2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Arthritis, Rheumatoid in 18 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the potential regulation of sphingosine kinase 1 (SPHK1) on the migration, invasion, and matrix metalloproteinase (MMP) expression in human rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS)." | 7.80 | Knockdown of sphingosine kinase 1 inhibits the migration and invasion of human rheumatoid arthritis fibroblast-like synoviocytes by down-regulating the PI3K/AKT activation and MMP-2/9 production in vitro. ( Ding, S; Fang, F; Gao, W; Qiu, Z; Xiao, W; Yang, P; Yuan, H; Zhou, D, 2014) |
| "To investigate the potential regulation of sphingosine kinase 1 (SPHK1) on the migration, invasion, and matrix metalloproteinase (MMP) expression in human rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS)." | 3.80 | Knockdown of sphingosine kinase 1 inhibits the migration and invasion of human rheumatoid arthritis fibroblast-like synoviocytes by down-regulating the PI3K/AKT activation and MMP-2/9 production in vitro. ( Ding, S; Fang, F; Gao, W; Qiu, Z; Xiao, W; Yang, P; Yuan, H; Zhou, D, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (50.00) | 29.6817 |
| 2010's | 8 (44.44) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Ma, Z | 1 |
| Yu, R | 1 |
| Zhu, Q | 1 |
| Sun, L | 2 |
| Jian, L | 1 |
| Wang, X | 1 |
| Zhao, J | 2 |
| Li, C | 2 |
| Liu, X | 2 |
| Li, TM | 1 |
| Liu, SC | 1 |
| Huang, YH | 1 |
| Huang, CC | 1 |
| Hsu, CJ | 1 |
| Tsai, CH | 1 |
| Wang, SW | 1 |
| Tang, CH | 1 |
| Clarimundo, VS | 1 |
| Farinon, M | 1 |
| Pedó, RT | 1 |
| Teixeira, VON | 1 |
| Nör, C | 1 |
| Gulko, PS | 1 |
| Xavier, RM | 1 |
| de Oliveira, PG | 1 |
| Liu, Y | 1 |
| Wei, W | 1 |
| Hong, C | 1 |
| Wang, Y | 1 |
| Sun, X | 1 |
| Ma, J | 1 |
| Zheng, F | 1 |
| Yuan, H | 1 |
| Yang, P | 1 |
| Zhou, D | 1 |
| Gao, W | 1 |
| Qiu, Z | 1 |
| Fang, F | 1 |
| Ding, S | 1 |
| Xiao, W | 1 |
| Xing, R | 1 |
| Jin, Y | 1 |
| Yang, L | 1 |
| Li, Z | 1 |
| Mainz, ER | 1 |
| Serafin, DS | 1 |
| Nguyen, TT | 1 |
| Tarrant, TK | 1 |
| Sims, CE | 1 |
| Allbritton, NL | 1 |
| Westra, J | 1 |
| Brouwer, E | 1 |
| Bouwman, E | 1 |
| Doornbos-van der Meer, B | 1 |
| Posthumus, MD | 1 |
| van Leeuwen, MA | 1 |
| Limburg, PC | 1 |
| Ueda, Y | 1 |
| Kallenberg, CG | 1 |
| Wu, MY | 1 |
| Lin, TH | 1 |
| Chiu, YC | 1 |
| Liou, HC | 1 |
| Yang, RS | 1 |
| Fu, WM | 1 |
| Li, GQ | 1 |
| Zhang, Y | 1 |
| Liu, D | 1 |
| Qian, YY | 1 |
| Zhang, H | 1 |
| Guo, SY | 1 |
| Sunagawa, M | 1 |
| Hisamitsu, T | 1 |
| Liu, YQ | 1 |
| Miyashita, T | 1 |
| Kawakami, A | 1 |
| Tamai, M | 1 |
| Izumi, Y | 1 |
| Mingguo, H | 1 |
| Tanaka, F | 1 |
| Abiru, S | 1 |
| Nakashima, K | 1 |
| Iwanaga, N | 1 |
| Aratake, K | 1 |
| Kamachi, M | 1 |
| Arima, K | 1 |
| Ida, H | 1 |
| Migita, K | 1 |
| Origuchi, T | 1 |
| Tagashira, S | 1 |
| Nishikaku, F | 1 |
| Eguchi, K | 1 |
| Kim, KW | 1 |
| Cho, ML | 1 |
| Park, MK | 1 |
| Yoon, CH | 1 |
| Park, SH | 1 |
| Lee, SH | 1 |
| Kim, HY | 1 |
| Liu, H | 1 |
| Huang, Q | 1 |
| Shi, B | 1 |
| Eksarko, P | 1 |
| Temkin, V | 1 |
| Pope, RM | 1 |
| Wang, CH | 1 |
| Chen, LN | 1 |
| Zhu, P | 1 |
| Fan, CM | 1 |
| Wang, YH | 1 |
| Jia, JF | 1 |
| Relic, B | 1 |
| Guicheux, J | 1 |
| Mezin, F | 1 |
| Lubberts, E | 1 |
| Togninalli, D | 1 |
| Garcia, I | 1 |
| van den Berg, WB | 1 |
| Guerne, PA | 1 |
| Brennan, FM | 1 |
| Hayes, AL | 1 |
| Ciesielski, CJ | 1 |
| Green, P | 2 |
| Foxwell, BM | 1 |
| Feldmann, M | 2 |
| Foey, A | 1 |
| Foxwell, B | 1 |
| Brennan, F | 1 |
| Morel, JC | 1 |
| Park, CC | 1 |
| Zhu, K | 1 |
| Kumar, P | 1 |
| Ruth, JH | 1 |
| Koch, AE | 1 |
18 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Arthritis, Rheumatoid
| Article | Year |
|---|---|
CXCL16/CXCR6 axis promotes bleomycin-induced fibrotic process in MRC-5 cells via the PI3K/AKT/FOXO3a pathway.
Topics: Adult; Aged; Arthritis, Rheumatoid; Bleomycin; Case-Control Studies; Cell Line; Cell Movement; Cell | 2020 |
YKL-40-Induced Inhibition of miR-590-3p Promotes Interleukin-18 Expression and Angiogenesis of Endothelial Progenitor Cells.
Topics: Animals; Antagomirs; Arthritis, Rheumatoid; Base Sequence; Cell Movement; Cells, Cultured; Chitinase | 2017 |
Gastrin-releasing peptide and its receptor increase arthritis fibroblast-like synoviocytes invasiveness through activating the PI3K/AKT pathway.
Topics: Animals; Arthritis, Rheumatoid; Cell Movement; Cell Proliferation; Chromones; Fibroblasts; Gastrin-R | 2017 |
Calreticulin induced endothelial ICAM-1 up-regulation associated with tristetraprolin expression alteration through PI3K/Akt/eNOS/p38 MAPK signaling pathway in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Calreticulin; Chromones; Female; Human Umbilical Vein Endothelial Cells; Huma | 2019 |
Knockdown of sphingosine kinase 1 inhibits the migration and invasion of human rheumatoid arthritis fibroblast-like synoviocytes by down-regulating the PI3K/AKT activation and MMP-2/9 production in vitro.
Topics: Arthritis, Rheumatoid; Cell Movement; Cells, Cultured; Chromones; Down-Regulation; Female; Fibroblas | 2014 |
Interleukin-21 induces migration and invasion of fibroblast-like synoviocytes from patients with rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Cadherins; CD4-Positive T-Lymphocytes; Cell Movement; Cells, Cul | 2016 |
Single Cell Chemical Cytometry of Akt Activity in Rheumatoid Arthritis and Normal Fibroblast-like Synoviocytes in Response to Tumor Necrosis Factor α.
Topics: Arthritis, Rheumatoid; Cells, Cultured; Chromones; Electrophoresis, Capillary; Fibroblasts; Humans; | 2016 |
Role for CaMKII inhibition in rheumatoid arthritis: effects on HIF-1-induced VEGF production by rheumatoid synovial fibroblasts.
Topics: Arthritis, Rheumatoid; Benzylamines; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinase | 2009 |
Involvement of 15-lipoxygenase in the inflammatory arthritis.
Topics: Animals; Arachidonate 15-Lipoxygenase; Arthritis, Experimental; Arthritis, Rheumatoid; Cells, Cultur | 2012 |
PI3 kinase/Akt/HIF-1α pathway is associated with hypoxia-induced epithelial-mesenchymal transition in fibroblast-like synoviocytes of rheumatoid arthritis.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Cell Hypoxia; Cell Movement; Chromones; Enz | 2013 |
Akt is an endogenous inhibitor toward tumor necrosis factor-related apoptosis inducing ligand-mediated apoptosis in rheumatoid synovial cells.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Arthritis, Rheumatoid; Cells, Cultured; Chromones; Enzyme | 2003 |
Increased interleukin-17 production via a phosphoinositide 3-kinase/Akt and nuclear factor kappaB-dependent pathway in patients with rheumatoid arthritis.
Topics: Adult; Aged; Androstadienes; Antibodies, Monoclonal; Arthritis, Rheumatoid; CD28 Antigens; CD3 Compl | 2005 |
Regulation of Mcl-1 expression in rheumatoid arthritis synovial macrophages.
Topics: Apoptosis; Arthritis, Rheumatoid; Cells, Cultured; Chromones; Enzyme Inhibitors; Gene Expression Reg | 2006 |
[CD147 stimulates the angiogenesis in rheumatoid synovium via the activation of vascular endothelial growth factor].
Topics: Adult; Aged; Anthracenes; Arthritis, Rheumatoid; Basigin; Calcium-Calmodulin-Dependent Protein Kinas | 2007 |
Il-4 and IL-13, but not IL-10, protect human synoviocytes from apoptosis.
Topics: Adjuvants, Immunologic; Apoptosis; Arthritis, Rheumatoid; Carbazoles; Chromones; Culture Techniques; | 2001 |
Evidence that rheumatoid arthritis synovial T cells are similar to cytokine-activated T cells: involvement of phosphatidylinositol 3-kinase and nuclear factor kappaB pathways in tumor necrosis factor alpha production in rheumatoid arthritis.
Topics: Adenoviridae; Androstadienes; Arthritis, Rheumatoid; CD3 Complex; Cell Communication; Chromones; Coc | 2002 |
Cytokine-stimulated T cells induce macrophage IL-10 production dependent on phosphatidylinositol 3-kinase and p70S6K: implications for rheumatoid arthritis.
Topics: Androstadienes; Arthritis, Rheumatoid; Cells, Cultured; Chromones; Coculture Techniques; Cytokines; | 2002 |
Signal transduction pathways involved in rheumatoid arthritis synovial fibroblast interleukin-18-induced vascular cell adhesion molecule-1 expression.
Topics: Arthritis, Rheumatoid; Base Sequence; Cells, Cultured; Chromones; DNA Primers; Enzyme Activation; En | 2002 |