Compounds > 2-(2-methoxyphenyl)-1H-indole

2-(2-methoxyphenyl)-1H-indole and Glioblastoma

2-(2-methoxyphenyl)-1H-indole has been researched along with Glioblastoma* in 1 studies

*Glioblastoma: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal gangl [MeSH]

Other Studies

1 other study(ies) available for 2-(2-methoxyphenyl)-1H-indole and Glioblastoma

Article	Year
Preliminary biological evaluation and mechanism of action studies of selected 2-arylindoles against glioblastoma. Bioorganic & medicinal chemistry, 2013, Apr-01, Volume: 21, Issue:7 A series of related 2-arylindoles have been evaluated for their anticancer activity against a range of glioblastoma cell lines using a number of different cell-based assays to determine cell viability after treatment with the compounds. The best indoles, which showed comparable activity to cisplatin against a U87MG cell line in the MTS assay, were taken forward and initial studies suggest that their mechanism of action is consistent with the generation of reactive oxygen species followed by autophagic cell death. Furthermore, activity was also observed in glioblastoma short-term cell cultures for the best lead compound and in some cases gave low micromolar IC50s. Topics: Antineoplastic Agents; Autophagy; Cell Line, Tumor; Cell Survival; Cisplatin; Glioblastoma; Humans; Indoles; Inhibitory Concentration 50; Reactive Oxygen Species	2013

Article

Year

Preliminary biological evaluation and mechanism of action studies of selected 2-arylindoles against glioblastoma.

Bioorganic & medicinal chemistry, 2013, Apr-01, Volume: 21, Issue:7

A series of related 2-arylindoles have been evaluated for their anticancer activity against a range of glioblastoma cell lines using a number of different cell-based assays to determine cell viability after treatment with the compounds. The best indoles, which showed comparable activity to cisplatin against a U87MG cell line in the MTS assay, were taken forward and initial studies suggest that their mechanism of action is consistent with the generation of reactive oxygen species followed by autophagic cell death. Furthermore, activity was also observed in glioblastoma short-term cell cultures for the best lead compound and in some cases gave low micromolar IC50s.

Topics: Antineoplastic Agents; Autophagy; Cell Line, Tumor; Cell Survival; Cisplatin; Glioblastoma; Humans; Indoles; Inhibitory Concentration 50; Reactive Oxygen Species

2013