2-(4--(methylamino)phenyl)-6-hydroxybenzothiazole and Immunoglobulin-Light-chain-Amyloidosis

This dual-site study evaluated the diagnostic accuracy of the method.. Pittsburgh compound ([. The study had 2 parts. In the initial study, 51 subjects were included, 36 patients with known CA and increased wall thickness (15 immunoglobulin light chain [AL] and 21 transthyretin [ATTR] amyloidosis) and 15 control patients (7 were nonamyloid hypertrophic and 8 healthy volunteers). Subjects underwent PIB-PET and echocardiography. Sensitivity and specificity of PIB-PET were established for 2 simple semiquantitative approaches, standardized uptake value ratio (SUVR) and retention index (RI). The second part of the study included 11 amyloidosis patients (5 AL and 6 hereditary ATTR) without increased wall thickness to which the optimal cutoff values of SUVR (>1.09) and RI (>0.037 min. The diagnostic accuracy of visual inspection of [. In a dual-center setting, [

Topics: Adult; Aged; Aged, 80 and over; Aniline Compounds; Carbon Radioisotopes; Cardiomyopathies; Case-Control Studies; Denmark; Female; Humans; Immunoglobulin Light-chain Amyloidosis; Male; Middle Aged; Positron Emission Tomography Computed Tomography; Predictive Value of Tests; Prospective Studies; Radiopharmaceuticals; Reproducibility of Results; Sweden; Thiazoles