2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Astrocytoma, Grade IV in 35 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
| Excerpt | Relevance | Reference |
|---|---|---|
| "Glioblastoma is a high-grade glioma with poor prognosis even after surgery and standard therapy." | 5.51 | Carnosine inhibits glioblastoma growth independent from PI3K/Akt/mTOR signaling. ( Faust, H; Gaunitz, F; Meixensberger, J; Oppermann, H; Yamanishi, U, 2019) |
| " This includes less toxic drugs, more selective towards tumor cells, causing less damage to the patient." | 5.43 | Phosphatidylinositol 3-Kinase/AKT Pathway Inhibition by Doxazosin Promotes Glioblastoma Cells Death, Upregulation of p53 and Triggers Low Neurotoxicity. ( Battastini, AM; Coelho, BP; de Quadros, AH; Gaelzer, MM; Gonçalves, CA; Guerra, MC; Guma, FC; Hoppe, JB; Salbego, CG; Setton-Avruj, P; Terra, SR; Usach, V, 2016) |
| "Ginsenoside Rh2 (GRh2) has been reported to have a therapeutic effect on some tumors, and we recently reported its inhibitory effect on GBM growth in vitro and in vivo, possibly through an epidermal growth factor receptor (EGFR) signaling pathway." | 5.42 | Ginsenoside Rh2 inhibits growth of glioblastoma multiforme through mTor. ( Gao, Y; Guo, W; Li, S; Liu, Y, 2015) |
| "The aim of the study was to investigate the anticancer potential of LY294002 (PI3K inhibitor) and temozolomide using glioblastoma multiforme (T98G) and anaplastic astrocytoma (MOGGCCM) cells." | 4.02 | Involvement of PI3K Pathway in Glioma Cell Resistance to Temozolomide Treatment. ( Bądziul, D; Hułas-Stasiak, M; Jakubowicz-Gil, J; Langner, E; Maciejczyk, A; Pawelec, J; Pawlikowska-Pawlęga, B; Reichert, M; Rzeski, W; Sumorek-Wiadro, J; Wasiak, M; Wertel, I; Zając, A, 2021) |
| " Here, we define the effects of the marine natural product fucoxanthin, separately and in combination with the prototypic phosphatidylinositol 3-kinase (PI3K) inhibitor LY-294002, on gene expression in a well-established human glioblastoma cell system, U87MG." | 3.96 | Transcriptomics predicts compound synergy in drug and natural product treated glioblastoma cells. ( Bailey, DS; Bender, A; Gomez, LD; Kletnieks, E; Kopanitsa, L; Módos, D; Pruteanu, LL; Samarova, E, 2020) |
| "Temozolomide (TMZ) is a promising chemotherapeutic agent for treating glioblastomas." | 3.81 | PI3K inhibitor combined with miR-125b inhibitor sensitize TMZ-induced anti-glioma stem cancer effects through inactivation of Wnt/β-catenin signaling pathway. ( Fei, X; Shi, L; Wang, Z; You, Y, 2015) |
| " In GS-2 glioblastoma cells, PI3K inhibition by LY294002 or everolimus caused hyperpolarized lactate to drop to 42 +/- 12% and to 76 +/- 5%, respectively." | 3.76 | Noninvasive detection of target modulation following phosphatidylinositol 3-kinase inhibition using hyperpolarized 13C magnetic resonance spectroscopy. ( Brandes, AH; Chaumeil, MM; Dafni, H; Haas-Kogan, DA; James, CD; Kurhanewicz, J; Nelson, SJ; Ronen, SM; Sukumar, S; Vancriekinge, M; Venkatesh, HS; Vigneron, DB; Ward, CS, 2010) |
| "Glioblastoma is a high-grade glioma with poor prognosis even after surgery and standard therapy." | 1.51 | Carnosine inhibits glioblastoma growth independent from PI3K/Akt/mTOR signaling. ( Faust, H; Gaunitz, F; Meixensberger, J; Oppermann, H; Yamanishi, U, 2019) |
| " This includes less toxic drugs, more selective towards tumor cells, causing less damage to the patient." | 1.43 | Phosphatidylinositol 3-Kinase/AKT Pathway Inhibition by Doxazosin Promotes Glioblastoma Cells Death, Upregulation of p53 and Triggers Low Neurotoxicity. ( Battastini, AM; Coelho, BP; de Quadros, AH; Gaelzer, MM; Gonçalves, CA; Guerra, MC; Guma, FC; Hoppe, JB; Salbego, CG; Setton-Avruj, P; Terra, SR; Usach, V, 2016) |
| "Glioblastoma is an aggressive brain cancer requiring improved treatments." | 1.43 | Developing a Novel Embryo-Larval Zebrafish Xenograft Assay to Prioritize Human Glioblastoma Therapeutics. ( Greenwood, JA; Punnoose, A; Tanguay, RL; Wehmas, LC, 2016) |
| "Ginsenoside Rh2 (GRh2) has been reported to have a therapeutic effect on some tumors, and we recently reported its inhibitory effect on GBM growth in vitro and in vivo, possibly through an epidermal growth factor receptor (EGFR) signaling pathway." | 1.42 | Ginsenoside Rh2 inhibits growth of glioblastoma multiforme through mTor. ( Gao, Y; Guo, W; Li, S; Liu, Y, 2015) |
| "Glioblastoma (GBM) is the most common brain cancer and is highly lethal in both adults and children." | 1.40 | PTEN status mediates 2ME2 anti-tumor efficacy in preclinical glioblastoma models: role of HIF1α suppression. ( Durden, DL; Joshi, S; Kesari, S; Makale, MT; Muh, CR; Singh, AR, 2014) |
| "Radiation therapy is a mainstay in the treatment of glioblastomas, but these tumors are often associated with radioresistance." | 1.34 | Inhibition of phosphatidylinositol-3-OH kinase/Akt signaling impairs DNA repair in glioblastoma cells following ionizing radiation. ( Fernandes, AM; Gupta, AK; Jiang, Z; Kao, GD; Maity, A, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 14 (40.00) | 29.6817 |
| 2010's | 18 (51.43) | 24.3611 |
| 2020's | 3 (8.57) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, L | 2 |
| Yu, J | 1 |
| Pan, H | 1 |
| Hu, P | 1 |
| Hao, Y | 1 |
| Cai, W | 1 |
| Zhu, H | 1 |
| Yu, AD | 1 |
| Xie, X | 1 |
| Ma, D | 1 |
| Yuan, J | 1 |
| Seifert, C | 1 |
| Balz, E | 1 |
| Herzog, S | 2 |
| Korolev, A | 1 |
| Gaßmann, S | 1 |
| Paland, H | 1 |
| Fink, MA | 2 |
| Grube, M | 1 |
| Marx, S | 1 |
| Jedlitschky, G | 1 |
| Tzvetkov, MV | 1 |
| Rauch, BH | 1 |
| Schroeder, HWS | 1 |
| Bien-Möller, S | 2 |
| Nie, X | 1 |
| Zhou, Y | 1 |
| Li, X | 1 |
| Xu, J | 1 |
| Pan, X | 1 |
| Yin, R | 1 |
| Lu, B | 1 |
| Wu, Y | 1 |
| Li, Z | 1 |
| Liu, G | 1 |
| Pruteanu, LL | 1 |
| Kopanitsa, L | 1 |
| Módos, D | 1 |
| Kletnieks, E | 1 |
| Samarova, E | 1 |
| Bender, A | 1 |
| Gomez, LD | 1 |
| Bailey, DS | 1 |
| Zając, A | 1 |
| Sumorek-Wiadro, J | 1 |
| Langner, E | 1 |
| Wertel, I | 1 |
| Maciejczyk, A | 1 |
| Pawlikowska-Pawlęga, B | 1 |
| Pawelec, J | 1 |
| Wasiak, M | 1 |
| Hułas-Stasiak, M | 1 |
| Bądziul, D | 1 |
| Rzeski, W | 1 |
| Reichert, M | 1 |
| Jakubowicz-Gil, J | 1 |
| Oppermann, H | 1 |
| Faust, H | 1 |
| Yamanishi, U | 1 |
| Meixensberger, J | 1 |
| Gaunitz, F | 1 |
| Friedman, MD | 1 |
| Jeevan, DS | 1 |
| Tobias, M | 1 |
| Murali, R | 2 |
| Jhanwar-Uniyal, M | 2 |
| Muh, CR | 1 |
| Joshi, S | 1 |
| Singh, AR | 1 |
| Kesari, S | 1 |
| Durden, DL | 1 |
| Makale, MT | 1 |
| Carminati, PO | 1 |
| Donaires, FS | 1 |
| Marques, MM | 1 |
| Donadi, EA | 1 |
| Passos, GA | 1 |
| Sakamoto-Hojo, ET | 1 |
| Wang, F | 1 |
| Xiao, W | 1 |
| Sun, J | 1 |
| Han, D | 1 |
| Zhu, Y | 1 |
| Weitmann, K | 1 |
| Friedel, C | 1 |
| Hadlich, S | 1 |
| Langner, S | 1 |
| Kindermann, K | 1 |
| Holm, T | 1 |
| Böhm, A | 1 |
| Eskilsson, E | 1 |
| Miletic, H | 1 |
| Hildner, M | 1 |
| Fritsch, M | 1 |
| Vogelgesang, S | 1 |
| Havemann, C | 1 |
| Ritter, CA | 1 |
| Meyer zu Schwabedissen, HE | 1 |
| Rauch, B | 1 |
| Hoffmann, W | 1 |
| Kroemer, HK | 1 |
| Schroeder, H | 1 |
| Gwak, HS | 1 |
| Park, MJ | 1 |
| Park, IC | 1 |
| Woo, SH | 1 |
| Jin, HO | 1 |
| Rhee, CH | 1 |
| Jung, HW | 1 |
| Li, S | 1 |
| Guo, W | 1 |
| Gao, Y | 1 |
| Liu, Y | 1 |
| Shi, L | 1 |
| Fei, X | 1 |
| Wang, Z | 1 |
| You, Y | 1 |
| Gaelzer, MM | 1 |
| Coelho, BP | 1 |
| de Quadros, AH | 1 |
| Hoppe, JB | 1 |
| Terra, SR | 1 |
| Guerra, MC | 1 |
| Usach, V | 1 |
| Guma, FC | 1 |
| Gonçalves, CA | 1 |
| Setton-Avruj, P | 1 |
| Battastini, AM | 1 |
| Salbego, CG | 1 |
| Wehmas, LC | 1 |
| Tanguay, RL | 1 |
| Punnoose, A | 1 |
| Greenwood, JA | 1 |
| Jalota, A | 1 |
| Kumar, M | 1 |
| Das, BC | 1 |
| Yadav, AK | 1 |
| Chosdol, K | 1 |
| Sinha, S | 1 |
| Pandher, R | 1 |
| Ducruix, C | 1 |
| Eccles, SA | 1 |
| Raynaud, FI | 1 |
| Johannessen, TC | 1 |
| Wang, J | 1 |
| Skaftnesmo, KO | 1 |
| Sakariassen, PØ | 1 |
| Enger, PØ | 1 |
| Petersen, K | 1 |
| Øyan, AM | 1 |
| Kalland, KH | 1 |
| Bjerkvig, R | 1 |
| Tysnes, BB | 1 |
| Westhoff, MA | 1 |
| Kandenwein, JA | 1 |
| Karl, S | 1 |
| Vellanki, SH | 1 |
| Braun, V | 1 |
| Eramo, A | 1 |
| Antoniadis, G | 1 |
| Debatin, KM | 1 |
| Fulda, S | 1 |
| Gulati, N | 1 |
| Karsy, M | 1 |
| Albert, L | 1 |
| Ward, CS | 2 |
| Venkatesh, HS | 2 |
| Chaumeil, MM | 2 |
| Brandes, AH | 1 |
| Vancriekinge, M | 1 |
| Dafni, H | 1 |
| Sukumar, S | 1 |
| Nelson, SJ | 1 |
| Vigneron, DB | 1 |
| Kurhanewicz, J | 1 |
| James, CD | 2 |
| Haas-Kogan, DA | 3 |
| Ronen, SM | 2 |
| Sunayama, J | 1 |
| Sato, A | 1 |
| Matsuda, K | 1 |
| Tachibana, K | 1 |
| Suzuki, K | 1 |
| Narita, Y | 1 |
| Shibui, S | 1 |
| Sakurada, K | 1 |
| Kayama, T | 1 |
| Tomiyama, A | 1 |
| Kitanaka, C | 1 |
| Zhang, LH | 1 |
| Yang, XL | 1 |
| Zhang, X | 1 |
| Cheng, JX | 1 |
| Zhang, W | 1 |
| Edwards, E | 1 |
| Geng, L | 1 |
| Tan, J | 1 |
| Onishko, H | 1 |
| Donnelly, E | 1 |
| Hallahan, DE | 1 |
| Yanamandra, N | 1 |
| Gumidyala, KV | 1 |
| Waldron, KG | 1 |
| Gujrati, M | 1 |
| Olivero, WC | 1 |
| Dinh, DH | 1 |
| Rao, JS | 1 |
| Mohanam, S | 1 |
| Aeder, SE | 1 |
| Martin, PM | 1 |
| Soh, JW | 1 |
| Hussaini, IM | 1 |
| Brandts, CH | 1 |
| Bilanges, B | 1 |
| Hare, G | 1 |
| McCormick, F | 1 |
| Stokoe, D | 2 |
| Zhan, Y | 1 |
| O'Rourke, DM | 1 |
| Nakamura, JL | 1 |
| Karlsson, A | 1 |
| Arvold, ND | 1 |
| Gottschalk, AR | 1 |
| Pieper, RO | 1 |
| Pore, N | 1 |
| Jiang, Z | 2 |
| Shu, HK | 1 |
| Bernhard, E | 1 |
| Kao, GD | 2 |
| Maity, A | 2 |
| Fernandes, AM | 1 |
| Gupta, AK | 1 |
| Huang, R | 1 |
| Liu, YG | 1 |
| Lin, Y | 1 |
| Fan, Y | 1 |
| Boynton, A | 1 |
| Yang, D | 1 |
| Huang, RP | 1 |
35 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Small molecule regulators of autophagy identified by an image-based high-throughput screen.
Topics: Autophagy; Calcium Channel Blockers; Cell Line, Tumor; Drug Evaluation, Preclinical; Fluspirilene; G | 2007 |
PIM1 Inhibition Affects Glioblastoma Stem Cell Behavior and Kills Glioblastoma Stem-like Cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Survival; Chromones; Drug Screening | 2021 |
Calycosin down-regulates c-Met to suppress development of glioblastomas.
Topics: Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromones; Gene Expression Regulatio | 2019 |
Tivantinib Hampers the Proliferation of Glioblastoma Cells via PI3K/Akt/Mammalian Target of Rapamycin (mTOR) Signaling.
Topics: Adult; Aged; Cell Line, Tumor; Cell Proliferation; China; Chromones; Female; Gene Expression; Gliobl | 2019 |
Transcriptomics predicts compound synergy in drug and natural product treated glioblastoma cells.
Topics: Apoptosis; Biological Products; Cell Line, Tumor; Cell Proliferation; Chromones; Combined Modality T | 2020 |
Involvement of PI3K Pathway in Glioma Cell Resistance to Temozolomide Treatment.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Biomarkers, Tumor; Cell Proliferation; Chromones; Drug | 2021 |
Carnosine inhibits glioblastoma growth independent from PI3K/Akt/mTOR signaling.
Topics: Brain Neoplasms; Carnosine; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chromones; Drug Scr | 2019 |
Targeting cancer stem cells in glioblastoma multiforme using mTOR inhibitors and the differentiating agent all-trans retinoic acid.
Topics: Antibiotics, Antineoplastic; Brain Neoplasms; Butadienes; Cell Differentiation; Cell Line, Tumor; Ce | 2013 |
PTEN status mediates 2ME2 anti-tumor efficacy in preclinical glioblastoma models: role of HIF1α suppression.
Topics: 2-Methoxyestradiol; Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Hypoxia; Cell L | 2014 |
Cisplatin associated with LY294002 increases cytotoxicity and induces changes in transcript profiles of glioblastoma cells.
Topics: Antineoplastic Agents; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Cell Line, Tumor; Cell Pro | 2014 |
MiRNA-181c inhibits EGFR-signaling-dependent MMP9 activation via suppressing Akt phosphorylation in glioblastoma.
Topics: Blotting, Western; Cell Line, Tumor; Chromones; Enzyme Activation; Enzyme Inhibitors; Epidermal Grow | 2014 |
Pim1 kinase is upregulated in glioblastoma multiforme and mediates tumor cell survival.
Topics: Animals; Apoptosis; Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Survival; Chromones; ErbB Re | 2015 |
Tetraarsenic oxide-induced inhibition of malignant glioma cell invasion in vitro via a decrease in matrix metalloproteinase secretion and protein kinase B phosphorylation.
Topics: Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Brain Neoplasms; Cell Line, Tumor; C | 2014 |
Ginsenoside Rh2 inhibits growth of glioblastoma multiforme through mTor.
Topics: Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Chromones; ErbB Receptors; Ginsenosides; Glio | 2015 |
PI3K inhibitor combined with miR-125b inhibitor sensitize TMZ-induced anti-glioma stem cancer effects through inactivation of Wnt/β-catenin signaling pathway.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; beta Catenin; Cell Movement; Cell Survival; Chromones; | 2015 |
Phosphatidylinositol 3-Kinase/AKT Pathway Inhibition by Doxazosin Promotes Glioblastoma Cells Death, Upregulation of p53 and Triggers Low Neurotoxicity.
Topics: Animals; Antineoplastic Agents; Apoptosis; Astrocytes; Brain Neoplasms; Caspase 3; Cell Line, Tumor; | 2016 |
Developing a Novel Embryo-Larval Zebrafish Xenograft Assay to Prioritize Human Glioblastoma Therapeutics.
Topics: Animals; Antineoplastic Agents; Chromones; Disease Models, Animal; Glioblastoma; Heterografts; Human | 2016 |
Synergistic increase in efficacy of a combination of 2-deoxy-D-glucose and cisplatin in normoxia and hypoxia: switch from autophagy to apoptosis.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; bcl-2-Associated X Protein; Blotting, Western; Cell Hyp | 2016 |
Cross-platform Q-TOF validation of global exo-metabolomic analysis: application to human glioblastoma cells treated with the standard PI 3-Kinase inhibitor LY294002.
Topics: Brain Neoplasms; Cell Line, Tumor; Chromones; Enzyme Inhibitors; Glioblastoma; Humans; Morpholines; | 2009 |
Highly infiltrative brain tumours show reduced chemosensitivity associated with a stem cell-like phenotype.
Topics: Animals; Antineoplastic Agents; Brain; Brain Neoplasms; Chromones; Doxorubicin; Enzyme Inhibitors; G | 2009 |
The pyridinylfuranopyrimidine inhibitor, PI-103, chemosensitizes glioblastoma cells for apoptosis by inhibiting DNA repair.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Chromones; DNA Damage; DNA Repair; DNA-Activated | 2009 |
Involvement of mTORC1 and mTORC2 in regulation of glioblastoma multiforme growth and motility.
Topics: Active Transport, Cell Nucleus; Adaptor Proteins, Signal Transducing; Antibiotics, Antineoplastic; C | 2009 |
Noninvasive detection of target modulation following phosphatidylinositol 3-kinase inhibition using hyperpolarized 13C magnetic resonance spectroscopy.
Topics: Animals; Carbon Isotopes; Chromones; Drug Delivery Systems; Enzyme Inhibitors; Everolimus; Glioblast | 2010 |
Dual blocking of mTor and PI3K elicits a prodifferentiation effect on glioblastoma stem-like cells.
Topics: Animals; Blotting, Western; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Chromones; D | 2010 |
Association of elevated GRP78 expression with increased astrocytoma malignancy via Akt and ERK pathways.
Topics: Antibodies, Neutralizing; Astrocytoma; Brain Neoplasms; Cell Division; Chromones; Endoplasmic Reticu | 2011 |
Reduced phosphocholine and hyperpolarized lactate provide magnetic resonance biomarkers of PI3K/Akt/mTOR inhibition in glioblastoma.
Topics: Antineoplastic Agents; Biomarkers; Cell Line, Tumor; Chromones; Enzyme Inhibitors; Everolimus; Gliob | 2012 |
Phosphatidylinositol 3-kinase/Akt signaling in the response of vascular endothelium to ionizing radiation.
Topics: Androstadienes; Animals; Apoptosis; Cell Survival; Cells, Cultured; Chromones; Endothelium, Vascular | 2002 |
Blockade of cathepsin B expression in human glioblastoma cells is associated with suppression of angiogenesis.
Topics: Angiogenesis Inhibitors; Animals; Biological Assay; Brain Neoplasms; Cathepsin B; Cell Line, Tumor; | 2004 |
PKC-eta mediates glioblastoma cell proliferation through the Akt and mTOR signaling pathways.
Topics: Brain Neoplasms; Cell Cycle; Chromones; Enzyme Inhibitors; Glioblastoma; Humans; Morpholines; Protei | 2004 |
Phosphorylation-independent stabilization of p27kip1 by the phosphoinositide 3-kinase pathway in glioblastoma cells.
Topics: Base Sequence; Cell Cycle Proteins; Cell Line, Tumor; Chromones; Cyclin-Dependent Kinase Inhibitor p | 2005 |
SHP-2-dependent mitogen-activated protein kinase activation regulates EGFRvIII but not wild-type epidermal growth factor receptor phosphorylation and glioblastoma cell survival.
Topics: Brain Neoplasms; Cell Line, Tumor; Chromones; Enzyme Activation; ErbB Receptors; Flavonoids; Gliobla | 2004 |
PKB/Akt mediates radiosensitization by the signaling inhibitor LY294002 in human malignant gliomas.
Topics: Agammaglobulinaemia Tyrosine Kinase; Analysis of Variance; Antibiotics, Antineoplastic; Brain Neopla | 2005 |
Akt1 activation can augment hypoxia-inducible factor-1alpha expression by increasing protein translation through a mammalian target of rapamycin-independent pathway.
Topics: Cell Line, Tumor; Chromones; Enzyme Activation; Enzyme Inhibitors; Glioblastoma; Humans; Hypoxia-Ind | 2006 |
Inhibition of phosphatidylinositol-3-OH kinase/Akt signaling impairs DNA repair in glioblastoma cells following ionizing radiation.
Topics: Cell Cycle; Cell Line, Tumor; Chromones; DNA Damage; DNA Repair; Dose-Response Relationship, Drug; D | 2007 |
Enhanced apoptosis under low serum conditions in human glioblastoma cells by connexin 43 (Cx43).
Topics: Apoptosis; Chromones; Connexin 43; Culture Media; Estrogens, Non-Steroidal; Gene Expression Regulati | 2001 |