2-(4-(dimethylamino)styryl)-1-methylpyridinium has been researched along with Myocardial-Ischemia* in 1 studies
1 other study(ies) available for 2-(4-(dimethylamino)styryl)-1-methylpyridinium and Myocardial-Ischemia
| Article | Year |
|---|---|
[Cardioprotection of 2-[p-(dimethylamino)styryl]pyridine methiodide against ischemic damage and myocardial lipid peroxidation].
Mice were injected ip DSPM 1 or 3 mg.kg-1 3 h prior to a subcutaneous injection of isoproterenol (Iso) 20 mg.kg-1 once daily for 2 d. Iso induced reductions of Se-glutathione peroxidase (Se-GSH-PX), superoxide dismutase (SOD) activities, and an increase of malondialdehyde (MDA) content in myocardium. DSPM 1 or 3 mg.kg-1 significantly abated reduction of Se-GSH-PX activity and decreased MDA production and DSPM 3 mg.kg-1 also abated reduction of SOD activity in the hearts from Iso-treated mice. The changes of above indices were in accordance with those of myocardial ultrastructure and creatine phosphokinase (CPK) concentration in serum. The results indicate that DSPM has a protective effect on myocardial ischemic injury probably by inhibiting oxygen free radicals and subsequent lipid peroxidation. Topics: Animals; Calcium Channel Blockers; Female; Isoproterenol; Lipid Peroxidation; Male; Mice; Mice, Inbred C57BL; Myocardial Ischemia; Myocardium; Pyridinium Compounds; Verapamil | 1993 |