Compounds > 2-(1-piperazinyl)-4-amino-6-7-dimethoxyquinazoline

2-(1-piperazinyl)-4-amino-6-7-dimethoxyquinazoline and Carcinoma

2-(1-piperazinyl)-4-amino-6-7-dimethoxyquinazoline has been researched along with Carcinoma* in 1 studies

Other Studies

1 other study(ies) available for 2-(1-piperazinyl)-4-amino-6-7-dimethoxyquinazoline and Carcinoma

Article	Year
Design, synthesis, and biological evaluation of prazosin-related derivatives as multipotent compounds. Journal of medicinal chemistry, 2005, Jan-13, Volume: 48, Issue:1 To combine in the same molecule alpha(1)-adrenoreceptor blocking and antioxidant properties, compounds 2-5 were designed and synthesized. All compounds were effective alpha(1)-adrenoreceptor antagonists and were tested in both functional and binding assays. In addition, compounds 2 and 5 also displayed significant capacity to inhibit intracellular oxidative stress, whereas 3-5 exerted potent antiproliferative activity in lymph node carcinoma of prostate cells. Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Antioxidants; Biochemistry; Carcinoma; CHO Cells; Cricetinae; Cricetulus; Drug Design; Drug Evaluation, Preclinical; Humans; In Vitro Techniques; Male; Prazosin; Prostatic Neoplasms; Rats; Reactive Oxygen Species; Receptors, Adrenergic, alpha-1; Structure-Activity Relationship; Thioctic Acid; Tumor Cells, Cultured; Vas Deferens	2005

Article

Year

Design, synthesis, and biological evaluation of prazosin-related derivatives as multipotent compounds.

Journal of medicinal chemistry, 2005, Jan-13, Volume: 48, Issue:1

To combine in the same molecule alpha(1)-adrenoreceptor blocking and antioxidant properties, compounds 2-5 were designed and synthesized. All compounds were effective alpha(1)-adrenoreceptor antagonists and were tested in both functional and binding assays. In addition, compounds 2 and 5 also displayed significant capacity to inhibit intracellular oxidative stress, whereas 3-5 exerted potent antiproliferative activity in lymph node carcinoma of prostate cells.

Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Antioxidants; Biochemistry; Carcinoma; CHO Cells; Cricetinae; Cricetulus; Drug Design; Drug Evaluation, Preclinical; Humans; In Vitro Techniques; Male; Prazosin; Prostatic Neoplasms; Rats; Reactive Oxygen Species; Receptors, Adrenergic, alpha-1; Structure-Activity Relationship; Thioctic Acid; Tumor Cells, Cultured; Vas Deferens

2005