2-(4--(methylamino)phenyl)-6-hydroxybenzothiazole has been researched along with Hyperglycemia* in 2 studies
2 other study(ies) available for 2-(4--(methylamino)phenyl)-6-hydroxybenzothiazole and Hyperglycemia
| Article | Year |
|---|---|
Insulin resistance predicts brain amyloid deposition in late middle-aged adults.
Insulin resistance (IR) increases Alzheimer's disease (AD) risk. IR is related to greater amyloid burden post-mortem and increased deposition within areas affected by early AD. No studies have examined if IR is associated with an in vivo index of amyloid in the human brain in late middle-aged participants at risk for AD.. Asymptomatic, late middle-aged adults (N = 186) from the Wisconsin Registry for Alzheimer's Prevention underwent [C-11]Pittsburgh compound B (PiB) positron emission tomography. The cross-sectional design tested the interaction between insulin resistance and glycemic status on PiB distribution volume ratio in three regions of interest (frontal, parietal, and temporal).. In participants with normoglycemia but not hyperglycemia, higher insulin resistance corresponded to higher PiB uptake in frontal and temporal areas, reflecting increased amyloid deposition.. This is the first human study to demonstrate that insulin resistance may contribute to amyloid deposition in brain regions affected by AD. Topics: Aged; Amyloid; Aniline Compounds; Apolipoproteins E; Body Mass Index; Brain; Female; Humans; Hyperglycemia; Imaging, Three-Dimensional; Insulin Resistance; Magnetic Resonance Imaging; Male; Mental Status Schedule; Middle Aged; Positron-Emission Tomography; Predictive Value of Tests; Thiazoles | 2015 |
Alzheimer's disease-like pattern of (18)F-FDG uptake during a hyperglycemic state and negative (11)C-PiB binding in a patient with mild cognitive impairment.
Increased plasma glucose levels can cause the regional reduction of fluorine-18-labeled fluorodeoxyglucose (18F-FDG) uptake in the posterior cingulate, precuneus, and/or temporoparietal cortices as an Alzheimer's disease (AD)-like pattern. However, the association of such an AD-like pattern of cerebral 18F-FDG uptake with AD pathophysiology is unknown. We report a case of a 70-year-old patient with mild cognitive impairment, and show that the AD-like pattern of cerebral 18F-FDG uptake during a hyperglycemic state could be reversible and is not associated with amyloid-β accumulation. Our case concludes that the AD-like pattern is dependent on the plasma glucose level and independent of AD pathophysiology. Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Benzothiazoles; Cognitive Dysfunction; Female; Fluorodeoxyglucose F18; Humans; Hyperglycemia; Male; Middle Aged; Positron-Emission Tomography; Thiazoles | 2014 |