2-(4-5-dihydro-1h-imidazol-2-yl)-1-methyl-1h-indole and Alzheimer-Disease

Post mortem neuropathology suggests that astrocyte reactivity may play a significant role in neurodegeneration in Alzheimer's disease. We explored this in vivo using multimodal PET and MRI imaging. Twenty subjects (11 older, cognitively impaired patients and 9 age-matched healthy controls) underwent brain scanning using the novel reactive astrocyte PET tracer

Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Astrocytes; Brain; Fluorodeoxyglucose F18; Glucose; Gray Matter; Humans; Imidazoles; Indoles; Magnetic Resonance Imaging; Positron-Emission Tomography

With reactive astrogliosis being established as one of the hallmarks of Alzheimer's disease (AD), there is high interest in developing novel positron emission tomography (PET) tracers to detect early astrocyte reactivity. BU99008, a novel astrocytic PET ligand targeting imidazoline-2 binding sites (I

Topics: Alzheimer Disease; Astrocytes; Binding Sites; Brain; Humans; Imidazoles; Indoles; Positron-Emission Tomography

Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Astrocytes; Brain; Cognitive Dysfunction; Humans; Imidazoles; Indoles; Positron-Emission Tomography

Imidazoline I

Topics: Alzheimer Disease; Animals; Chlorocebus aethiops; Cycloaddition Reaction; Dogs; Female; HeLa Cells; Hippocampus; Humans; Imidazoles; Imidazoline Receptors; Ligands; Madin Darby Canine Kidney Cells; Mice; Molecular Structure; Nootropic Agents; Organophosphonates; Quantitative Structure-Activity Relationship; Vero Cells