2-(4--(methylamino)phenyl)-6-hydroxybenzothiazole and Amyloid-Neuropathies--Familial

To investigate the utility of the combined use of. Whole-body. Cardiac amyloidosis was detectable by. All three major types of cardiac amyloidosis can be detected and differentiated non-invasively by combined use of the two amyloid imaging methods and

Topics: Adult; Aged; Aged, 80 and over; Amyloid Neuropathies, Familial; Aniline Compounds; Cardiomyopathies; Female; Humans; Male; Middle Aged; Positron-Emission Tomography; Prealbumin; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Pyrophosphate; Thiazoles; Young Adult

DPD scintigraphy has been advocated for imaging cardiac amyloid in ATTR amyloidosis. PET utilizing. Ten patients with biopsy-proven V30M ATTR amyloidosis and discrete or no signs of cardiac involvement were included. Patients were grouped according to TTR-fragmentation. All underwent DPD scintigraphy, echocardiography, and PIB-PET. A left ventricular PIB-retention index (PIB-RI) was established and compared to five normal volunteers.. PIB-RI was increased in all patients (P < 0.001), but was significantly higher in type B than in type A (0.129 ± 0.041 vs 0.040 ± 0.006 min. PIB-PET, in contrast to DPD scintigraphy, has the potential to specifically identify cardiac amyloid depositions irrespective of amyloid fibril composition. The heart appears to be a target organ for amyloid deposition in ATTR amyloidosis.

Topics: Aged; Alzheimer Disease; Amyloid; Amyloid Neuropathies, Familial; Aniline Compounds; Biopsy; Brain; Carbon Radioisotopes; Echocardiography; Female; Healthy Volunteers; Heart; Heart Ventricles; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Radionuclide Imaging; Thiazoles

Topics: Amyloid Neuropathies, Familial; Aniline Compounds; Cerebral Amyloid Angiopathy, Familial; Humans; Positron-Emission Tomography; Prealbumin; Thiazoles