Compounds > 2-(4--(methylamino)phenyl)-6-hydroxybenzothiazole

2-(4--(methylamino)phenyl)-6-hydroxybenzothiazole and Amyotrophic-Lateral-Sclerosis

2-(4--(methylamino)phenyl)-6-hydroxybenzothiazole has been researched along with Amyotrophic-Lateral-Sclerosis* in 1 studies

Other Studies

1 other study(ies) available for 2-(4--(methylamino)phenyl)-6-hydroxybenzothiazole and Amyotrophic-Lateral-Sclerosis

Article	Year
Brain ¹⁸F-FDG and ¹¹C-PiB PET findings in two siblings with FTD/ALS associated with the C9ORF72 repeat expansion. Neurocase, 2014, Volume: 20, Issue:2 The C9ORF72 hexanucleotide expansion is a major pathological expansion pattern found in patients with frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (C9FTD/ALS). We describe a patient in whom early clinical evaluation, MRI and fluorodeoxyglucose (FDG) positron emission tomography (PET) findings failed to definitively differentiate between FTD and Alzheimer's disease (AD), whereas (11)C-Pittsburgh compound B (PiB) PET was negative for amyloid pathology. He later developed ALS symptoms, and post mortem neuropathological findings were diagnostic of FTD-ALS, while no findings suggested AD. His sister was diagnosed with FTD, and the C9ORF72 expansion was detected in both siblings. We conclude that ¹¹C-PiB PET imaging may help the early differential diagnosis between AD and FTD, including C9FTD/ALS. Topics: Amyotrophic Lateral Sclerosis; Aniline Compounds; Brain; C9orf72 Protein; Diagnosis, Differential; DNA Repeat Expansion; Female; Fluorodeoxyglucose F18; Frontotemporal Dementia; Humans; Male; Middle Aged; Neurons; Positron-Emission Tomography; Proteins; Siblings; Thiazoles	2014

Article

Year

Brain ¹⁸F-FDG and ¹¹C-PiB PET findings in two siblings with FTD/ALS associated with the C9ORF72 repeat expansion.

Neurocase, 2014, Volume: 20, Issue:2

The C9ORF72 hexanucleotide expansion is a major pathological expansion pattern found in patients with frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (C9FTD/ALS). We describe a patient in whom early clinical evaluation, MRI and fluorodeoxyglucose (FDG) positron emission tomography (PET) findings failed to definitively differentiate between FTD and Alzheimer's disease (AD), whereas (11)C-Pittsburgh compound B (PiB) PET was negative for amyloid pathology. He later developed ALS symptoms, and post mortem neuropathological findings were diagnostic of FTD-ALS, while no findings suggested AD. His sister was diagnosed with FTD, and the C9ORF72 expansion was detected in both siblings. We conclude that ¹¹C-PiB PET imaging may help the early differential diagnosis between AD and FTD, including C9FTD/ALS.

Topics: Amyotrophic Lateral Sclerosis; Aniline Compounds; Brain; C9orf72 Protein; Diagnosis, Differential; DNA Repeat Expansion; Female; Fluorodeoxyglucose F18; Frontotemporal Dementia; Humans; Male; Middle Aged; Neurons; Positron-Emission Tomography; Proteins; Siblings; Thiazoles

2014