Compounds > 2-(2-benzofuranyl)-2-imidazoline

2-(2-benzofuranyl)-2-imidazoline and Neurodegenerative-Diseases

2-(2-benzofuranyl)-2-imidazoline has been researched along with Neurodegenerative-Diseases* in 1 studies

Other Studies

1 other study(ies) available for 2-(2-benzofuranyl)-2-imidazoline and Neurodegenerative-Diseases

ArticleYear
Novel monoamine oxidase inhibitors based on the privileged 2-imidazoline molecular framework.
    Bioorganic & medicinal chemistry letters, 2019, 01-01, Volume: 29, Issue:1

    Series of structurally diverse 2-imidazoline derivatives have been synthesized by condensation of substituted aldehydes with ethylenediamine, Pd-catalyzed N-arylation of 2-imidazolines and by the formation of 1,2,4-oxadiazoles and benzoxazepines from 2-imidazoline-containing precursors. The 2-imidazoline derivatives were evaluated as potential inhibitors of human monoamine oxidase (MAO) A and B. Among the 2-imidazolines, good potency inhibitors were discovered with compound 9p (IC

    Topics: Dose-Response Relationship, Drug; Humans; Imidazoles; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurodegenerative Diseases; Structure-Activity Relationship

2019