Compounds > 2-(4-amylcinnamoyl)amino-4-chlorobenzoic-acid

2-(4-amylcinnamoyl)amino-4-chlorobenzoic-acid and Reperfusion-Injury

2-(4-amylcinnamoyl)amino-4-chlorobenzoic-acid has been researched along with Reperfusion-Injury* in 1 studies

Other Studies

1 other study(ies) available for 2-(4-amylcinnamoyl)amino-4-chlorobenzoic-acid and Reperfusion-Injury

Article	Year
The Discovery of Novel ACA Derivatives as Specific TRPM2 Inhibitors that Reduce Ischemic Injury Both In Vitro and In Vivo. Journal of medicinal chemistry, 2021, 04-08, Volume: 64, Issue:7 The transient receptor potential melastatin 2 (TRPM2) channel is associated with ischemia/reperfusion injury, inflammation, cancer, and neurodegenerative diseases. However, the limit of specific inhibitors impedes the development of TRPM2-targeted therapeutic agents. To discover more potent and selective TRPM2 inhibitors, 59 Topics: Animals; Cell Line, Tumor; Cinnamates; Glucose; HEK293 Cells; Humans; Infarction, Middle Cerebral Artery; Male; Mice, Inbred C57BL; Molecular Structure; Neuroprotective Agents; ortho-Aminobenzoates; Oxygen; Reperfusion Injury; Structure-Activity Relationship; TRPM Cation Channels	2021

Article

Year

The Discovery of Novel ACA Derivatives as Specific TRPM2 Inhibitors that Reduce Ischemic Injury Both In Vitro and In Vivo.

Journal of medicinal chemistry, 2021, 04-08, Volume: 64, Issue:7

The transient receptor potential melastatin 2 (TRPM2) channel is associated with ischemia/reperfusion injury, inflammation, cancer, and neurodegenerative diseases. However, the limit of specific inhibitors impedes the development of TRPM2-targeted therapeutic agents. To discover more potent and selective TRPM2 inhibitors, 59

Topics: Animals; Cell Line, Tumor; Cinnamates; Glucose; HEK293 Cells; Humans; Infarction, Middle Cerebral Artery; Male; Mice, Inbred C57BL; Molecular Structure; Neuroprotective Agents; ortho-Aminobenzoates; Oxygen; Reperfusion Injury; Structure-Activity Relationship; TRPM Cation Channels

2021