2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with B-Cell Chronic Lymphocytic Leukemia in 11 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although B chronic lymphocytic leukemia (B-CLL) cells express the alpha chain of the interleukin-2 (IL-2) receptor CD25, little is known about the effect of IL-2 on apoptosis in B-CLL cells." | 1.36 | Antiapoptotic effect of interleukin-2 (IL-2) in B-CLL cells with low and high affinity IL-2 receptors. ( Bogner, C; Decker, T; Oelsner, M; Peschel, C; Ringshausen, I, 2010) |
| "The development and the propagation of chronic lymphocytic leukemia (CLL) has been linked to signaling via the B-cell receptor (BCR)." | 1.35 | PKCbeta is essential for the development of chronic lymphocytic leukemia in the TCL1 transgenic mouse model: validation of PKCbeta as a therapeutic target in chronic lymphocytic leukemia. ( Denk, U; Egle, A; Greil, R; Heyder, C; Hofbauer, S; Holler, C; Piñón, JD, 2009) |
| "Apoptosis of B cell chronic lymphocytic leukemia (B-CLL) cells is regulated by the PI-3K-Akt pathway." | 1.33 | Regulation of Akt/PKB by phosphatidylinositol 3-kinase-dependent and -independent pathways in B-cell chronic lymphocytic leukemia cells: role of protein kinase C{beta}. ( Barragán, M; Campàs, C; Castaño, E; Coll-Mulet, L; Cosialls, AM; de Frias, M; Domingo, A; Gil, J; Iglesias-Serret, D; Pons, G; Santidrián, AF, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (81.82) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mango, RL | 1 |
| Wu, QP | 1 |
| West, M | 1 |
| McCook, EC | 1 |
| Serody, JS | 1 |
| van Deventer, HW | 1 |
| Holler, C | 1 |
| Piñón, JD | 1 |
| Denk, U | 1 |
| Heyder, C | 1 |
| Hofbauer, S | 1 |
| Greil, R | 1 |
| Egle, A | 1 |
| Niedermeier, M | 1 |
| Hennessy, BT | 1 |
| Knight, ZA | 1 |
| Henneberg, M | 1 |
| Hu, J | 1 |
| Kurtova, AV | 1 |
| Wierda, WG | 1 |
| Keating, MJ | 1 |
| Shokat, KM | 1 |
| Burger, JA | 1 |
| Decker, T | 1 |
| Bogner, C | 1 |
| Oelsner, M | 1 |
| Peschel, C | 1 |
| Ringshausen, I | 1 |
| Jones, DT | 2 |
| Ganeshaguru, K | 2 |
| Anderson, RJ | 1 |
| Jackson, TR | 1 |
| Bruckdorfer, KR | 1 |
| Low, SY | 1 |
| Palmqvist, L | 1 |
| Prentice, HG | 2 |
| Hoffbrand, AV | 2 |
| Mehta, AB | 2 |
| Wickremasinghe, RG | 2 |
| Mone, AP | 1 |
| Huang, P | 1 |
| Pelicano, H | 1 |
| Cheney, CM | 1 |
| Green, JM | 1 |
| Tso, JY | 1 |
| Johnson, AJ | 1 |
| Jefferson, S | 1 |
| Lin, TS | 1 |
| Byrd, JC | 1 |
| Plate, JM | 1 |
| Breslin, EM | 1 |
| White, PC | 1 |
| Shore, AM | 1 |
| Clement, M | 1 |
| Brennan, P | 1 |
| Kawauchi, K | 1 |
| Ihjima, K | 1 |
| Yamada, O | 1 |
| Barragán, M | 1 |
| de Frias, M | 1 |
| Iglesias-Serret, D | 1 |
| Campàs, C | 1 |
| Castaño, E | 1 |
| Santidrián, AF | 1 |
| Coll-Mulet, L | 1 |
| Cosialls, AM | 1 |
| Domingo, A | 1 |
| Pons, G | 1 |
| Gil, J | 1 |
| Lindsay, C | 1 |
| Spanswick, VJ | 1 |
| Hartley, JA | 1 |
| Wadhwa, M | 1 |
| Thorpe, R | 1 |
11 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and B-Cell Chronic Lymphocytic Leukemia
| Article | Year |
|---|---|
C-C chemokine receptor 5 on pulmonary mesenchymal cells promotes experimental metastasis via the induction of erythroid differentiation regulator 1.
Topics: Animals; CCR5 Receptor Antagonists; Cell Line, Tumor; Chromones; Coculture Techniques; Female; Gene | 2014 |
PKCbeta is essential for the development of chronic lymphocytic leukemia in the TCL1 transgenic mouse model: validation of PKCbeta as a therapeutic target in chronic lymphocytic leukemia.
Topics: Aged; Aged, 80 and over; Alleles; Animals; B-Lymphocytes; CD5 Antigens; Cell Line, Tumor; Chromones; | 2009 |
Isoform-selective phosphoinositide 3'-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: a novel therapeutic approach.
Topics: 1-Phosphatidylinositol 4-Kinase; Actin Cytoskeleton; Antineoplastic Combined Chemotherapy Protocols; | 2009 |
Antiapoptotic effect of interleukin-2 (IL-2) in B-CLL cells with low and high affinity IL-2 receptors.
Topics: Apoptosis; Chromones; Humans; Interleukin-2; Interleukin-2 Receptor alpha Subunit; Leukemia, Lymphoc | 2010 |
Albumin activates the AKT signaling pathway and protects B-chronic lymphocytic leukemia cells from chlorambucil- and radiation-induced apoptosis.
Topics: Apoptosis; Chlorambucil; Chromones; Endocytosis; Enzyme Inhibitors; Gamma Rays; Humans; Leukemia, Ly | 2003 |
Hu1D10 induces apoptosis concurrent with activation of the AKT survival pathway in human chronic lymphocytic leukemia cells.
Topics: Acetylcysteine; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Ap | 2004 |
PI3-kinase regulates survival of chronic lymphocytic leukemia B-cells by preventing caspase 8 activation.
Topics: Apoptosis; Calpain; Caspase 8; Caspase Inhibitors; Caspases; Cell Cycle; Cell Survival; Chromones; C | 2004 |
LY294002 and rapamycin co-operate to inhibit T-cell proliferation.
Topics: Cell Line, Tumor; Cell Proliferation; Cell Survival; Chromones; Drug Interactions; Enzyme Inhibitors | 2005 |
IL-2 increases human telomerase reverse transcriptase activity transcriptionally and posttranslationally through phosphatidylinositol 3'-kinase/Akt, heat shock protein 90, and mammalian target of rapamycin in transformed NK cells.
Topics: Cell Line, Transformed; Chromones; DNA-Binding Proteins; Enzyme Inhibitors; Extracellular Signal-Reg | 2005 |
Regulation of Akt/PKB by phosphatidylinositol 3-kinase-dependent and -independent pathways in B-cell chronic lymphocytic leukemia cells: role of protein kinase C{beta}.
Topics: Apoptosis; Carcinogens; Chromones; Enzyme Inhibitors; Humans; Leukemia, Lymphocytic, Chronic, B-Cell | 2006 |
Autologous plasma activates Akt/protein kinase B and enhances basal survival and resistance to DNA damage-induced apoptosis in B-chronic lymphocytic leukaemia cells.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Blotting, Western; Chlorambucil; Chromones; Drug Resis | 2001 |