2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Angiogenesis, Pathologic in 53 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
| Excerpt | Relevance | Reference |
|---|---|---|
| "The current study demonstrated the antiangiogenic properties of propranolol in vitro and that the drug was able to induce the regression of hemangioma cells via the inhibition of cell cycle progression, invasion, and tube formation, concomitantly with decreased NO and VEGF levels through the down-regulation of the PI3K/Akt/eNOS/VEGF pathway." | 7.81 | Propranolol induces regression of hemangioma cells via the down-regulation of the PI3K/Akt/eNOS/VEGF pathway. ( Gao, Y; Guo, ZT; Huang, Q; Li, P; Pan, WK, 2015) |
| "These data demonstrate that hypoxia can induce resistance of pancreatic cancer cells to gemcitabine mainly through the PI3K/Akt/NF-kappa B pathways and partially through the MAPK(Erk) signaling pathway." | 7.72 | Hypoxia increases resistance of human pancreatic cancer cells to apoptosis induced by gemcitabine. ( Fidler, IJ; Yokoi, K, 2004) |
| "Here we demonstrate that in human prostate cancer cells, basal-, growth factor-, and mitogen-induced expression of hypoxia-inducible factor 1 (HIF-1) alpha, the regulated subunit of the transcription factor HIF-1, is blocked by LY294002 and rapamycin, inhibitors of PI3K and FRAP, respectively." | 5.31 | Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. ( Chiles, K; Feldser, D; Georgescu, MM; Hanrahan, C; Laughner, E; Semenza, GL; Simons, JW; Zhong, H, 2000) |
| "The current study demonstrated the antiangiogenic properties of propranolol in vitro and that the drug was able to induce the regression of hemangioma cells via the inhibition of cell cycle progression, invasion, and tube formation, concomitantly with decreased NO and VEGF levels through the down-regulation of the PI3K/Akt/eNOS/VEGF pathway." | 3.81 | Propranolol induces regression of hemangioma cells via the down-regulation of the PI3K/Akt/eNOS/VEGF pathway. ( Gao, Y; Guo, ZT; Huang, Q; Li, P; Pan, WK, 2015) |
| "These data demonstrate that hypoxia can induce resistance of pancreatic cancer cells to gemcitabine mainly through the PI3K/Akt/NF-kappa B pathways and partially through the MAPK(Erk) signaling pathway." | 3.72 | Hypoxia increases resistance of human pancreatic cancer cells to apoptosis induced by gemcitabine. ( Fidler, IJ; Yokoi, K, 2004) |
| "The treatment with metformin and LY294002 was able to reduce the cellular viability after 24 hours." | 1.51 | Evaluation of Angiogenesis Process after Metformin and LY294002 Treatment in Mammary Tumor. ( Borin, TF; Carvalho, LGS; de Campos Zuccari, DAP; Ferreira, LC; Gelaleti, GB; Hellmén, E; Jardim-Perassi, BV; Leonel, C; Maschio-Signorini, LB; Moschetta, MG; Sonehara, NM, 2019) |
| " LY294002 and gemcitabine hydrochloride combined with IR better inhibited cell migration, VM formation and MMP-2 mRNA expression of Panc-1 cells in vitro, and we also proved that the novel therapeutic regimen better inhibited tumor growth, tumor metastasis and VM formation of orthotopic Panc-1 xenografts by suppressing the PI3K/MMPs/Ln-5γ2 signaling pathway in vivo." | 1.43 | The effect of PI3K inhibitor LY294002 and gemcitabine hydrochloride combined with ionizing radiation on the formation of vasculogenic mimicry of Panc-1 cells in vitro and in vivo. ( Bai, R; Ding, T; Lan, X; Liu, S; Yin, L; Yu, Y; Zhang, L; Zhao, J, 2016) |
| "The level of LVD in gastric cancer specimens was significant higher than that of normal gastric tissue and was positively correlated with p-Akt, p-mTOR, VEGF-C and VEGF-D." | 1.42 | Lymphangiogenesis in gastric cancer regulated through Akt/mTOR-VEGF-C/VEGF-D axis. ( Chen, C; Chen, H; Chen, J; Dou, R; Ge, Q; Guan, R; Lei, Y; Liu, H; Qi, X; Zhang, X; Zhou, X, 2015) |
| "Here, role of the CXCR7 receptor in bladder cancer was further explored." | 1.38 | Role of chemokine receptor CXCR7 in bladder cancer progression. ( Bo, J; Chen, X; Hao, M; Hou, K; Lu, X; Shen, K; Wang, J; Xu, C; Zheng, J, 2012) |
| "Human cervical cancer cell lines C-33A and HeLa were transiently cotransfected with pSG5-HPV-16 E6 or 16 E7 constructs along with HIF-1 alpha small interfering RNA (siRNA) or nonspecific siRNA." | 1.34 | Overexpression of human papillomavirus type 16 oncoproteins enhances hypoxia-inducible factor 1 alpha protein accumulation and vascular endothelial growth factor expression in human cervical carcinoma cells. ( Brown, J; Le, AD; Nishitani, J; Shi, S; Tang, X; Zhang, Q, 2007) |
| "Release of VEGF from a breast cancer cell line (T47D) was quantitated by enzyme linked immunosorbent assay (ELISA)." | 1.34 | Basic FGF augments hypoxia induced HIF-1-alpha expression and VEGF release in T47D breast cancer cells. ( Bingle, L; Corke, KP; Fang, WG; Gong, LH; Shi, YH; Wang, YX, 2007) |
| "with cells from the human ovarian cancer cell line, OVCAR-3." | 1.33 | Phosphatidylinositol 3-kinase mediates angiogenesis and vascular permeability associated with ovarian carcinoma. ( Hofmann, J; Hu, L; Jaffe, RB, 2005) |
| "Here we demonstrate that in human prostate cancer cells, basal-, growth factor-, and mitogen-induced expression of hypoxia-inducible factor 1 (HIF-1) alpha, the regulated subunit of the transcription factor HIF-1, is blocked by LY294002 and rapamycin, inhibitors of PI3K and FRAP, respectively." | 1.31 | Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. ( Chiles, K; Feldser, D; Georgescu, MM; Hanrahan, C; Laughner, E; Semenza, GL; Simons, JW; Zhong, H, 2000) |
| "Inflammatory breast cancer (IBC) is the most lethal form of locally advanced breast cancer known." | 1.31 | Mitogen activated protein kinase pathway is involved in RhoC GTPase induced motility, invasion and angiogenesis in inflammatory breast cancer. ( Bao, LW; Merajver, SD; Miller, FR; Pan, Q; van Golen, KL; Wu, ZF, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 27 (50.94) | 29.6817 |
| 2010's | 25 (47.17) | 24.3611 |
| 2020's | 1 (1.89) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, L | 1 |
| Liu, WX | 1 |
| Huang, XG | 1 |
| Kim, BR | 1 |
| Kwon, YW | 1 |
| Park, GT | 1 |
| Choi, EJ | 1 |
| Seo, JK | 1 |
| Jang, IH | 1 |
| Kim, SC | 1 |
| Ko, HC | 1 |
| Lee, SC | 1 |
| Kim, JH | 1 |
| Ding, X | 1 |
| Xi, W | 1 |
| Ji, J | 1 |
| Cai, Q | 1 |
| Jiang, J | 1 |
| Shi, M | 1 |
| Yu, Y | 2 |
| Zhu, Z | 1 |
| Zhang, J | 1 |
| Moschetta, MG | 1 |
| Leonel, C | 1 |
| Maschio-Signorini, LB | 1 |
| Borin, TF | 1 |
| Gelaleti, GB | 1 |
| Jardim-Perassi, BV | 1 |
| Ferreira, LC | 1 |
| Sonehara, NM | 1 |
| Carvalho, LGS | 1 |
| Hellmén, E | 1 |
| de Campos Zuccari, DAP | 1 |
| Choorapoikayil, S | 1 |
| Weijts, B | 1 |
| Kers, R | 1 |
| de Bruin, A | 1 |
| den Hertog, J | 1 |
| Altaany, Z | 1 |
| Yang, G | 1 |
| Wang, R | 1 |
| De Luisi, A | 1 |
| Binetti, L | 1 |
| Ria, R | 1 |
| Ruggieri, S | 1 |
| Berardi, S | 1 |
| Catacchio, I | 1 |
| Racanelli, V | 1 |
| Pavone, V | 1 |
| Rossini, B | 1 |
| Vacca, A | 1 |
| Ribatti, D | 1 |
| Song, Y | 1 |
| Zhao, XP | 1 |
| Song, K | 1 |
| Shang, ZJ | 1 |
| Soumya, SJ | 1 |
| Binu, S | 1 |
| Helen, A | 1 |
| Reddanna, P | 1 |
| Sudhakaran, PR | 2 |
| Zhang, B | 2 |
| Chen, X | 3 |
| Bae, S | 1 |
| Singh, K | 1 |
| Washington, MK | 1 |
| Datta, PK | 1 |
| Wang, RK | 1 |
| Li, YY | 1 |
| Li, G | 1 |
| Lin, WH | 1 |
| Sun, JE | 1 |
| Liang, ZW | 1 |
| Wang, XH | 1 |
| Mabeta, P | 1 |
| Pan, WK | 1 |
| Li, P | 1 |
| Guo, ZT | 1 |
| Huang, Q | 1 |
| Gao, Y | 1 |
| Chen, H | 2 |
| Guan, R | 1 |
| Lei, Y | 1 |
| Chen, J | 2 |
| Ge, Q | 1 |
| Zhang, X | 3 |
| Dou, R | 1 |
| Liu, H | 1 |
| Qi, X | 1 |
| Zhou, X | 1 |
| Chen, C | 1 |
| Bai, R | 1 |
| Ding, T | 1 |
| Zhao, J | 1 |
| Liu, S | 1 |
| Zhang, L | 2 |
| Lan, X | 1 |
| Yin, L | 1 |
| Tsvetkov, D | 1 |
| Shymanets, A | 1 |
| Huang, Y | 1 |
| Bucher, K | 1 |
| Piekorz, R | 1 |
| Hirsch, E | 1 |
| Beer-Hammer, S | 1 |
| Harteneck, C | 1 |
| Gollasch, M | 1 |
| Nürnberg, B | 1 |
| Di, Y | 1 |
| Zhang, Y | 1 |
| Hui, L | 1 |
| Yang, H | 1 |
| Yang, Y | 1 |
| Wang, A | 1 |
| Adya, R | 1 |
| Tan, BK | 1 |
| Randeva, HS | 1 |
| Zhou, YH | 1 |
| Hu, Y | 1 |
| Mayes, D | 1 |
| Siegel, E | 1 |
| Kim, JG | 1 |
| Mathews, MS | 1 |
| Hsu, N | 1 |
| Eskander, D | 1 |
| Yu, O | 1 |
| Tromberg, BJ | 1 |
| Linskey, ME | 1 |
| Harfouche, R | 1 |
| Basu, S | 1 |
| Soni, S | 1 |
| Hentschel, DM | 1 |
| Mashelkar, RA | 1 |
| Sengupta, S | 1 |
| Sheikpranbabu, S | 1 |
| Haribalaganesh, R | 1 |
| Banumathi, E | 1 |
| Sirishkumar, N | 1 |
| Lee, KJ | 1 |
| Gurunathan, S | 1 |
| Alvarez, Y | 1 |
| Astudillo, O | 1 |
| Jensen, L | 1 |
| Reynolds, AL | 1 |
| Waghorne, N | 1 |
| Brazil, DP | 1 |
| Cao, Y | 1 |
| O'Connor, JJ | 1 |
| Kennedy, BN | 1 |
| Devi, MS | 1 |
| Xue, Y | 2 |
| Li, NL | 1 |
| Yang, JY | 1 |
| Chen, Y | 2 |
| Yang, LL | 1 |
| Liu, WC | 1 |
| Mallawaaratchy, DM | 1 |
| Mactier, S | 1 |
| Kaufman, KL | 1 |
| Blomfield, K | 1 |
| Christopherson, RI | 1 |
| Miyazaki, R | 1 |
| Ichiki, T | 1 |
| Hashimoto, T | 1 |
| Ikeda, J | 1 |
| Kamiharaguchi, A | 1 |
| Narabayashi, E | 1 |
| Matsuura, H | 1 |
| Takeda, K | 1 |
| Sunagawa, K | 1 |
| Kawamoto, T | 1 |
| Ohga, N | 1 |
| Akiyama, K | 1 |
| Hirata, N | 1 |
| Kitahara, S | 1 |
| Maishi, N | 1 |
| Osawa, T | 1 |
| Yamamoto, K | 1 |
| Kondoh, M | 1 |
| Shindoh, M | 1 |
| Hida, Y | 1 |
| Hida, K | 1 |
| Hao, M | 1 |
| Zheng, J | 1 |
| Hou, K | 1 |
| Wang, J | 2 |
| Lu, X | 1 |
| Bo, J | 1 |
| Xu, C | 2 |
| Shen, K | 1 |
| Doucette, CD | 1 |
| Hilchie, AL | 1 |
| Liwski, R | 1 |
| Hoskin, DW | 1 |
| Yang, XJ | 1 |
| Chen, GL | 1 |
| Yu, SC | 1 |
| Xin, YH | 1 |
| Li, TT | 1 |
| Shi, Y | 2 |
| Gu, A | 1 |
| Duan, JJ | 1 |
| Qian, C | 1 |
| Cui, YH | 1 |
| Bian, XW | 1 |
| Steinle, JJ | 1 |
| Meininger, CJ | 1 |
| Forough, R | 1 |
| Wu, G | 1 |
| Wu, MH | 1 |
| Granger, HJ | 1 |
| Woods, SA | 1 |
| McGlade, CJ | 1 |
| Guha, A | 1 |
| Deregibus, MC | 2 |
| Buttiglieri, S | 1 |
| Russo, S | 1 |
| Bussolati, B | 2 |
| Camussi, G | 2 |
| Su, JD | 1 |
| Mayo, LD | 1 |
| Donner, DB | 1 |
| Durden, DL | 1 |
| Yang, N | 1 |
| Katsaros, D | 1 |
| Huang, W | 1 |
| Park, JW | 1 |
| Fracchioli, S | 1 |
| Vezzani, C | 1 |
| Rigault de la Longrais, IA | 1 |
| Yao, W | 1 |
| Rubin, SC | 1 |
| Coukos, G | 1 |
| Ouchi, N | 1 |
| Kobayashi, H | 1 |
| Kihara, S | 1 |
| Kumada, M | 1 |
| Sato, K | 1 |
| Inoue, T | 1 |
| Funahashi, T | 1 |
| Walsh, K | 1 |
| Yanamandra, N | 1 |
| Gumidyala, KV | 1 |
| Waldron, KG | 1 |
| Gujrati, M | 1 |
| Olivero, WC | 1 |
| Dinh, DH | 1 |
| Rao, JS | 1 |
| Mohanam, S | 1 |
| Bedogni, B | 2 |
| O'Neill, MS | 1 |
| Welford, SM | 2 |
| Bouley, DM | 1 |
| Giaccia, AJ | 1 |
| Denko, NC | 1 |
| Powell, MB | 2 |
| Yokoi, K | 1 |
| Fidler, IJ | 1 |
| Parsons, R | 1 |
| Hu, L | 1 |
| Hofmann, J | 1 |
| Jaffe, RB | 1 |
| Bi, F | 1 |
| Zhang, S | 1 |
| Pan, Y | 1 |
| Liu, N | 1 |
| Yao, X | 1 |
| Zheng, Y | 1 |
| Fan, D | 1 |
| Nie, D | 1 |
| Krishnamoorthy, S | 1 |
| Jin, R | 1 |
| Tang, K | 1 |
| Qiao, Y | 1 |
| Zacharek, A | 1 |
| Guo, Y | 1 |
| Milanini, J | 1 |
| Pages, G | 1 |
| Honn, KV | 1 |
| Assenzio, B | 1 |
| Kwan, AC | 1 |
| Ranger-Moore, J | 1 |
| Saboda, K | 1 |
| Tang, X | 1 |
| Zhang, Q | 1 |
| Nishitani, J | 1 |
| Brown, J | 1 |
| Shi, S | 1 |
| Le, AD | 1 |
| Wang, CH | 1 |
| Chen, LN | 1 |
| Zhu, P | 1 |
| Fan, CM | 1 |
| Wang, YH | 1 |
| Jia, JF | 1 |
| Shi, YH | 1 |
| Bingle, L | 1 |
| Gong, LH | 1 |
| Wang, YX | 1 |
| Corke, KP | 1 |
| Fang, WG | 1 |
| Fang, J | 1 |
| Ding, M | 1 |
| Yang, L | 1 |
| Liu, LZ | 1 |
| Jiang, BH | 1 |
| Rak, J | 1 |
| Mitsuhashi, Y | 1 |
| Sheehan, C | 1 |
| Tamir, A | 1 |
| Viloria-Petit, A | 1 |
| Filmus, J | 1 |
| Mansour, SJ | 1 |
| Ahn, NG | 1 |
| Kerbel, RS | 1 |
| Zhong, H | 1 |
| Chiles, K | 1 |
| Feldser, D | 1 |
| Laughner, E | 1 |
| Hanrahan, C | 1 |
| Georgescu, MM | 1 |
| Simons, JW | 1 |
| Semenza, GL | 1 |
| Zhu, L | 1 |
| Fukuda, S | 1 |
| Cordis, G | 1 |
| Das, DK | 1 |
| Maulik, N | 1 |
| van Golen, KL | 1 |
| Bao, LW | 1 |
| Pan, Q | 1 |
| Miller, FR | 1 |
| Wu, ZF | 1 |
| Merajver, SD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effects of Exercise Training on Tumor Vascularity and Response to Neoadjuvant Therapy in Operable Breast Cancer: A Phase I-II Study[NCT00405678] | Phase 1/Phase 2 | 23 participants (Actual) | Interventional | 2006-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
53 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Angiogenesis, Pathologic
| Article | Year |
|---|---|
MicroRNA-199a-3p inhibits angiogenesis by targeting the VEGF/PI3K/AKT signalling pathway in an in vitro model of diabetic retinopathy.
Topics: Apoptosis; Cell Movement; Cell Proliferation; Chromones; Diabetic Retinopathy; Endothelial Cells; Ge | 2020 |
Identification of a novel angiogenic peptide from periostin.
Topics: Androstadienes; Angiogenic Proteins; Antibodies, Neutralizing; Butadienes; Cell Adhesion Molecules; | 2017 |
HGF derived from cancer‑associated fibroblasts promotes vascularization in gastric cancer via PI3K/AKT and ERK1/2 signaling.
Topics: Butadienes; Cancer-Associated Fibroblasts; Cell Line; Cell Line, Tumor; Cell Movement; Cell Prolifer | 2018 |
Evaluation of Angiogenesis Process after Metformin and LY294002 Treatment in Mammary Tumor.
Topics: Animals; Cell Line, Tumor; Chromones; Cobalt; Dog Diseases; Dogs; Female; Hypoxia-Inducible Factor 1 | 2019 |
Loss of Pten promotes angiogenesis and enhanced vegfaa expression in zebrafish.
Topics: Animals; Chromones; Drug Therapy, Combination; Endothelial Cells; Haploinsufficiency; Hemangiosarcom | 2013 |
Crosstalk between hydrogen sulfide and nitric oxide in endothelial cells.
Topics: Cell Proliferation; Chromones; Collagen; Cystathionine gamma-Lyase; Drug Combinations; Endothelial C | 2013 |
Erythropoietin is involved in the angiogenic potential of bone marrow macrophages in multiple myeloma.
Topics: Aged; Androstadienes; Angiogenic Proteins; Animals; Bone Marrow; Bone Marrow Cells; Capillaries; Cel | 2013 |
Ephrin-A1 is up-regulated by hypoxia in cancer cells and promotes angiogenesis of HUVECs through a coordinated cross-talk with eNOS.
Topics: Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Chromones; Coculture Techniques; Enzyme Inhibito | 2013 |
15(S)-HETE-induced angiogenesis in adipose tissue is mediated through activation of PI3K/Akt/mTOR signaling pathway.
Topics: Adipose Tissue; Animals; Chromones; Endothelial Cells; Enzyme Inhibitors; Epididymis; Gene Expressio | 2013 |
Loss of Smad4 in colorectal cancer induces resistance to 5-fluorouracil through activating Akt pathway.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis Regulatory Proteins; Cell Cycle Proteins; Cell L | 2014 |
[The effects of intergrin-linked kinase on angiogenesis in hypertrophic scar].
Topics: Cell Movement; Cell Proliferation; Chromones; Cicatrix, Hypertrophic; Endothelial Cells; Humans; Lip | 2013 |
Inhibition of phosphoinositide 3-kinase is associated with reduced angiogenesis and an altered expression of angiogenic markers in endothelioma cells.
Topics: Angiogenesis Inducing Agents; Animals; Aorta; Biomarkers, Tumor; Caspases; Cell Movement; Cell Proli | 2014 |
Propranolol induces regression of hemangioma cells via the down-regulation of the PI3K/Akt/eNOS/VEGF pathway.
Topics: Adrenergic beta-Antagonists; Angiogenesis Inhibitors; Cell Cycle Checkpoints; Cell Proliferation; Ce | 2015 |
Lymphangiogenesis in gastric cancer regulated through Akt/mTOR-VEGF-C/VEGF-D axis.
Topics: Biomarkers, Tumor; Chromones; Enzyme Inhibitors; Female; Humans; Immunohistochemistry; Male; Morphol | 2015 |
The effect of PI3K inhibitor LY294002 and gemcitabine hydrochloride combined with ionizing radiation on the formation of vasculogenic mimicry of Panc-1 cells in vitro and in vivo.
Topics: Antineoplastic Agents; Apoptosis; Chromones; Deoxycytidine; Gemcitabine; Humans; Morpholines; Neovas | 2016 |
Better Understanding of Phosphoinositide 3-Kinase (PI3K) Pathways in Vasculature: Towards Precision Therapy Targeting Angiogenesis and Tumor Blood Supply.
Topics: Androstadienes; Animals; Chromones; Class I Phosphatidylinositol 3-Kinases; Class Ib Phosphatidylino | 2016 |
Cysteine‑rich 61 RNA interference inhibits pathological angiogenesis via the phosphatidylinositol 3‑kinase/Akt‑vascular endothelial growth factor signaling pathway in endothelial cells.
Topics: Apoptosis; Cell Hypoxia; Cell Proliferation; Chromones; Cysteine-Rich Protein 61; Gene Expression Re | 2016 |
Pre-B cell colony enhancing factor (PBEF)/visfatin induces secretion of MCP-1 in human endothelial cells: role in visfatin-induced angiogenesis.
Topics: Butadienes; Cell Movement; Chemokine CCL2; Chromones; Cytokines; Endothelial Cells; Enzyme Inhibitor | 2009 |
PAX6 suppression of glioma angiogenesis and the expression of vascular endothelial growth factor A.
Topics: Analysis of Variance; Animals; Cell Line, Tumor; Chromones; Enzyme Inhibitors; Enzyme-Linked Immunos | 2010 |
Nanoparticle-mediated targeting of phosphatidylinositol-3-kinase signaling inhibits angiogenesis.
Topics: Adenocarcinoma; Animals; Breast Neoplasms; Carcinoma, Lewis Lung; Cell Line, Tumor; Cells, Cultured; | 2009 |
Pigment epithelium-derived factor inhibits advanced glycation end-product-induced angiogenesis and stimulates apoptosis in retinal endothelial cells.
Topics: Animals; Apoptosis; Blotting, Western; Caspase 3; Cattle; Cell Survival; Cells, Cultured; Chromones; | 2009 |
Selective inhibition of retinal angiogenesis by targeting PI3 kinase.
Topics: Animals; Chromones; Electroretinography; Enzyme Inhibitors; Gene Expression Regulation, Developmenta | 2009 |
Differential modulation of angiogenesis by advanced glycation end products.
Topics: Acetylcysteine; Animals; Antioxidants; Aorta, Thoracic; Ascorbic Acid; Cells, Cultured; Chick Embryo | 2011 |
Phosphatidylinositol 3'-kinase signaling pathway is essential for Rac1-induced hypoxia-inducible factor-1(alpha) and vascular endothelial growth factor expression.
Topics: Cell Line, Tumor; Chromones; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Hypo | 2011 |
The phosphoinositide 3-kinase inhibitor LY294002, decreases aminoacyl-tRNA synthetases, chaperones and glycolytic enzymes in human HT-29 colorectal cancer cells.
Topics: Adenosine Triphosphate; Amino Acyl-tRNA Synthetases; Apoptosis; Cell Line, Tumor; Chromones; Colorec | 2012 |
Acetylcholinesterase inhibitors attenuate angiogenesis.
Topics: Acetylcholine; Animals; Cells, Cultured; Cholinesterase Inhibitors; Chromones; Donepezil; Hindlimb; | 2012 |
Tumor-derived microvesicles induce proangiogenic phenotype in endothelial cells via endocytosis.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Separation; Cells, Cultured; Chromone | 2012 |
Role of chemokine receptor CXCR7 in bladder cancer progression.
Topics: Animals; Butadienes; Chromones; Disease Progression; Epithelial-Mesenchymal Transition; Gene Express | 2012 |
Piperine, a dietary phytochemical, inhibits angiogenesis.
Topics: Alkaloids; Angiogenesis Inhibitors; Animals; Aorta; Benzodioxoles; Breast Neoplasms; Cell Movement; | 2013 |
TGF-β1 enhances tumor-induced angiogenesis via JNK pathway and macrophage infiltration in an improved zebrafish embryo/xenograft glioma model.
Topics: Angiogenesis Inhibitors; Animals; Animals, Genetically Modified; Anthracenes; Cell Line, Tumor; Cell | 2013 |
Eph B4 receptor signaling mediates endothelial cell migration and proliferation via the phosphatidylinositol 3-kinase pathway.
Topics: Alkaloids; Azepines; Blotting, Western; Calcium; Carbazoles; Cell Division; Cell Movement; Cells, Cu | 2002 |
Phosphatidylinositol 3'-kinase and MAPK/ERK kinase 1/2 differentially regulate expression of vascular endothelial growth factor in human malignant astrocytoma cells.
Topics: Astrocytoma; Blotting, Northern; Blotting, Western; Butadienes; Cell Hypoxia; Cell Line; Central Ner | 2002 |
CD40-dependent activation of phosphatidylinositol 3-kinase/Akt pathway mediates endothelial cell survival and in vitro angiogenesis.
Topics: Androstadienes; Apoptosis; Blotting, Western; Bromodeoxyuridine; CD40 Antigens; CD40 Ligand; Cell Di | 2003 |
PTEN and phosphatidylinositol 3'-kinase inhibitors up-regulate p53 and block tumor-induced angiogenesis: evidence for an effect on the tumor and endothelial compartment.
Topics: Angiogenesis Inhibitors; Brain Neoplasms; Cell Division; Cell Line; Cell Survival; Cerebrovascular C | 2003 |
The oncogene phosphatidylinositol 3'-kinase catalytic subunit alpha promotes angiogenesis via vascular endothelial growth factor in ovarian carcinoma.
Topics: Apoptosis; Catalytic Domain; Cell Division; Chromones; Endothelial Growth Factors; Enzyme Inhibitors | 2003 |
Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells.
Topics: Adenoviridae; Adiponectin; AMP-Activated Protein Kinases; Animals; Blotting, Western; Cell Different | 2004 |
Blockade of cathepsin B expression in human glioblastoma cells is associated with suppression of angiogenesis.
Topics: Angiogenesis Inhibitors; Animals; Biological Assay; Brain Neoplasms; Cathepsin B; Cell Line, Tumor; | 2004 |
Topical treatment with inhibitors of the phosphatidylinositol 3'-kinase/Akt and Raf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathways reduces melanoma development in severe combined immunodeficient mice.
Topics: Administration, Topical; Animals; Butadienes; Chromones; Down-Regulation; Endothelium, Vascular; Enz | 2004 |
Hypoxia increases resistance of human pancreatic cancer cells to apoptosis induced by gemcitabine.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Blotting, Western; Butadienes; Ce | 2004 |
Phosphatidylinositol 3-kinase inhibitors are a triple threat to ovarian cancer.
Topics: Animals; Capillary Permeability; Cell Line, Tumor; Chromones; Enzyme Inhibitors; Female; Humans; Mic | 2005 |
Phosphatidylinositol 3-kinase mediates angiogenesis and vascular permeability associated with ovarian carcinoma.
Topics: Animals; Ascites; Capillary Permeability; Cell Line, Tumor; Chromones; Enzyme Inhibitors; Female; Hu | 2005 |
Role of Rac1 and Cdc42 in hypoxia induced p53 and von Hippel-Lindau suppression and HIF1alpha activation.
Topics: Blotting, Western; Carcinoma, Hepatocellular; cdc42 GTP-Binding Protein; Cell Hypoxia; Cell Line, Tu | 2006 |
Mechanisms regulating tumor angiogenesis by 12-lipoxygenase in prostate cancer cells.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Arachidonate 12-Lipoxygenase; Cell Line, Tumor; Cell Mov | 2006 |
The proangiogenic phenotype of human tumor-derived endothelial cells depends on thrombospondin-1 downregulation via phosphatidylinositol 3-kinase/Akt pathway.
Topics: Adult; Androstadienes; Apoptosis; Blotting, Western; Carcinoma, Renal Cell; Cell Line; Chromones; Do | 2006 |
Inhibition of phosphatidylinositol-3-kinase and mitogen-activated protein kinase kinase 1/2 prevents melanoma development and promotes melanoma regression in the transgenic TPRas mouse model.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Butadienes; Chromones; Enzyme In | 2006 |
Overexpression of human papillomavirus type 16 oncoproteins enhances hypoxia-inducible factor 1 alpha protein accumulation and vascular endothelial growth factor expression in human cervical carcinoma cells.
Topics: Anticarcinogenic Agents; Carcinoma; Chromones; Female; Flavonoids; HeLa Cells; Humans; Hypoxia-Induc | 2007 |
[CD147 stimulates the angiogenesis in rheumatoid synovium via the activation of vascular endothelial growth factor].
Topics: Adult; Aged; Anthracenes; Arthritis, Rheumatoid; Basigin; Calcium-Calmodulin-Dependent Protein Kinas | 2007 |
Basic FGF augments hypoxia induced HIF-1-alpha expression and VEGF release in T47D breast cancer cells.
Topics: Breast Neoplasms; Cell Hypoxia; Cell Line, Tumor; Chromones; Enzyme Inhibitors; Extracellular Signal | 2007 |
PI3K/PTEN/AKT signaling regulates prostate tumor angiogenesis.
Topics: Angiogenesis Inhibitors; Animals; Cell Line, Tumor; Chick Embryo; Chromones; Dose-Response Relations | 2007 |
Oncogenes and tumor angiogenesis: differential modes of vascular endothelial growth factor up-regulation in ras-transformed epithelial cells and fibroblasts.
Topics: 3T3 Cells; Animals; Cell Division; Cell Line; Cell Transformation, Neoplastic; Chromones; Endothelia | 2000 |
Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics.
Topics: Carrier Proteins; Chromones; Culture Media, Serum-Free; DNA-Binding Proteins; Endothelial Growth Fac | 2000 |
Anti-apoptotic protein survivin plays a significant role in tubular morphogenesis of human coronary arteriolar endothelial cells by hypoxic preconditioning.
Topics: Apoptosis; Arterioles; Cell Hypoxia; Chromones; Chromosomal Proteins, Non-Histone; Coronary Vessels; | 2001 |
Mitogen activated protein kinase pathway is involved in RhoC GTPase induced motility, invasion and angiogenesis in inflammatory breast cancer.
Topics: Adenocarcinoma; ADP Ribose Transferases; Botulinum Toxins; Breast Neoplasms; Chromones; Endothelial | 2002 |