1h-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one has been researched along with Pulmonary Hypertension in 5 studies
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one: structure given in first source; inhibits guanylyl cyclase
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one : A member of the class of oxadiazoloquinoxalines that is 1H-[1,2,4]oxadiazolo[4,3-a]quinoxaline substituted at position 1 by an oxo group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study addressed whether combined treatment with a phosphodiesterase type 5 inhibitor, sildenafil, and a nitric oxide donor, molsidomine, prevents development of pulmonary hypertension in chronic hypoxic rats." | 7.73 | Lack of synergistic effect of molsidomine and sildenafil on development of pulmonary hypertension in chronic hypoxic rats. ( Andersen, CU; Mulvany, MJ; Simonsen, U, 2005) |
| " In this study, responses to intravenous injections of the sGC activator BAY 60-2770 were investigated under baseline and elevated tone conditions induced by the thromboxane mimic U-46619 when NO synthesis was inhibited by N(ω)-nitro-L-arginine methyl ester hydrochloride (L-NAME), when sGC activity was inhibited by 1H-[1,2,4]-oxadizaolo[4,3]quinoxaline-1-one (ODQ), an agent that oxidizes sGC, and in animals with monocrotaline-induced pulmonary hypertension." | 3.77 | Pulmonary and systemic vasodilator responses to the soluble guanylyl cyclase activator, BAY 60-2770, are not dependent on endogenous nitric oxide or reduced heme. ( Badejo, AM; Bhartiya, M; Haider, U; Kadowitz, PJ; Murthy, SN; Nossaman, BD; Pankey, EA; Stasch, JP, 2011) |
| "The present study addressed whether combined treatment with a phosphodiesterase type 5 inhibitor, sildenafil, and a nitric oxide donor, molsidomine, prevents development of pulmonary hypertension in chronic hypoxic rats." | 3.73 | Lack of synergistic effect of molsidomine and sildenafil on development of pulmonary hypertension in chronic hypoxic rats. ( Andersen, CU; Mulvany, MJ; Simonsen, U, 2005) |
| "Carbon monoxide (CO) has been proposed to attenuate the vasoconstrictor response to local hypoxia that contributes to pulmonary hypertension." | 3.71 | Homogeneous segmental profile of carbon monoxide-mediated pulmonary vasodilation in rats. ( Naik, JS; Walker, BR, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chester, M | 1 |
| Tourneux, P | 1 |
| Seedorf, G | 1 |
| Grover, TR | 1 |
| Gien, J | 1 |
| Abman, SH | 1 |
| Pankey, EA | 1 |
| Bhartiya, M | 1 |
| Badejo, AM | 1 |
| Haider, U | 1 |
| Stasch, JP | 1 |
| Murthy, SN | 1 |
| Nossaman, BD | 1 |
| Kadowitz, PJ | 1 |
| Andersen, CU | 1 |
| Mulvany, MJ | 1 |
| Simonsen, U | 1 |
| Fouty, B | 1 |
| Komalavilas, P | 1 |
| Muramatsu, M | 1 |
| Cohen, A | 1 |
| McMurtry, IF | 1 |
| Lincoln, TM | 1 |
| Rodman, DM | 1 |
| Naik, JS | 1 |
| Walker, BR | 1 |
5 other studies available for 1h-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one and Pulmonary Hypertension
| Article | Year |
|---|---|
Cinaciguat, a soluble guanylate cyclase activator, causes potent and sustained pulmonary vasodilation in the ovine fetus.
Topics: Acetylcholine; Animals; Animals, Newborn; Benzoates; Cells, Cultured; Cyclic GMP; Dose-Response Rela | 2009 |
Pulmonary and systemic vasodilator responses to the soluble guanylyl cyclase activator, BAY 60-2770, are not dependent on endogenous nitric oxide or reduced heme.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Benzoates; Biphenyl Com | 2011 |
Lack of synergistic effect of molsidomine and sildenafil on development of pulmonary hypertension in chronic hypoxic rats.
Topics: Acetylcholine; Actins; Animals; Atrial Natriuretic Factor; Body Weight; Dose-Response Relationship, | 2005 |
Protein kinase G is not essential to NO-cGMP modulation of basal tone in rat pulmonary circulation.
Topics: Alkaloids; Animals; Blood Pressure; Carbazoles; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Hy | 1998 |
Homogeneous segmental profile of carbon monoxide-mediated pulmonary vasodilation in rats.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Carbon Monoxide; Cyclic | 2001 |