1h-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one has been researched along with Muscle Relaxation in 93 studies
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one: structure given in first source; inhibits guanylyl cyclase
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one : A member of the class of oxadiazoloquinoxalines that is 1H-[1,2,4]oxadiazolo[4,3-a]quinoxaline substituted at position 1 by an oxo group.
Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of the present study was to ascertain the role of adenylate (AC) versus guanylate cyclase (GC) signaling pathways in the internal anal sphincter (IAS) smooth muscle relaxation by beta(1)-, beta(2)-, and beta(3)-adrenoceptor (AR) activation by xamoterol, procaterol, and disodium 5-[(2R)-2-(3-chlorophenyl)-2-hydroxy-ethyl]amino)propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316243), respectively." | 3.72 | Role of adenylate and guanylate cyclases in beta1-, beta2-, and beta3-adrenoceptor-mediated relaxation of internal anal sphincter smooth muscle. ( De Godoy, M; Li, F; Rattan, S, 2004) |
| "To clarify further the role of cyclic GMP in mediating the relaxant response in guinea-pig trachea induced by sodium nitroprusside (SNP), the effects of soluble guanylyl cyclase inhibitors, methylene blue and 1H-[1,2,4]oxadiazolo[4,3,-a]quinoxalin-1-one (ODQ) on SNP-induced muscle relaxation and cyclic GMP accumulation were determined." | 3.70 | Comparison of two soluble guanylyl cyclase inhibitors, methylene blue and ODQ, on sodium nitroprusside-induced relaxation in guinea-pig trachea. ( Hwang, TL; Teng, CM; Wu, CC, 1998) |
| " Ryanodine-sensitive, Ca(2+) release ('Ca(2+) sparks') from the sarcoplasmic reticulum (SR) can activate plasmalemmal Ca(2+)-activated K(+) channels (K(Ca)) to cause membrane hyperpolarization and smooth muscle relaxation." | 3.70 | Nitrergic relaxation of the mouse gastric fundus is mediated by cyclic GMP-dependent and ryanodine-sensitive mechanisms. ( Cocks, TM; Selemidis, S, 2000) |
| "Carbon monoxide (CO), a vasodilator, has been implicated as an activator of soluble guanylyl cyclase (sGC) to effect smooth muscle relaxation; however, this idea has not received universal support." | 3.69 | The soluble guanylyl cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3-alpha]quinoxalin-1-one (ODQ) inhibits relaxation of rabbit aortic rings induced by carbon monoxide, nitric oxide, and glyceryl trinitrate. ( Brien, JF; Hussain, AS; Marks, GS; Nakatsu, K, 1997) |
| "Capillarisin was also applied to PCC tissues contracted with Phe, which were pre-incubated with phosphodiesterase type 5 inhibitors (PDE5 Is)." | 1.38 | The role of capillarisin from Artemisia capillaris on penile erection. ( Bak, YO; Choi, BR; Jeon, JH; Kim, HK; Lee, SW; Park, JK; So, I; Zhao, C, 2012) |
| "Nicorandil may also activate Maxi K(+) channels, possibly through the NO-cGMP pathway, and the interaction of K ATP channels and Maxi K(+) channels may affect the relaxant effect of nicorandilin bovine tracheal smooth muscle." | 1.38 | The relaxant action of nicorandil in bovine tracheal smooth muscle. ( Ishii, K; Moriuchi, H; Nakahara, T; Sakamoto, K; Yunoki, M, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 22 (23.66) | 18.2507 |
| 2000's | 57 (61.29) | 29.6817 |
| 2010's | 14 (15.05) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Potje, SR | 1 |
| Troiano, JA | 1 |
| Grando, MD | 1 |
| Graton, ME | 1 |
| da Silva, RS | 1 |
| Bendhack, LM | 2 |
| Antoniali, C | 1 |
| Fernandes, VS | 1 |
| Ribeiro, AS | 1 |
| Martínez-Sáenz, A | 1 |
| Blaha, I | 1 |
| Serrano-Margüello, D | 1 |
| Recio, P | 2 |
| Martínez, AC | 1 |
| Bustamante, S | 1 |
| Vázquez-Alba, D | 1 |
| Carballido, J | 1 |
| García-Sacristán, A | 2 |
| Hernández, M | 2 |
| Kurtz, KH | 1 |
| Moor, AN | 1 |
| Souza-Smith, FM | 1 |
| Breslin, JW | 1 |
| Reinke, Y | 1 |
| Gross, S | 1 |
| Eckerle, LG | 1 |
| Hertrich, I | 1 |
| Busch, M | 1 |
| Busch, R | 1 |
| Riad, A | 1 |
| Rauch, BH | 1 |
| Stasch, JP | 1 |
| Dörr, M | 1 |
| Felix, SB | 1 |
| Hotta, Y | 1 |
| Ieda, N | 1 |
| Fukamoto, A | 1 |
| Kataoka, T | 1 |
| Kawade, Y | 1 |
| Maeda, Y | 1 |
| Nakagawa, H | 1 |
| Kimura, K | 1 |
| Dhaese, I | 1 |
| Vanneste, G | 1 |
| Sips, P | 1 |
| Buys, E | 1 |
| Brouckaert, P | 1 |
| Lefebvre, RA | 4 |
| Karimollah, AR | 1 |
| Ghasemi, M | 1 |
| Ghahremani, MH | 1 |
| Dehpour, AR | 1 |
| Chen, J | 1 |
| Liu, J | 1 |
| Wang, T | 1 |
| Xiao, H | 1 |
| Yin, C | 1 |
| Yang, J | 1 |
| Chen, X | 1 |
| Ye, Z | 1 |
| Kito, Y | 1 |
| Suzuki, H | 2 |
| Stepanović-Petrović, RM | 1 |
| Savić, V | 1 |
| Tomić, MA | 1 |
| Tokic-Vujosević, Z | 1 |
| Simić, M | 1 |
| Stepanović, JM | 1 |
| Jokanović, M | 1 |
| Micov, A | 1 |
| Toque, HA | 1 |
| Mónica, FZ | 1 |
| Morganti, RP | 1 |
| De Nucci, G | 3 |
| Antunes, E | 3 |
| Sarac, B | 1 |
| Durmus, N | 1 |
| Bagcivan, I | 1 |
| Altun, A | 1 |
| Turan, M | 1 |
| Sencan, M | 1 |
| Kim, HK | 1 |
| Choi, BR | 1 |
| Bak, YO | 1 |
| Zhao, C | 1 |
| Lee, SW | 1 |
| Jeon, JH | 1 |
| So, I | 1 |
| Park, JK | 1 |
| Cosyns, SM | 1 |
| Yunoki, M | 1 |
| Nakahara, T | 1 |
| Moriuchi, H | 1 |
| Sakamoto, K | 1 |
| Ishii, K | 1 |
| Gil, V | 1 |
| Gallego, D | 1 |
| Moha Ou Maati, H | 1 |
| Peyronnet, R | 1 |
| Martínez-Cutillas, M | 1 |
| Heurteaux, C | 1 |
| Borsotto, M | 1 |
| Jiménez, M | 2 |
| Chen, Y | 1 |
| Chitapanarux, T | 1 |
| Wu, J | 1 |
| Soon, RK | 1 |
| Melton, AC | 1 |
| Yee, HF | 1 |
| Ademoğlu, F | 1 |
| Başgut, B | 1 |
| Abacioğlu, N | 1 |
| Cakici, I | 1 |
| Vetrovsky, P | 1 |
| Boucher, JL | 1 |
| Schott, C | 1 |
| Beranova, P | 1 |
| Chalupsky, K | 1 |
| Callizot, N | 1 |
| Muller, B | 1 |
| Entlicher, G | 1 |
| Mansuy, D | 1 |
| Stoclet, JC | 1 |
| Kalsi, JS | 1 |
| Rees, RW | 1 |
| Hobbs, AJ | 2 |
| Royle, M | 1 |
| Kell, PD | 1 |
| Ralph, DJ | 1 |
| Moncada, S | 4 |
| Cellek, S | 4 |
| Melarange, R | 1 |
| Elphick, MR | 1 |
| Inoue, M | 1 |
| Kitazawa, T | 1 |
| Cao, J | 1 |
| Taneike, T | 1 |
| Filippi, S | 1 |
| Crescioli, C | 1 |
| Vannelli, GB | 1 |
| Fazzini, A | 1 |
| Natali, A | 1 |
| Riffaud, JP | 1 |
| Maggi, M | 1 |
| Ledda, F | 1 |
| Chen, SJ | 2 |
| Chen, KH | 1 |
| Webb, RC | 2 |
| Yen, MH | 2 |
| Wu, CC | 3 |
| Madhani, M | 1 |
| Scotland, RS | 1 |
| MacAllister, RJ | 1 |
| Tasatargil, A | 1 |
| Sadan, G | 1 |
| Ozdem, SS | 1 |
| Jun, CH | 1 |
| Lee, TS | 1 |
| Sohn, UD | 1 |
| Li, F | 1 |
| De Godoy, M | 1 |
| Rattan, S | 1 |
| Teixeira, CE | 2 |
| de Oliveira, JF | 1 |
| Baracat, JS | 2 |
| Priviero, FB | 2 |
| Okuyama, CE | 1 |
| Rodrigues Netto, N | 1 |
| Fregonesi, A | 1 |
| Shelkovnikov, S | 1 |
| Merlic, CA | 1 |
| Gonick, HC | 1 |
| Orshal, JM | 1 |
| Khalil, RA | 1 |
| Boussery, K | 1 |
| Delaey, C | 1 |
| Van de Voorde, J | 1 |
| Bawankule, DU | 1 |
| Sathishkumar, K | 1 |
| Sardar, KK | 1 |
| Chanda, D | 1 |
| Krishna, AV | 1 |
| Prakash, VR | 1 |
| Mishra, SK | 1 |
| Shukla, N | 1 |
| Jones, R | 1 |
| Persad, R | 1 |
| Angelini, GD | 1 |
| Jeremy, JY | 1 |
| Elmedal Laursen, B | 1 |
| Mulvany, MJ | 2 |
| Simonsen, U | 2 |
| El-Yazbi, AF | 1 |
| Cho, WJ | 1 |
| Boddy, G | 1 |
| Schulz, R | 1 |
| Daniel, EE | 2 |
| Claudino, MA | 1 |
| Mulè, F | 1 |
| Zizzo, MG | 1 |
| Amato, A | 1 |
| Feo, S | 1 |
| Serio, R | 1 |
| Benkó, R | 2 |
| Undi, S | 2 |
| Wolf, M | 2 |
| Magyar, K | 2 |
| Tóvölgyi, Z | 1 |
| Rumbus, Z | 1 |
| Barthó, L | 2 |
| Lau, LC | 1 |
| Adaikan, PG | 1 |
| Hamrouni, AM | 1 |
| Gudka, N | 1 |
| Broadley, KJ | 1 |
| Kim, M | 1 |
| Perrino, BA | 1 |
| Vereczkei, A | 1 |
| Illényi, L | 1 |
| Kassai, M | 1 |
| Cseke, L | 1 |
| Kelemen, D | 1 |
| Horváth, OP | 1 |
| Antal, A | 1 |
| Graça, C | 1 |
| Baggio, CH | 1 |
| Freitas, CS | 1 |
| Rattmann, YD | 1 |
| de Souza, LM | 1 |
| Cipriani, TR | 1 |
| Sassaki, GL | 1 |
| Rieck, L | 1 |
| Pontarolo, R | 1 |
| da Silva-Santos, JE | 1 |
| Marques, MC | 1 |
| Jiang, B | 1 |
| Wu, L | 1 |
| Wang, R | 1 |
| Bassil, M | 1 |
| Li, Y | 1 |
| Anand-Srivastava, MB | 1 |
| Kasakov, L | 1 |
| Young, HM | 1 |
| Ciampoli, D | 1 |
| Johnson, PJ | 1 |
| Stebbing, MJ | 1 |
| Olson, LJ | 1 |
| Knych, ET | 1 |
| Herzig, TC | 1 |
| Drewett, JG | 1 |
| Hussain, AS | 1 |
| Marks, GS | 1 |
| Brien, JF | 1 |
| Nakatsu, K | 1 |
| Pérez Vallina, JR | 1 |
| Menéndez Antolin, L | 1 |
| Cantabrana, B | 1 |
| Sánchez, M | 1 |
| Hidalgo, A | 1 |
| Faraci, FM | 1 |
| Sigmund, CD | 1 |
| Shesely, EG | 1 |
| Maeda, N | 1 |
| Heistad, DD | 1 |
| Olgart, C | 1 |
| Hallén, K | 1 |
| Wiklund, NP | 1 |
| Iversen, HH | 1 |
| Gustafsson, LE | 1 |
| Onoue, H | 1 |
| Katusic, ZS | 1 |
| Bayguinov, O | 1 |
| Sanders, KM | 2 |
| Li, L | 1 |
| Vaali, K | 1 |
| Paakkari, I | 1 |
| Vapaatalo, H | 1 |
| López, PG | 1 |
| Prieto, D | 1 |
| Contreras, J | 1 |
| White, R | 1 |
| Hiley, CR | 1 |
| Ruiz, E | 1 |
| Tejerina, T | 1 |
| Hwang, TL | 1 |
| Teng, CM | 1 |
| Weisbrod, RM | 1 |
| Griswold, MC | 1 |
| Yaghoubi, M | 1 |
| Komalavilas, P | 1 |
| Lincoln, TM | 1 |
| Cohen, RA | 1 |
| Galle, J | 1 |
| Zabel, U | 1 |
| Hübner, U | 1 |
| Hatzelmann, A | 1 |
| Wagner, B | 1 |
| Wanner, C | 1 |
| Schmidt, HH | 1 |
| O'Kane, K | 1 |
| Gibson, A | 1 |
| Shuttleworth, CW | 1 |
| Sweeney, KM | 1 |
| Koshita, M | 1 |
| Takano, H | 1 |
| Nakahira, Y | 1 |
| Ekblad, E | 1 |
| Garcia-Pascual, A | 2 |
| Labadia, A | 2 |
| Costa, G | 2 |
| Triguero, D | 2 |
| Buus, NH | 1 |
| Pilegaard, HK | 1 |
| Jiménez, E | 1 |
| Selemidis, S | 1 |
| Cocks, TM | 1 |
| Dick, JM | 1 |
| Nakagawa, M | 1 |
| Takeuchi, T | 1 |
| Niioka, S | 1 |
| Yamaji, M | 1 |
| Okishio, Y | 1 |
| Nishio, H | 1 |
| Hata, F | 2 |
| Vemulapalli, S | 2 |
| Kurowski, S | 2 |
| Yang, SN | 1 |
| Lin, CI | 1 |
| Takagi, M | 1 |
| Mochida, H | 1 |
| Noto, T | 1 |
| Yano, K | 1 |
| Inoue, H | 1 |
| Ikeo, T | 1 |
| Kikkawa, K | 1 |
| Baccari, MC | 1 |
| Calamai, F | 1 |
| Uc, A | 1 |
| Murray, JA | 1 |
| Kooy, N | 1 |
| Conklin, JL | 1 |
| Kwon, S | 1 |
| Chung, S | 1 |
| Ahn, D | 1 |
| Yeon, D | 1 |
| Nam, T | 1 |
| Oğülener, N | 1 |
| Ergün, Y | 1 |
| Döndaş, N | 1 |
| Dikmen, A | 1 |
| Ceron, PI | 1 |
| Cremonez, DC | 1 |
| Tedesco, AC | 1 |
| Hsieh, GC | 1 |
| Kolasa, T | 1 |
| Sullivan, JP | 1 |
| Brioni, JD | 1 |
| Tanović, A | 1 |
| Fernández, E | 1 |
| Buxton, IL | 1 |
| Kaiser, RA | 1 |
| Malmquist, NA | 1 |
| Tichenor, S | 1 |
| Takeuch, T | 1 |
| Sugimoto, K | 1 |
| Morimoto, H | 1 |
| Fujita, A | 1 |
| Devillier, P | 1 |
| Corompt, E | 1 |
| Bréant, D | 1 |
| Caron, F | 1 |
| Bessard, G | 1 |
| Tolsa, JF | 1 |
| Gao, Y | 1 |
| Sander, FC | 1 |
| Souici, AC | 1 |
| Moessinger, A | 1 |
| Raj, JU | 1 |
| Shahidullah, M | 1 |
| Duncan, A | 1 |
| Strachan, PD | 1 |
| Rafique, KM | 1 |
| Ball, SL | 1 |
| McPate, MJ | 1 |
| Nelli, S | 1 |
| Martin, W | 1 |
| Ziessen, T | 1 |
| Storr, M | 1 |
| Folmer, R | 1 |
| Kurjak, M | 1 |
| Schusdziarra, V | 1 |
| Allescher, HD | 1 |
| Bowes, TJ | 1 |
| Jury, J | 1 |
93 other studies available for 1h-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one and Muscle Relaxation
| Article | Year |
|---|---|
Endothelial modulation of a nitric oxide donor complex-induced relaxation in normotensive and spontaneously hypertensive rats.
Topics: Animals; Coordination Complexes; Dose-Response Relationship, Drug; Endothelium, Vascular; Guanylate | 2018 |
Underlying mechanisms involved in progesterone-induced relaxation to the pig bladder neck.
Topics: Animals; Calcium; Cyclooxygenase Inhibitors; Female; Guanylate Cyclase; In Vitro Techniques; Indomet | 2014 |
Involvement of H1 and H2 receptors and soluble guanylate cyclase in histamine-induced relaxation of rat mesenteric collecting lymphatics.
Topics: Animals; Cimetidine; Endothelium, Lymphatic; Guanylate Cyclase; Histamine H1 Antagonists; Histamine | 2014 |
The soluble guanylate cyclase stimulator riociguat and the soluble guanylate cyclase activator cinaciguat exert no direct effects on contractility and relaxation of cardiac myocytes from normal rats.
Topics: Animals; Benzoates; Calcium; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Drug Synergis | 2015 |
Light-controlled relaxation of the rat penile corpus cavernosum using NOBL-1, a novel nitric oxide releaser.
Topics: Animals; Guanylate Cyclase; Male; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitric Oxide Dono | 2016 |
Involvement of soluble guanylate cyclase alpha(1) and alpha(2), and SK(Ca) channels in NANC relaxation of mouse distal colon.
Topics: Animals; Apamin; Blotting, Western; Colon; Cyclic GMP; Dose-Response Relationship, Drug; Electric St | 2008 |
Inhibition by lithium of the nitrergic relaxation of rat anococcygeus muscle.
Topics: Analysis of Variance; Animals; Arginine; Electric Stimulation; Lithium Chloride; Male; Muscle Relaxa | 2009 |
The relaxation mechanisms of tetrandrine on the rabbit corpus cavernosum tissue in vitro.
Topics: 4-Aminopyridine; Animals; Benzylisoquinolines; Drugs, Chinese Herbal; Enzyme Inhibitors; Glyburide; | 2009 |
Properties of Rikkunshi-to (TJ-43)-induced relaxation of rat gastric fundus smooth muscles.
Topics: Animals; Apamin; Drugs, Chinese Herbal; Enprostil; Gastric Fundus; Hesperidin; Membrane Potentials; | 2010 |
Comparison of vasorelaxant effect and tolerance profile of a novel isosorbide-5-mononitrate derivative with its stereoisomer and parent drug on rat mesenteric artery.
Topics: Animals; Dose-Response Relationship, Drug; Drug Tolerance; Electrophoresis, Capillary; Endothelium, | 2010 |
Mechanisms of relaxant activity of the nitric oxide-independent soluble guanylyl cyclase stimulator BAY 41-2272 in rat tracheal smooth muscle.
Topics: Animals; Cyclic GMP; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Activation; Enzy | 2010 |
Investigation of relaxant effects of new agents affecting nitric oxide/cyclic guanosine monophosphate pathway on sheep oddi sphincter.
Topics: Animals; Carbachol; Cyclic GMP; Dose-Response Relationship, Drug; Guanylate Cyclase; In Vitro Techni | 2010 |
The role of capillarisin from Artemisia capillaris on penile erection.
Topics: Animals; Artemisia; Chromones; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; | 2012 |
Mechanism of relaxation and interaction with nitric oxide of the soluble guanylate cyclase stimulator BAY 41-2272 in mouse gastric fundus and colon.
Topics: Animals; Colon; Cyclic GMP; Enzyme Inhibitors; Gastric Fundus; Guanylate Cyclase; In Vitro Technique | 2012 |
The relaxant action of nicorandil in bovine tracheal smooth muscle.
Topics: Animals; Cattle; Cromakalim; Enzyme Inhibitors; Glyburide; Guanylate Cyclase; In Vitro Techniques; M | 2012 |
Relative contribution of SKCa and TREK1 channels in purinergic and nitrergic neuromuscular transmission in the rat colon.
Topics: Animals; Apamin; Colon; Cysteine; Male; Methionine; Muscle Relaxation; Nitroarginine; Nitroprusside; | 2012 |
Inducible NOS mediates CNP-induced relaxation of intestinal myofibroblasts.
Topics: Animals; Cyclic GMP; Guanylate Cyclase; Humans; Mice; Muscle Relaxation; Myofibroblasts; Natriuretic | 2013 |
The mechanisms of peroxynitrite-induced relaxations in isolated rat anococcygeus muscle.
Topics: Animals; Antioxidants; Glyburide; Guanylate Cyclase; In Vitro Techniques; Male; Muscle Relaxation; M | 2002 |
Involvement of NO in the endothelium-independent relaxing effects of N(omega)-hydroxy-L-arginine and other compounds bearing a C=NOH function in the rat aorta.
Topics: Animals; Aorta, Thoracic; Arginine; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Guanylate | 2002 |
BAY41-2272, a novel nitric oxide independent soluble guanylate cyclase activator, relaxes human and rabbit corpus cavernosum in vitro.
Topics: Animals; Guanylate Cyclase; Humans; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; NG | 2003 |
Comparative analysis of nitric oxide and SALMFamide neuropeptides as general muscle relaxants in starfish.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Cyclic GMP; Muscle Relaxation; Neuropeptides; Nitr | 2003 |
5-HT7 receptor-mediated relaxation of the oviduct in nonpregnant proestrus pigs.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Binding, Competitive; Cyclic AMP; Dose-Response Relati | 2003 |
Effects of NCX 4050, a new NO donor, in rabbit and human corpus cavernosum.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultur | 2003 |
Abnormal activation of Na+-K+ pump in aortas from rats with endotoxaemia.
Topics: Animals; Aorta, Thoracic; Endotoxemia; Enzyme Inhibitors; Escherichia coli; In Vitro Techniques; Lip | 2003 |
Vascular natriuretic peptide receptor-linked particulate guanylate cyclases are modulated by nitric oxide-cyclic GMP signalling.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Aorta, T | 2003 |
The effects of selective phosphodiesterase III and V inhibitors on adrenergic and non-adrenergic, non-cholinergic relaxation responses of guinea-pig pulmonary arteries.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Adenosine; Animals; Argini | 2003 |
NO/cyclic GMP pathway mediates the relaxation of feline lower oesophageal sphincter.
Topics: Aminoquinolines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cats; Cyclic GMP; Dose-Response R | 2003 |
Role of adenylate and guanylate cyclases in beta1-, beta2-, and beta3-adrenoceptor-mediated relaxation of internal anal sphincter smooth muscle.
Topics: Adenine; Adenylyl Cyclases; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Blotting | 2004 |
Nitric oxide release from human corpus cavernosum induced by a purified scorpion toxin.
Topics: Adolescent; Adult; Child; Cyclic GMP; Drug Evaluation, Preclinical; Electric Stimulation; Enzyme Inh | 2004 |
Influence of nitric oxide donors and peroxynitrite on the contractile effect and concentration of norepinephrine.
Topics: Animals; Aorta, Thoracic; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Dr | 2004 |
Interleukin-6 impairs endothelium-dependent NO-cGMP-mediated relaxation and enhances contraction in systemic vessels of pregnant rats.
Topics: Acetylcholine; Animals; Blotting, Western; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Est | 2004 |
The vasorelaxing effect of CGRP and natriuretic peptides in isolated bovine retinal arteries.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Catt | 2005 |
BAY 41-2272 [5-cyclopropyl-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridine-3-yl]pyrimidin-4-ylamine]-induced dilation in ovine pulmonary artery: role of sodium pump.
Topics: Animals; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dos | 2005 |
Effect of sildenafil citrate and a nitric oxide donating sildenafil derivative, NCX 911, on cavernosal relaxation and superoxide formation in hypercholesterolaemic rabbits.
Topics: Acetophenones; Allopurinol; Animals; Carbachol; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme | 2005 |
Involvement of guanylyl cyclase, protein kinase A and Na+ K+ ATPase in relaxations of bovine isolated bronchioles induced by GEA 3175, an NO donor.
Topics: Animals; Bronchi; Calcium; Cattle; Colforsin; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein K | 2006 |
Impact of caveolin-1 knockout on NANC relaxation in circular muscles of the mouse small intestine compared with longitudinal muscles.
Topics: Animals; Apamin; Autonomic Nervous System; Caveolin 1; Immunohistochemistry; In Vitro Techniques; Je | 2006 |
Stimulation of soluble guanylyl cyclase by BAY 41-2272 relaxes anococcygeus muscle: interaction with nitric oxide.
Topics: Animals; Carbachol; Carbolines; Colforsin; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; | 2006 |
Evidence for a role of inducible nitric oxide synthase in gastric relaxation of mdx mice.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Imines; Male; Mice; Mice, Inbred mdx; Muscle Rel | 2006 |
P(2) purinoceptors account for the non-nitrergic NANC relaxation in the rat ileum.
Topics: Animals; Electric Stimulation; Enzyme Inhibitors; Female; Guanylate Cyclase; Ileum; In Vitro Techniq | 2006 |
Mechanisms of direct relaxant effect of sildenafil, tadalafil and vardenafil on corpus cavernosum.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Calcium; Carbolines; Dose-Response Relationship, Drug; | 2006 |
Investigation of the mechanism for the relaxation of rat duodenum mediated via M1 muscarinic receptors.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Bicuculline; Dose-Res | 2006 |
CaM kinase II activation and phospholamban phosphorylation by SNP in murine gastric antrum smooth muscles.
Topics: Animals; Benzylamines; Calcium Signaling; Calcium-Binding Proteins; Calcium-Calmodulin-Dependent Pro | 2007 |
P2 purinoceptor antagonists inhibit the non-adrenergic, non-cholinergic relaxation of the human colon in vitro.
Topics: Adenosine Triphosphate; Colon, Sigmoid; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; | 2007 |
In vivo assessment of safety and mechanisms underlying in vitro relaxation induced by Mikania laevigata Schultz Bip. ex Baker in the rat trachea.
Topics: 4-Aminopyridine; Acetylcholine; Animals; Brazil; Coumarins; Dose-Response Relationship, Drug; Female | 2007 |
Sulphonylureas induced vasorelaxation of mouse arteries.
Topics: Adamantane; Animals; Arteries; Endothelium, Vascular; Glyburide; In Vitro Techniques; KATP Channels; | 2007 |
Peroxynitrite inhibits the expression of G(i)alpha protein and adenylyl cyclase signaling in vascular smooth muscle cells.
Topics: Adenylyl Cyclase Inhibitors; Animals; Aorta, Thoracic; Blotting, Western; Carbazoles; Cells, Culture | 2008 |
Inhibition of nitrergic relaxations by a selective inhibitor of the soluble guanylate cyclase.
Topics: Animals; Cyclic GMP; Electric Stimulation; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques | 1996 |
Inhibitory transmission to the longitudinal muscle of the mouse caecum is mediated largely by nitric oxide acting via soluble guanylyl cyclase.
Topics: Animals; Cecum; Electric Stimulation; Enzyme Inhibitors; Guanylate Cyclase; Histocytochemistry; Immu | 1996 |
Selective guanylyl cyclase inhibitor reverses nitric oxide-induced vasorelaxation.
Topics: Animals; Aorta; COS Cells; Cyclic GMP; Guanosine Triphosphate; Male; Muscle Relaxation; Muscle, Smoo | 1997 |
The soluble guanylyl cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3-alpha]quinoxalin-1-one (ODQ) inhibits relaxation of rabbit aortic rings induced by carbon monoxide, nitric oxide, and glyceryl trinitrate.
Topics: Animals; Aorta; Carbon Monoxide; Enzyme Inhibitors; Guanylate Cyclase; Muscle Relaxation; Muscle, Sm | 1997 |
Nitric oxide and cyclic nucleotides participate in the relaxation of diclofenac on rat uterine smooth muscle.
Topics: Adenylyl Cyclases; Animals; Cyclic GMP; Cyclooxygenase Inhibitors; Diclofenac; Drug Interactions; En | 1998 |
Responses of carotid artery in mice deficient in expression of the gene for endothelial NO synthase.
Topics: Acetylcholine; Animals; Carotid Arteries; Endothelium, Vascular; Enzyme Inhibitors; Gene Deletion; G | 1998 |
Blockade of nitrergic neuroeffector transmission in guinea-pig colon by a selective inhibitor of soluble guanylyl cyclase.
Topics: Animals; Colon; Electrophysiology; Enzyme Inhibitors; Guanylate Cyclase; Guinea Pigs; In Vitro Techn | 1998 |
The effect of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) and charybdotoxin (CTX) on relaxations of isolated cerebral arteries to nitric oxide.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bradykinin; Cerebral Arteries; Charybdotoxin; Colforsin; Cycli | 1998 |
Dissociation between electrical and mechanical responses to nitrergic stimulation in the canine gastric fundus.
Topics: Animals; Arginine; Atropine; Calcium; Cytosol; Dogs; Electric Stimulation; Female; Gastric Fundus; G | 1998 |
Involvement of bradykinin B1 and B2 receptors in relaxation of mouse isolated trachea.
Topics: Animals; Bradykinin; Bradykinin Receptor Antagonists; Dinoprostone; Enzyme Inhibitors; Female; Guany | 1998 |
Nitrergic relaxation of the horse corpus cavernosum. Role of cGMP.
Topics: Adenosine Triphosphate; Animals; Calcium; Cyclic GMP; Electric Stimulation; Enzyme Inhibitors; Horse | 1998 |
Modulation of relaxation to levcromakalim by S-nitroso-N-acetylpenicillamine (SNAP) and 8-bromo cyclic GMP in the rat isolated mesenteric artery.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cromakalim; In Vitro Techniques; Male; Mesenteric A | 1998 |
Influence of a selective guanylate cyclase inhibitor, and of the contraction level, on nitrergic relaxations in the gastric fundus.
Topics: Animals; Chymotrypsin; Electric Stimulation; Enzyme Inhibitors; Gastric Fundus; Guanylate Cyclase; M | 1998 |
Relaxant effects of L-citrulline in rabbit vascular smooth muscle.
Topics: Animals; Aorta; Cells, Cultured; Citrulline; Cyclic GMP; Dexamethasone; Endothelium, Vascular; In Vi | 1998 |
Comparison of two soluble guanylyl cyclase inhibitors, methylene blue and ODQ, on sodium nitroprusside-induced relaxation in guinea-pig trachea.
Topics: Animals; Cyclic GMP; Drug Interactions; Enzyme Inhibitors; Guanylate Cyclase; Guinea Pigs; Methylene | 1998 |
Nitrergic neurotransmission mediates the non-adrenergic non-cholinergic responses in the clitoral corpus cavernosum of the rabbit.
Topics: Animals; Arginine; Clitoris; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibito | 1998 |
Evidence that additional mechanisms to cyclic GMP mediate the decrease in intracellular calcium and relaxation of rabbit aortic smooth muscle to nitric oxide.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Angiotensin II; Animals; Aorta; Ca | 1998 |
Effects of the soluble guanylyl cyclase activator, YC-1, on vascular tone, cyclic GMP levels and phosphodiesterase activity.
Topics: Animals; Aorta, Thoracic; Cyclic GMP; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; In Vi | 1999 |
Characterisation of nitrergic transmission in the isolated anococcygeus muscle of the female mouse.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Catechols; Dose-Response Relationship, Drug; Electric Stimulat | 1999 |
Evidence that nitric oxide acts as an inhibitory neurotransmitter supplying taenia from the guinea-pig caecum.
Topics: Animals; Cecum; Dimethylphenylpiperazinium Iodide; Dose-Response Relationship, Drug; Electric Stimul | 1999 |
Pranidipine enhances relaxation produced by endothelium-derived relaxing factor in carotid artery.
Topics: Acetylcholine; Animals; Calcium Channel Blockers; Carotid Arteries; Dihydropyridines; Dose-Response | 1999 |
Pharmacological evidence for both neuronal and smooth muscular PAC1 receptors and a VIP-specific receptor in rat colon.
Topics: Animals; Apamin; Colon; Female; Indazoles; Muscle Relaxation; Muscle, Smooth; Myenteric Plexus; Neur | 1999 |
Effects of superoxide anion generators and thiol modulators on nitrergic transmission and relaxation to exogenous nitric oxide in the sheep urethra.
Topics: Animals; Ascorbate Oxidase; Benzoates; Ditiocarb; Electric Stimulation; Enzyme Inhibitors; Female; G | 2000 |
Nitric oxide, prostanoid and non-NO, non-prostanoid involvement in acetylcholine relaxation of isolated human small arteries.
Topics: Acetylcholine; Adenylyl Cyclase Inhibitors; Animals; Arteries; Cytochrome P-450 Enzyme System; Endot | 2000 |
Spontaneous photo-relaxation of urethral smooth muscle from sheep, pig and rat and its relationship with nitrergic neurotransmission.
Topics: Adenine; Animals; Citrulline; Cold Temperature; Culture Techniques; Electric Stimulation; Enzyme Inh | 2000 |
Nitrergic relaxation of the mouse gastric fundus is mediated by cyclic GMP-dependent and ryanodine-sensitive mechanisms.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Triphosphate; Animals; | 2000 |
Interplay between nitric oxide and vasoactive intestinal polypeptide in the pig gastric fundus smooth muscle.
Topics: Adenine; Adenylyl Cyclase Inhibitors; Amidines; Animals; Arginine; Benzylamines; Carbazoles; Colfors | 2000 |
1H-[1,2,4] oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) inhibits cyclic GMP-PKG pathway-independent nonadrenergic, noncholinergic relaxation in longitudinal muscle of the rectum of Wistar-ST rats.
Topics: Animals; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Guanylate Cyclase; In | 2000 |
Sildenafil relaxes rabbit clitoral corpus cavernosum.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Clitoris; Electric Stimulation; Female; Guanylate Cycl | 2000 |
Abnormal activation of K(+) channels in aortic smooth muscle of rats with endotoxic shock: electrophysiological and functional evidence.
Topics: Animals; Aorta; Apamin; Benzimidazoles; Charybdotoxin; Drug Interactions; Enzyme Inhibitors; Glyburi | 2000 |
Pharmacological profile of T-1032, a novel specific phosphodiesterase type 5 inhibitor, in isolated rat aorta and rabbit corpus cavernosum.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Aorta, Thoracic; Arginine; Cyclic Nucleotide Phosphodi | 2001 |
Modulation of nitrergic relaxant responses by peptides in the mouse gastric fundus.
Topics: Animals; Apamin; Carbachol; Cholinergic Agonists; Chymotrypsin; Electric Stimulation; Enzyme Inhibit | 2001 |
Effect of peroxynitrite on motor function of the opossum esophagus.
Topics: Animals; Enzyme Inhibitors; Esophagitis; Esophagogastric Junction; Female; Guanylate Cyclase; In Vit | 2001 |
Mechanism of carbon monoxide-induced relaxation in the guinea pig ileal smooth muscle.
Topics: Animals; Calcium; Calcium Channels; Carbon Monoxide; Cyclic GMP; Dose-Response Relationship, Drug; D | 2001 |
The influence of nitric oxide donors on the responses to nitrergic nerve stimulation in the mouse duodenum.
Topics: Animals; Dose-Response Relationship, Drug; Duodenum; Electric Stimulation; Enzyme Inhibitors; Ethylm | 2001 |
The relaxation induced by S-nitroso-glutathione and S-nitroso-N-acetylcysteine in rat aorta is not related to nitric oxide production.
Topics: Acetylcysteine; Animals; Aorta, Thoracic; Endothelium, Vascular; Enzyme Inhibitors; Glutathione; Hyd | 2001 |
Phentolamine mesylate relaxes rabbit corpus cavernosum by a nonadrenergic, noncholinergic mechanism.
Topics: Adrenergic alpha-Antagonists; Animals; Cyclic GMP-Dependent Protein Kinases; Electric Stimulation; E | 2001 |
Dual mechanism of action of nicorandil on rabbit corpus cavernosal smooth muscle tone.
Topics: Adenosine Triphosphate; Adrenergic alpha-Agonists; Animals; Enzyme Activation; Enzyme Inhibitors; Gl | 2001 |
Actions of NO donors and endogenous nitrergic transmitter on the longitudinal muscle of rat ileum in vitro: mechanisms involved.
Topics: Animals; Apamin; Atropine; Calcium Channels; Charybdotoxin; Dose-Response Relationship, Drug; Drug I | 2001 |
NO-induced relaxation of labouring and non-labouring human myometrium is not mediated by cyclic GMP.
Topics: Charybdotoxin; Cyclic GMP; Cysteine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gu | 2001 |
Mechanism of a nitric oxide donor NOR 1-induced relaxation in longitudinal muscle of rat proximal colon.
Topics: Animals; Calcium; Carbachol; Colon; Culture Techniques; Cyclic GMP; DNA-Binding Proteins; Dose-Respo | 2001 |
Relaxation and modulation of cyclic AMP production in response to atrial natriuretic peptides in guinea pig tracheal smooth muscle.
Topics: Adenylyl Cyclases; Animals; Apamin; Atrial Natriuretic Factor; Colforsin; Cyclic AMP; Dose-Response | 2001 |
Differential responses of newborn pulmonary arteries and veins to atrial and C-type natriuretic peptides.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Atrial Natriuretic Factor; Cyclic GMP; Gene | 2002 |
Role of catalase in the smooth muscle relaxant actions of sodium azide and cyanamide.
Topics: Amitrole; Animals; Aorta; Catalase; Cattle; Cyanamide; Electrochemistry; Enzyme Inhibitors; Hemoglob | 2002 |
Characterization of the non-nitrergic NANC relaxation responses in the rabbit vaginal wall.
Topics: Adrenergic Fibers; Animals; Cholinergic Fibers; Chymotrypsin; Electric Stimulation; Enzyme Inhibitor | 2002 |
Okadaic acid inhibits relaxant neural transmission in rat gastric fundus in vitro.
Topics: Animals; Carbazoles; Electric Stimulation; Enzyme Inhibitors; Gastric Fundus; Gastrointestinal Agent | 2002 |
Roles of guanylate cyclase in responses to myogenic and neural nitric oxide in canine lower esophageal sphincter.
Topics: Animals; Dogs; Enzyme Inhibitors; Esophagogastric Junction; Female; Guanylate Cyclase; Male; Muscle | 2002 |