2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Adenocarcinoma Of Kidney in 14 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clear cell renal cell carcinoma (ccRCC) has been associated with one of the highest mortality rates among all cancers." | 1.51 | FABP5 regulates the proliferation of clear cell renal cell carcinoma cells via the PI3K/AKT signaling pathway. ( Ding, Q; Han, X; Le, W; Li, H; Lv, Q; Ma, C; Wang, G; Wang, P; Zhang, M; Zhang, Y, 2019) |
| "Metastatic renal cell carcinoma is resistant to current therapies." | 1.33 | The phosphoinositide 3-kinase/Akt pathway: a new target in human renal cell carcinoma therapy. ( Agouni, A; Danilin, S; Helwig, JJ; Jacqmin, D; Lang, H; Lindner, V; Massfelder, T; Rothhut, S; Schordan, E; Sourbier, C, 2006) |
| "A panel of breast cancer cell lines reflecting the different genetic changes occurring in human breast cancer was analyzed." | 1.31 | Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3'-kinase/Akt signaling pathway. ( Blancher, C; Harris, AL; Moore, JW; Robertson, N, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (35.71) | 29.6817 |
| 2010's | 8 (57.14) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, DE | 1 |
| Lee, J | 1 |
| Park, JW | 1 |
| Kang, H | 1 |
| Nam, YR | 1 |
| Kwon, TK | 1 |
| Kim, KS | 1 |
| Kim, S | 1 |
| Lv, Q | 1 |
| Wang, G | 1 |
| Zhang, Y | 1 |
| Han, X | 1 |
| Li, H | 1 |
| Le, W | 1 |
| Zhang, M | 1 |
| Ma, C | 1 |
| Wang, P | 1 |
| Ding, Q | 1 |
| Yamada, T | 1 |
| Horinaka, M | 1 |
| Shinnoh, M | 1 |
| Yoshioka, T | 1 |
| Miki, T | 1 |
| Sakai, T | 1 |
| Harada, K | 1 |
| Miyake, H | 1 |
| Kumano, M | 1 |
| Fujisawa, M | 1 |
| Weissinger, D | 1 |
| Tagscherer, KE | 1 |
| Macher-Göppinger, S | 1 |
| Haferkamp, A | 1 |
| Wagener, N | 1 |
| Roth, W | 1 |
| Ito, H | 1 |
| Ichiyanagi, O | 1 |
| Naito, S | 1 |
| Bilim, VN | 1 |
| Tomita, Y | 1 |
| Kato, T | 1 |
| Nagaoka, A | 1 |
| Tsuchiya, N | 1 |
| Elfiky, AA | 1 |
| Aziz, SA | 1 |
| Conrad, PJ | 1 |
| Siddiqui, S | 1 |
| Hackl, W | 1 |
| Maira, M | 1 |
| Robert, CL | 1 |
| Kluger, HM | 1 |
| Ho, MY | 1 |
| Tang, SJ | 1 |
| Chuang, MJ | 1 |
| Cha, TL | 1 |
| Li, JY | 1 |
| Sun, GH | 1 |
| Sun, KH | 1 |
| Zhu, S | 1 |
| Cohen, MB | 1 |
| Bjorge, JD | 1 |
| Mier, JW | 1 |
| Cho, DC | 1 |
| Kolb, TM | 1 |
| Duan, L | 1 |
| Davis, MA | 1 |
| Pflug, BR | 1 |
| Zheng, H | 1 |
| Udan, MS | 1 |
| D'Antonio, JM | 1 |
| Marshall, FF | 1 |
| Brooks, JD | 1 |
| Nelson, JB | 1 |
| Sourbier, C | 1 |
| Lindner, V | 1 |
| Lang, H | 1 |
| Agouni, A | 1 |
| Schordan, E | 1 |
| Danilin, S | 1 |
| Rothhut, S | 1 |
| Jacqmin, D | 1 |
| Helwig, JJ | 1 |
| Massfelder, T | 1 |
| Bussolati, B | 1 |
| Assenzio, B | 1 |
| Deregibus, MC | 1 |
| Camussi, G | 1 |
| Blancher, C | 1 |
| Moore, JW | 1 |
| Robertson, N | 1 |
| Harris, AL | 1 |
14 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Adenocarcinoma Of Kidney
| Article | Year |
|---|---|
Cyclin-Dependent Kinase Inhibitor BMI-1026 Induces Apoptosis by Downregulating Mcl-1 (L) and c-FLIP (L) and Inactivating p-Akt in Human Renal Carcinoma Cells.
Topics: Apoptosis; Blotting, Western; Carcinoma, Renal Cell; CASP8 and FADD-Like Apoptosis Regulating Protei | 2021 |
FABP5 regulates the proliferation of clear cell renal cell carcinoma cells via the PI3K/AKT signaling pathway.
Topics: Animals; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Proliferation; Chromones; Computational Biolo | 2019 |
A novel HDAC inhibitor OBP-801 and a PI3K inhibitor LY294002 synergistically induce apoptosis via the suppression of survivin and XIAP in renal cell carcinoma.
Topics: Apoptosis; Carcinoma, Renal Cell; Caspase 3; Cell Line, Tumor; Chromones; Drug Synergism; Enzyme Inh | 2013 |
Acquired resistance to temsirolimus in human renal cell carcinoma cells is mediated by the constitutive activation of signal transduction pathways through mTORC2.
Topics: Animals; Apoptosis; Butadienes; Carcinoma, Renal Cell; Cell Line, Tumor; Chromones; Drug Resistance, | 2013 |
The soluble Decoy Receptor 3 is regulated by a PI3K-dependent mechanism and promotes migration and invasion in renal cell carcinoma.
Topics: Carcinoma, Renal Cell; Cell Adhesion; Cell Line, Tumor; Cell Movement; Chromones; Fibronectins; Gene | 2013 |
GSK-3 directly regulates phospho-4EBP1 in renal cell carcinoma cell-line: an intrinsic subcellular mechanism for resistance to mTORC1 inhibition.
Topics: Adaptor Proteins, Signal Transducing; Carcinoma, Renal Cell; Cell Cycle Proteins; Cell Line, Tumor; | 2016 |
Characterization and targeting of phosphatidylinositol-3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in renal cell cancer.
Topics: Apoptosis; Automation; Biomarkers, Tumor; Carcinoma, Renal Cell; Cell Line, Tumor; Chromones; Drug S | 2011 |
TNF-α induces epithelial-mesenchymal transition of renal cell carcinoma cells via a GSK3β-dependent mechanism.
Topics: Animals; Cadherins; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Transformation, Neoplastic; Chromo | 2012 |
PI3K inhibition potentiates Bcl-2-dependent apoptosis in renal carcinoma cells.
Topics: Apoptosis; Biphenyl Compounds; Blotting, Western; Carcinoma, Renal Cell; Caspase 3; Caspase 8; Cell | 2013 |
Tsc2 expression increases the susceptibility of renal tumor cells to apoptosis.
Topics: Animals; Apoptosis; Carcinoma, Renal Cell; Caspase 3; Caspases; Cell Adhesion; Cell Line, Tumor; Cel | 2005 |
Endothelin-1 promotes cell survival in renal cell carcinoma through the ET(A) receptor.
Topics: Androstadienes; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Renal Cell; Cell Line, Tumo | 2007 |
The phosphoinositide 3-kinase/Akt pathway: a new target in human renal cell carcinoma therapy.
Topics: Animals; Carcinoma, Renal Cell; Cell Growth Processes; Cell Line, Tumor; Chromones; Enzyme Inhibitor | 2006 |
The proangiogenic phenotype of human tumor-derived endothelial cells depends on thrombospondin-1 downregulation via phosphatidylinositol 3-kinase/Akt pathway.
Topics: Adult; Androstadienes; Apoptosis; Blotting, Western; Carcinoma, Renal Cell; Cell Line; Chromones; Do | 2006 |
Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3'-kinase/Akt signaling pathway.
Topics: Basic Helix-Loop-Helix Transcription Factors; Blotting, Western; Breast Neoplasms; Carcinoma, Renal | 2001 |