1h-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one has been researched along with Hypoxia in 11 studies
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one: structure given in first source; inhibits guanylyl cyclase
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one : A member of the class of oxadiazoloquinoxalines that is 1H-[1,2,4]oxadiazolo[4,3-a]quinoxaline substituted at position 1 by an oxo group.
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study addressed whether combined treatment with a phosphodiesterase type 5 inhibitor, sildenafil, and a nitric oxide donor, molsidomine, prevents development of pulmonary hypertension in chronic hypoxic rats." | 7.73 | Lack of synergistic effect of molsidomine and sildenafil on development of pulmonary hypertension in chronic hypoxic rats. ( Andersen, CU; Mulvany, MJ; Simonsen, U, 2005) |
| "The objective of this study was to investigate the effect of L-arginine supplementation on myocardial cell death secondary to hypoxia-reoxygenation." | 7.70 | L-arginine limits myocardial cell death secondary to hypoxia-reoxygenation by a cGMP-dependent mechanism. ( Agulló, L; García-Dorado, D; Inserte, J; Llevadot, J; Paniagua, A; Pyrhonen, P; Soler-Soler, J, 1999) |
| " In thoracic aortic rings from CH rats, cumulative dose-response curves to phenylephrine (PE) in the presence of the nitric oxide (NO) synthase inhibitor Nomega-nitro-L-arginine (L-NNA) and the HO inhibitor zinc protoporphyrin 9 (ZnPPIX) elicited increased contractility compared with CH rings treated with only L-NNA." | 5.30 | Role of endothelial carbon monoxide in attenuated vasoreactivity following chronic hypoxia. ( Caudill, TK; Kanagy, NL; Resta, TC; Walker, BR, 1998) |
| "The present study addressed whether combined treatment with a phosphodiesterase type 5 inhibitor, sildenafil, and a nitric oxide donor, molsidomine, prevents development of pulmonary hypertension in chronic hypoxic rats." | 3.73 | Lack of synergistic effect of molsidomine and sildenafil on development of pulmonary hypertension in chronic hypoxic rats. ( Andersen, CU; Mulvany, MJ; Simonsen, U, 2005) |
| "The objective of this study was to investigate the effect of L-arginine supplementation on myocardial cell death secondary to hypoxia-reoxygenation." | 3.70 | L-arginine limits myocardial cell death secondary to hypoxia-reoxygenation by a cGMP-dependent mechanism. ( Agulló, L; García-Dorado, D; Inserte, J; Llevadot, J; Paniagua, A; Pyrhonen, P; Soler-Soler, J, 1999) |
| " In thoracic aortic rings from CH rats, cumulative dose-response curves to phenylephrine (PE) in the presence of the nitric oxide (NO) synthase inhibitor Nomega-nitro-L-arginine (L-NNA) and the HO inhibitor zinc protoporphyrin 9 (ZnPPIX) elicited increased contractility compared with CH rings treated with only L-NNA." | 1.30 | Role of endothelial carbon monoxide in attenuated vasoreactivity following chronic hypoxia. ( Caudill, TK; Kanagy, NL; Resta, TC; Walker, BR, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 7 (63.64) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pearce, WJ | 1 |
| Williams, JM | 1 |
| White, CR | 1 |
| Lincoln, TM | 1 |
| Spohr, F | 1 |
| Busch, CJ | 1 |
| Teschendorf, P | 1 |
| Weimann, J | 1 |
| Zoer, B | 1 |
| Blanco, CE | 1 |
| Villamor, E | 1 |
| Yoo, HY | 1 |
| Park, SJ | 1 |
| Bahk, JH | 1 |
| Kim, SJ | 1 |
| Boussery, K | 1 |
| Delaey, C | 1 |
| Van de Voorde, J | 1 |
| Cameron, JS | 1 |
| Hoffmann, KE | 1 |
| Zia, C | 1 |
| Hemmett, HM | 1 |
| Kronsteiner, A | 1 |
| Lee, CM | 1 |
| Andersen, CU | 1 |
| Mulvany, MJ | 1 |
| Simonsen, U | 1 |
| Gupte, SA | 1 |
| Okada, T | 1 |
| McMurtry, IF | 1 |
| Oka, M | 1 |
| Caudill, TK | 1 |
| Resta, TC | 1 |
| Kanagy, NL | 1 |
| Walker, BR | 1 |
| Agulló, L | 1 |
| García-Dorado, D | 1 |
| Inserte, J | 1 |
| Paniagua, A | 1 |
| Pyrhonen, P | 1 |
| Llevadot, J | 1 |
| Soler-Soler, J | 1 |
| Modin, A | 1 |
| Björne, H | 1 |
| Herulf, M | 1 |
| Alving, K | 1 |
| Weitzberg, E | 1 |
| Lundberg, JO | 1 |
11 other studies available for 1h-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one and Hypoxia
| Article | Year |
|---|---|
Effects of chronic hypoxia on soluble guanylate cyclase activity in fetal and adult ovine cerebral arteries.
Topics: Altitude Sickness; Animals; Cerebral Arteries; Chronic Disease; Cyclic GMP; Cyclic GMP-Dependent Pro | 2009 |
Selective inhibition of guanylate cyclase prevents impairment of hypoxic pulmonary vasoconstriction in endotoxemic mice.
Topics: Animals; Dose-Response Relationship, Drug; Endotoxemia; Guanylate Cyclase; Hypoxia; In Vitro Techniq | 2009 |
Role of Rho-kinase in mediating contraction of chicken embryo femoral arteries.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13 | 2010 |
Inhibition of hypoxic pulmonary vasoconstriction of rats by carbon monoxide.
Topics: Animals; Carbon Monoxide; Guanylate Cyclase; Hypoxia; NG-Nitroarginine Methyl Ester; Nitric Oxide Sy | 2010 |
Rat retinal tissue releases a vasorelaxing factor.
Topics: Acute Disease; Animals; Calcium-Transporting ATPases; Carotid Arteries; Cyclooxygenase Inhibitors; D | 2002 |
A role for nitric oxide in hypoxia-induced activation of cardiac KATP channels in goldfish (Carassius auratus).
Topics: Action Potentials; Analysis of Variance; Animals; Diacetyl; Goldfish; Hypoxia; Myocardium; NG-Nitroa | 2003 |
Lack of synergistic effect of molsidomine and sildenafil on development of pulmonary hypertension in chronic hypoxic rats.
Topics: Acetylcholine; Actins; Animals; Atrial Natriuretic Factor; Body Weight; Dose-Response Relationship, | 2005 |
Role of pentose phosphate pathway-derived NADPH in hypoxic pulmonary vasoconstriction.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 6-Aminonicotinamide; Androsteron | 2006 |
Role of endothelial carbon monoxide in attenuated vasoreactivity following chronic hypoxia.
Topics: Animals; Aorta, Thoracic; Arsenites; Carbon Monoxide; Endothelium, Vascular; Enzyme Inhibitors; Guan | 1998 |
L-arginine limits myocardial cell death secondary to hypoxia-reoxygenation by a cGMP-dependent mechanism.
Topics: Animals; Arginine; Cell Death; Cells, Cultured; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Hy | 1999 |
Nitrite-derived nitric oxide: a possible mediator of 'acidic-metabolic' vasodilation.
Topics: Acidosis; Animals; Aorta; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hypoxia; In Vitro Tec | 2001 |