinase activities in cancer cells by mass spectrometry.
Topics: Butadienes; Cell Line, Tumor; Chromones; Enzyme Inhibitors; Humans; Morpholines; Neoplasm Proteins; | 2012 |
LY294002, an inhibitor of phosphatidylinositol-3-kinase, causes preferential induction of apoptosis in human multidrug resistant cells.
Topics: Apoptosis; Blotting, Western; Cell Line; Cell Survival; Chromones; Culture Media, Serum-Free; Drug R | 2003 |
IkappaB kinase-independent IkappaBalpha degradation pathway: functional NF-kappaB activity and implications for cancer therapy.
Topics: Animals; Base Sequence; Cells, Cultured; Chemotherapy, Adjuvant; Chromones; Cysteine Endopeptidases; | 2003 |
Blockade of cathepsin B expression in human glioblastoma cells is associated with suppression of angiogenesis.
Topics: Angiogenesis Inhibitors; Animals; Biological Assay; Brain Neoplasms; Cathepsin B; Cell Line, Tumor; | 2004 |
Tumor cell sensitization to apoptotic stimuli by selective inhibition of specific Akt/PKB family members.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Antibiotics, Antineoplastic; Apoptosis; Caspase 3; Cas | 2005 |
Phosphoinositide 3-kinase accelerates postoperative tumor growth by inhibiting apoptosis and enhancing resistance to chemotherapy-induced apoptosis. Novel role for an old enemy.
Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Cell Li | 2005 |
Plasmalemmal vesicle-associated protein (PLVAP) is expressed by tumour endothelium and is upregulated by vascular endothelial growth factor-A (VEGF).
Topics: Carrier Proteins; Cell Line, Tumor; Cells, Cultured; Chromones; Endothelial Cells; Enzyme Inhibitors | 2005 |
Inhibition of phosphatidylinositol-3-kinase synergizes with gemcitabine in low-passage tumor cell lines correlating with Bax translocation to the mitochondria.
Topics: bcl-2-Associated X Protein; bcl-X Protein; Carcinoma; Cell Line, Tumor; Cell Proliferation; Cell Sur | 2005 |
Somatic mutation and gain of copy number of PIK3CA in human breast cancer.
Topics: Apoptosis; Biomarkers, Tumor; Breast Neoplasms; Cell Division; Cell Line, Tumor; Cell Survival; Chro | 2005 |
Spectrum of activity and molecular correlates of response to phosphatidylinositol ether lipid analogues, novel lipid-based inhibitors of Akt.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Chromones; Humans; Morpholines; Neoplas | 2006 |
Proteomics-based identification of biomarkers for predicting sensitivity to a PI3-kinase inhibitor in cancer.
Topics: Antineoplastic Agents; Biomarkers, Tumor; Cell Line, Tumor; Cell Survival; Chromones; Dose-Response | 2007 |
Blockade of the phosphatidylinositol-3-kinase-Akt signaling pathway enhances the induction of apoptosis by microtubule-destabilizing agents in tumor cells in which the pathway is constitutively activated.
Topics: Antineoplastic Agents; Apoptosis; Cell Communication; Cell Differentiation; Chromones; Enzyme Inhibi | 2007 |
A platelet biomarker for assessing phosphoinositide 3-kinase inhibition during cancer chemotherapy.
Topics: Androstadienes; Animals; Blood Platelets; Chromones; Enzyme Inhibitors; Female; Flow Cytometry; Huma | 2007 |
Phospholipase D provides a survival signal in human cancer cells with activated H-Ras or K-Ras.
Topics: Apoptosis; Blotting, Western; Cell Line, Tumor; Chromones; Culture Media, Serum-Free; Enzyme Activat | 2007 |