1h-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one has been researched along with Sepsis in 8 studies
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one: structure given in first source; inhibits guanylyl cyclase
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one : A member of the class of oxadiazoloquinoxalines that is 1H-[1,2,4]oxadiazolo[4,3-a]quinoxaline substituted at position 1 by an oxo group.
Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Atorvastatin pretreatment, however, prevented the decrease in α(1D)-adrenoceptor mRNA expression in septic animals." | 5.37 | Atorvastatin prevents vascular hyporeactivity to norepinephrine in sepsis: role of nitric oxide and α₁-adrenoceptor mRNA expression. ( Ahanger, AA; Choudhury, S; Kandasamy, K; Mishra, SK; More, AS; Parida, S; Prawez, S; Singh, TU, 2011) |
| " In a phenylephrine-contracted canine carotid artery ring preparation, we found that both canine and human Lzm-S, at concentrations similar to those found in sepsis, produced vasorelaxation." | 3.74 | Lysozyme, a mediator of sepsis that produces vasodilation by hydrogen peroxide signaling in an arterial preparation. ( Bose, R; Cheng, ZQ; Jacobs, H; Kasian, K; Light, RB; Mink, SN; Santos Martinez, LE, 2008) |
| "Sepsis was induced by cecal ligation and puncture (CLP)." | 1.56 | Perivascular adipose tissue phenotype and sepsis vascular dysfunction: Differential contribution of NO, ROS and beta 3-adrenergic receptor. ( Assreuy, J; Barp, CG; Benedet, PO, 2020) |
| "Atorvastatin pretreatment, however, prevented the decrease in α(1D)-adrenoceptor mRNA expression in septic animals." | 1.37 | Atorvastatin prevents vascular hyporeactivity to norepinephrine in sepsis: role of nitric oxide and α₁-adrenoceptor mRNA expression. ( Ahanger, AA; Choudhury, S; Kandasamy, K; Mishra, SK; More, AS; Parida, S; Prawez, S; Singh, TU, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (62.50) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Barp, CG | 1 |
| Benedet, PO | 1 |
| Assreuy, J | 2 |
| Fernandes, D | 1 |
| Sordi, R | 1 |
| Pacheco, LK | 1 |
| Nardi, GM | 1 |
| Heckert, BT | 1 |
| Villela, CG | 1 |
| Lobo, AR | 1 |
| Barja-Fidalgo, C | 1 |
| Oliveira-Pelegrin, GR | 1 |
| Aguila, FA | 1 |
| Basso, PJ | 1 |
| Rocha, MJ | 1 |
| Kandasamy, K | 1 |
| Prawez, S | 1 |
| Choudhury, S | 1 |
| More, AS | 1 |
| Ahanger, AA | 1 |
| Singh, TU | 1 |
| Parida, S | 1 |
| Mishra, SK | 1 |
| Williams, M | 1 |
| Kerkar, S | 1 |
| Tyburski, JG | 1 |
| Steffes, CP | 1 |
| Carlin, AM | 1 |
| Wilson, RF | 1 |
| Wang, C | 1 |
| Mansard, A | 1 |
| Giummelly, P | 1 |
| Atkinson, J | 1 |
| Mink, SN | 2 |
| Bose, R | 2 |
| Roberts, DE | 1 |
| Jacobs, H | 2 |
| Duke, K | 1 |
| Bose, D | 1 |
| Cheng, ZQ | 2 |
| Light, RB | 2 |
| Kasian, K | 1 |
| Santos Martinez, LE | 1 |
8 other studies available for 1h-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one and Sepsis
| Article | Year |
|---|---|
Perivascular adipose tissue phenotype and sepsis vascular dysfunction: Differential contribution of NO, ROS and beta 3-adrenergic receptor.
Topics: Acetophenones; Adipose Tissue; Adrenergic beta-3 Receptor Agonists; Animals; Aorta; Cyclic N-Oxides; | 2020 |
Late, but not early, inhibition of soluble guanylate cyclase decreases mortality in a rat sepsis model.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Cecum; Cyclic GMP; Disease Models, Animal; Drug Administra | 2009 |
Role of central NO-cGMP pathway in vasopressin and oxytocin gene expression during sepsis.
Topics: Animals; Arginine Vasopressin; Cyclic GMP; Enzyme Inhibitors; Gene Expression Regulation; Male; Nitr | 2010 |
Atorvastatin prevents vascular hyporeactivity to norepinephrine in sepsis: role of nitric oxide and α₁-adrenoceptor mRNA expression.
Topics: Animals; Atorvastatin; Enzyme Inhibitors; Guanylate Cyclase; Heptanoic Acids; Mice; Nitric Oxide; No | 2011 |
The roles of cyclic adenosine monophosphate- and cyclic guanosine monophosphate-dependent protein kinase pathways in hydrogen peroxide-induced contractility of microvascular lung pericytes.
Topics: Adenine; Adenylyl Cyclase Inhibitors; Analysis of Variance; Animals; Cell Survival; Cells, Cultured; | 2003 |
Decreased aortic smooth muscle contraction in a rat model of multibacterial sepsis.
Topics: Animals; Aorta; Disease Models, Animal; Endothelial Cells; Enzyme Inhibitors; Guanylate Cyclase; In | 2004 |
Lysozyme binding to endocardial endothelium mediates myocardial depression by the nitric oxide guanosine 3',5' monophosphate pathway in sepsis.
Topics: Animals; Cell Membrane; Cyclic GMP; Dogs; Endocardium; Endothelium; In Vitro Techniques; Muramidase; | 2005 |
Lysozyme, a mediator of sepsis that produces vasodilation by hydrogen peroxide signaling in an arterial preparation.
Topics: Aminoquinolines; Animals; Carotid Artery, Internal; Catalase; Cyclic GMP; Cyclic GMP-Dependent Prote | 2008 |