2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Asthma in 23 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
| Excerpt | Relevance | Reference |
|---|---|---|
| "We sought to determine whether a bronchial epithelial dysfunction of the leptin/leptin receptor pathway contributes to asthma pathogenesis and severity." | 7.75 | Leptin and leptin receptor expression in asthma. ( Bruno, A; Chanez, P; Chiappara, G; Gerbino, S; Gjomarkaj, M; Gras, D; La Guardia, M; Pace, E; Profita, M; Vachier, I, 2009) |
| "Ovalbumin (OVA) sensitized murine model of asthma was used to investigate the expression of cyclin D1, cyclin A, and p27kip1 by splenic CD4(+) T lymphocytes." | 3.79 | PI3K and Notch signal pathways coordinately regulate the activation and proliferation of T lymphocytes in asthma. ( Cai, X; Chong, L; Li, C; Liang, Y; Lin, B; Nie, Y; Zhang, H; Zhang, W, 2013) |
| "Responsiveness to corticosteroids dexamethasone (Dex), budesonide (Bud) and fluticasone propionate (FP) was determined, as IC(50) values on TNF-α-induced interleukin 8 release, in U937 monocytic cell line treated with hydrogen peroxide (H(2) O(2) ) or peripheral blood mononuclear cells (PBMCs) from patients with COPD or severe asthma." | 3.78 | Corticosteroid insensitivity is reversed by formoterol via phosphoinositide-3-kinase inhibition. ( Barnes, PJ; Ito, K; Ito, M; Osoata, G; Rossios, C; To, Y, 2012) |
| "We sought to determine whether a bronchial epithelial dysfunction of the leptin/leptin receptor pathway contributes to asthma pathogenesis and severity." | 3.75 | Leptin and leptin receptor expression in asthma. ( Bruno, A; Chanez, P; Chiappara, G; Gerbino, S; Gjomarkaj, M; Gras, D; La Guardia, M; Pace, E; Profita, M; Vachier, I, 2009) |
| "To observe the effect of acupuncture preconditioning combined with PI3K blocker LY294002 on the expression of PI3K and Akt proteins and genes in the lung tissue and the contents of serum IL-12 and IL-13 in asthmatic rats, so as to explore its preprotective mechanism underlying improving asthma." | 1.72 | [Effect of acupuncture preconditioning combined with PI3K blocker LY294002 on airway inflammation in asthmatic rats]. ( Chen, F; Gong, JJ; Hua, JS; Li, HJ; Yan, HY; Zhang, YY, 2022) |
| "Airway remodeling is the important reason of refractory asthma and is associated with differentiation of airway epithelia into myofibroblasts via epithelial-mesenchymal transition (EMT) to increase the process of subepithelial fibrosis." | 1.46 | Autophagy plays a role in FSTL1-induced epithelial mesenchymal transition and airway remodeling in asthma. ( Broide, DH; Cao, L; Dong, L; Li, S; Liu, L; Liu, T; Liu, Y; Miller, M; Wang, J; Wu, J; Xu, J; Zhao, J; Zou, M, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (26.09) | 29.6817 |
| 2010's | 14 (60.87) | 24.3611 |
| 2020's | 3 (13.04) | 2.80 |
| Authors | Studies |
|---|---|
| Hua, JS | 1 |
| Li, HJ | 1 |
| Chen, F | 1 |
| Gong, JJ | 1 |
| Zhang, YY | 1 |
| Yan, HY | 1 |
| Ye, C | 1 |
| Huang, C | 2 |
| Zou, M | 3 |
| Hu, Y | 2 |
| Luo, L | 2 |
| Wei, Y | 1 |
| Wan, X | 1 |
| Zhao, H | 3 |
| Li, W | 2 |
| Cai, S | 3 |
| Dong, H | 3 |
| He, S | 1 |
| Chen, M | 1 |
| Lin, X | 1 |
| Lv, Z | 1 |
| Liang, R | 1 |
| Huang, L | 1 |
| Ma, B | 1 |
| Athari, SS | 1 |
| Mehrabi Nasab, E | 1 |
| Zhao, L | 1 |
| Yu, C | 1 |
| Chen, J | 1 |
| Xie, Z | 1 |
| Le, Y | 1 |
| Zou, F | 2 |
| Liu, L | 2 |
| Liu, T | 1 |
| Liu, Y | 1 |
| Miller, M | 1 |
| Cao, L | 1 |
| Zhao, J | 1 |
| Wu, J | 1 |
| Wang, J | 1 |
| Li, S | 1 |
| Xu, J | 1 |
| Broide, DH | 1 |
| Dong, L | 1 |
| Feng, S | 1 |
| Zhang, L | 1 |
| Bian, XH | 1 |
| Luo, Y | 1 |
| Qin, GH | 1 |
| Shi, RM | 1 |
| Tang, L | 1 |
| Chen, Q | 1 |
| Meng, Z | 1 |
| Sun, L | 1 |
| Zhu, L | 1 |
| Liu, J | 1 |
| Hu, J | 1 |
| Ni, Z | 1 |
| Wang, X | 1 |
| Huang, X | 1 |
| Qu, D | 1 |
| Liang, Y | 2 |
| Huang, Q | 1 |
| Li, M | 1 |
| Hou, C | 1 |
| Zhang, W | 1 |
| Nie, Y | 1 |
| Chong, L | 1 |
| Cai, X | 1 |
| Zhang, H | 1 |
| Lin, B | 1 |
| Li, C | 1 |
| Okayasu, K | 1 |
| Tamaoka, M | 1 |
| Takayama, S | 1 |
| Miyazaki, Y | 1 |
| Sumi, Y | 1 |
| Inase, N | 1 |
| Yoshizawa, Y | 1 |
| Yan, F | 1 |
| Zhou, H | 1 |
| Wu, Y | 1 |
| Ying, S | 1 |
| Chen, Z | 1 |
| Shen, H | 1 |
| Yao, L | 1 |
| Tang, H | 1 |
| Song, J | 1 |
| Bruno, A | 1 |
| Pace, E | 1 |
| Chanez, P | 1 |
| Gras, D | 1 |
| Vachier, I | 1 |
| Chiappara, G | 1 |
| La Guardia, M | 1 |
| Gerbino, S | 1 |
| Profita, M | 1 |
| Gjomarkaj, M | 1 |
| Ge, Q | 1 |
| Moir, LM | 1 |
| Trian, T | 1 |
| Niimi, K | 1 |
| Poniris, M | 1 |
| Shepherd, PR | 1 |
| Black, JL | 1 |
| Oliver, BG | 1 |
| Burgess, JK | 1 |
| Rossios, C | 1 |
| To, Y | 1 |
| Osoata, G | 1 |
| Ito, M | 1 |
| Barnes, PJ | 1 |
| Ito, K | 1 |
| Jude, JA | 1 |
| Tirumurugaan, KG | 1 |
| Kang, BN | 1 |
| Panettieri, RA | 1 |
| Walseth, TF | 1 |
| Kannan, MS | 1 |
| Staples, KJ | 1 |
| Hinks, TS | 1 |
| Ward, JA | 1 |
| Gunn, V | 1 |
| Smith, C | 1 |
| Djukanović, R | 1 |
| Kwak, YG | 1 |
| Song, CH | 1 |
| Yi, HK | 1 |
| Hwang, PH | 1 |
| Kim, JS | 1 |
| Lee, KS | 2 |
| Lee, YC | 2 |
| Duan, W | 1 |
| Aguinaldo Datiles, AM | 1 |
| Leung, BP | 1 |
| Vlahos, CJ | 1 |
| Wong, WS | 1 |
| Ibe, BO | 1 |
| Portugal, AM | 1 |
| Raj, JU | 1 |
| Kim, SR | 1 |
| Park, SJ | 1 |
| Lee, HK | 1 |
| Park, HS | 1 |
| Min, KH | 1 |
| Jin, SM | 1 |
| Bracke, M | 1 |
| van de Graaf, E | 1 |
| Lammers, JW | 1 |
| Coffer, PJ | 1 |
| Koenderman, L | 1 |
23 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Asthma
| Article | Year |
|---|---|
[Effect of acupuncture preconditioning combined with PI3K blocker LY294002 on airway inflammation in asthmatic rats].
Topics: Acupuncture Therapy; Animals; Asthma; Chromones; Inflammation; Interleukin-12; Interleukin-13; Male; | 2022 |
The role of secreted Hsp90α in HDM-induced asthmatic airway epithelial barrier dysfunction.
Topics: Animals; Asthma; Bronchi; Cadherins; Cell Line; Chromones; Cytokines; Electric Impedance; Epithelial | 2019 |
Triptolide inhibits PDGF-induced proliferation of ASMCs through G0/G1 cell cycle arrest and suppression of the AKT/NF-κB/cyclinD1 signaling pathway.
Topics: Airway Remodeling; Animals; Asthma; Bronchi; Cell Proliferation; Cells, Cultured; Chromones; Cyclin | 2020 |
PI3K/AKT/mTOR and TLR4/MyD88/NF-κB Signaling Inhibitors Attenuate Pathological Mechanisms of Allergic Asthma.
Topics: Animals; Anti-Asthmatic Agents; Asthma; Chromones; Female; Metformin; Mice; Mice, Inbred BALB C; Mor | 2021 |
TSLP signaling blocking alleviates E-cadherin dysfunction of airway epithelium in a HDM-induced asthma model.
Topics: Administration, Inhalation; Animals; Antibodies, Monoclonal; Asthma; beta Catenin; Bronchi; Bronchia | 2017 |
Autophagy plays a role in FSTL1-induced epithelial mesenchymal transition and airway remodeling in asthma.
Topics: Adult; Airway Remodeling; Animals; Asthma; Autophagosomes; Autophagy; Biomarkers; Bronchoalveolar La | 2017 |
Role of the TSLP-DC-OX40L pathway in asthma pathogenesis and airway inflammation in mice.
Topics: Animals; Asthma; Chromones; Cytokines; Dendritic Cells; Disease Models, Animal; Eosinophils; Immunog | 2018 |
Suppression of Sirtuin-1 Increases IL-6 Expression by Activation of the Akt Pathway During Allergic Asthma.
Topics: Animals; Asthma; Blotting, Western; Cell Line; Chromones; Disease Models, Animal; Enzyme Inhibitors; | 2017 |
Elevated S100A4 in asthmatics and an allergen-induced mouse asthma model.
Topics: Allergens; Animals; Asthma; Chromones; Disease Models, Animal; Female; Humans; Male; Mice; Mice, Inb | 2019 |
PI3K and Notch signal pathways coordinately regulate the activation and proliferation of T lymphocytes in asthma.
Topics: Animals; Asthma; CD4-Positive T-Lymphocytes; Cell Proliferation; Chromones; Cyclin A; Cyclin D1; Cyc | 2013 |
RANTES expression induced by Toll-like receptor 4 ligand in rat airway smooth muscle cells.
Topics: Animals; Asthma; Cell Culture Techniques; Cells, Cultured; Chemokine CCL11; Chemokine CCL5; Chromone | 2010 |
Interleukin-13-induced MUC5AC expression is regulated by a PI3K-NFAT3 pathway in mouse tracheal epithelial cells.
Topics: Animals; Asthma; Cells, Cultured; Chloride Channels; Chromones; Cyclosporine; Hepatocyte Nuclear Fac | 2014 |
Phosphatidylinositol 3-Kinase Mediates β-Catenin Dysfunction of Airway Epithelium in a Toluene Diisocyanate-Induced Murine Asthma Model.
Topics: Animals; Asthma; beta Catenin; Cadherins; Chromones; Enzyme Inhibitors; Interleukins; Male; MAP Kina | 2015 |
Leptin and leptin receptor expression in asthma.
Topics: Adult; Androstadienes; Asthma; Bronchi; Cell Line; Cell Proliferation; Chromones; Enzyme Inhibitors; | 2009 |
The phosphoinositide 3'-kinase p110δ modulates contractile protein production and IL-6 release in human airway smooth muscle.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Asthma; Benzamides; Cells, Cultured; Chromones; Class I Pho | 2012 |
Corticosteroid insensitivity is reversed by formoterol via phosphoinositide-3-kinase inhibition.
Topics: 1-Phosphatidylinositol 4-Kinase; Adenine; Adrenal Cortex Hormones; Adrenergic beta-2 Receptor Agonis | 2012 |
Regulation of CD38 expression in human airway smooth muscle cells: role of class I phosphatidylinositol 3 kinases.
Topics: ADP-ribosyl Cyclase 1; Asthma; Cells, Cultured; Chromones; Class Ia Phosphatidylinositol 3-Kinase; E | 2012 |
Phenotypic characterization of lung macrophages in asthmatic patients: overexpression of CCL17.
Topics: Adrenal Cortex Hormones; Adult; Asthma; Biomarkers; Chemokine CCL17; Chromones; Eosinophils; Female; | 2012 |
Involvement of PTEN in airway hyperresponsiveness and inflammation in bronchial asthma.
Topics: Allergens; Androstadienes; Animals; Asthma; Blood Proteins; Blotting, Western; Bronchoalveolar Lavag | 2003 |
An anti-inflammatory role for a phosphoinositide 3-kinase inhibitor LY294002 in a mouse asthma model.
Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Cell Movement; Chromones; C | 2005 |
Levalbuterol inhibits human airway smooth muscle cell proliferation: therapeutic implications in the management of asthma.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Albuterol; Asthma; Bronchodilator Agents; Cel | 2006 |
Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) reduces vascular endothelial growth factor expression in allergen-induced airway inflammation.
Topics: Adenoviridae; Allergens; Androstadienes; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cell Adhesio | 2006 |
In vivo priming of FcalphaR functioning on eosinophils of allergic asthmatics.
Topics: Adolescent; Adult; Antigens, CD; Asthma; Chromones; Enzyme Activation; Enzyme Inhibitors; Eosinophil | 2000 |