2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Alloxan Diabetes in 26 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diabetic patients are more vulnerable to cerebral ischemia-reperfusion (CIR) injury and have a worse prognosis and higher mortality after ischemic stroke than non-diabetic counterparts." | 5.62 | Melatonin protects against focal cerebral ischemia-reperfusion injury in diabetic mice by ameliorating mitochondrial impairments: involvement of the Akt-SIRT3-SOD2 signaling pathway. ( Cao, Q; Gao, W; Li, B; Liu, L; Xia, Z; Zhao, B, 2021) |
| "Diabetic patients are more vulnerable to cerebral ischemia-reperfusion (CIR) injury and have a worse prognosis and higher mortality after ischemic stroke than non-diabetic counterparts." | 1.62 | Melatonin protects against focal cerebral ischemia-reperfusion injury in diabetic mice by ameliorating mitochondrial impairments: involvement of the Akt-SIRT3-SOD2 signaling pathway. ( Cao, Q; Gao, W; Li, B; Liu, L; Xia, Z; Zhao, B, 2021) |
| "Forty SD rats with diabetic nephropathy induced by intraperitoneal injection of 65 mg/kg streptozotocin were randomized equally into 5 groups, including a diabetic nephropathy model group and 4 treatment groups, with 8 normal SD rats as the normal control group." | 1.48 | [Correlation between expressions of VEGF and TRPC6 and their roles in podocyte injury in rats with diabetic nephropathy]. ( Dong, P; Wang, YH; Wu, JJ; Zhang, M; Zhu, XN, 2018) |
| "The molecular pathogenesis of diabetic nephropathy (DN), the leading cause of end-stage renal disease worldwide, is complex and not fully understood." | 1.35 | Protein kinase B/Akt activity is involved in renal TGF-beta1-driven epithelial-mesenchymal transition in vitro and in vivo. ( Brazil, DP; Carew, RM; Godson, C; Heljic, M; Kattla, JJ, 2008) |
| " In this report, we have studied the effects of insulin and ethanol on ADH gene expression in a highly differentiated rat hepatoma cell line (FGC-4), as well as the in vivo effects of chronic intake of an ethanol-containing diet on hepatic insulin signaling." | 1.33 | Chronic ethanol intake impairs insulin signaling in rats by disrupting Akt association with the cell membrane. Role of TRB3 in inhibition of Akt/protein kinase B activation. ( Badger, TM; He, L; Mehendale, HM; Ronis, MJ; Simmen, FA, 2006) |
| " Chronic administration of D-pinitol (100 mg kg(-1) i." | 1.31 | Insulin-like effect of pinitol. ( Bailey, CJ; Bates, SH; Jones, RB, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (7.69) | 18.2507 |
| 2000's | 9 (34.62) | 29.6817 |
| 2010's | 11 (42.31) | 24.3611 |
| 2020's | 4 (15.38) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, S | 1 |
| Liu, Y | 1 |
| Huang, S | 1 |
| Jin, F | 1 |
| Qi, F | 1 |
| Yang, H | 1 |
| Cao, Q | 2 |
| Xiong, X | 1 |
| Zhao, P | 1 |
| Shen, D | 1 |
| Zhang, Y | 1 |
| Zhang, N | 1 |
| Yagubova, SS | 1 |
| Ostrovskaya, RU | 1 |
| Gudasheva, TA | 1 |
| Seredenin, SB | 1 |
| Liu, L | 1 |
| Gao, W | 1 |
| Li, B | 1 |
| Xia, Z | 1 |
| Zhao, B | 1 |
| Su, D | 1 |
| Zhou, Y | 1 |
| Hu, S | 1 |
| Guan, L | 1 |
| Shi, C | 1 |
| Wang, Q | 1 |
| Chen, Y | 2 |
| Lu, C | 1 |
| Li, Q | 1 |
| Ma, X | 1 |
| Qiu, Y | 1 |
| Wu, Y | 1 |
| Meng, M | 1 |
| Luo, M | 1 |
| Zhao, H | 1 |
| Sun, H | 1 |
| Gao, S | 1 |
| Zhu, XN | 1 |
| Wang, YH | 1 |
| Wu, JJ | 1 |
| Dong, P | 1 |
| Zhang, M | 1 |
| Quan, XJ | 1 |
| Liang, CL | 1 |
| Sun, MZ | 1 |
| Zhang, L | 1 |
| Li, XL | 1 |
| Habash, T | 1 |
| Saleh, A | 1 |
| Roy Chowdhury, SK | 1 |
| Smith, DR | 1 |
| Fernyhough, P | 1 |
| Zhu, L | 1 |
| Zhao, S | 1 |
| Liu, S | 1 |
| Liu, Q | 1 |
| Li, F | 1 |
| Hao, J | 1 |
| Cai, M | 1 |
| Deng, J | 1 |
| Tian, L | 1 |
| Wang, S | 1 |
| Tong, L | 1 |
| Dong, H | 1 |
| Xiong, L | 1 |
| Katare, RG | 1 |
| Caporali, A | 1 |
| Oikawa, A | 1 |
| Meloni, M | 1 |
| Emanueli, C | 1 |
| Madeddu, P | 1 |
| Ning, J | 1 |
| Hong, T | 1 |
| Yang, X | 1 |
| Mei, S | 1 |
| Liu, Z | 1 |
| Liu, HY | 1 |
| Cao, W | 1 |
| Lima, MH | 1 |
| Caricilli, AM | 1 |
| de Abreu, LL | 1 |
| Araújo, EP | 1 |
| Pelegrinelli, FF | 1 |
| Thirone, AC | 1 |
| Tsukumo, DM | 1 |
| Pessoa, AF | 1 |
| dos Santos, MF | 1 |
| de Moraes, MA | 1 |
| Carvalheira, JB | 1 |
| Velloso, LA | 1 |
| Saad, MJ | 1 |
| Benter, IF | 1 |
| Al-Rashdan, I | 1 |
| Juggi, JS | 1 |
| Yousif, MH | 2 |
| Akhtar, S | 1 |
| Kamata, K | 1 |
| Kanie, N | 1 |
| Matsumoto, T | 1 |
| Kobayashi, T | 1 |
| Nagai, K | 1 |
| Matsubara, T | 1 |
| Mima, A | 1 |
| Sumi, E | 1 |
| Kanamori, H | 1 |
| Iehara, N | 1 |
| Fukatsu, A | 1 |
| Yanagita, M | 1 |
| Nakano, T | 1 |
| Ishimoto, Y | 1 |
| Kita, T | 1 |
| Doi, T | 1 |
| Arai, H | 1 |
| Gelling, RW | 1 |
| Morton, GJ | 1 |
| Morrison, CD | 1 |
| Niswender, KD | 1 |
| Myers, MG | 1 |
| Rhodes, CJ | 1 |
| Schwartz, MW | 1 |
| He, L | 1 |
| Simmen, FA | 1 |
| Mehendale, HM | 1 |
| Ronis, MJ | 1 |
| Badger, TM | 1 |
| Chi, TC | 1 |
| Chen, WP | 1 |
| Chi, TL | 1 |
| Kuo, TF | 1 |
| Lee, SS | 1 |
| Cheng, JT | 1 |
| Su, MJ | 1 |
| Yea, K | 1 |
| Kim, J | 1 |
| Lim, S | 1 |
| Park, HS | 1 |
| Park, KS | 1 |
| Suh, PG | 1 |
| Ryu, SH | 1 |
| Kattla, JJ | 1 |
| Carew, RM | 1 |
| Heljic, M | 1 |
| Godson, C | 1 |
| Brazil, DP | 1 |
| Bragado, MJ | 1 |
| Groblewski, GE | 1 |
| Williams, JA | 1 |
| Grzelkowska, K | 1 |
| Dardevet, D | 1 |
| Balage, M | 1 |
| Grizard, J | 1 |
| Bates, SH | 1 |
| Jones, RB | 1 |
| Bailey, CJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Topic Insulin Accelerates Wound in Diabetes[NCT01295177] | Phase 1/Phase 2 | 22 participants (Actual) | Interventional | 2004-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Alloxan Diabetes
| Article | Year |
|---|---|
Topical insulin accelerates wound healing in diabetes by enhancing the AKT and ERK pathways: a double-blind placebo-controlled clinical trial.
Topics: Administration, Topical; Aged; Animals; Bone Marrow; Chemokine CXCL12; Chromones; Diabetes Complicat | 2012 |
25 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Alloxan Diabetes
| Article | Year |
|---|---|
Sevoflurane and isoflurane inhibit KCl-induced, Rho kinase-mediated, and PI3K-participated vasoconstriction in aged diabetic rat aortas.
Topics: Aging; Amides; Anesthetics, Inhalation; Animals; Aorta; Chromones; Diabetes Mellitus, Experimental; | 2021 |
Fluoxetine regulates glucose and lipid metabolism via the PI3K‑AKT signaling pathway in diabetic rats.
Topics: Animals; Cell Line; Chromones; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Fluoxetin | 2020 |
The PI3K/Akt Cascade Is Involved in the Antidiabetic Effect of Compound GSB-214, a Low-Molecular-Weight BDNF Mimetic.
Topics: Animals; Blood Glucose; Brain-Derived Neurotrophic Factor; Chromones; Diabetes Mellitus, Experimenta | 2020 |
Melatonin protects against focal cerebral ischemia-reperfusion injury in diabetic mice by ameliorating mitochondrial impairments: involvement of the Akt-SIRT3-SOD2 signaling pathway.
Topics: Animals; Apoptosis; Brain Edema; Brain Ischemia; Cell Line; Cell Survival; Chromones; Diabetes Melli | 2021 |
Role of GAB1/PI3K/AKT signaling high glucose-induced cardiomyocyte apoptosis.
Topics: Animals; Apoptosis; Cell Line; Chromones; Diabetes Mellitus, Experimental; Diabetes, Gestational; Fe | 2017 |
GYY4137 protects against myocardial ischemia/reperfusion injury via activation of the PHLPP-1/Akt/Nrf2 signaling pathway in diabetic mice.
Topics: Animals; Cardiotonic Agents; Cell Line; Chromones; Diabetes Mellitus, Experimental; Humans; Male; Mi | 2018 |
[Correlation between expressions of VEGF and TRPC6 and their roles in podocyte injury in rats with diabetic nephropathy].
Topics: Animals; Chromones; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Indoles; Kidney; Membra | 2018 |
Overexpression of steroid receptor coactivators alleviates hyperglycemia-induced endothelial cell injury in rats through activating the PI3K/Akt pathway.
Topics: Animals; Aorta; Apoptosis; Cell Survival; Cellular Senescence; Chromones; Diabetes Mellitus, Experim | 2019 |
The proinflammatory cytokine, interleukin-17A, augments mitochondrial function and neurite outgrowth of cultured adult sensory neurons derived from normal and diabetic rats.
Topics: Animals; Antibiotics, Antineoplastic; Butadienes; Cells, Cultured; Chromones; Diabetes Mellitus, Exp | 2015 |
PTEN Regulates Renal Extracellular Matrix Deposit via Increased CTGF in Diabetes Mellitus.
Topics: Animals; Blotting, Western; Cells, Cultured; Chromones; Connective Tissue Growth Factor; Diabetes Me | 2016 |
Elevated Expression of Carboxy-Terminal Modulator Protein (CTMP) Aggravates Brain Ischemic Injury in Diabetic db/db Mice.
Topics: Animals; Brain; Brain Ischemia; Carrier Proteins; Chromones; Diabetes Mellitus, Experimental; Male; | 2016 |
Vitamin B1 analog benfotiamine prevents diabetes-induced diastolic dysfunction and heart failure through Akt/Pim-1-mediated survival pathway.
Topics: Analysis of Variance; Animals; Apoptosis; Blood Flow Velocity; Blotting, Western; Carrier Proteins; | 2010 |
Insulin and insulin signaling play a critical role in fat induction of insulin resistance in mouse.
Topics: Acyl Coenzyme A; Adenosine Diphosphate; Adenosine Triphosphate; Adipose Tissue; Animals; Carcinoma, | 2011 |
Chronic treatment with LY294002, an inhibitor of phosphatidylinositol 3-kinase, attenuates ischemia/reperfusion-induced cardiac dysfunction in normotensive and hypertensive diabetic animals.
Topics: Animals; Cardiotonic Agents; Chromones; Coronary Vessels; Diabetes Mellitus, Experimental; Hypertens | 2013 |
Endothelin-1-induced impairment of endothelium-dependent relaxation in aortas isolated from controls and diabetic rats.
Topics: Acetylcholine; Animals; Aorta; Chromones; Diabetes Mellitus, Experimental; Dose-Response Relationshi | 2004 |
Gas6 induces Akt/mTOR-mediated mesangial hypertrophy in diabetic nephropathy.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antibiotics, Antineoplastic; Butadienes; Carrier Prot | 2005 |
Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes.
Topics: Animals; Blood Glucose; Brain; Chromones; Diabetes Mellitus, Experimental; Insulin; Male; Morpholine | 2006 |
Chronic ethanol intake impairs insulin signaling in rats by disrupting Akt association with the cell membrane. Role of TRB3 in inhibition of Akt/protein kinase B activation.
Topics: Alcohol Dehydrogenase; Animals; Binding Sites; Blotting, Northern; Blotting, Western; Cell Different | 2006 |
Phosphatidylinositol-3-kinase is involved in the antihyperglycemic effect induced by resveratrol in streptozotocin-induced diabetic rats.
Topics: Androstadienes; Animals; Antioxidants; Blood Glucose; Carboxy-Lyases; Chromones; Diabetes Mellitus, | 2007 |
Lysophosphatidic acid regulates blood glucose by stimulating myotube and adipocyte glucose uptake.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Blood Glucose; Cell Membrane; Chromones; Diabetes Mellitus, Exper | 2008 |
Phosphoinositide 3-kinase contributes to diabetes-induced abnormal vascular reactivity in rat perfused mesenteric bed.
Topics: Animals; Body Weight; Chromones; Diabetes Mellitus, Experimental; Hyperglycemia; Morpholines; Phosph | 2008 |
Protein kinase B/Akt activity is involved in renal TGF-beta1-driven epithelial-mesenchymal transition in vitro and in vivo.
Topics: Animals; Cell Transdifferentiation; Chromones; Diabetes Mellitus, Experimental; Diabetes Mellitus, T | 2008 |
Regulation of protein synthesis by cholecystokinin in rat pancreatic acini involves PHAS-I and the p70 S6 kinase pathway.
Topics: Androstadienes; Animals; Bombesin; Carbachol; Carrier Proteins; Cholecystokinin; Chromones; Diabetes | 1998 |
Involvement of the rapamycin-sensitive pathway in the insulin regulation of muscle protein synthesis in streptozotocin-diabetic rats.
Topics: Analysis of Variance; Animals; Blotting, Western; Chromones; Diabetes Mellitus, Experimental; Enzyme | 1999 |
Insulin-like effect of pinitol.
Topics: Animals; Blood Glucose; Cell Line; Chromones; Deoxyglucose; Diabetes Mellitus, Experimental; Dose-Re | 2000 |