1h-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one has been researched along with Disease Models, Animal in 19 studies
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one: structure given in first source; inhibits guanylyl cyclase
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one : A member of the class of oxadiazoloquinoxalines that is 1H-[1,2,4]oxadiazolo[4,3-a]quinoxaline substituted at position 1 by an oxo group.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "enalapril alone to enhance vascular effects, increase LV contractility and prevent unfavorable remodeling and are consistent with vascular delivery of exogenous NO." | 5.32 | A nitric oxide-releasing derivative of enalapril, NCX 899, prevents progressive cardiac dysfunction and remodeling in hamsters with heart failure. ( Condorelli, G; Del Soldato, P; Dieterle, T; Gu, Y; Iwanaga, Y; Ongini, E; Peterson, KL; Presotto, C; Ross, J, 2004) |
| " Results VL-102-evoked acute and chronic mechanical cephalic and hind-paw allodynia in a dose-dependent manner, which was blocked by the migraine medications sumatriptan, propranolol, and topiramate." | 3.88 | Soluble guanylyl cyclase is a critical regulator of migraine-associated pain. ( Ben Aissa, M; Bennett, BM; Bertels, Z; Gaisina, IN; Gandhi, R; Lee, SH; Litosh, V; Moye, LS; Novack, M; Pradhan, AA; Thatcher, GR; Tipton, AF; Wang, Y, 2018) |
| " We have previously demonstrated that mesenteric lymphatic pumping was compromised in the guinea pig model of 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced ileitis, corroborating clinical and experimental observations of a dilated and/or obstructed phenotype of these vessels in inflammatory bowel disease." | 3.79 | Involvement of the NO-cGMP-K(ATP) channel pathway in the mesenteric lymphatic pump dysfunction observed in the guinea pig model of TNBS-induced ileitis. ( Mathias, R; von der Weid, PY, 2013) |
| "enalapril alone to enhance vascular effects, increase LV contractility and prevent unfavorable remodeling and are consistent with vascular delivery of exogenous NO." | 1.32 | A nitric oxide-releasing derivative of enalapril, NCX 899, prevents progressive cardiac dysfunction and remodeling in hamsters with heart failure. ( Condorelli, G; Del Soldato, P; Dieterle, T; Gu, Y; Iwanaga, Y; Ongini, E; Peterson, KL; Presotto, C; Ross, J, 2004) |
| "The influence of left ventricular hypertrophy (LVH) on the endothelial function of resistance endocardial arteries is not well established." | 1.32 | Loss of endothelial KATP channel-dependent, NO-mediated dilation of endocardial resistance coronary arteries in pigs with left ventricular hypertrophy. ( Gendron, ME; Perrault, LP; Thorin, E, 2004) |
| "Allodynia was also intensified by SNAP (5% or 30%) in rats pretreated with intraplantar 1H-[1,2,4]oxadiazolo[4,3-alpha]quinoxalin-1-one (ODQ, 4 microg), a guanylate cyclase inhibitor." | 1.31 | Dual effect of local application of nitric oxide donors in a model of incision pain in rats. ( Cunha, FQ; Prado, WA; Schiavon, VF, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 13 (68.42) | 29.6817 |
| 2010's | 5 (26.32) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Ben Aissa, M | 1 |
| Tipton, AF | 1 |
| Bertels, Z | 1 |
| Gandhi, R | 1 |
| Moye, LS | 1 |
| Novack, M | 1 |
| Bennett, BM | 1 |
| Wang, Y | 1 |
| Litosh, V | 1 |
| Lee, SH | 1 |
| Gaisina, IN | 1 |
| Thatcher, GR | 1 |
| Pradhan, AA | 1 |
| Sosroseno, W | 1 |
| Bird, PS | 1 |
| Seymour, GJ | 1 |
| Fernandes, D | 1 |
| Sordi, R | 1 |
| Pacheco, LK | 1 |
| Nardi, GM | 1 |
| Heckert, BT | 1 |
| Villela, CG | 1 |
| Lobo, AR | 1 |
| Barja-Fidalgo, C | 1 |
| Assreuy, J | 1 |
| Pearce, WJ | 1 |
| Williams, JM | 1 |
| White, CR | 1 |
| Lincoln, TM | 1 |
| Jonasson, S | 1 |
| Hedenstierna, G | 1 |
| Hjoberg, J | 1 |
| Chester, M | 1 |
| Seedorf, G | 1 |
| Tourneux, P | 1 |
| Gien, J | 1 |
| Tseng, N | 1 |
| Grover, T | 1 |
| Wright, J | 1 |
| Stasch, JP | 1 |
| Abman, SH | 1 |
| Mathias, R | 1 |
| von der Weid, PY | 1 |
| Iwanaga, Y | 1 |
| Gu, Y | 1 |
| Dieterle, T | 1 |
| Presotto, C | 1 |
| Del Soldato, P | 1 |
| Peterson, KL | 1 |
| Ongini, E | 1 |
| Condorelli, G | 1 |
| Ross, J | 1 |
| Gendron, ME | 1 |
| Thorin, E | 1 |
| Perrault, LP | 1 |
| Wang, C | 1 |
| Mansard, A | 1 |
| Giummelly, P | 1 |
| Atkinson, J | 1 |
| Mulè, F | 1 |
| Zizzo, MG | 1 |
| Amato, A | 1 |
| Feo, S | 1 |
| Serio, R | 1 |
| Malik, V | 1 |
| Holobotovskyy, VV | 1 |
| Phillips, JK | 1 |
| McKitrick, DJ | 1 |
| Arnolda, LF | 1 |
| Malakul, W | 1 |
| Thirawarapan, S | 1 |
| Suvitayavat, W | 1 |
| Woodman, OL | 1 |
| Van Crombruggen, K | 1 |
| Van Nassauw, L | 1 |
| Demetter, P | 1 |
| Cuvelier, C | 1 |
| Timmermans, JP | 1 |
| Lefebvre, RA | 1 |
| Medeiros, JV | 1 |
| Gadelha, GG | 1 |
| Lima, SJ | 1 |
| Garcia, JA | 1 |
| Soares, PM | 1 |
| Santos, AA | 1 |
| Brito, GA | 1 |
| Ribeiro, RA | 1 |
| Souza, MH | 1 |
| Didion, SP | 1 |
| Heistad, DD | 1 |
| Faraci, FM | 1 |
| Prado, WA | 1 |
| Schiavon, VF | 1 |
| Cunha, FQ | 1 |
19 other studies available for 1h-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Soluble guanylyl cyclase is a critical regulator of migraine-associated pain.
Topics: Adrenergic beta-Antagonists; Allosteric Regulation; Animals; Anticonvulsants; Calcitonin Gene-Relate | 2018 |
Effect of exogenous nitric oxide on murine immune response induced by Aggregatibacter actinomycetemcomitans lipopolysaccharide.
Topics: Actinobacillus Infections; Aggregatibacter actinomycetemcomitans; Animals; Antibodies, Bacterial; Be | 2009 |
Late, but not early, inhibition of soluble guanylate cyclase decreases mortality in a rat sepsis model.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Cecum; Cyclic GMP; Disease Models, Animal; Drug Administra | 2009 |
Effects of chronic hypoxia on soluble guanylate cyclase activity in fetal and adult ovine cerebral arteries.
Topics: Altitude Sickness; Animals; Cerebral Arteries; Chronic Disease; Cyclic GMP; Cyclic GMP-Dependent Pro | 2009 |
Concomitant administration of nitric oxide and glucocorticoids improves protection against bronchoconstriction in a murine model of asthma.
Topics: Administration, Inhalation; Animals; Anti-Asthmatic Agents; Asthma; Bronchial Provocation Tests; Bro | 2010 |
Cinaciguat, a soluble guanylate cyclase activator, augments cGMP after oxidative stress and causes pulmonary vasodilation in neonatal pulmonary hypertension.
Topics: Animals; Benzoates; Cells, Cultured; Cyclic GMP; Disease Models, Animal; Female; Fetus; Guanylate Cy | 2011 |
Involvement of the NO-cGMP-K(ATP) channel pathway in the mesenteric lymphatic pump dysfunction observed in the guinea pig model of TNBS-induced ileitis.
Topics: Animals; ATP-Binding Cassette Transporters; Disease Models, Animal; Enzyme Inhibitors; Glyburide; Gu | 2013 |
A nitric oxide-releasing derivative of enalapril, NCX 899, prevents progressive cardiac dysfunction and remodeling in hamsters with heart failure.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta; Cardiomyopathy, Dilated; Cricetinae; Cytos | 2004 |
Loss of endothelial KATP channel-dependent, NO-mediated dilation of endocardial resistance coronary arteries in pigs with left ventricular hypertrophy.
Topics: Adenosine Triphosphate; Animals; Bradykinin; Brimonidine Tartrate; Canada; Charybdotoxin; Coronary V | 2004 |
Decreased aortic smooth muscle contraction in a rat model of multibacterial sepsis.
Topics: Animals; Aorta; Disease Models, Animal; Endothelial Cells; Enzyme Inhibitors; Guanylate Cyclase; In | 2004 |
Evidence for a role of inducible nitric oxide synthase in gastric relaxation of mdx mice.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Imines; Male; Mice; Mice, Inbred mdx; Muscle Rel | 2006 |
Intrathecal cGMP elicits pressor responses and maintains mean blood pressure during haemorrhage in anaesthetized rats.
Topics: Anesthesia; Animals; Arginine; Blood Pressure; Cyclic GMP; Disease Models, Animal; Dose-Response Rel | 2007 |
Type 1 diabetes and hypercholesterolaemia reveal the contribution of endothelium-derived hyperpolarizing factor to endothelium-dependent relaxation of the rat aorta.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Apamin; Biological Factors; Blood Glucose; Body Weight; Cha | 2008 |
Influence of soluble guanylate cyclase inhibition on inflammation and motility disturbances in DSS-induced colitis.
Topics: Animals; Colitis; Cyclic GMP; Dextran Sulfate; Disease Models, Animal; Enzyme Inhibitors; Guanylate | 2008 |
Role of the NO/cGMP/K(ATP) pathway in the protective effects of sildenafil against ethanol-induced gastric damage in rats.
Topics: Animals; Arginine; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Diazoxide; Disease Mode | 2008 |
Mechanisms that produce nitric oxide-mediated relaxation of cerebral arteries during atherosclerosis.
Topics: Animals; Basilar Artery; Cerebral Arteries; Cholesterol; Diet, Atherogenic; Dinoprost; Disease Model | 2001 |
Dual effect of local application of nitric oxide donors in a model of incision pain in rats.
Topics: Animals; Disease Models, Animal; Diuretics, Osmotic; Dose-Response Relationship, Drug; Enzyme Inhibi | 2002 |