2-(3-4-dimethoxyphenyl)-1-(5-methoxy-2-2-dimethyl-2h-chromen-6-yl)ethanone and Breast-Neoplasms

2-(3-4-dimethoxyphenyl)-1-(5-methoxy-2-2-dimethyl-2h-chromen-6-yl)ethanone has been researched along with Breast-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for 2-(3-4-dimethoxyphenyl)-1-(5-methoxy-2-2-dimethyl-2h-chromen-6-yl)ethanone and Breast-Neoplasms

Article	Year
Identification of small molecule inhibitors of the STAT3 signaling pathway: Insights into their structural features and mode of action. Bioorganic & medicinal chemistry letters, 2015, Nov-15, Volume: 25, Issue:22 A series of novel STAT3 inhibitors consisting of Michael acceptor has been identified through assays of the focused in-house library. In addition, their mode of action and structural feature responsible for the STAT3 inhibition were investigated. In particular, analog 6 revealed promising STAT3 inhibitory activity in HeLa cell lines. The analog also exhibited selective inhibition of STAT3 phosphorylation without affecting STAT1 phosphorylation and cytostatic effect in human breast epithelial cells (MCF10A-ras), which supports cancer cell-specific inhibitory properties. Topics: Breast Neoplasms; Cell Line, Tumor; Cell Survival; Female; HeLa Cells; Humans; Immunoblotting; Phosphorylation; Signal Transduction; Small Molecule Libraries; STAT3 Transcription Factor	2015

Article

Year

Identification of small molecule inhibitors of the STAT3 signaling pathway: Insights into their structural features and mode of action.

Bioorganic & medicinal chemistry letters, 2015, Nov-15, Volume: 25, Issue:22

A series of novel STAT3 inhibitors consisting of Michael acceptor has been identified through assays of the focused in-house library. In addition, their mode of action and structural feature responsible for the STAT3 inhibition were investigated. In particular, analog 6 revealed promising STAT3 inhibitory activity in HeLa cell lines. The analog also exhibited selective inhibition of STAT3 phosphorylation without affecting STAT1 phosphorylation and cytostatic effect in human breast epithelial cells (MCF10A-ras), which supports cancer cell-specific inhibitory properties.

Topics: Breast Neoplasms; Cell Line, Tumor; Cell Survival; Female; HeLa Cells; Humans; Immunoblotting; Phosphorylation; Signal Transduction; Small Molecule Libraries; STAT3 Transcription Factor

2015