Compounds > 2-(4--(methylamino)phenyl)-6-hydroxybenzothiazole

2-(4--(methylamino)phenyl)-6-hydroxybenzothiazole and Seizures

2-(4--(methylamino)phenyl)-6-hydroxybenzothiazole has been researched along with Seizures* in 1 studies

Other Studies

1 other study(ies) available for 2-(4--(methylamino)phenyl)-6-hydroxybenzothiazole and Seizures

Article	Year
Quantitative PET and Histology of Brain Biopsy Reveal Lack of Selective Pittsburgh Compound-B Binding to Intracerebral Amyloidoma. Journal of Alzheimer's disease : JAD, 2018, Volume: 65, Issue:1 This single case study examines selective Pittsburgh compound-B (PiB) binding to an intracerebral light-chain amyloidoma using a 90-minute dynamic [11C]PiB-PET scan and brain biopsy tissue. Parametric non-displaceable binding potential (BPND) images showed low specific binding in the amyloidoma (BPND = 0.23), while relative tracer delivery was adequate (R1 = 0.44). Histology of the tissue revealed strong coloring with Congo-red, thioflavin-S, and X-34, indicating presence of amyloid. However, immunological staining with 6F/3D revealed absence of amyloid-β and histofluorescence of 6-CN-PiB, a highly fluorescent derivative of PiB, was at background levels. Our results suggest that PiB does not detect the atypical amyloid pathology associated with an intracerebral light-chain amyloidoma. These findings are of interest to clinicians and researchers applying [11C]PiB-PET to detect atypical forms of amyloid pathology. Topics: Amyloidosis; Aniline Compounds; Biopsy; Brain; Female; Humans; Magnetic Resonance Imaging; Middle Aged; Positron-Emission Tomography; Seizures; Thiazoles	2018

Article

Year

Quantitative PET and Histology of Brain Biopsy Reveal Lack of Selective Pittsburgh Compound-B Binding to Intracerebral Amyloidoma.

Journal of Alzheimer's disease : JAD, 2018, Volume: 65, Issue:1

This single case study examines selective Pittsburgh compound-B (PiB) binding to an intracerebral light-chain amyloidoma using a 90-minute dynamic [11C]PiB-PET scan and brain biopsy tissue. Parametric non-displaceable binding potential (BPND) images showed low specific binding in the amyloidoma (BPND = 0.23), while relative tracer delivery was adequate (R1 = 0.44). Histology of the tissue revealed strong coloring with Congo-red, thioflavin-S, and X-34, indicating presence of amyloid. However, immunological staining with 6F/3D revealed absence of amyloid-β and histofluorescence of 6-CN-PiB, a highly fluorescent derivative of PiB, was at background levels. Our results suggest that PiB does not detect the atypical amyloid pathology associated with an intracerebral light-chain amyloidoma. These findings are of interest to clinicians and researchers applying [11C]PiB-PET to detect atypical forms of amyloid pathology.

Topics: Amyloidosis; Aniline Compounds; Biopsy; Brain; Female; Humans; Magnetic Resonance Imaging; Middle Aged; Positron-Emission Tomography; Seizures; Thiazoles

2018