2-(4--(methylamino)phenyl)-6-hydroxybenzothiazole and Heart-Failure

It remains unknown whether the noninvasive evaluation of the degree of amyloid deposition in the myocardium can predict the prognosis of patients with light chain (AL) cardiac amyloidosis.. The purpose of this study was to demonstrate that. This study consecutively enrolled 41 chemotherapy-naïve AL cardiac amyloidosis patients. The amyloid deposit was quantitatively assessed with amyloid P immunohistochemistry in endomyocardial biopsy specimens and was compared with the degree of myocardial. These proof-of-concept results show that noninvasive evaluation of myocardial amyloid load by

Topics: Aged; Amyloidosis; Aniline Compounds; Biopsy; Female; Heart; Heart Failure; Humans; Immunohistochemistry; Male; Middle Aged; Myocardium; Positron-Emission Tomography; Prognosis; Proportional Hazards Models; Prospective Studies; Thiazoles

(11)C-PIB PET is a promising non-invasive diagnostic tool for cardiac amyloidosis. Semiautomatic analysis of PET data is now available but it is not known how accurate these methods are for amyloid imaging. The aim of this study was to evaluate the feasibility of one semiautomatic software tool for analysis and visualization of (11)C-PIB left ventricular retention index (RI) in cardiac amyloidosis.. Patients with systemic amyloidosis and cardiac involvement (n = 10) and healthy controls (n = 5) were investigated with dynamic (11)C-PIB PET. Two observers analyzed the PET studies with semiautomatic software to calculate the left ventricular RI of (11)C-PIB and to create parametric images. The mean RI at 15-25 min from the semiautomatic analysis was compared with RI based on manual analysis and showed comparable values (0.056 vs 0.054 min(-1) for amyloidosis patients and 0.024 vs 0.025 min(-1) in healthy controls; P = .78) and the correlation was excellent (r = 0.98). Inter-reader reproducibility also was excellent (intraclass correlation coefficient, ICC > 0.98). Parametric polarmaps and histograms made visual separation of amyloidosis patients and healthy controls fast and simple.. Accurate semiautomatic analysis of cardiac (11)C-PIB RI in amyloidosis patients is feasible. Parametric polarmaps and histograms make visual interpretation fast and simple.

Topics: Aged; Amyloidosis; Aniline Compounds; Benzothiazoles; Biomarkers; Female; Heart; Heart Failure; Humans; Image Enhancement; Image Interpretation, Computer-Assisted; Male; Middle Aged; Myocardium; Observer Variation; Pattern Recognition, Automated; Positron-Emission Tomography; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Thiazoles; Tissue Distribution

Topics: Aged; Amyloidosis; Aniline Compounds; Carbon Radioisotopes; Cardiomyopathies; Echocardiography; Heart Failure; Humans; Hypertrophy, Right Ventricular; Male; Multimodal Imaging; Positron Emission Tomography Computed Tomography; Radiopharmaceuticals; Recurrence; Sarcoidosis; Thiazoles