2-(2-phenylethyl)chromone and Atherosclerosis

Chinese agarwood, derived from the Aquilaria sinensis (Lour.) Gilg (Thymelaeaceae), has a long history of use in Traditional Chinese Medicine for the management of cardiovascular disease. However, the specific active ingredients responsible for its impact on atherosclerosis are yet to be fully understood.. The aim of this study is to investigate the anti-atherosclerotic effectiveness of the 2-(2-phenylethyl)chromone-enriched extract derived from Chinese agarwood (CPE) through the ER stress-mediated CD36 pathway.. To assess the effectiveness of CPE, an atherosclerotic mouse model was established using ApoE. Our in vivo research confirmed that CPE effectively reduces the formation of aortic plaques in atherosclerotic ApoE. CPE demonstrated significant efficacy to inhibit the atherosclerosis. The ER stress/P-JNK/PPARγ/CD36 signaling pathway plays critical involvement in modulating the foam cell formation in vitro and in vivo. These findings underscore the efficacy of CPE as a viable therapeutic intervention for the treatment of atherosclerosis.

Topics: Animals; Apolipoproteins E; Atherosclerosis; CD36 Antigens; Chromones; Endoplasmic Reticulum Stress; Macrophages; Mice; Thymelaeaceae