2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Astrocytoma in 5 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
Astrocytoma: Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, we report on the ability of carbachol to stimulate the phosphorylation of Akt/PKB, an important target of phosphatidylinositol 3 kinase (PI3 kinase) in 1321N1 human astrocytoma cells." | 3.71 | Activation of phosphatidylinositol 3 kinase by muscarinic receptors in astrocytoma cells. ( Costa, LG; Guizzetti, M, 2001) |
| "Phenserine treatment resulted in decreased secretion of soluble betaAPP and Abeta into the conditioned media of human neuroblastoma cells without cellular toxicity." | 1.31 | Phenserine regulates translation of beta -amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development. ( Brossi, A; Ge, YW; Greig, NH; Lahiri, DK; Rogers, J; Sambamurti, K; Shaw, KT; Utsuki, T; Yu, QS, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (80.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, LH | 1 |
| Yang, XL | 1 |
| Zhang, X | 1 |
| Cheng, JX | 1 |
| Zhang, W | 1 |
| Woods, SA | 1 |
| McGlade, CJ | 1 |
| Guha, A | 1 |
| Sellers, LA | 1 |
| Simon, J | 1 |
| Lundahl, TS | 1 |
| Cousens, DJ | 1 |
| Humphrey, PP | 1 |
| Barnard, EA | 1 |
| Shaw, KT | 1 |
| Utsuki, T | 1 |
| Rogers, J | 1 |
| Yu, QS | 1 |
| Sambamurti, K | 1 |
| Brossi, A | 1 |
| Ge, YW | 1 |
| Lahiri, DK | 1 |
| Greig, NH | 1 |
| Guizzetti, M | 1 |
| Costa, LG | 1 |
5 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Astrocytoma
| Article | Year |
|---|---|
Association of elevated GRP78 expression with increased astrocytoma malignancy via Akt and ERK pathways.
Topics: Antibodies, Neutralizing; Astrocytoma; Brain Neoplasms; Cell Division; Chromones; Endoplasmic Reticu | 2011 |
Phosphatidylinositol 3'-kinase and MAPK/ERK kinase 1/2 differentially regulate expression of vascular endothelial growth factor in human malignant astrocytoma cells.
Topics: Astrocytoma; Blotting, Northern; Blotting, Western; Butadienes; Cell Hypoxia; Cell Line; Central Ner | 2002 |
Adenosine nucleotides acting at the human P2Y1 receptor stimulate mitogen-activated protein kinases and induce apoptosis.
Topics: Adenine Nucleotides; Adenosine Diphosphate; Annexin A5; Apoptosis; Astrocytoma; Carbachol; Carbazole | 2001 |
Phenserine regulates translation of beta -amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development.
Topics: 5' Untranslated Regions; Amyloid beta-Protein Precursor; Astrocytoma; Cell Survival; Chloramphenicol | 2001 |
Activation of phosphatidylinositol 3 kinase by muscarinic receptors in astrocytoma cells.
Topics: Androstadienes; Astrocytoma; Carbachol; Cholinergic Agonists; Chromones; Enzyme Inhibitors; Humans; | 2001 |